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11. 发明专利

PL1653807T3 Zastosowanie mikronarządów skórnych 未知
公开(公告)号：PL1653807T3
公开(公告)日：2012-10-31
申请号：PL04760621
申请日：2004-04-29
申请人： MEDGENICS INC
发明人： BELLOMO STEPHEN F , LIPPIN ITZHAK , PIVA GUILLERMO ALBERTO , ROSENBERG LIOR , BUKHMAN MORDECHAY , STERN BARUCH S , SHALHEVET DAVID , SHAVITT MENACHEM D , PEARLMAN ANDREW L , NOAM SHANI , ALMON EINAT
IPC分类号： C12N5/071 , A01N63/00 , A61B10/02 , A61B17/28 , A61K48/00 , C12M20060101 , C12N5/00 , C12N5/02

12. 发明专利

AU2010212435A1 Dermal micro organs, methods and apparatuses for producing and using the same 未知
公开(公告)号：AU2010212435A1
公开(公告)日：2010-09-09
申请号：AU2010212435
申请日：2010-08-19
申请人： MEDGENICS INC
发明人： BELLOMO STEPHEN F , LIPPIN ITZHAK , PIVA GUILLERMO ALBERTO , ROSENBERG LIOR , BUKHMAN MORDECHAY , STERN BARUCH S , SHALHEVET DAVID , PEARLMAN ANDREW L , NOAM SHANI , ALMON EINAT , SHAVITT MENACHEM D
IPC分类号： C12N5/02 , A01N63/00 , A01N65/00 , A61B10/02 , A61B17/28 , A61K48/00 , C12M20060101 , C12N5/00
摘要： The present invention is directed to an apparatus for harvesting a dermal micro-organ. In particular, the apparatus comprises a support configuration to support a skin-related tissue structure from which said dermal micro-organ is to be harvested and a cutting tool able to separate said dermal micro-organ from said skin-related tissue structure. The present invention is also directed to a method for harvesting a dermal micro-organ. In particular, the method comprises supporting a skin-related tissue structure from which said dermal micro-organ is harvested and separating said dermal micro-organ from said skin-related tissue structure.

13. 发明专利

CA2523706A1 DERMAL MICRO ORGANS, METHODS AND APPARATUSES FOR PRODUCING AND USING THE SAME 未知
公开(公告)号：CA2523706A1
公开(公告)日：2004-11-18
申请号：CA2523706
申请日：2004-04-29
申请人： MEDGENICS INC
发明人： ROSENBERG LIOR , BUKHMAN MORDECHAY , SHAVITT MENACHEM D , PEARLMAN ANDREW L , SHALHEVET DAVID , STERN BARUCH S , BELLOMO STEPHEN F , PIVA GUILLERMO ALBERTO , LIPPIN ITZHAK
IPC分类号： A01N63/00 , A61B10/02 , A61B17/28 , A61K48/00 , C12M20060101 , C12N5/00 , C12N5/02 , A01N65/00
摘要： Embodiments of the present invention provide Dermal Micro Organs (DMOs), methods and apparatuses for producing the same. Some embodiments of the invention provide a DMO including a plurality of dermal components, which substantially retain the micro-architecture and three dimensional structure of the dermal tissue from which they are derived, having dimensions selected so as to allow passive diffusion of adequate nutrients and gases to cells of th e DMO and diffusion of cellular waste out of the cells so as to minimize cellular toxicity and concomitant death due to insufficient nutrition and accumulation of waste in the DMO. Some embodiments of the invention provide methods and apparatuses for harvesting the DMO. An apparatus for harvesting the DMO may include, according to some exemplary embodiments, a support configuration to support a skin-related tissue structure from which the DMO is to be harvested, and a cutting tool able to separate the DMO from the skin- related tissue structure. Other embodiments are described and claimed.

14. 发明公开

EP1653807A4 DERMAL MICRO ORGANS, METHODS AND APPARATUSES FOR PRODUCING AND USING THE SAME 有权
标题翻译：德米克兰戈内
公开(公告)号：EP1653807A4
公开(公告)日：2009-05-27
申请号：EP04760621
申请日：2004-04-29
申请人： MEDGENICS INC
发明人： BELLOMO STEPHEN F , LIPPIN ITZHAK , PIVA GUILLERMO ALBERTO , ROSENBERG LIOR , BUKHMAN MORDECHAY , STERN BARUCH S , SHALHEVET DAVID , SHAVITT MENACHEM D , PEARLMAN ANDREW L , NOAM SHANI , ALMON EINAT
IPC分类号： A01N63/00 , A01N65/00 , A61B10/02 , A61B17/28 , A61K48/00 , C12M20060101 , C12N5/00 , C12N5/02
CPC分类号： A61B17/3468 , A61B10/0275 , A61B17/32053 , A61B17/322 , A61B2017/0023 , A61B2017/00969 , A61B2017/2808 , A61B2017/320052 , A61B2017/320064 , A61B2017/3225 , A61B2217/005 , A61F2/105 , A61K35/36 , A61K38/1816 , A61K38/193 , A61K38/2066 , A61K38/215 , A61K38/27 , A61K38/28 , A61M5/425 , C12N5/0698 , C12N2502/094 , C12N2502/1323 , C12N2510/00 , Y10T83/929
摘要： The present invention is directed to a dermal micro-organ, wherein said dermal micro-organ is an explant of living tissue consisting essentially of a plurality of dermal components and not including epidermal layers, which retains the micro-architecture and three dimensional structure of the dermal tissue from which it is derived, having dimensions selected so as to allow passive diffusion of adequate nutrients and gases to cells of said dermal micro-organ and diffusion of cellular waste out of said cells so as to minimize cellular toxicity and concomitant death due to insufficient nutrition and accumulation of waste in said Dermal micro-organ, wherein a dimension of length is 5-100 mm.
摘要翻译：本发明涉及真皮微器官，其中所述皮肤微器官是活组织的外植体，其基本上由多个皮肤成分组成，并且不包括表皮层，其保留了微结构和三维结构其衍生的真皮组织，其尺寸被选择为允许足够的营养物和气体被活化地扩散到所述皮肤微器官的细胞并将细胞废物从所述细胞扩散，以使细胞毒性最小化并伴随死亡在所述真皮微器官中营养不良和废物积累不足，其中长度为5-100mm。

16. 发明专利

DK1653807T3 Anvendelse af dermale mikroorganer 未知
公开(公告)号：DK1653807T3
公开(公告)日：2012-09-03
申请号：DK04760621
申请日：2004-04-29
申请人： MEDGENICS INC
发明人： BELLOMO STEPHEN F , LIPPIN ITZHAK , PIVA GUILLERMO ALBERTO , ROSENBERG LIOR , BUKHMAN MORDECHAY , STERN BARUCH S , SHALHEVET DAVID , SHAVITT MENACHEM D , PEARLMAN ANDREW L , NOAM SHANI , ALMON EINAT
IPC分类号： C12N5/071 , A01N63/00 , A61B10/02 , A61B17/28 , A61K48/00 , C12M20060101 , C12N5/00 , C12N5/02

17. 发明专利

SI1653807T1 Uporaba dermalnih mikroorganov 未知
公开(公告)号：SI1653807T1
公开(公告)日：2012-08-31
申请号：SI200431901
申请日：2004-04-29
申请人： MEDGENICS INC
发明人： BELLOMO STEPHEN F , LIPPIN ITZHAK , PIVA GUILLERMO ALBERTO , ROSENBERG LIOR , BUKHMAN MORDECHAY , STERN BARUCH S , SHALHEVET DAVID , SHAVITT MENACHEM D , PEARLMAN ANDREW L , NOAM SHANI , ALMON EINAT
IPC分类号： C12N5/00

18. 发明专利

CY1112988T1 ΧΡΗΣΗ ΔΕΡΜΙΚΩΝ ΜΙΚΡΟΟΡΓΑΝΩΝ 未知
公开(公告)号：CY1112988T1
公开(公告)日：2016-04-13
申请号：CY121100681
申请日：2012-08-01
申请人： MEDGENICS INC
发明人： BELLOMO STEPHEN F , LIPPIN ITZHAK , PIVA GUILLERMO ALBERTO , ROSENBERG LIOR , BUKHMAN MORDECHAY , STERN BARUCH S , SHALHEVET DAVID , SHAVITT MENACHEM D , PEARLMAN ANDREW L , NOAM SHANI , ALMON EINAT
IPC分类号： C12N5/071 , A01N63/00 , A61B10/02 , A61B17/28 , A61K48/00 , C12M20060101 , C12N5/00 , C12N5/02
摘要： Οιενσωματώσειςτηςπαρούσαςεφεύρεσηςπαρέχουνδερμικάμικροόργανα (DΜΟ), μεθόδουςκαιεξοπλισμούςγιατηνπαραγωγήτους. Μερικέςενσωματώσειςτηςεφεύρεσηςπαρέχουνένα DΜΟπουπεριλαμβάνειπληθώραδερμικώνεξαρτημάτων, πουδιατηρούνουσιαστικάτημικροαρχιτεκτονικήκαιτηντρισδιάστατηδομήτουδερμικούιστούαπότονοποίοπροέρχονται, έχονταςδιαστάσειςεπιλεγμένεςώστενακαθίσταταιδυνατήη παθητικήδιάχυσηεπαρκώνθρεπτικώνουσιώνκαιαερίωνστακύτταρατου DΜΟκαιη διάχυσητωνκυτταρικώναποβλήτωνέξωαπότακύτταραώστεναελαχιστοποιείταιη κυτταρικήτοξικότητακαιο συνακόλουθοςθάνατοςλόγωανεπαρκούςθρέψηςκαισυσσώρευσηςαποβλήτωνστο DΜΟ. Μερικέςενσωματώσειςτηςεφεύρεσηςπαρέχουνμεθόδουςκαιεξοπλισμούςγιατησυγκομιδήτου DΜΟ. Έναεξοπλισμόςγιατησυγκομιδήτου DΜΟμπορείναπεριλαμβάνει, σύμφωναμεμερικέςενσωματώσειςπαραδείγματα, μιαδιάταξηυποστήριξηςγιαυποστήριξημιαςσυγγενούςμετοδέρμαδομήςιστούαπότηνοποίαπρόκειταινασυγκομιστείτο DΜΟκαιένακοπτικόεργαλείοικανόναδιαχωρίσειτο DΜΟαπότησυγγενήμετοδέρμαδομήιστού. Περιγράφονταικαιαξιώνονταιάλλεςενσωματώσεις.

19. 发明专利

HRP20120673T1 UPORABA DERMALNIH MIKROORGANA 未知
公开(公告)号：HRP20120673T1
公开(公告)日：2012-10-31
申请号：HRP20120673
申请日：2012-08-23
申请人： MEDGENICS INC
发明人： BELLOMO STEPHEN F , LIPPIN ITZHAK , PIVA GUILLERMO ALBERTO , ROSENBERG LIOR , BUKHMAN MORDECHAY , STERN BARUCH S , SHALHEVET DAVID , SHAVITT MENACHEM D , PEARLMAN ANDREW L , NOAM SHANI , ALMON EINAT
IPC分类号： C12N5/071 , A01N63/00 , A61B10/02 , A61B17/28 , A61K48/00 , C12M20060101 , C12N5/00 , C12N5/02

20. 发明专利

AU2004236678B2 Dermal micro organs, methods and apparatuses for producing and using the same 未知
公开(公告)号：AU2004236678B2
公开(公告)日：2010-05-20
申请号：AU2004236678
申请日：2004-04-29
申请人： MEDGENICS INC
发明人： SHAVITT MENACHEM D , BELLOMO STEPHEN F , ROSENBERG LIOR , STERN BARUCH S , PEARLMAN ANDREW L , NOAM SHANI , LIPPIN ITZHAK , SHALHEVET DAVID , BUKHMAN MORDECHAY , PIVA GUILLERMO ALBERTO , ALMON EINAT
IPC分类号： C12N5/02 , A01N63/00 , A01N65/00 , A61B10/02 , A61B17/28 , A61K48/00 , C12M20060101 , C12N5/00
摘要： The present invention is directed to an apparatus for harvesting a dermal micro-organ. In particular, the apparatus comprises a support configuration to support a skin-related tissue structure from which said dermal micro-organ is to be harvested and a cutting tool able to separate said dermal micro-organ from said skin-related tissue structure. The present invention is also directed to a method for harvesting a dermal micro-organ. In particular, the method comprises supporting a skin-related tissue structure from which said dermal micro-organ is harvested and separating said dermal micro-organ from said skin-related tissue structure.

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