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11. 发明授权

US08206966B2 Alpha-amylase variants with altered properties 有权
标题翻译：具有改变性质的α-淀粉酶变体
公开(公告)号：US08206966B2
公开(公告)日：2012-06-26
申请号：US12263886
申请日：2008-11-03
申请人： Luis G. Cascāo-Pereira , James T. Kellis, Jr. , Bradley A. Paulson , Scott D. Power , Sandra W. Ramer , Vivek Sharma , Andrew Shaw , Jayarama K. Shetty , Donald E. Ward
发明人： Luis G. Cascāo-Pereira , James T. Kellis, Jr. , Bradley A. Paulson , Scott D. Power , Sandra W. Ramer , Vivek Sharma , Andrew Shaw , Jayarama K. Shetty , Donald E. Ward
IPC分类号： C12N9/26 , C12N9/28 , C12N9/14 , C12N9/16 , C12N1/20 , C12N15/00 , C12P19/14 , C12P21/06 , C12P19/34 , C07H21/04 , C12C11/00 , A21D2/16 , C07K1/00
CPC分类号： C11D3/38681 , C11D3/386 , C12N9/2417 , D06M16/003
摘要： Disclosed are compositions comprising variants of alpha-amylase that have alpha-amylase activity and which exhibit altered properties relative to a parent AmyS-like alpha-amylase from which they are derived. The compositions comprise an additional enzyme such as a phytase. Also disclosed are methods of using the compositions, and kits related thereto.
摘要翻译：公开了包含α-淀粉酶变体的组合物，其具有α-淀粉酶活性，并且相对于其来源的亲本AmyS样α-淀粉酶表现出改变的性质。组合物包含另外的酶如植酸酶。还公开了使用组合物的方法和与其相关的试剂盒。

12. 发明授权

US06297037B1 Oxidatively stable alpha-amylase 失效
标题翻译：氧化稳定的α-淀粉酶
公开(公告)号：US06297037B1
公开(公告)日：2001-10-02
申请号：US08194664
申请日：1994-02-10
申请人： Christopher C. Barnett , Colin Mitchinson , Scott D. Power , Carol A. Requadt
发明人： Christopher C. Barnett , Colin Mitchinson , Scott D. Power , Carol A. Requadt
IPC分类号： C12N928
CPC分类号： C12N9/2417 , C11D3/386 , C12N15/75 , C12P19/14
摘要： Novel alpha-amylase mutants derived from the DNA sequences of naturally occurring or recombinant alpha-amylases are disclosed. The mutant alpha-amylases, in general, are obtained by in vitro modifications of a precursor DNA sequence encoding the naturally occurring or recombinant alpha-amylase to generate the substitution (replacement) or deletion of one or more oxidizable amino acid residues in the amino acid sequence of a precursor alpha-amylase. Such mutant alpha-amylases have altered oxidative stability and/or altered pH performance profiles and/or altered thermal stability as compared to the precursor. Also disclosed are detergent and starch liquefaction compositions comprising the mutant amylases, as well as methods of using the mutant amylases.
摘要翻译：公开了衍生自天然存在或重组α-淀粉酶的DNA序列的新型α-淀粉酶突变体。通常，通过体外修饰编码天然存在或重组α-淀粉酶的前体DNA序列以产生氨基酸中一个或多个可氧化氨基酸残基的取代（置换）或缺失，获得突变体α-淀粉酶前体α-淀粉酶的序列。与前体相比，这种突变型α-淀粉酶具有改变的氧化稳定性和/或改变的pH性能特征和/或改变的热稳定性。还公开了包含突变淀粉酶的洗涤剂和淀粉液化组合物，以及使用突变淀粉酶的方法。

13. 发明授权

US5824532A Oxidativley stable alpha-amylase 失效
标题翻译： Oxidativley稳定的α-淀粉酶
公开(公告)号：US5824532A
公开(公告)日：1998-10-20
申请号：US468220
申请日：1995-06-06
申请人： Christopher C. Barnett , Colin Mitchinson , Scott D. Power , Carol A. Requadt
发明人： Christopher C. Barnett , Colin Mitchinson , Scott D. Power , Carol A. Requadt
IPC分类号： C12N15/09 , C11D3/386 , C12N1/21 , C12N5/10 , C12N9/26 , C12N9/28 , C12N15/56 , C12N15/75 , C12P19/14 , C12N15/63
CPC分类号： C12N9/2417 , C11D3/386 , C12N15/75 , C12P19/14
摘要： Novel alpha-amylase mutants derived from the DNA sequences of naturally occurring or recombinant alpha-amylases are disclosed. The mutant alpha-amylases, in general, are obtained by in vitro modifications of a precursor DNA sequence encoding the naturally occurring or recombinant alpha-amylase to generate the substitution (replacement) or deletion of one or more oxidizable amino acid residues in the amino acid sequence of a precursor alpha-amylase. Such mutant alpha-amylases have altered oxidative stability and/or altered pH performance profiles and/or altered thermal stability as compared to the precursor. Also disclosed are detergent and starch liquefaction compositions comprising the mutant amylases, as well as methods of using the mutant amylases.
摘要翻译：公开了衍生自天然存在或重组α-淀粉酶的DNA序列的新型α-淀粉酶突变体。通常，通过体外修饰编码天然存在或重组α-淀粉酶的前体DNA序列以产生氨基酸中一个或多个可氧化氨基酸残基的取代（置换）或缺失，获得突变体α-淀粉酶前体α-淀粉酶的序列。与前体相比，这种突变型α-淀粉酶具有改变的氧化稳定性和/或改变的pH性能特征和/或改变的热稳定性。还公开了包含突变淀粉酶的洗涤剂和淀粉液化组合物，以及使用突变淀粉酶的方法。

14. 发明授权

US5849549A Oxidatively stable alpha-amylase 失效
标题翻译：氧化稳定的α-淀粉酶
公开(公告)号：US5849549A
公开(公告)日：1998-12-15
申请号：US468698
申请日：1995-06-06
申请人： Christopher C. Barnett , Leif P. Solheim , Colin Mitchinson , Scott D. Power , Carol A. Requadt
发明人： Christopher C. Barnett , Leif P. Solheim , Colin Mitchinson , Scott D. Power , Carol A. Requadt
IPC分类号： C12N15/09 , C11D3/386 , C12N1/21 , C12N5/10 , C12N9/26 , C12N9/28 , C12N15/56 , C12N15/75 , C12P19/14
CPC分类号： C12N9/2417 , C11D3/386 , C12N15/75 , C12P19/14
摘要： Novel alpha-amylase mutants derived from the DNA sequences of naturally occurring or recombinant alpha-amylases are disclosed. The mutant alpha-amylases, in general, are obtained by in vitro modifications of a precursor DNA sequence encoding the naturally occurring or recombinant alpha-amylase to generate the substitution (replacement) or deletion of one or more oxidizable amino acid residues in the amino acid sequence of a precursor alpha-amylase. Such mutant alpha-amylases have altered oxidative stability and/or altered pH performance profiles and/or altered thermal stability as compared to the precursor. Also disclosed are detergent and starch liquefaction compositions comprising the mutant amylases, as well as methods of using the mutant amylases.
摘要翻译：公开了衍生自天然存在或重组α-淀粉酶的DNA序列的新型α-淀粉酶突变体。通常，通过体外修饰编码天然存在或重组α-淀粉酶的前体DNA序列以产生氨基酸中一个或多个可氧化氨基酸残基的取代（置换）或缺失，获得突变体α-淀粉酶前体α-淀粉酶的序列。与前体相比，这种突变型α-淀粉酶具有改变的氧化稳定性和/或改变的pH性能特征和/或改变的热稳定性。还公开了包含突变淀粉酶的洗涤剂和淀粉液化组合物，以及使用突变淀粉酶的方法。

15. 发明申请

US20080299622A1 Starch Hydrolysis Using Phytase with an Alpha Amylase 审中-公开
标题翻译：使用植酸酶与α淀粉酶进行淀粉水解
公开(公告)号：US20080299622A1
公开(公告)日：2008-12-04
申请号：US12027104
申请日：2008-02-06
申请人： Bradley A. Paulson , Scott D. Power , Sandra W. Ramer , Jayarama K. Shetty , Donald E. Ward
发明人： Bradley A. Paulson , Scott D. Power , Sandra W. Ramer , Jayarama K. Shetty , Donald E. Ward
IPC分类号： C12P19/14 , C12N9/16 , C12P7/14
CPC分类号： C12N9/16 , C12N9/242 , C12P7/06 , C12P19/14 , Y02E50/17
摘要： The present invention relates to a method for liquefying starch comprising contacting a slurry of a starch substrate with an enzyme composition comprising a phytase and an alpha amylase. The invention also relates to an enzyme mixture comprising a phytase derived from Buttiauxella sp. and variants thereof and an alpha amylase.
摘要翻译：本发明涉及一种用于液化淀粉的方法，包括使淀粉底物的浆液与包含植酸酶和α淀粉酶的酶组合物接触。本发明还涉及包含源自Buttiauxella sp。的植酸酶的酶混合物。及其变体和α淀粉酶。

16. 发明授权

US08394941B2 Modified variant Bowman Birk Protease Inhibitors 有权
标题翻译：改良型Bowman Birk蛋白酶抑制剂
公开(公告)号：US08394941B2
公开(公告)日：2013-03-12
申请号：US13082979
申请日：2011-04-08
申请人： Neelam S. Amin , Katherine D. Collier , Melodie Estabrook , David A. Estell , Bryan P. Fox , Scott D. Power , Brian F. Schmidt , Gudrun Vogtentanz
发明人： Neelam S. Amin , Katherine D. Collier , Melodie Estabrook , David A. Estell , Bryan P. Fox , Scott D. Power , Brian F. Schmidt , Gudrun Vogtentanz
IPC分类号： C12N15/00
CPC分类号： C07K14/811 , A61K8/64 , A61Q7/02
摘要： The present invention relates to modified variant Bowman Birk Protease Inhibitor proteins (BBPIs) that comprise peptides that bind target proteins, and that are further modified to have greater protease inhibitory activity and/or be produced at greater yields than the unmodified BBPIs. The invention encompasses polynucleotide constructs and expression vectors containing polynucleotide sequences that encode the modified variant BBPIs, the transformed host cells that express and produce the modified variant BBPIs, the modified variant BBPI proteins, the compositions comprising the modified variant BBPIs, and the methods for making and using the modified variant BBPIs in personal care.
摘要翻译：本发明涉及包含结合靶蛋白的肽的修饰变体Bowman Birk蛋白酶抑制剂蛋白（BBPI），并且被进一步修饰以具有比未修饰的BBPI更大的蛋白酶抑制活性和/或以更高的产量产生。本发明包括多核苷酸构建体和含有编码修饰变体BBPI的多核苷酸序列的表达载体，表达和产生修饰变体BBPI的转化宿主细胞，修饰变体BBPI蛋白，包含修饰变体BBPI的组合物和制备方法并在个人护理中使用修改后的变体BBPI。

17. 发明申请

US20120014885A1 Personal Care Compositions and Methods for Their Use 有权
标题翻译：个人护理组合及其使用方法
公开(公告)号：US20120014885A1
公开(公告)日：2012-01-19
申请号：US11919717
申请日：2006-04-25
申请人： Katherine D. Collier , Anthony Day , Hans de Nobel , David A. Estell , Grant C. Ganshaw , Marc Kolkman , Raj Lad , Jeffrey V. Miller , Christopher J. Murray , Scott D. Power , Brian Schmidt , Anita Van Kimmenade , Gudrun Vogtentanz
发明人： Katherine D. Collier , Anthony Day , Hans de Nobel , David A. Estell , Grant C. Ganshaw , Marc Kolkman , Raj Lad , Jeffrey V. Miller , Christopher J. Murray , Scott D. Power , Brian Schmidt , Anita Van Kimmenade , Gudrun Vogtentanz
IPC分类号： A61K8/64 , A61Q17/04 , A61Q5/00 , A61Q1/02 , A61Q19/10 , A61Q1/10 , A61K38/08 , A61K38/16 , A61Q7/02 , C07K19/00 , A61Q15/00 , A61Q1/06
CPC分类号： A61K8/64 , A61K8/66 , A61Q1/02 , A61Q1/04 , A61Q1/10 , A61Q7/02 , A61Q9/00 , A61Q15/00 , A61Q17/04 , A61Q19/00 , A61Q19/02 , A61Q19/04 , A61Q19/10 , C07K7/06
摘要： The present invention provides peptides and supported peptides for treating various diseases and conditions. In particularly preferred embodiments, the present invention provides compositions and methods for personal care. In some embodiments, the present invention provides compositions for use in skin and/or hair care, as well as cosmetic compositions. In alternative particularly preferred embodiments, the present invention provides peptides and supported peptides for treating diseases of the skin, such as rosacea. In some particularly preferred embodiments, the supported peptides of the present invention are anti-VEGF peptides. In alternative particularly preferred embodiments, the anti-VEGF peptides are expressed on a scaffold protein. In some most preferred embodiments, the scaffold protein comprises BBI.
摘要翻译：本发明提供用于治疗各种疾病和病症的肽和负载肽。在特别优选的实施方案中，本发明提供用于个人护理的组合物和方法。在一些实施方案中，本发明提供用于皮肤和/或头发护理以及化妆品组合物的组合物。在替代的特别优选的实施方案中，本发明提供用于治疗皮肤疾病的肽和负载的肽，例如红斑痤疮。在一些特别优选的实施方案中，本发明的负载型肽是抗VEGF肽。在替代的特别优选的实施方案中，抗VEGF肽在支架蛋白上表达。在一些最优选的实施方案中，支架蛋白包含BBI。

18. 发明申请

US20100221780A1 Modified Variant Bowman Birk Protease Inhibitors 有权
标题翻译：改良变体Bowman Birk蛋白酶抑制剂
公开(公告)号：US20100221780A1
公开(公告)日：2010-09-02
申请号：US12779793
申请日：2010-05-13
申请人： Neelam S. Amin , Katherine D. Collier , Melodie Estabrook , David A. Estell , Bryan P. Fox , Scott D. Power , Brian F. Schmidt , Gudrun Vogtentanz
发明人： Neelam S. Amin , Katherine D. Collier , Melodie Estabrook , David A. Estell , Bryan P. Fox , Scott D. Power , Brian F. Schmidt , Gudrun Vogtentanz
IPC分类号： C12P21/00
CPC分类号： C07K14/811 , A61K8/64 , A61Q7/02
摘要： The present invention relates to modified variant Bowman Birk Protease Inhibitor proteins (BBPIs) that comprise peptides that bind target proteins, and that are further modified to have greater protease inhibitory activity and/or be produced at greater yields than the unmodified BBPIs. The invention encompasses polynucleotide constructs and expression vectors containing polynucleotide sequences that encode the modified variant BBPIs, the transformed host cells that express and produce the modified variant BBPIs, the modified variant BBPI proteins, the compositions comprising the modified variant BBPIs, and the methods for making and using the modified variant BBPIs in personal care.
摘要翻译：本发明涉及包含结合靶蛋白的肽的修饰变体Bowman Birk蛋白酶抑制剂蛋白（BBPI），并且被进一步修饰以具有比未修饰的BBPI更大的蛋白酶抑制活性和/或以更高的产量产生。本发明包括多核苷酸构建体和含有编码修饰变体BBPI的多核苷酸序列的表达载体，表达和产生修饰变体BBPI的转化宿主细胞，修饰变体BBPI蛋白，包含修饰变体BBPI的组合物和制备方法并在个人护理中使用修改后的变体BBPI。

19. 发明授权

US07524816B2 Peptides and supported peptides for treating skin diseases 有权
标题翻译：用于治疗皮肤疾病的肽和支持的肽
公开(公告)号：US07524816B2
公开(公告)日：2009-04-28
申请号：US10984270
申请日：2004-11-08
申请人： Anthony G. Day , David A. Estell , Christopher J. Murray , Scott D. Power
发明人： Anthony G. Day , David A. Estell , Christopher J. Murray , Scott D. Power
IPC分类号： A61K38/16
CPC分类号： C07K14/81 , A61K38/00 , C07K7/06 , C07K14/811 , C07K2319/00 , C12N15/62
摘要： The present invention provides peptides and supported peptides for treating proliferative diseases. In particularly preferred embodiments, the present invention provides peptides and supported peptides for treating diseases of the skin, such as rosacea. In some particularly preferred embodiments, the supported peptides of the present invention are anti-VEGF peptides. In alternative particularly preferred embodiments, the anti-VEGF peptides are expressed on a scaffold protein. In some most preferred embodiments, the scaffold proteins is BBI.
摘要翻译：本发明提供用于治疗增殖性疾病的肽和负载肽。在特别优选的实施方案中，本发明提供用于治疗皮肤疾病的肽和负载肽，例如红斑痤疮。在一些特别优选的实施方案中，本发明的负载型肽是抗VEGF肽。在替代的特别优选的实施方案中，抗VEGF肽在支架蛋白上表达。在一些最优选的实施方案中，支架蛋白是BBI。

20. 发明申请

US20080131932A1 EXPRESSION IN FILAMENTOUS FUNGI OF PROTEASE INHIBITORS AND VARIANTS THEREOF 有权
公开(公告)号：US20080131932A1
公开(公告)日：2008-06-05
申请号：US11848213
申请日：2007-08-30
申请人： Hans De Nobel , David A. Estell , Wei Liu , Scott D. Power , Brian Schmidt , Huaming Wang
发明人： Hans De Nobel , David A. Estell , Wei Liu , Scott D. Power , Brian Schmidt , Huaming Wang
IPC分类号： C07H21/04 , C12P1/00 , C12N15/00 , C12N15/74 , C12N5/02 , C12P21/04
CPC分类号： C12N15/80 , C07K14/811
摘要： Described herein are protease inhibitors, variants thereof and methods for their production.

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