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11. 发明授权

US06254839B1 Apparatus for converting hydrocarbon fuel into hydrogen gas and carbon dioxide 有权
标题翻译：将烃燃料转化为氢气和二氧化碳的设备
公开(公告)号：US06254839B1
公开(公告)日：2001-07-03
申请号：US09185393
申请日：1998-11-03
申请人： Lawrence G. Clawson , William L. Mitchell , Jeffrey M. Bentley , Johannes H. J. Thijssen
发明人： Lawrence G. Clawson , William L. Mitchell , Jeffrey M. Bentley , Johannes H. J. Thijssen
IPC分类号： B01J804
CPC分类号： H01M8/0631 , B01J8/0278 , B01J8/0285 , B01J8/0465 , B01J8/0469 , B01J8/048 , B01J8/0492 , B01J8/0496 , B01J2208/00203 , B01J2208/0053 , B01J2208/00849 , C01B3/382 , C01B3/384 , C01B3/48 , C01B2203/0233 , C01B2203/0244 , C01B2203/0261 , C01B2203/0283 , C01B2203/0288 , C01B2203/0455 , C01B2203/0465 , C01B2203/0485 , C01B2203/0844 , C01B2203/0877 , C01B2203/0883 , C01B2203/1041 , C01B2203/1047 , C01B2203/1052 , C01B2203/1064 , C01B2203/1076 , C01B2203/1205 , C01B2203/1223 , C01B2203/1229 , C01B2203/1241 , C01B2203/1247 , C01B2203/1258 , C01B2203/1276 , C01B2203/141 , C01B2203/142 , C01B2203/80 , C01B2203/82 , H01M8/0612 , H01M2250/20 , Y02T90/32
摘要： A hydrocarbon fuel reformer (200) is disclosed suitable for producing synthesis hydrogen gas from reactions with hydrocarbons fuels, oxygen, and steam. The reformer (200) comprises first and second tubes (208,218). The first tube (208) includes a first catalyst (214) and receives a first mixture of steam and a first fuel. The second tube (218) is annularly disposed about the first tube (208) and receives a second mixture of an oxygen-containing gas and a second fuel. In one embodiment, a third tube (224) is annularly disposed about the second tube (218) and receives a first reaction reformate from the first tube (208) and a second reaction reformate from the second tube (218). A catalyst reforming zone (260) annularly disposed about the third tube (224) may be provided to subject reformate constituents to a shift reaction. In another embodiment, a fractionator is provided to distill first and second fuels from a fuel supply source.
摘要翻译：公开了一种烃燃料重整器（200），其适用于通过与烃燃料，氧气和蒸汽的反应产生合成氢气。重整器（200）包括第一和第二管（208,218）。第一管（208）包括第一催化剂（214）并且接收蒸汽和第一燃料的第一混合物。第二管（218）环绕第一管（208）设置并接收含氧气体和第二燃料的第二混合物。在一个实施例中，第三管（224）围绕第二管（218）环形设置，并且从第一管（208）接收第一反应重整产物，并从第二管（218）接收第二反应重整产物。可以提供围绕第三管（224）环形设置的催化剂重整区（260），以使重整产物成分转化为转化反应。在另一个实施例中，提供分馏器以从燃料供应源蒸馏第一和第二燃料。

12. 发明授权

US5109023A Phenethanolamine derivatives 失效
公开(公告)号：US5109023A
公开(公告)日：1992-04-28
申请号：US622505
申请日：1990-12-05
申请人： William L. Mitchell , Ian F. Skidmore , Lawrence H. C. Lunts , Harry Finch , Alan Naylor , David Hartley
发明人： William L. Mitchell , Ian F. Skidmore , Lawrence H. C. Lunts , Harry Finch , Alan Naylor , David Hartley
IPC分类号： C07C307/10 , C07C65/11 , C07C217/08 , C07C231/12 , C07C233/43 , C07C275/34 , C07C311/08 , C07C323/12 , C07C323/16 , C07C323/25
CPC分类号： C07C65/11 , Y10S514/819 , Y10S514/826 , Y10S514/886 , Y10S514/887 , Y10S514/913 , Y10S514/925 , Y10S514/927
摘要： The invention provides a method of treatment of diseases associated with reversible airways obstruction such as asthma and chronic bronchitis, utilizing the compounds of the formula ##STR1## or a physiological acceptable salt or solvate thereof, wherein Q represents a 1- or 2- naphthalenyl group.

13. 发明授权

US5283262A Phenethanolamine derivatives 失效
标题翻译：苯乙醇胺衍生物
公开(公告)号：US5283262A
公开(公告)日：1994-02-01
申请号：US812757
申请日：1991-12-23
申请人： William L. Mitchell , Ian F. Skidmore , Lawrence H. C. Lunts , Harry Finch , Alan Naylor , David Hartley
发明人： William L. Mitchell , Ian F. Skidmore , Lawrence H. C. Lunts , Harry Finch , Alan Naylor , David Hartley
IPC分类号： C07C307/10 , C07C65/11 , C07C217/08 , C07C231/12 , C07C233/43 , C07C275/34 , C07C311/08 , C07C323/12 , C07C323/16 , C07C323/25 , A61K31/135
CPC分类号： C07C65/11 , Y10S514/819 , Y10S514/826 , Y10S514/886 , Y10S514/887 , Y10S514/913 , Y10S514/925 , Y10S514/927
摘要： The invention provides compounds of the general formula (I) ##STR1## or a physiologically acceptable salt or solvate thereof, wherein Q represents a 1- or 2-naphthalenyl group.The compounds have a stimulant action at .beta..sub.2 -adrenoreceptors and may be used in the treatment of diseases associated with reversible airways obstruction such as asthma and chronic bronchitis.
摘要翻译：本发明提供通式（I）的化合物或其生理学上可接受的盐或溶剂化物，其中Q表示1-或2-萘基。化合物在β2肾上腺素受体具有刺激作用，可用于治疗与可逆气道阻塞如哮喘和慢性支气管炎相关的疾病。

14. 发明授权

US5202343A Tricyclic ketones useful as HT.sub.3 -receptor antagonists 失效
标题翻译： TRICYCLIC KETONES有用作为HT3受体拮抗剂
公开(公告)号：US5202343A
公开(公告)日：1993-04-13
申请号：US887607
申请日：1992-05-22
申请人： Ian H. Coates , John Bradshaw , James A. Bell , David C. Humber , George B. Ewan , William L. Mitchell , Barry J. Price
发明人： Ian H. Coates , John Bradshaw , James A. Bell , David C. Humber , George B. Ewan , William L. Mitchell , Barry J. Price
IPC分类号： C07D403/06
CPC分类号： C07D403/06
摘要： The invention relates to compounds of the general formula (I): ##STR1## wherein Im represents an imidazolyl group of the formula: ##STR2## R.sup.1 represents a hydrogen atom or a group selected from C.sub.1-6 alkyl, C.sub.3-6 alkenyl, C.sub.3-10 alkynyl, C.sub.3-7 cycloalkyl, C.sub.3-7 cycloalkylC.sub.1-4 alkyl, phenyl, phenylC.sub.1-3 alkyl, --CO.sub.2 R.sup.5, --COR.sup.5, --CONR.sup.5 R.sup.6 or --SO.sub.2 R.sup.5 ;R.sup.5 and R.sup.6, which may be the same or different, each represents a hydrogen atom, a C.sub.1-6 alkyl or C.sub.3-7 cycloalkyl group, or a phenyl or phenylC.sub.1-4 alkyl group, in which the phenyl group is optionally substituted by one or more C.sub.1-4 alkyl, C.sub.1-4 alkoxy or hydroxy groups or halogen atoms, with the proviso that R.sup.5 does not represent a hydrogen atom when R.sup.1 represents a group --CO.sub.2 R.sup.5 or --SO.sub.2 R.sup.5 ;one of the groups represented by R.sup.2, R.sup.3 and R.sup.4 is a hydrogen atom or a C.sub.1-6 alkyl, C.sub.3-7 cycloalkyl, C.sub.3-6 alkenyl, phenyl or phenylC.sub.1-3 alkyl group, and each of the other two groups, which may be the same or different, represents a hydrogen atom or a C.sub.1-6 alkyl group;Q represents a hydrogen or a halogen atom, or a hydroxy, C.sub.1-4 alkoxy, phenylC.sub.1-3 alkoxy or C.sub.1-6 alkyl group or a group --NR.sup.7 R.sup.8 or --CONR.sup.7 R.sup.8 ;R.sup.7 and R.sup.8, which may be the same or different, each represents a hydrogen atom or a C.sub.1-4 alkyl or C.sub.3-4 alkenyl group, or together with the nitrogen atom to which they are attached form a saturated 5 to 7 membered ring;n represents 1, 2 or 3; andA-B represents the group CH--CH.sub.2 or C.dbd.CH; and physiologically acceptable salts and solvates thereof.The compounds are potent and selective antagonists of the effect of 5-HT at 5-HT.sub.3 receptors and are useful, for example, in the treatment of psychotic disorders, anxiety, and nausea and vomiting.
摘要翻译：本发明涉及通式（I）的化合物：其中Im表示下式的咪唑基：R1表示氢原子或选自C1-6烷基，C3-6烯基， C 3-10炔基，C 3-7环烷基，C 3-7环烷基C 1-4烷基，苯基，苯基C 1-3烷基，-CO 2 R 5，-COR 5，-CONR 5 R 6或-SO 2 R 5; R 5和R 6可以相同或不同，表示氢原子，C 1-6烷基或C 3-7环烷基或苯基或苯基C 1-4烷基，其中苯基任选被一个或多个C 1 -4-烷基，C 1-4烷氧基或羟基或卤素原子，条件是当R 1表示-CO 2 R 5或-SO 2 R 5基团时，R 5不表示氢原子; 由R 2，R 3和R 4表示的基团之一是氢原子或C 1-6烷基，C 3-7环烷基，C 3-6烯基，苯基或苯基C 1-3烷基，其它两个基团可以相同或不同的是氢原子或C1-6烷基; Q表示氢或卤素原子，或羟基，C 1-4烷氧基，苯基C 1-3烷氧基或C 1-6烷基或基团-NR 7 R 8或-CONR 7 R 8; R 7和R 8可以相同或不同，各自表示氢原子或C 1-4烷基或C 3-4烯基，或与它们所连接的氮原子一起形成饱和的5至7元环; n表示1,2或3; A-B表示基团CH-CH 2或C = CH; 及其生理上可接受的盐和溶剂合物。这些化合物是5-HT在5-HT 3受体上的作用的有效和选择性拮抗剂，可用于治疗精神病，焦虑和恶心和呕吐。

15. 发明授权

US5045545A [(Imidazol-4(and 5)-yl)methyl] tetracyclic ketones having 5-HT.sub.3 antagonist activity 失效
标题翻译：具有5-HT 3拮抗活性的[（咪唑-4（和5） - 基）甲基]四环酮
公开(公告)号：US5045545A
公开(公告)日：1991-09-03
申请号：US357183
申请日：1989-05-26
申请人： David E. Bays , Ian H. Coates , John Bradshaw , William L. Mitchell
发明人： David E. Bays , Ian H. Coates , John Bradshaw , William L. Mitchell
IPC分类号： A61K31/415 , A61K31/435 , A61K31/505 , A61K31/535 , A61K31/55 , A61P43/00 , C07D471/06 , C07D487/06 , C07D498/06 , C07D513/06
CPC分类号： C07D471/06 , C07D487/06
摘要： The invention relates to tetracyclic ketones of the general formula (I) ##STR1## wherein n represents 1, 2 or 3;Im represents an imidazolyl group of the formula: ##STR2## wherein one of the groups represented by R.sup.1, R.sup.2 and R.sup.3 is a hydrogen atom or a C.sub.1-6 alkyl, C.sub.3 -7cycloalkyl, C.sub.3-6 alkenyl, phenyl or phenylC.sub.1-3 alkyl group, and each of the other two groups, which may be the same or different, represents a hydrogen atom or a C.sub.1-6 alkyl group;Y represents a group --(CH.sub.2)m--, where m represents 2, 3 or 4, or a group --X(CH.sub.2).sub.p --, where p represents 2 or 3, X represents an oxygen or a sulphur atom or a group NR.sup.4, where R.sup.4 is a C.sub.1-6 alkyl group, and X is attached to the benzene ring moiety of the molecule;and physiologically acceptable salts and solvates thereof.The compounds are potent and selective antagonists of the effect of 5-HT at 5-HT.sub.3 receptors and are useful, for example, in the treatment of psychotic disorders, anxiety, and nausea and vomiting.

16. 发明授权

US4950681A Ketone derivatives 失效
标题翻译：酮衍生物
公开(公告)号：US4950681A
公开(公告)日：1990-08-21
申请号：US239750
申请日：1988-09-02
申请人： David J. Cavalla , William L. Mitchell
发明人： David J. Cavalla , William L. Mitchell
IPC分类号： A61K31/415 , A61P25/00 , C07D403/06
CPC分类号： C07D403/06
摘要： The invention relates to ketones of the general formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom or a group selected from C.sub.1-6 alkyl, C.sub.3-6 alkenyl, C.sub.3-10 alkynyl, C.sub.3-7 cycloalkyl, C.sub.3-7 cycloalkylC.sub.1-4 alkyl, phenyl, phenylC.sub.1-3 alkyl, --CO.sub.2 R.sup.8, --COR.sup.8, --CONR.sup.8 R.sup.9 or --SO.sub.2 R.sup.8 (wherein R.sup.8 and R.sup.9, which may be the same or different, each represents a hydrogen atom, a C.sub.1-6 alkyl or C.sub.3-7 cycloalkyl group, or a phenyl or phenylC.sub.1-4 alkyl group, in which the phenyl group is optionally substituted by one or more C.sub.1-4 -alkyl, C.sub.1-4 alkoxy or hydroxy groups or halogen atoms, with the proviso that R.sup.8 does not represent a hydrogen atom when R.sup.1 represents a group --CO.sub.2 R.sup.8 or --SO.sub.2 R.sup.8);R.sup.2 represents a hydrogen atom or a C.sub.1-6 alkyl, C.sub.3-6 alkenyl, C.sub.3-7 cycloalkyl, phenyl or phenylC.sub.1-3 alkyl group;R.sup.3 and R.sup.4, which may be the same or different, each represents a hydrogen atom or a C.sub.1-6 alkyl group; or R.sup.2 and R.sup.3 may together represent an alkylene chain -(CH.sub.2).sub.n --, where n represents 1, 2 or 3;one of the groups represented by R.sup.5, R.sup.6 and R.sup.7 is a hydrogen atom or a C.sub.1-6 alkyl, C.sub.3-7 cycloalkyl, C.sub.3-6 alkenyl, phenyl or phenylC.sub.1-3 alkyl group, and each of the other two groups, which may be the same or different, represents a hydrogen atom or a C.sub.1-6 alkyl group;Q represents a hydrogen atom or a halogen atom or a hydroxy, C.sub.1-4 alkoxy, phenylC.sub.1-3 alkoxy or C.sub.1-6 alkyl group or a group --NR.sup.10 R.sup.11 or --CONR.sup.10 R.sup.11 (wherein R.sup.10 and R.sup.11, which may be the same or different, each represents a hydrogen atom or a C.sub.1-4 alkyl or C.sub.3-4 alkenyl group, or together with the nitrogen atom to which they are attached form a saturated 5 to 7 membered ring);and physiologically acceptable salts and solvates thereof.The compounds are potent and selective antagonists of the effect of 5-HT and 5-HT.sub.3 receptors and are useful, for example, in the treatment of psychotic disorders, anxiety, and nausea and vomiting.

17. 发明授权

US4822881A Tetrahydro carbazolone intermediates 失效
标题翻译：四氢咔唑酮中间体
公开(公告)号：US4822881A
公开(公告)日：1989-04-18
申请号：US126202
申请日：1987-11-27
申请人： Ian H. Coates , John Bradshaw , James A. Bell , David C. Humber , George B. Ewan , William L. Mitchell
发明人： Ian H. Coates , John Bradshaw , James A. Bell , David C. Humber , George B. Ewan , William L. Mitchell
IPC分类号： A61K31/415 , C07D403/06
CPC分类号： C07D403/06
摘要： The invention relates to compounds of the general formula (I): ##STR1## wherein Im represents an imidazolyl group of the formula: ##STR2## and the various substituents are defined hereinbelow. The compounds are potent and selective antagonists of the effect of 5-HT at 5-HT.sub.3 receptors and are useful, for example, in the treatment of psychotic disorders, anxiety, and nausea and vomiting.
摘要翻译：本发明涉及通式（I）的化合物：其中Im表示下式的咪唑基：其中各种取代基如下所定义。这些化合物是5-HT在5-HT 3受体上的作用的有效和选择性拮抗剂，可用于治疗精神病，焦虑和恶心和呕吐。

18. 发明授权

US5066678A Phenethandamine derivatives and pharmaceutical use thereof 失效
标题翻译：苯并咪唑衍生物及其药物用途
公开(公告)号：US5066678A
公开(公告)日：1991-11-19
申请号：US512874
申请日：1990-04-23
申请人： Ian F. Skidmore , Lawrence H. C. Lunts , Harry Finch , Alan Naylor , Ian B. Campbell , Charles Willbe , William L. Mitchell , Stephen Swanson , Brian D. Judkins
发明人： Ian F. Skidmore , Lawrence H. C. Lunts , Harry Finch , Alan Naylor , Ian B. Campbell , Charles Willbe , William L. Mitchell , Stephen Swanson , Brian D. Judkins
IPC分类号： C07C307/06 , A61K31/135 , A61K31/18 , C07C213/00 , C07C217/08 , C07C217/46 , C07C233/36 , C07C233/43 , C07C275/10 , C07C275/14 , C07C311/04 , C07C311/08 , C07C311/35
CPC分类号： C07C217/08 , C07C311/35 , C07C2101/08 , C07C2101/14
摘要： The invention relates to compounds of the general formula (I) ##STR1## and physiologically acceptable salts and solvates thereof; wherein;R.sup.1 and R.sup.2 each independently represent a hydrogen atom or a C.sub.1-3 -alkyl group with the proviso that the sum total of carbon atom in R.sup.1 and R.sup.2 is not more than 4;X represents a direct bond or a C.sub.1-7 alkylene, C.sub.2-7 alkenylene or C.sub.2-7 alkynylene group and Y represents a direct bond or a C.sub.1-6 alkylene C.sub.2-6 alkenylene or C.sub.2-6 alknylene group with the proviso that the sum total of carbon atoms in X and Y is not more than 10;W represents a group ##STR2## wherein Z represents a group R.sup.3 (CH.sub.2).sub.q where q is 0, 1 or 2 and R.sup.3 is a group R.sup.4 CONH--, R.sup.4 NHCONH--, R.sup.4 R.sup.5 NSO.sub.2 NH--, R.sup.6 SO.sub.2 NH-- or --OH;R.sup.4 and R.sup.5 each represent a hydrogen atom or a C.sub.1-3 alkyl group;R.sup.6 represents a C.sub.1-3 alkyl group;R.sup.7 represents a chlorine atom or the group --CF.sub.3 ;A represents a straight or branched C.sub.1-6 alkyl group, a C.sub.3-8 cycloalkyl group, either of which may be saturated or unsaturated, or a C.sub.1-6 alkoxy group, with the proviso that the sum total of carbon atoms in A and Y is not less than 5;having a stimulant action at .beta..sub.2 -adrenoreceptors and are useful in the treatment of diseases associated with reversible airways obstruction such as asthma and chronic bronchitis.

19. 发明授权

US4937268A Chemical compounds 失效
标题翻译：化合物
公开(公告)号：US4937268A
公开(公告)日：1990-06-26
申请号：US166975
申请日：1988-03-11
申请人： Ian F. Skidmore , Harry Finch , Alan Naylor , Lawrence H. C. Lunts , David Hartley , William L. Mitchell
发明人： Ian F. Skidmore , Harry Finch , Alan Naylor , Lawrence H. C. Lunts , David Hartley , William L. Mitchell
IPC分类号： A61K31/395 , A61K31/135 , A61K31/165 , A61K31/18 , A61K31/19 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4418 , A61K31/47 , A61P1/04 , A61P9/00 , A61P13/02 , A61P15/00 , A61P25/24 , A61P25/26 , A61P27/02 , A61P27/14 , A61P29/00 , A61P37/08 , C07D213/30 , C07D213/32 , C07D213/63 , C07D213/65 , C07D215/26 , C07D295/18
CPC分类号： C07D213/30 , C07D213/32 , C07D213/63
摘要： This invention relates to compounds of the general formula (I) and physiologically acceptable salts and solvates thereof whereinAr represents ##STR1## where R.sup.3 is a bond or a straight or branched C.sub.1-2 alkylene group,R.sup.4 is a hydroxy group or a group R.sup.5 NH-- whereR.sup.5 represents a group CH.sub.3 SO.sub.2 --, HCO-- or NH.sub.2 CO--, ##STR2## where R.sup.6 is a chlorine atom or the group F.sub.3 C--, ##STR3## k represents an integer from 1 to 8, m represents zero or an integer from 2 to 7 andn represents an integer from 2 to 7 with the proviso that the sum total of k, m and n is 4 to 12;R.sup.1 and R.sup.2 each represents a hydrogen atom or a methyl or ethyl group with the proviso that the sum total of carbon atoms in R.sup.1 and R.sup.2 is not more than 2;R.sup.30 represents hydrogen or C.sub.1-2 alkyl;X represents an oxygen or sulphur atom; andY and Q may each represent a bond or an oxygen or sulphur atom with the provisos that at least one of Y and Q represents an oxygen or sulphur atom and when Y is a bond m is zero, or when Y represents an oxygen or sulphur atom m is an integer from 2 to 7;P represents a phenyl group optionally substituted by one or more substituents selected from halogen atoms, or the groups C.sub.1-3 alkyl, C.sub.1-3 alkoxy, hydroxy, --CH.sub.2 OH--, --(CH.sub.2).sub.2 OH, --CO.sub.2 H, --CO.sub.2 CH.sub.3, --CO.sub.2 (CH.sub.2).sub.2 CH.sub.3, --R.sup.7, COR.sup.7, --NHCOR.sup.8 and --NR.sup.9 SO.sub.2 R.sup.10 ; whereR.sup.7 represents an amino, aminoC.sub.1-3 alkyl, aminoC.sub.1-3 dialkyl, pyrrolidino, piperidino, hexamethyleneimino, piperazino, N-methylpiperazino or morpholino group;R.sup.8 represents a hydrogen atom or a C.sub.1-4 alkyl, C.sub.1-4 alkoxy, phenyl or amino group;R.sup.9 represents a hydrogen atom or a methyl group;R.sup.10 represents a methyl, phenyl, amino or dimethylamino group;or P represents a pyridyl group optionally substituted by one or two substitutents selected from halogen atoms or hydroxy, C.sub.1-3 alkyl and C.sub.1-3 alkoxy groups.The compounds have a stimulant action at .beta..sub.2 -adrenoreceptors and are useful, in particular, in the treatment of diseases associated with reversible airways obstruction such as asthma and chronic bronchitis.

20. 发明授权

US5510350A Benzanilide derivatives 失效
标题翻译：苯甲酰苯胺衍生物
公开(公告)号：US5510350A
公开(公告)日：1996-04-23
申请号：US237297
申请日：1994-05-03
申请人： Alexander W. Oxford , William L. Mitchell , John Bradshaw , John W. Clitherow , Malcolm Carter
发明人： Alexander W. Oxford , William L. Mitchell , John Bradshaw , John W. Clitherow , Malcolm Carter
IPC分类号： A61K31/495 , A61K20060101 , A61K31/165 , A61K31/41 , A61K31/496 , A61K31/53 , A61P5/00 , A61P9/12 , A61P15/10 , A61P25/00 , A61P25/16 , A61P25/22 , A61P25/24 , A61P25/26 , A61P25/28 , C07D20060101 , C07D249/04 , C07D249/06 , C07D249/08 , C07D249/14 , C07D271/06 , C07D271/07 , C07D271/08 , C07D271/10 , C07D271/107 , C07D285/06 , C07D285/08 , C07D285/10 , C07D285/12 , C07D285/125 , C07D403/12 , C07D413/12 , C07D417/12
CPC分类号： C07D249/08 , C07D249/06 , C07D271/06 , C07D271/07 , C07D271/107 , C07D285/06 , C07D285/08 , C07D285/12
摘要： The invention provides compounds of formula (I): ##STR1## or a physiologically acceptable salt or solvate thereof wherein R.sup.1 represents a hydrogen atom or a halogen atom or a group selected from C.sub.1-6 alkyl and C.sub.1-6 alkoxy;R.sup.2 represents a phenyl group substituted by a group selected from ##STR2## and optionally further substituted by one or two substituents selected from halogen atoms, C.sub.1-6 alkoxy, hydroxy, and C.sub.1-6 alkyl;R.sup.3 represents the group ##STR3## R.sup.4 and R.sup.5, which may be the same or different, each independently represent a hydrogen atom or a halogen atom or a group selected from hydroxy, C.sub.1-6 alkoxy and C.sub.1-6 alkyl;R.sup.6 represents a hydrogen atom or a group selected from --NR.sup.9 R.sup.10 and a C.sub.1-6 alkyl group optionally substituted by one or two substituents selected from C.sub.1-6 alkoxy, hydroxy, C.sub.1-6 acyloxy and --SO.sub.2 R.sup.11 ;R.sup.7, R.sup.8 and R.sup.9, which may be the same or different, each independently represent a hydrogen atom or a C.sub.1-6 alkyl group;R.sup.10 represents a hydrogen atom or a group selected from C.sub.1-6 alkyl, C.sub.1-6 acyl, benzoyl and --SO.sub.2 R.sup.11 ;R.sup.11 represents a C.sub.1-6 alkyl group or a phenyl group;Z represents an oxygen atom or a group selected from NR.sup.8 and S(O).sub.k ; andk represents zero, 1 or 2.The compounds may be used in the treatment or prophylaxis of depression and other CNS disorders.
摘要翻译：本发明提供式（I）化合物：其中R 1表示氢原子或卤素原子或选自C 1-6烷基和C 1-6烷氧基的基团;或其生理学上可接受的盐或溶剂化物。 R 2表示被选自下列基团取代的苯基，并任选进一步被一个或两个选自卤素原子，C 1-6烷氧基，羟基和C 1-6烷基的取代基取代; R 3表示基团R 4和R 5可以相同或不同，各自独立地表示氢原子或卤素原子或选自羟基，C 1-6烷氧基和C 1-6烷基的基团。 R6表示氢原子或选自-NR9R10和任选被一个或两个选自C 1-6烷氧基，C 1-6酰氧基和-SO 2 R 11的取代基取代的C 1-6烷基的基团; R 7，R 8和R 9可以相同或不同，各自独立地表示氢原子或C 1-6烷基; R 10表示氢原子或选自C 1-6烷基，C 1-6酰基，苯甲酰基和-SO 2 R 11的基团; R11表示C1-6烷基或苯基; Z表示氧原子或选自NR8和S（O）k的基团; 并且k代表0,1或2.化合物可用于治疗或预防抑郁症和其它CNS疾病。

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