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11. 发明专利

NO20050145A 未知
公开(公告)号：NO20050145A
公开(公告)日：2005-01-11
申请号：NO20050145
申请日：2005-01-11
申请人： LUNDBECK & CO AS H
发明人： WETZEL JOHN M , ANDERSEN KIM , DELEON JOHN E , JIANG YU , CHEN CHIEN-AN , LU KAI , MARZABADI MOHAMMAD
IPC分类号： A61K31/438 , C07D221/20 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D491/10
CPC分类号： C07D221/20 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D491/10

12. 发明专利

NO20050113L 未知
公开(公告)号：NO20050113L
公开(公告)日：2005-01-10
申请号：NO20050113
申请日：2005-01-10
申请人： LUNDBECK & CO AS H
发明人： WETZEL JOHN M , DELEON JOHN E , JIANG YU , CHEN CHIEN-AN , LU KAI , MARZABADI MOHAMMAD
IPC分类号： C07D211/26 , A61K31/44 , A61K31/451 , A61K31/4545 , A61K31/506 , A61P3/04 , A61P13/02 , A61P25/22 , A61P25/24 , A61P43/00 , C07D211/70 , C07D401/12
摘要： This invention is directed to compounds which are selective antagonists for melanin concentrating hormone-1 (MCH1) receptors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of the compound of the invention and a pharmaceutically acceptable carrier. This invention provides a pharmaceutical composition made by combining a therapeutically effective amount of the compound of this invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of the compounds of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of reducing the body mass of a subject which comprises administering to the subject an amount of a compound of the invention effective to reduce the body mass of the subject. This invention further provides a method of treating a subject suffering from depression and/or anxiety which comprises administering to the subject an amount of a compound of the invention effective to treat the subject=s depression and/or anxiety. This invention further provides a method of treating a subject suffering from a urinary disorder.

13. 发明专利

CA2485375A1 SPIROCYCLIC PIPERIDINES AS MCH1 ANTAGONISTS AND USES THEREOF 未知
公开(公告)号：CA2485375A1
公开(公告)日：2004-07-15
申请号：CA2485375
申请日：2003-07-03
申请人： LUNDBECK & CO AS H
发明人： JIANG YU , DELEON JOHN , CHEN CHIEN-AN , LU KAI , WETZEL JOHN , MARZABADI MOHAMMAD , ANDERSEN KIM
IPC分类号： A61K31/438 , C07D221/20 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D491/10 , C07D491/107 , A61P3/04 , A61P25/22 , A61P25/24
摘要： This invention is directed to compounds which are selective antagonists for melanin concentrating hormone-1 (MCH1) receptors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of the compound of the invention and a pharmaceutically acceptable carrier. Thi s invention provides a pharmaceutical composition made by combining a therapeutically effective amount of the compound of this invention and a pharmaceutically acceptable carrier. This invention further provides a proce ss for making a pharmaceutical composition comprising combining a therapeutical ly effective amount of the compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of reducing the bo dy mass of a subject which comprises administering to the subject an amount of a compound of the invention effective to reduce the body mass of the subject. This invention further provides a method of treating a subject suffering fro m depression and/or anxiety which comprises administering to the subject an amount of a compound of the invention effective to treat the subject=s depression and/or anxiety. This invention further provides a method of treating a subject suffering from a urinary disorder.

14. 发明专利

HK1080471A1 Secondary amino anilinic piperidines as mch1 antagonists and uses thereof 未知
公开(公告)号：HK1080471A1
公开(公告)日：2006-04-28
申请号：HK06100334
申请日：2006-01-09
申请人： LUNDBECK & CO AS H
发明人： MARZABADI MOHAMMAD , JIANG YU , LU KAI , CHEN CHIEN-AN , DELEON JOHN , WETZEL JOHN
IPC分类号： C07D20060101 , A61K20060101 , A61K31/44 , A61K31/451 , A61K31/4545 , A61K31/506 , A61P3/04 , A61P13/02 , A61P25/22 , A61P25/24 , A61P43/00 , C07D211/26 , C07D211/70 , C07D401/12
摘要： This invention is directed to compounds which are selective antagonists for melanin concentrating hormone-1 (MCH1) receptors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of the compound of the invention and a pharmaceutically acceptable carrier. This invention provides a pharmaceutical composition made by combining a therapeutically effective amount of the compound of this invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of the compounds of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of reducing the body mass of a subject which comprises administering to the subject an amount of a compound of the invention effective to reduce the body mass of the subject. This invention further provides a method of treating a subject suffering from depression and/or anxiety which comprises administering to the subject an amount of a compound of the invention effective to treat the subject=s depression and/or anxiety. This invention further provides a method of treating a subject suffering from a urinary disorder.

15. 发明专利

BR0312256A 未知
公开(公告)号：BR0312256A
公开(公告)日：2005-04-26
申请号：BR0312256
申请日：2003-07-03
申请人： LUNDBECK & CO AS H
发明人： MARZABADI MOHAMMAD , JIANG YU , LU KAI , CHEN CHIEN-AN , DELEON JOHN , WETZEL JOHN , ANDERSEN KIM
IPC分类号： A61K31/438 , C07D221/20 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D491/10
摘要： This invention is directed to compounds which are selective antagonists for melanin concentrating hormone-1 (MCH1) receptors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of the compound of the invention and a pharmaceutically acceptable carrier. This invention provides a pharmaceutical composition made by combining a therapeutically effective amount of the compound of this invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of the compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of reducing the body mass of a subject which comprises administering to the subject an amount of a compound of the invention effective to reduce the body mass of the subject. This invention further provides a method of treating a subject suffering from depression and/or anxiety which comprises administering to the subject an amount of a compound of the invention effective to treat the subject=s depression and/or anxiety. This invention further provides a method of treating a subject suffering from a urinary disorder.

16. 发明专利

IS7559A Spírósýklísk piperidín sem MCH1 mótlyf og notkun á þeim 未知
公开(公告)号：IS7559A
公开(公告)日：2004-11-26
申请号：IS7559
申请日：2004-11-26
申请人： LUNDBECK & CO AS H
发明人： MARZABADI MOHAMMAD , JIANG YU , LU KAI , CHEN CHIEN-AN , DELEON JOHN , WETZEL JOHN , ANDERSEN KIM
IPC分类号： A61K31/438 , C07D221/20 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D491/10

17. 发明专利

ES2318165T3 PIPERIDINAS ESPIROCICLICAS COMO AGONISTAS DE MCH1 Y SUS USOS. 未知
公开(公告)号：ES2318165T3
公开(公告)日：2009-05-01
申请号：ES03763351
申请日：2003-07-03
申请人： LUNDBECK & CO AS H
发明人： MARZABADI MOHAMMAD , JIANG ALLEN , LU KAI , CHEN CHIEN-AN , DELEON JOHN , WETZEL JOHN
IPC分类号： C07D221/20 , A61K31/438 , A61P3/04 , A61P25/00 , A61P25/24 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D491/10
摘要： Un compuesto que tiene la estructura: ** ver fórmula** en la que - - - - - es CH2, O, -CO-, -CO2-, -CH2-CH2- o -CHCH-; en la que t es 0 ó 1, y donde el anillo cíclico que contiene t tiene 5 ó 6 miembros; en la que n es un número entero de 1 a 6 inclusive; en la que cada R 1 y R 2 es independientemente -H, -F, -Cl, -Br, -I; alquilo C 1-C 7 lineal o ramificado, monofluoroalquilo o polifluoroalquilo, arilo o heteroarilo; en la que cada R3 es independientemente -H; alquilo C1-C6 lineal o ramificado; arilo o heteroarilo, en el que el arilo o heteroarilo está opcionalmente sustituido con uno o más -F, -Cl, -Br, -I, -R2, alquilo C1-C7 lineal o ramificado, arilo, fenoxi o heteroarilo; y en la que dos restos R3 tomados juntos pueden formar un cicloalquilo C3-C6; o su sal farmacéuticamente aceptable.

18. 发明专利

NZ536329A Secondary amino anilinic piperidines as MCH1 antagonists and uses thereof 未知
公开(公告)号：NZ536329A
公开(公告)日：2007-06-29
申请号：NZ53632903
申请日：2003-07-03
申请人： LUNDBECK & CO AS H
发明人： MARZABADI MOHAMMAD , JIANG YU , LU KAI , CHEN CHIEN-AN , WETZEL JOHN , DELEON JOHN
IPC分类号： A61K31/44 , A61K31/451 , A61K31/4545 , A61K31/506 , A61P3/04 , A61P13/02 , A61P25/22 , A61P25/24 , A61P43/00 , C07D211/26 , C07D211/70 , C07D401/12
摘要： Disclosed is a compound of the structure shown in which A is independently -H, -F, -Cl, -Br, -I, -CN, -NO2, -OR3 or straight chained or branched C1-C7 alkyl; each B is independently N or CH; Z is CO or SO2 and all other substituents are as described in the specification. These compounds are selective antagonists for melanin concentrating hormone-1 (MCH1) receptors and can be used in medicaments for the treatment of depression, anxiety, urinary incontinence and obesity.

19. 发明专利

AT361917T 未知
公开(公告)号：AT361917T
公开(公告)日：2007-06-15
申请号：AT00923566
申请日：2000-04-21
申请人： LUNDBECK & CO AS H
发明人： MARZABADI MOHAMMAD , WONG WAI , NOBLE STEWART , DESAI MAHESH
IPC分类号： C07D251/70 , A61K31/427 , A61K31/429 , A61K31/4427 , A61K31/4439 , A61K31/53 , A61K31/5377 , A61P3/00 , A61P3/04 , A61P7/04 , A61P9/04 , A61P9/10 , A61P9/12 , A61P15/08 , A61P25/08 , A61P25/20 , A61P25/24 , A61P43/00 , C07D251/50 , C07D277/28 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D409/12 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14 , C07D513/04 , C07D519/00
摘要： This invention is directed to triazine derivatives, bicyclic compounds and tricyclic compounds which are selective antagonists for a NPY (Y5) receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention provides a pharmaceutical composition made by combining a therapeutically effective amount of a compound of this invention and a pharmaceutically acceptable carrier. This invention provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. The invention further provides the use of a compound of the invention for the preparation of a pharmaceutical composition for treating an abnormality, wherein the abnormality is alleviated by decreasing the activity of a human Y5 receptor.

20. 发明专利

EA007387B1 СПИРОЦИКЛИЧЕСКИЕ ПИПЕРИДИНЫ, ИСПОЛЬЗУЕМЫЕ В КАЧЕСТВЕ АНТАГОНИСТОВ МКГ1, И ИХ ПРИМЕНЕНИЕ 未知
公开(公告)号：EA007387B1
公开(公告)日：2006-10-27
申请号：EA200500156
申请日：2003-07-03
申请人： LUNDBECK & CO AS H
发明人： MARZABADI MOHAMMAD , JIANG ALLEN , LU KAI , CHEN CHIEN-AN , DELEON JOHN , WETZEL JOHN , ANDERSEN KIM
IPC分类号： A61K31/438 , C07D221/20 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D491/10
摘要： Изобретениеотноситсяк соединениям, которыеявляютсяселективнымиантагонистамирецепторовмеланин-концентрирующегогормона-1 (МКГ1). Настоящееизобретениетакжеотноситсяк фармацевтическимкомпозициям, содержащимтерапевтическиэффективноеколичествосоединенияпоизобретениюи фармацевтическиприемлемыйноситель. Крометого, настоящееизобретениеотноситсяк фармацевтическойкомпозиции, полученнойпутемсмешиваниятерапевтическиэффективногоколичествасоединенияпоизобретениюи фармацевтическиприемлемогоносителя. Настоящееизобретениетакжеотноситсяк способуполученияфармацевтическойкомпозиции, предусматривающемусмешиваниетерапевтическиэффективногоколичествасоединениянастоящегоизобретенияи фармацевтическиприемлемогоносителя. Крометого, изобретениеотноситсяк способуснижениямассытелапациента, предусматривающемувведениеуказанномуиндивидуумусоединенияпоизобретениюв количестве, эффективномдляснижениямассытеладанногоиндивидуума. Настоящееизобретениетакжеотноситсяк способулеченияиндивидуума, страдающегодепрессиейи/илитревожнымсостоянием, гдеуказанныйспособпредусматриваетвведениеуказанномуиндивидуумутерапевтическиэффективногоколичествасоединенияпоизобретению, являющегосяэффективнымдлялечениядепрессиии/илитревожногосостояния. Крометого, изобретениеотноситсяк способулеченияпациента, страдающегорасстройствоммочеиспускания.

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