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11. 发明申请

WO2018109008A1 MICROFLUIDIC DEVICE FOR ACCOMMODATING, ISOLATING, TREATING AND/OR PROCESSING CELLS HAVING AN INLET CHAMBER WITH A CHUTE STRUCTURE. 审中-公开
公开(公告)号：WO2018109008A1
公开(公告)日：2018-06-21
申请号：PCT/EP2017/082623
申请日：2017-12-13
申请人： KONINKLIJKE PHILIPS N.V.
发明人： VAN DER ZAAG, Pieter, Jan , VULDERS, Roland, Cornelis, Martinus , MARIE, Podenphant, Jensen
IPC分类号： B01L3/00
摘要： The present invention relates to a microfluidic device suitable for accommodating, isolating, treating and/or processing cells. The device comprises an inlet chamber in fluid communication with at least one feeding channel being arranged in an essentially horizontal direction. The inlet chamber is suitable for receiving a volume of a liquid sample comprising at least one cell, and has an opening at its upward facing end which has a circular, ellipsoidal or polygonal cross-section. Further, the microfluidic device has a chute structure which defines a flow path for guiding the cells from the inlet chamber into the at least one feeding channel.

12. 发明申请

WO2013140316A3 MANUFACTURING METHOD OF AN APPARATUS FOR THE PROCESSING OF SINGLE MOLECULES 审中-公开
公开(公告)号：WO2013140316A3
公开(公告)日：2013-09-26
申请号：PCT/IB2013/052026
申请日：2013-03-14
申请人： KONINKLIJKE PHILIPS N.V.
发明人： VAN DER ZAAG, Pieter, Jan , PEETERS, Emiel , KOOLE, Roelof , VAN DELFT, Falco, Cornelius, Marinus, Jacobus, Maria
IPC分类号： G03F7/00 , B82Y15/00 , G01N33/487
摘要： The invention relates to a method for manufacturing an apparatus for the processing of single molecules. According to this method, a self-assembling resist (155) is deposited on a processing layer (110, PL) and allowed to self-assemble into a pattern of two phases (155a, 155b). One of these phases (155a) is then selectively removed, and at least one aperture is generated in the processing layer (110, PL) through the mask of the remaining resist (155b). Thus apertures of small size can readily be produced that allow for the processing of single molecules (M), for example in DNA sequencing.

13. 发明申请

WO2019096974A1 A MULTI-MODE IMAGER 审中-公开
公开(公告)号：WO2019096974A1
公开(公告)日：2019-05-23
申请号：PCT/EP2018/081519
申请日：2018-11-16
申请人： KONINKLIJKE PHILIPS N.V.
发明人： BOAMFA, Marius, Iosif , VAN DER ZAAG, Pieter, Jan , LARSEN, Niels, Agersnap , ASSELMAN, Michel, Jozef, Agnes , VULDERS, Roland, Cornelis, Martinus
IPC分类号： G02B21/16 , G02B21/36
CPC分类号： G02B21/16 , G02B21/365
摘要： Conventionally, the acquisition of bright-field images and fluorescence images using the same device has required an imager equipped with a mechanical movement, able to mechanically interchange filters in-between a sample stage and an imaging element, dependent on whether a bright-field or a fluorescence exposure is being made. The present application discusses a multi-mode imager comprising a brightfield light source and a first excitation light source for exciting fluorescent dyes in a biopsy sample. An optical filter arrangement is provided enabling the multi-mode scanning of the biopsy without the need to use a mechanism for interchanging filters.

14. 发明申请

WO2017194563A1 BIOPSY CONTAINER 审中-公开
标题翻译：生物容器
公开(公告)号：WO2017194563A1
公开(公告)日：2017-11-16
申请号：PCT/EP2017/061098
申请日：2017-05-09
申请人： KONINKLIJKE PHILIPS N.V.
发明人： VAN DER ZAAG, Pieter, Jan , HENDRIKS, Bernardus, Hendrikus, Wilhelmus , VAREKAMP, Christiaan
IPC分类号： A61B10/02 , A61B10/00 , G01N33/48 , A61B90/00
摘要： The invention relates to a biopsy container, a biopsy device, an imaging system, and a method for processing images of a biopsy container. The biopsy container comprises a container orientation mark and an alignment mark. The container orientation mark is configured for a cooperation with a corresponding shaft orientation mark arranged on a tube shaft of a biopsy device to indicate a specific orientation of the biopsy container relative to the tube shaft. The alignment mark is configured for a registration of images of the biopsy container.
摘要翻译：活检容器，活检装置，成像系统和用于处理活检容器的图像的方法技术领域本发明涉及活检容器，活检装置，成像系统和用于处理活检容器的图像的方法。活检容器包括容器定位标记和对准标记。容器定向标记被配置为与布置在活检装置的管轴上的相应的轴定向标记协作以指示活检容器相对于管轴的特定定向。对准标记被配置用于对活检容器的图像进行配准。

15. 发明申请

WO2017108591A1 METHOD OF CREATING A NANO-SIZED RECESS 审中-公开
标题翻译：创建纳米尺寸凹槽的方法
公开(公告)号：WO2017108591A1
公开(公告)日：2017-06-29
申请号：PCT/EP2016/081326
申请日：2016-12-16
申请人： KONINKLIJKE PHILIPS N.V.
发明人： VERSCHUUREN, Marcus, Antonius , VAN DER ZAAG, Pieter, Jan
IPC分类号： G01N33/487
CPC分类号： G01N33/48721
摘要： The invention relates to creating a nano-sized recess into a layer of material. For that, a first layer (100) is provided, which defines a first recess (101). The first layer (100) is then conformally covered with a second layer (107) such that the second layer evenly covers the boundaries of the first recess. In this way, the second layer defines a nano-sized recess. Furthermore, the invention relates to using such a structure with a second nano-sized recess for etching a nanoslit into a graphene layer. Furthermore, such a graphene layer with a nanoslit is described to be used for creating a crossed-nanoslit device for sequencing molecules.
摘要翻译：本发明涉及在材料层中形成纳米尺寸的凹陷。为此，提供了第一层（100），其限定第一凹部（101）。然后用第二层（107）共形地覆盖第一层（100），使得第二层均匀地覆盖第一凹槽的边界。这样，第二层限定了纳米尺寸的凹陷。此外，本发明涉及使用具有第二纳米尺寸的凹部的这种结构用于将纳米狭缝蚀刻成石墨烯层。此外，这种具有纳米缝的石墨烯层被描述为用于创建用于测序分子的交叉纳米器件。

16. 发明申请

WO2017085032A1 MICROFLUIDIC DEVICE POSSESSING STRUCTURES ENABLING DIFFERENTIAL ANALYSIS OF A SINGLE CELL'S CONSTITUENTS 审中-公开
标题翻译：微流体装置具有结构使得能够对单个细胞组分进行差异分析
公开(公告)号：WO2017085032A1
公开(公告)日：2017-05-26
申请号：PCT/EP2016/077621
申请日：2016-11-15
申请人： KONINKLIJKE PHILIPS N.V. , DANMARKS TEKNISKE UNIVERSITET
发明人： VAN DER ZAAG, Pieter, Jan , MARIE, Rodolphe, Charly, Willy , VAN STRIJP, Dianne, Arnoldina, Margaretha, Wilhelmina , OLESEN, Tom , VULDERS, Roland, Cornelis, Martinus , KRISTENSEN, Anders
IPC分类号： B01L3/00
CPC分类号： B01L3/502761 , B01L2200/0668 , B01L2300/0816 , B01L2300/0864 , B01L2400/06 , B01L2400/0622 , C12M47/06 , C12N15/1003
摘要： A method and a micro fluidic device comprising at least one micro fluidic structure for differential extraction of nuclear and extra-nuclear constituents of a single cell, said micro fluidic structure comprising a feeding channel for receiving a volume of a sample containing at least one cell, at least one trapping structure for capturing a single cell, and at least one output channel in fluid connection with the at least one trapping structure, wherein the at least one trapping structure extends from one side of the feeding channel substantially perpendicular to longitudinal axis of the feeding channel, the at least one trapping structure possessing an aperture at its end opposite to the fluid channel and in fluid communication with an output channel, said aperture being configured to provide a narrow section such that the nucleus of a cell captured in the trapping structure cannot pass through said narrow section into the output channel.
摘要翻译：一种方法和一种微流体装置，其包括至少一个微流体结构，用于差分提取单个细胞的核和外核组分，所述微流体结构包括用于接收一定体积的包含至少一个细胞的样品，用于捕获单个细胞的至少一个捕获结构以及与所述至少一个捕获结构流体连接的至少一个输出通道，其中所述至少一个捕获结构从所述进料的一侧延伸所述至少一个捕获结构在其与所述流体通道相对的端部处具有孔并与输出通道流体连通，所述孔被配置成提供窄的部分，使得所述核捕获在捕获结构中的细胞不能通过所述狭窄部分进入输出通道。

17. 发明公开

EP4062414A1 APPARATUS FOR DIAGNOSTIC IMAGE ACQUISITION DETERMINATION 审中-公开
公开(公告)号：EP4062414A1
公开(公告)日：2022-09-28
申请号：EP20804296.0
申请日：2020-11-17
申请人： Koninklijke Philips N.V.
发明人： VAN DER ZAAG, Pieter, Jan , VERHAEGH, Wilhelmus, Franciscus, Johannes , KEUPP, Jochen
IPC分类号： G16H20/10 , G16H20/17 , G16H20/40 , G16H30/00 , G16H40/63 , G16H50/20

18. 发明公开

EP2718866A2 PROVIDING NUCLEOTIDE SEQUENCE DATA 有权转让
标题翻译：供养核苷酸序列数据
公开(公告)号：EP2718866A2
公开(公告)日：2014-04-16
申请号：EP12721352.8
申请日：2012-04-17
申请人： Koninklijke Philips N.V. , Philips Intellectual Property & Standards GmbH
发明人： VAN DER ZAAG, Pieter, Jan , AMBERG, Ronny , VERHAEGH, Wilhelmus, Franciscus, Johannes , BEYERLEIN, Peter , BOETTCHER, Rene
IPC分类号： G06F19/20 , G06F19/22 , C12Q1/68
摘要： A sequencer device generates basic nucleotide sequence data 30 comprising probe data 34 of a capture probe in the sequencer device 10 and a determined sequence of identifiers 32 of a fragment of nucleic acids captured by the probe. The sequencer device outputs enriched nucleotide sequence data 36 that is enriched with data comprising a reference to a sequence 38 that is expected for the fragment of nucleic acids.

19. 发明公开

EP2688673A1 METHOD FOR PERFORMING MOLECULAR REACTIONS BY USING IMMISCIBLE INTERMEDIATE FLUIDS 审中-公开
标题翻译：程序分子反应从不混溶液体之间的使用该实现
公开(公告)号：EP2688673A1
公开(公告)日：2014-01-29
申请号：EP12712753.8
申请日：2012-03-20
申请人： Koninklijke Philips N.V.
发明人： WIMBERGER-FRIEDL, Reinhold , VAN DER ZAAG, Pieter, Jan , SERVOLI, Eva
IPC分类号： B01L3/00 , C12Q1/68 , B01J19/00 , G01N35/08
CPC分类号： C12Q1/6869 , B01L3/502784 , B01L7/52 , B01L2200/0673 , B01L2200/16 , B01L2300/0636 , B01L2300/088 , B01L2400/0487 , G01N35/08
摘要： The present invention relates to a method for performing molecular reactions in a device comprising the steps of (a) introducing one or more reagent solution(s) and an immiscible intermediate fluid into the device, wherein the device comprises a substrate, on which chemically or biochemically recognizable entities are immobilized; (b) performing molecular reactions between the immobilized chemically or biochemically recognizable entities and the reagent solution(s); or on the immobilized chemically or biochemically recognizable entities in the presence of the reagent solution(s); (c) displacing the reagent solution(s) present on the substrate by the immiscible intermediate fluid; (d) separating the immiscible intermediate fluid and the reagent solution(s); and reusing the reagent solution(s) and/or immiscible intermediate fluid for one or more repetitions of steps (a) to (e). The invention further relates to a device for performing a molecular reaction, comprising a reaction zone, reservoirs and liquid connections and a collection and regeneration zone wherein the immiscible intermediate fluid and the reagent solution(s) are separable by gravitational separation; or a redirection and distribution module, wherein the immiscible intermediate fluid and reagent solution(s) are separated. The invention also relates to the use of an immiscible intermediate fluid for displacing a reagent solution present in a reaction zone in a microfluidic device, as well as the use of a corresponding device for performing a sequencing reaction or a nucleic acid synthesis reaction.

20. 发明公开

EP4046160A1 METHOD AND APPARATUS FOR ASSESSING PATIENT'S RESPONSES TO THERAPY 审中-公开
公开(公告)号：EP4046160A1
公开(公告)日：2022-08-24
申请号：EP20789602.8
申请日：2020-10-13
申请人： Koninklijke Philips N.V.
发明人： VAN DER ZAAG, Pieter, Jan , VERHAEGH, Wilhelmus, Franciscus, Johannes
IPC分类号： G16B40/30

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