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11. 发明申请

US20130330345A1 MULTI-SPECIFIC ANTIGEN-BINDING MOLECULE HAVING ALTERNATIVE FUNCTION TO FUNCTION OF BLOOD COAGULATION FACTOR VIII 有权
标题翻译：具有替代功能的多特异性抗原结合分子对血液凝血因子VIII的功能
公开(公告)号：US20130330345A1
公开(公告)日：2013-12-12
申请号：US13885421
申请日：2011-11-17
申请人： Tomoyuki Igawa , Zenjiro Sampei , Tetsuo Kojima , Tetsuhiro Soeda , Atsushi Muto , Takehisa Kitazawa , Yukiko Nishida , Chifumi Imai , Tsukasa Suzuki , Kazutaka Yoshihashi
发明人： Tomoyuki Igawa , Zenjiro Sampei , Tetsuo Kojima , Tetsuhiro Soeda , Atsushi Muto , Takehisa Kitazawa , Yukiko Nishida , Chifumi Imai , Tsukasa Suzuki , Kazutaka Yoshihashi
IPC分类号： C07K16/40
CPC分类号： C07K16/40 , C07K16/36 , C07K2317/31 , C07K2317/51 , C07K2317/56 , C07K2317/565 , C07K2317/75 , C07K2317/76 , C07K2317/94
摘要： Various bispecific antibodies that specifically bind to both blood coagulation factor IX/activated blood coagulation factor IX and blood coagulation factor X and functionally substitute for the cofactor function of blood coagulation factor VIII, that is, the function to promote activation of blood coagulation factor X by activated blood coagulation factor IX, were produced. From these antibodies, multispecific antigen-binding molecules having a high activity of functionally substituting for blood coagulation factor VIII were successfully discovered.
摘要翻译：各种双特异性抗体特异性结合血液凝固因子IX /活化血液凝固因子IX和血液凝固因子X，并功能取代血液凝固因子VIII的辅因子功能，即促进凝血因子X活化的功能活化血液凝固因子IX。从这些抗体中，成功发现了具有高功能取代凝血因子VIII活性的多特异性抗原结合分子。

12. 发明授权

US08597911B2 Process for producing antibodies 失效
标题翻译：生产抗体的方法
公开(公告)号：US08597911B2
公开(公告)日：2013-12-03
申请号：US10560098
申请日：2004-06-11
申请人： Taro Miyazaki , Tetsuo Kojima
发明人： Taro Miyazaki , Tetsuo Kojima
IPC分类号： C12N15/13
CPC分类号： C07K16/468 , C07K16/00 , C07K16/2866 , C07K2317/626 , C12N2510/02
摘要： Focusing on the fact that antibody molecules with one H chain are not secreted when using the “knobs-into-holes” method, the present inventors revealed that desired bispecific antibodies can be preferentially formed by first expressing the H and L chains of one arm, and then suppressing their expression, followed by expressing the H and L chains of the other arm so that first desired HL molecules (HaLa and HbLb) are constructed, and then the H chains are paired with each other (H2L2). The present invention was thus completed.
摘要翻译：关注当使用“旋钮孔”方法时，不分泌具有一个H链的抗体分子的事实，本发明人揭示了可以通过首先表达一个臂的H和L链来优先形成所需的双特异性抗体，然后抑制其表达，然后表达另一臂的H链和L链，使得构建第一所需的HL分子（HaLa和HbLb），然后H链彼此配对（H2L2）。从而完成了本发明。

13. 发明申请

US20120224396A1 DC POWER SUPPLY 有权
标题翻译：直流电源
公开(公告)号：US20120224396A1
公开(公告)日：2012-09-06
申请号：US13367653
申请日：2012-02-07
申请人： Yuichiro NOZAKI , Tetsuo Kojima , Masafumi Makino
发明人： Yuichiro NOZAKI , Tetsuo Kojima , Masafumi Makino
IPC分类号： H02M3/335
CPC分类号： H02M3/3378 , Y02B70/1433
摘要： In a DC power supply in which a DC power source and a transformer are connected via a power conversion circuit and a secondary winding of the transformer is connected to a load via a rectifier diode bridge and a filter circuit to supply power to the load, a resonance reactor is provided on an output side of the transformer, a resonant switch circuit including a parallel circuit of a diode and a semiconductor switch and a resonant capacitor is connected in parallel to the rectifier diode bridge and a snubber circuit including a snubber capacitor, a snubber diode and a diode for discharge is connected to a serial resonant circuit including the resonance reactor and the resonant capacitor in the resonant switch circuit to absorb a surge voltage.
摘要翻译：在其中直流电源和变压器通过功率转换电路连接的直流电源和变压器的次级绕组经由整流二极管桥和滤波电路连接到负载以向负载供电，谐振电抗器设置在变压器的输出侧，包括二极管和半导体开关的并联电路和谐振电容器的谐振开关电路并联连接到整流二极管桥和包括缓冲电容器的缓冲电路，缓冲二极管和用于放电的二极管连接到包括谐振电抗器和谐振开关电路中的谐振电容器的串联谐振电路以吸收浪涌电压。

14. 发明申请

US20100003254A1 Antibody Substituting for Function of Blood Coagulation Factor VIII 审中-公开
标题翻译：抗体代替血液凝固因子VIII的功能
公开(公告)号：US20100003254A1
公开(公告)日：2010-01-07
申请号：US11910836
申请日：2006-03-31
申请人： Kunihiro Hattori , Tetsuo Kojima , Hiroyuki Saito , Taro Miyazaki , Tetsuhiro Soeda
发明人： Kunihiro Hattori , Tetsuo Kojima , Hiroyuki Saito , Taro Miyazaki , Tetsuhiro Soeda
IPC分类号： A61K39/395 , C07K16/00 , A61P7/00
CPC分类号： C07K16/36 , C07K16/40 , C07K16/468 , C07K2317/24 , C07K2317/31 , C07K2317/56 , C07K2317/622 , C07K2317/75
摘要： The present inventors produced a variety of bispecific antibodies that specifically bind to both F. IX/F. IXa and F. X, and functionally substitute for F. VIIIa, i.e., have a cofactor function to promote F. X activation via F. IXa. Among these antibodies, the antibody A44/B26 reduced coagulation time by 50 seconds or more as compared to that observed when the antibody was not added. The present inventors produced a commonly shared L chain antibody from this antibody using L chains of A44, and showed that A44L can be used as commonly shared L chains, although the activity of the resulting antibody is reduced compared to the original antibody (A44HL-B26HL). Further, with appropriate CDR shuffling, the present inventors successfully produced highly active multispecific antibodies that functionally substitute for coagulation factor VIII.
摘要翻译：本发明人生产了特异性结合F.IX / F两种的各种双特异性抗体。 IXa和F.X，并且功能上替代F.CⅧa，即具有辅因子功能以通过F.Ixa促进F.X活化。在这些抗体中，与未添加抗体时相比，抗体A44 / B26的凝固时间缩短了50秒以上。本发明人使用A44的L链从该抗体生产共同的L链抗体，并且表明尽管与原始抗体（A44HL-B26HL）相比，所得抗体的活性降低，但A44L可以用作共同的L链）。此外，通过适当的CDR改组，本发明人成功地制备了功能性替代凝血因子VIII的高活性多特异性抗体。

15. 发明申请

US20050232328A1 Solid-state laser system 失效
标题翻译：固态激光系统
公开(公告)号：US20050232328A1
公开(公告)日：2005-10-20
申请号：US11090174
申请日：2005-03-28
申请人： Junichi Nishimae , Tetsuo Kojima
发明人： Junichi Nishimae , Tetsuo Kojima
IPC分类号： H01S3/08 , G02B27/09 , H01S3/00 , H01S3/06 , H01S3/07 , H01S3/081 , H01S3/091 , H01S3/10 , H01S3/16 , H01S3/23
CPC分类号： H01S3/0602 , H01S3/005 , H01S3/07 , H01S3/08 , H01S3/08072 , H01S3/0815 , H01S3/091 , H01S3/2316
摘要： A simple and high-reliability constitution provides a solid-state laser system that allows a high-output, long-pulse-width laser beam to be obtained. A solid-state laser system that includes a solid-state laser medium 1, a light source 2 for pumping the solid-state laser medium 1, two reflecting mirrors 3 and 4 for flanking the solid-state laser medium 1, thereby constituting a laser resonator, is constituted in such a manner that a virtual-mirror plane 5 is defined in the space between the solid-state laser medium 1 and the reflecting mirror 4; a lens 6 is provided between the virtual-mirror plane 5 and the reflecting mirror 4; and, by means of the forward and backward paths along the route from the virtual-mirror plane to the reflecting mirror by way of the lens, the virtual-mirror plane in the forward path and the virtual-mirror plane in the backward path are made in an optically conjugated relationship with each other.
摘要翻译：简单且高可靠性的结构提供了一种能够获得高输出，长脉冲宽度的激光束的固态激光系统。一种固态激光系统，包括固体激光介质1，用于泵浦固态激光介质1的光源2，用于固定固体激光介质1侧面的两个反射镜3和4，从而构成激光谐振器构成为在固体激光介质1和反射镜4之间的空间中限定虚拟镜面5; 在虚拟镜面5和反射镜4之间设置透镜6; 借助于通过镜头从虚拟镜面到反射镜的路径的前进和后退路径，使前向路径中的虚拟镜面和后向路径中的虚拟镜面成为彼此具有光学共轭关系。

16. 发明申请

US20050068998A1 Wavelength conversion apparatus 有权
标题翻译：波长转换装置
公开(公告)号：US20050068998A1
公开(公告)日：2005-03-31
申请号：US10940817
申请日：2004-09-15
申请人： Tomotaka Katsura , Susumu Konno , Tetsuo Kojima , Junichi Nishimae
发明人： Tomotaka Katsura , Susumu Konno , Tetsuo Kojima , Junichi Nishimae
IPC分类号： G02F1/37 , G02F1/015 , G02F2/02 , H01L21/02 , H01S3/00 , H01S3/10 , H01S3/109 , H01S3/16
CPC分类号： H01S3/109 , G02F2001/3503 , G02F2001/3505 , G02F2001/354 , H01S3/005 , H01S3/1611 , H01S3/1643
摘要： A wavelength conversion apparatus in which output direction of a wavelength-converted laser beam, having a wavelength converted by a nonlinear optical crystal and emitted through an output-window, can be brought close to the direction of optical axis of the laser beam passing through the nonlinear optical crystal. In addition, axial deviation of the wavelength-converted laser beam converted by the nonlinear optical crystal and emitted through an output-window, can be reduced when the position of the nonlinear optical crystal is moved. The output facet of the nonlinear optical crystal is inclined at Brewster's angle with respect to the wavelength-converted laser beam. An output-window of a case containing the nonlinear optical crystal has a prism form in which the distance between a laser beam input facet and a laser beam output facet of the output-window is reduced along a direction in which the wavelength-converted laser beam, emitted from the nonlinear optical crystal, inclines.
摘要翻译：一种波长转换装置，其中具有由非线性光学晶体转换并通过输出窗口发射的波长的波长转换激光束的输出方向可以靠近通过该激光束的激光束的光轴方向非线性光学晶体。此外，当非线性光学晶体的位置移动时，可以减少由非线性光学晶体转换并通过输出窗口发射的波长转换的激光束的轴向偏移。非线性光学晶体的输出面相对于波长转换的激光束以布鲁斯特角倾斜。包含非线性光学晶体的壳体的输出窗口具有棱镜形式，其中激光束输入面与输出窗口的激光束输出面之间的距离沿着波长转换激光束，从非线性光学晶体发射，倾斜。

17. 发明授权

US5883737A Diode laser excitation solid-state laser amplifier and diode laser excitation solid-state laser 失效
标题翻译：二极管激光激光固态激光放大器和二极管激光激光固态激光器
公开(公告)号：US5883737A
公开(公告)日：1999-03-16
申请号：US823582
申请日：1997-03-25
申请人： Shuichi Fujikawa , Tetsuo Kojima
发明人： Shuichi Fujikawa , Tetsuo Kojima
IPC分类号： H01S3/0933 , H01S3/0941 , H01S5/40 , H01S3/00 , H01S3/093
CPC分类号： H01S3/0941 , H01S3/025 , H01S3/0407 , H01S3/061 , H01S3/094057 , H01S3/09408
摘要： A diode laser excitation sold-state laser amplifier capable of withstanding a mechanical disturbance, is easily fabricated and adjusted, can stably generate a high-efficiency high-quality laser beam and easily realize a large output. A diode laser excitation solid-state laser using this amplifier, including: a solid-state laser rod extending along the optical axis of a laser beam and including an active medium therein; two side plates for supporting both ends of the solid-state laser rod respectively; a flow tube provided to enclose the solid-state laser rod and containing a cooling medium; a plurality of excitation modules each having a flat substrate, with a hole formed at the center thereof through which the solid-state laser rod is passed, and at least one excitation light source, for providing excitation light from the lateral of the solid-state laser rod; and connecting and fixing means and for connecting a plurality of the excitation modules to each other and fixing them to the side plates.
摘要翻译：能够承受机械扰动的二极管激光激光售卖激光放大器易于制造和调整，可以稳定地产生高效率的高品质激光束，并且容易实现大的输出。一种使用该放大器的二极管激光激光固态激光器，包括：固体激光棒，其沿着激光束的光轴延伸并且包括其中的活性介质; 两个侧板分别用于支撑固态激光棒的两端; 设置为包围固态激光棒并容纳冷却介质的流管; 多个激励模块，每个激励模块均具有平坦的基板，在其中心处形成有固体激光棒通过的孔，以及至少一个激发光源，用于从固态的侧面提供激发光激光棒; 以及连接和固定装置，用于将多个激励模块彼此连接并将它们固定在侧板上。

18. 外观设计

USD680916S1 Side cover for a motor scooter 有权
标题翻译：汽车摩托车侧盖
公开(公告)号：USD680916S1
公开(公告)日：2013-04-30
申请号：US29401280
申请日：2011-09-09
申请人： Tetsuo Kojima , Kouhei Suzuki
设计人： Tetsuo Kojima , Kouhei Suzuki

19. 发明授权

US08062635B2 Bispecific antibody substituting for functional proteins 有权
标题翻译：替代功能蛋白的双特异性抗体
公开(公告)号：US08062635B2
公开(公告)日：2011-11-22
申请号：US10575193
申请日：2004-10-08
申请人： Kunihiro Hattori , Tetsuo Kojima , Taro Miyazaki , Tetsuhiro Soeda
发明人： Kunihiro Hattori , Tetsuo Kojima , Taro Miyazaki , Tetsuhiro Soeda
IPC分类号： A61K39/395
CPC分类号： C07K16/36 , C07K16/2866 , C07K2317/24 , C07K2317/31 , C07K2317/622
摘要： The present inventors succeeded in constructing bispecific antibodies, which bind to both the blood coagulation factor IX/activated blood coagulation factor IX and blood coagulation factor X, and functionally substitute for blood coagulation factor VIII/activated blood coagulation factor VIII which enhances the enzymatic reaction.
摘要翻译：本发明人成功构建了结合凝血因子IX /活化凝血因子IX和血液凝固因子X两者的双特异性抗体，并且功能性地代替增强酶促反应的凝血因子VIII /活化凝血因子VIII。

20. 发明申请

US20110245473A1 Anti-IL-6 Receptor Antibody 审中-公开
标题翻译：抗IL-6受体抗体
公开(公告)号：US20110245473A1
公开(公告)日：2011-10-06
申请号：US12680112
申请日：2008-09-26
申请人： Tomoyuki Igawa , Mika Sakurai , Tetsuo Kojima , Tatsuhiko Tachibana , Hirotake Shiraiwa , Hiroyuki Tsunoda , Atsuhiko Maeda
发明人： Tomoyuki Igawa , Mika Sakurai , Tetsuo Kojima , Tatsuhiko Tachibana , Hirotake Shiraiwa , Hiroyuki Tsunoda , Atsuhiko Maeda
IPC分类号： C07K16/28
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/24 , C07K2317/53 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , G01N33/6854 , G01N33/6869 , G01N2333/7155 , G01N2500/04 , G01N2500/10
摘要： The present inventors succeeded in discovering specific amino acid mutations in the variable region, framework region, and constant region of TOCILIZUMAB, and this enables to reduce immunogenicity risk and the heterogeneity originated from disulfide bonds in the hinge region, as well as to improve antigen binding activity, pharmacokinetics, stability under acidic conditions, and stability in high concentration preparations.
摘要翻译：本发明人成功地发现了TOCILIZUMAB的可变区，框架区和恒定区中的特异性氨基酸突变，这使得能够降低源自铰链区的二硫键的免疫原性风险和异质性，并且改善抗原结合活性，药代动力学，酸性条件下的稳定性和高浓度制剂中的稳定性。

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