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11. 发明授权

US06211145B1 Bicyclic depsipeptides 失效
标题翻译：双环脱肽
公开(公告)号：US06211145B1
公开(公告)日：2001-04-03
申请号：US09212481
申请日：1998-12-16
申请人： Makoto Yanai , Masashi Suzuki , Norio Oshida , Koji Kawamura , Shigeru Hiramoto , Orie Yasuda , Nobuhiro Kinoshita , Akiko Shingai , Masako Takasu
发明人： Makoto Yanai , Masashi Suzuki , Norio Oshida , Koji Kawamura , Shigeru Hiramoto , Orie Yasuda , Nobuhiro Kinoshita , Akiko Shingai , Masako Takasu
IPC分类号： A61K3808
CPC分类号： C07K7/06 , A61K38/00 , C07K7/56 , C07K7/64
摘要： The present invention provides a bicyclic depsipeptide having the formula (1) wherein: R is a straight or branched alkyl group of 5-20 carbon atoms or a straight or branched alkoxymethyl group of 5-15 carbon atoms; A, D, E and J independently are a residue of an amino acid selected from the group of alanine, valine, leucine, etc.; B and F are the same or different and a residue of an amino acid selected from the group consisting of cysteine, aspartic acid, glutamic acid, lysine, hydroxylysine and serine; G is a disulfide bond, an amido bond or an ester bond; W is a residue of an amino acid selected from the group consisting of aspartic acid and glutamic acid; Z is a residue of an amino acid selected from the group consisting of aspartic acid, asparagine, glutamic acid and glutamine; l, m, n, p and q independently are 0 or 1; or a pharmacologically acceptable salt thereof.
摘要翻译：本发明提供具有式（1）的双环脱肽酶，其中：R是5-20个碳原子的直链或支链烷基或5-15个碳原子的直链或支链烷氧基甲基; A，D，E和J独立地是选自丙氨酸，缬氨酸，亮氨酸等的氨基酸的残基; B和F相同或不同，并且选自半胱氨酸，天冬氨酸，谷氨酸，赖氨酸，羟赖氨酸和丝氨酸的氨基酸残基; G是二硫键，酰胺键或酯键; W是选自天冬氨酸和谷氨酸的氨基酸残基; Z是选自天冬氨酸，天冬酰胺，谷氨酸和谷氨酰胺的氨基酸的残基; l，m，n，p和q独立地为0或1; 或其药理学上可接受的盐。

12. 发明申请

US20080194826A1 Novel 4-(2-furoyl) aminopiperidienes, intermediates for synthesizing the same, processes for preparing the same and medicinal use of the same 审中-公开
标题翻译：新型4-（2-糠酰基）氨基哌啶子，其合成中间体，其制备方法及其医药用途
公开(公告)号：US20080194826A1
公开(公告)日：2008-08-14
申请号：US12077687
申请日：2008-03-20
申请人： Ryuuta Fukutomi , Hitoshi Inoue , Koji Kawamura , Takuya Kishimoto , Masashi Suzuki , Rie Shibayama , Kazuko Kojima , Kouichirou Hagihara
发明人： Ryuuta Fukutomi , Hitoshi Inoue , Koji Kawamura , Takuya Kishimoto , Masashi Suzuki , Rie Shibayama , Kazuko Kojima , Kouichirou Hagihara
IPC分类号： C07D401/12 , C07D211/58
CPC分类号： C07D401/12 , C07D211/58 , C07D405/12 , C07D405/14 , C07D413/14
摘要： A compound represented the general formula (V): wherein X is CH or N; and Ya is a group of the general formula selected from:
摘要翻译：化合物为通式（Ⅴ）：其中X为CH或N; 并且Y a a是选自以下的通式的基团：

13. 发明授权

US07375115B2 4-(2-furoyl) aminopiperidines, intermediates in synthesizing the same, process for producing the same and medicinal use of the same 失效
标题翻译： 4-（2-糠酰基）氨基哌啶，其合成中间体，其制备方法及其药学用途
公开(公告)号：US07375115B2
公开(公告)日：2008-05-20
申请号：US10492065
申请日：2002-10-08
申请人： Ryuuta Fukutomi , Hitoshi Inoue , Koji Kawamura , Takuya Kishimoto , Masashi Suzuki , Rie Shibayama , Kazuko Kojima , Kouichirou Hagihara
发明人： Ryuuta Fukutomi , Hitoshi Inoue , Koji Kawamura , Takuya Kishimoto , Masashi Suzuki , Rie Shibayama , Kazuko Kojima , Kouichirou Hagihara
IPC分类号： A01N43/40 , C07D401/00
CPC分类号： C07D401/12 , C07D211/58 , C07D405/12 , C07D405/14 , C07D413/14
摘要： There are provided novel 4(2-furoyl)aminopiperidines represented by the general formula (I), their synthetic intermediates, processes for their preparation and medicaments containing them. In the above formula, X is OH or N, and Y is a group of the following general formula (II), formula (II-a) or formula (III): wherein a, b and c are each an integer of 0-6; Z is CH2 or NH; W is O or S; T is O or N—R15 wherein R15 is H, a C1-C6 alkyl group, a benzyl group or a phenethyl group; and R1 is H, a C1-C6 alkoxycarbonyl group, a benzyloxy-carbonyl group, or the like. The 4-(2-furoyl)aminopiperidine derivatives according to this invention possess opioid μ antagonistic activity and are useful for the treatment or prevention of side effects which are caused by μ receptors agonist and which are selected from constipation, nausea/emesis or itch, or for the treatment or prevention of idiopathic constipation, postoperative ileus, paralytic ileus, irritable bowel syndrome or chronic pruritus.
摘要翻译：提供由通式（I）表示的新型4（2-糠酰基）氨基哌啶，其合成中间体，其制备方法和含有它们的药物。在上式中，X为OH或N，Y为下列通式（II），式（II-a）或式（III）的基团：其中a，b和c各自为0〜 6; Z是CH 2或NH; W为O或S; T是O或N-R 15，其中R 15是H，C 1 -C 6烷基，苄基或苯乙基; R 1是H，C 1 -C 6烷氧基羰基，苄氧基羰基等。根据本发明的4-（2-糠酰基）氨基哌啶衍生物具有阿片样物质μ拮抗活性，可用于治疗或预防由mu受体激动剂引起的副作用，其选自便秘，恶心/呕吐或瘙痒，或用于治疗或预防特发性便秘，术后肠梗阻，麻痹性肠梗阻，肠易激综合征或慢性瘙痒。

14. 发明申请

US20050085508A1 Novel 4-(2-furoyl) aminopiperidines, intermediates in synthesizing the same, process for producing the same and medicinal use of the same 失效
标题翻译：新型4-（2-糠酰基）氨基哌啶，其合成中间体，其制备方法及其医药用途
公开(公告)号：US20050085508A1
公开(公告)日：2005-04-21
申请号：US10492065
申请日：2002-10-08
申请人： Ryuuta Fukutomi , Hitoshi Inoue , Koji Kawamura , Takuya Kishimoto , Masashi Suzuki , Rie Shibayama , Kazuko Kojima , Kouichirou Hagihara
发明人： Ryuuta Fukutomi , Hitoshi Inoue , Koji Kawamura , Takuya Kishimoto , Masashi Suzuki , Rie Shibayama , Kazuko Kojima , Kouichirou Hagihara
IPC分类号： A61P1/04 , A61P1/08 , A61P1/10 , A61P17/04 , A61P43/00 , C07D211/58 , C07D401/12 , C07D405/12 , C07D405/14 , C07D413/14 , A61K31/445
CPC分类号： C07D401/12 , C07D211/58 , C07D405/12 , C07D405/14 , C07D413/14
摘要： There are provided novel 4-(2-furoyl)aminopiperidines represented by the general formula (I), their synthetic intermediates, processes for their preparation and medicaments containing them. In the above formula, X is CH or N, and Y is a group of the following general formula (II), formula (II-a) or formula (III): wherein a, b and c are each an integer of 0-6; Z is CH2 or NH; W is O or S; T is O or N—R15 wherein R15 is H, a C1-C6 alkyl group, a benzyl group or a phenethyl group; and R1 is H, a C1-C6 alkoxycarbonyl group, a benzyloxycarbonyl group, or the like. The 4-(2-furoyl)aminopiperidine derivatives according to this invention possess opioid μ antagonistic activity and are useful for the treatment or prevention of side effects which are caused by μ receptors agonist and which are selected from constipation, nausea/emesis or itch, or for the treatment or prevention of idiopathic constipation, postoperative ileus, paralytic ileus, irritable bowel syndrome or chronic pruritus.
摘要翻译：提供由通式（I）表示的新型4-（2-糠酰基）氨基哌啶，其合成中间体，其制备方法和含有它们的药物。在上式中，X是CH或N，Y是下列通式（II），式（II-a）或式（III）的基团：其中a，b和c各自为0〜 6; Z是CH 2或NH; W为O或S; T是O或N-R 15，其中R 15是H，C 1 -C 6烷基，苄基或苯乙基; R 1是H，C 1 -C 6烷氧基羰基，苄氧基羰基等。根据本发明的4-（2-糠酰基）氨基哌啶衍生物具有阿片样物质μ拮抗活性，可用于治疗或预防由mu受体激动剂引起的副作用，其选自便秘，恶心/呕吐或瘙痒，或用于治疗或预防特发性便秘，术后肠梗阻，麻痹性肠梗阻，肠易激综合征或慢性瘙痒。

15. 发明申请

US20120220972A1 ABSORBENT ARTICLE 审中-公开
标题翻译：吸收品
公开(公告)号：US20120220972A1
公开(公告)日：2012-08-30
申请号：US13508130
申请日：2010-11-10
申请人： Koji Kawamura , Noriyuki Kurita
发明人： Koji Kawamura , Noriyuki Kurita
IPC分类号： A61F13/512
CPC分类号： A61F13/535 , A61F13/49001
摘要： An absorbent article adapted to accelerate an absorption rate of the absorbent member, to enlarge an absorption area in the absorbent member and to improve an absorption capacity of the absorbent member. A urine absorption pad includes a topsheet, a backsheet, a first layer element and a second layer element. The first layer element is formed with a slot-like first through hole extending nearly vertically in a thickness direction from its upper surface to its lower surface. The second layer element is formed with a slot-like second through hole extending nearly vertically in the thickness direction from its upper surface to its lower surface and overlapping with the first through hole. An opening area of the first through hole is larger than that of the second through hole and, in an overlapping state of the first through hole and the second through hole, front and rear ends and opposite side edges of the second through hole extend inward from front and rear ends and opposite side edges of the first through hole so as to define a stepped region between the first through hole and the second through hole.
摘要翻译：适合于加速吸收体的吸收速度的吸收性物品，增大吸收体的吸收面积，提高吸收体的吸收能力。吸尿垫包括顶片，底片，第一层元件和第二层元件。第一层元件形成有从其上表面到其下表面在厚度方向上几乎垂直延伸的槽状第一通孔。第二层元件形成有从其上表面到其下表面在厚度方向上几乎垂直延伸并且与第一通孔重叠的槽状的第二通孔。第一通孔的开口面积大于第二通孔的开口面积，并且在第一通孔和第二通孔的重叠状态下，第二通孔的前后端和相对侧边缘从前端和后端以及第一通孔的相对侧边缘，以便限定第一通孔和第二通孔之间的台阶区域。

16. 发明授权

US08116664B2 Image forming apparatus with member for switching between driving force modes 有权
标题翻译：具有用于在驱动力模式之间切换的构件的图像形成装置
公开(公告)号：US08116664B2
公开(公告)日：2012-02-14
申请号：US12891159
申请日：2010-09-27
申请人： Koji Kawamura
发明人： Koji Kawamura
IPC分类号： G03G15/01
CPC分类号： G03G15/0896 , G03G15/0121 , G03G2221/1657
摘要： An image forming apparatus forming a color image on a recording material mounts black and non-black process cartridges including a photosensitive drum and a developing roller and includes a driving source; first and second clutches connecting and disconnecting the driving source and the developing roller of the black and non-black cartridges, respectively; first and second members actable on the first and second clutches, respectively, each for switching between operation and non-operation states for respectively transmitting and not transmitting a driving force to the developing rollers; and a switching member, movable by the driving force of the driving source and actable on the first and second members for switching among first, second, and third modes, for respectively transmitting the driving force to the developing rollers of all of the process cartridges, to any one of the developing rollers, and only to the developing roller of the black process cartridge.
摘要翻译：在记录材料上形成彩色图像的图像形成装置安装包括感光鼓和显影辊的黑色和非黑色处理盒，并且包括驱动源; 第一和第二离合器分别连接和断开黑色和非黑色墨盒的驱动源和显影辊; 第一和第二构件分别在第一和第二离合器上起作用，用于在操作和非操作状态之间切换，用于分别传递和不传递驱动力到显影辊; 以及切换构件，其可通过所述驱动源的驱动力移动并且可在所述第一和第二构件上作用以在第一，第二和第三模式之间切换，以分别将驱动力传递到所有处理盒的显影辊，到任何一个显影辊，并且仅到黑色处理盒的显影辊。

17. 发明申请

US20080179820A1 SHEET FEEDING DEVICE AND IMAGE FORMING APPARATUS 有权
标题翻译：纸张进给装置和图像形成装置
公开(公告)号：US20080179820A1
公开(公告)日：2008-07-31
申请号：US12019107
申请日：2008-01-24
申请人： Koji Kawamura , Yasuzumi Taba
发明人： Koji Kawamura , Yasuzumi Taba
IPC分类号： B65H1/08 , B41F13/00
CPC分类号： B65H1/26 , B65H2402/5151 , B65H2405/11164 , B65H2405/1122 , B65H2511/10 , B65H2511/20 , B65H2801/06 , G03G15/6502 , B65H2220/01 , B65H2220/04
摘要： A slide cassette is slidably provided in a main cassette of a sheet cassette. When a sheet with a size larger than that of a sheet which may be stored in the main cassette is stored, the slide cassette is sled and moved to extend the sheet cassette. There is provided a fixing portion which may fix the slide cassette and the main cassette in a state in which the sheet cassette is in a shortened or an extended state by sliding the slide cassette. The fixing portion releases the fixing by an operation in which the slide cassette is sled in a shortening direction or extending direction.
摘要翻译：滑动盒可滑动地设置在纸盒的主盒中。当存储尺寸大于可以存储在主盒中的片材的片材的片材被存储时，滑动盒被滑动并移动以延伸片材盒。提供了一种固定部分，其可以通过滑动滑动盒来将滑动盒和主盒固定在片材盒处于缩短或延伸状态的状态。固定部通过滑动盒在缩短方向或延伸方向上滑动的操作而释放固定。

18. 发明申请

US20050007607A1 Printing apparatus and printing data control method 失效
标题翻译：打印设备和打印数据控制方法
公开(公告)号：US20050007607A1
公开(公告)日：2005-01-13
申请号：US10805324
申请日：2004-03-22
申请人： Hiroki Kitamura , Hisashi Ishikawa , Koji Kawamura
发明人： Hiroki Kitamura , Hisashi Ishikawa , Koji Kawamura
IPC分类号： G06F15/00 , G06K15/10
CPC分类号： G06K15/102
摘要： In a printing apparatus which performs printing by scanning a carriage that supports a printhead having a plurality of printing elements arrayed in a predetermined direction, on a printing medium in a direction perpendicular to the predetermined direction, printing data of a raster format obtained by processing transmitted image information into data used for printing, or printing data transmitted in the raster format is stored in a printing data memory. The printing data stored in the printing data memory is stored in a buffer memory having a storage area corresponding to each printing element. This arrangement adopts a head parameter unit which stores information on the printhead arrangement. Processing of reading out the printing data stored in the printing data memory and storing the printing data in the buffer memory, and processing of reading out the printing data stored in the buffer memory are controlled in accordance with the information stored in the head parameter unit.
摘要翻译：在通过扫描支撑具有沿预定方向排列的多个打印元件的打印头的托架进行打印的打印设备中，在与所述预定方向垂直的方向上的打印介质上打印通过处理传送的光栅格式的数据将图像信息转换为用于打印的数据或以光栅格式发送的数据被存储在打印数据存储器中。存储在打印数据存储器中的打印数据被存储在具有对应于每个打印元件的存储区域的缓冲存储器中。这种布置采用头部参数单元，其存储关于打印头布置的信息。根据存储在头部参数单元中的信息来控制读出存储在打印数据存储器中的打印数据并将打印数据存储在缓冲存储器中的处理以及读出存储在缓冲存储器中的打印数据的处理。

19. 发明授权

US06204935B1 Image processing method and an image processing apparatus 失效
标题翻译：图像处理方法和图像处理装置
公开(公告)号：US06204935B1
公开(公告)日：2001-03-20
申请号：US08518326
申请日：1995-08-23
申请人： Tsunenori Soma , Katsumi Masaki , Masayuki Takayama , Hiroshi Netsu , Masashi Takizawa , Makoto Nihei , Koji Kawamura
发明人： Tsunenori Soma , Katsumi Masaki , Masayuki Takayama , Hiroshi Netsu , Masashi Takizawa , Makoto Nihei , Koji Kawamura
IPC分类号： H04N140
CPC分类号： H04N1/32133 , H04N1/00204 , H04N1/00968 , H04N1/3871 , H04N1/3875 , H04N2201/0081 , H04N2201/0082 , H04N2201/3242 , H04N2201/3269
摘要： An image processor reads an original that includes an original image and an attribute instruction image, for designating the contents of the image processing that is performed on the original image. This ensures that image processing is performed in consonance with the contents of the attribute instructions that are indicated by the attribute instruction image. A scanner reads a format original wherein instructions for data attributes, such as a range for a character frame and a character color, are expressed with a bar code. The pattern of the read bar code is analyzed, and the attribute instruction data, such as the range for a character frame and a character color, are temporarily stored in a RAM. An original to be output is read by the scanner and is stored as image data in the RAM. Image processing (color conversion, etc.) that correspond to the attribute instruction data is performed on the image data, and a printer prints image data obtained by performing all of the instructed image processes.
摘要翻译：图像处理器读取包括原始图像和属性指令图像的原稿，用于指定对原始图像执行的图像处理的内容。这确保了根据由属性指令图像指示的属性指令的内容来执行图像处理。扫描器读取格式原件，其中用条形码表示数据属性的指令，例如字符帧和字符颜色的范围。分析读取条形码的图案，将诸如字符帧和字符颜色的范围的属性指令数据临时存储在RAM中。要输出的原稿由扫描仪读取，并作为图像数据存储在RAM中。对图像数据执行与属性指示数据相对应的图像处理（颜色转换等），并且打印机打印通过执行所有指示的图像处理而获得的图像数据。

20. 发明授权

US6077047A Variable displacement compressor 失效
标题翻译：可变排量压缩机
公开(公告)号：US6077047A
公开(公告)日：2000-06-20
申请号：US12696
申请日：1998-01-23
申请人： Hiroyuki Nagai , Masahiro Kawaguchi , Masanori Sonobe , Ken Suitou , Takuya Okuno , Koji Kawamura
发明人： Hiroyuki Nagai , Masahiro Kawaguchi , Masanori Sonobe , Ken Suitou , Takuya Okuno , Koji Kawamura
IPC分类号： F04B27/10 , F04B27/18 , F04B1/26
CPC分类号： F04B27/1804 , F04B27/1072 , F04B2027/1813 , F04B2027/1827 , F04B2027/1854 , F04B2027/1859
摘要： A variable displacement type compressor is disclosed. The compressor includes a housing, a cylinder bore within the housing, a piston located in the cylinder bore, a drive shaft rotatably supported by the housing, a rotary support mounted on the drive shaft, and a cam plate connected to the piston. The cam plate is supported tiltably on the drive shaft and is slidable in axial directions of the drive shaft. The cam plate inclines between a maximum inclination position and a minimum inclination position when the displacement of the compressor is changed. A first moment is applied to the cam plate by a compression reaction force of the piston when the compressor is operating. A hinge mechanism is located between the rotary support and the cam plate. The cam plate is rotated integrally with the drive shaft, the rotary support, and the hinge mechanism. An urging device is located between the rotary support and the cam plate for urging the cam plate toward the minimum go inclination angle position An applying mechanism applies a second moment to the swash plate in the same direction as the first moment when the compressor is not operating.
摘要翻译：公开了一种可变排量型压缩机。压缩机包括壳体，壳体内的气缸孔，位于气缸孔中的活塞，由壳体可旋转地支撑的驱动轴，安装在驱动轴上的旋转支撑件和连接到活塞的凸轮板。凸轮板可倾斜地支撑在驱动轴上并且可沿驱动轴的轴向方向滑动。当压缩机的位移改变时，凸轮板在最大倾斜位置和最小倾斜位置之间倾斜。当压缩机运行时，通过活塞的压缩反作用力将凸轮板施加第一时刻。铰链机构位于旋转支架和凸轮板之间。凸轮板与驱动轴，旋转支撑件和铰链机构一体地旋转。推动装置位于旋转支撑件和凸轮板之间，用于将凸轮板朝向最小向下倾斜角度位置推动。施加机构沿着与压缩机不工作的第一时刻相同的方向向斜盘施加第二力矩。

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