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11. 发明申请

US20060105440A1 Method of producing polyhydroxyalkanoate 审中-公开
标题翻译：聚羟基链烷酸酯的制备方法
公开(公告)号：US20060105440A1
公开(公告)日：2006-05-18
申请号：US11237686
申请日：2005-09-29
申请人： Koichi Kinoshita , Yoshifumi Yanagida , Fumio Osakada , Yasuyoshi Ueda
发明人： Koichi Kinoshita , Yoshifumi Yanagida , Fumio Osakada , Yasuyoshi Ueda
IPC分类号： C12P7/62
CPC分类号： C12P7/62 , C08G63/89
摘要： The present invention has its object to provide a method of producing PHA by extracting, separating, and purifying PHA from biomass containing PHA having an weight average molecular weight of more than 2,000,000, by which smooth stirring can be carried out during extraction and filterability of a residue becomes good to thereby efficiently produce PHA with good operability. In the present invention, PHA is extracted, separated, and purified from biomass by a method of producing polyhydroxyalkanoate by extracting and isolating polyhydroxyalkanoate by using an aprotic organic solvent from biomass containing polyhydroxyalkanoate having a weight average molecular weight of more than 2,000,000, which comprises decreasing the weight average molecular weight of the polyhydroxyalkanoate through any one of the following treatments: (a) the biomass is heated at 40 to 500° C. before addition of the aprotic organic solvent; (b) the biomass is heated at 40 to 500° C. before addition of the aprotic organic solvent, and is further heated at 40 to 200° C. in the aprotic organic solvent; (c) the biomass is heated at 40 to 500° C. before addition of the aprotic organic solvent, and is further heated at 40 to 200° C. in the aprotic organic solvent in the presence of water and/or an alcohol; (d) the biomass is not heated before addition of the aprotic organic solvent, but is heated at 40 to 200° C. in the aprotic organic solvent; and (e) the biomass is not heated before addition of the aprotic organic solvent, but is heated at 40 to 200° C. in the aprotic organic solvent in the presence of water and/or an alcohol.
摘要翻译：本发明的目的是提供一种通过从重均分子量大于2,000,000的PHA的生物质中提取，分离和纯化PHA来生产PHA的方法，通过该方法可以在提取过程中进行平稳的搅拌和过滤性残留物变得良好，从而有效地产生具有良好可操作性的PHA。在本发明中，通过使用含有重均分子量大于2,000,000的聚羟基链烷酸酯的生物质的非质子有机溶剂提取和分离聚羟基链烷酸酯的方法，从生物质中提取，分离和纯化PHA，其包括降低通过以下任何一种处理，聚羟基链烷酸酯的重均分子量：（a）在加入非质子有机溶剂之前，将生物质在40-500℃下加热; （b）在加入非质子有机溶剂之前将生物质在40-500℃加热，并在非质子有机溶剂中在40〜200℃下进一步加热; （c）在加入非质子有机溶剂之前将生物质加热至40-500℃，并在水和/或醇存在下，在非质子有机溶剂中在40〜200℃下进一步加热; （d）在加入非质子有机溶剂之前，不加热生物质，但在非质子有机溶剂中在40〜200℃下加热生物质; 和（e）生物质在加入非质子有机溶剂之前不被加热，但在水和/或醇的存在下，在非质子传递的有机溶剂中在40-200℃下加热。

12. 发明申请

US20100016634A1 METHOD FOR STABILIZING CARBODIIMIDE DERIVATIVE AND STABILIZED COMPOSITION THEREOF 审中-公开
标题翻译：用于稳定碳二亚胺衍生物和稳定化合物的方法
公开(公告)号：US20100016634A1
公开(公告)日：2010-01-21
申请号：US12439005
申请日：2007-08-30
申请人： Kunihiko Seno , Masao Okuda , Hiroaki Kawasaki , Tadashi Moroshima , Yasuyoshi Ueda
发明人： Kunihiko Seno , Masao Okuda , Hiroaki Kawasaki , Tadashi Moroshima , Yasuyoshi Ueda
IPC分类号： C07C267/00
CPC分类号： C07C267/00
摘要： Disclosed is a method for stabilizing a carbodiimide derivative (1) which is a condensing agent useful for production of general synthetic chemical products. Also disclosed is a stabilized composition of the carbodiimide derivative. The method is characterized in that the carbodiimide derivative (1) is handled in an atmosphere wherein the concentration of molecular oxygen in the gas phase within a container is set at not more than 3% by volume and/or in the co-presence of at least one compound selected from the group consisting of antioxidants, N-oxyl compounds, sulfur compounds, amines and Lewis acids.
摘要翻译：公开了一种稳定碳二亚胺衍生物（1）的方法，碳二亚胺衍生物（1）是可用于生产一般合成化学产品的缩合剂。还公开了碳二亚胺衍生物的稳定化组合物。该方法的特征在于，将碳二亚胺衍生物（1）在容器内气相中的分子氧浓度设定为3体积％以下和/或共存于选自抗氧化剂，N-氧基化合物，硫化合物，胺和路易斯酸的至少一种化合物。

13. 发明授权

US07230126B2 Method for obtaining optically active epoxide 失效
标题翻译：获得光学活性环氧化物的方法
公开(公告)号：US07230126B2
公开(公告)日：2007-06-12
申请号：US10475122
申请日：2002-05-10
申请人： Tadashi Moroshima , Yasuyoshi Ueda
发明人： Tadashi Moroshima , Yasuyoshi Ueda
IPC分类号： C07D301/02
CPC分类号： C07D301/36 , C07D301/32 , C07D303/08
摘要： The present invention provides a method capable of suppressing a decrease in optical purity due to the exposure to heat during distillation of an optically active epoxide to permit an optically active epoxide of high quality to be simply obtained on an industrial scale. In the method, an optically active epoxide is distilled in the presence of a base to suppress a decrease in optical purity.
摘要翻译：本发明提供了一种能够抑制光学活性环氧化物蒸馏期间暴露于热量时光学纯度降低的方法，以便以工业规模简单地获得高质量的光学活性环氧化物。在该方法中，在碱的存在下蒸发光学活性环氧化物以抑制光学纯度的降低。

14. 发明授权

US4994600A Process for preparing trans-.beta.-benzoylacrylic acid ester 失效
标题翻译：反式β-苯甲酰丙烯酸酯的制备方法
公开(公告)号：US4994600A
公开(公告)日：1991-02-19
申请号：US869782
申请日：1986-06-02
申请人： Satomi Takahashi , Yasuyoshi Ueda , Yoshifumi Yanagida , Namito Yoshio , Takehisa Ohashi , Kiyoshi Watanabe
发明人： Satomi Takahashi , Yasuyoshi Ueda , Yoshifumi Yanagida , Namito Yoshio , Takehisa Ohashi , Kiyoshi Watanabe
IPC分类号： C07C69/738 , B01J27/02 , B01J31/02 , B01J31/14 , C07B61/00 , C07C67/327
CPC分类号： C07C67/327
摘要： A process for preparing trans-.beta.-benzoylacrylic acid ester having the general formula (I): ##STR1## wherein R is alkyl group or aralkyl group, which comprises dealcoholizing .beta.-benzoyl-.alpha.-alkoxypropionic acid ester having the general formula (II): ##STR2## wherein R is above, in the presence of an acid catalyst to give trans-.beta.-benzoylacrylic acid ester having the general formula (I).According to the process of the present invention, the by-product (II) produced in the esterification reaction of .beta.-benzoylacrylic acid (III) with the alcohol (V) by the dehydration reaction can be converted into the compound (I) by the dealcoholization reaction in the presence of the acid catalyst and thus trans-.beta.-benzoylacrylic acid ester (I) with a high purity can be produced in an industrially advantageous manner.
摘要翻译：制备具有通式（I）的反式-β-苯甲酰基丙烯酸酯的方法：其中R是烷基或芳烷基，其包括使具有通式（I）的β-苯甲酰基-α-烷氧基丙酸酯脱醇（II）：其中R在上面，在酸催化剂存在下，得到具有通式（I）的反式-β-苯甲酰基丙烯酸酯。根据本发明的方法，通过脱水反应在β-苯甲酰基丙烯酸（III）与醇（V）的酯化反应中产生的副产物（II）可以通过在酸催化剂存在下脱醇反应，从而可以以工业上有利的方式生产具有高纯度的反式-β-苯甲酰基丙烯酸酯（I）。

15. 发明申请

US20060247458A1 Process for the production of optically active compounds having substituents at the 2-position 审中-公开
标题翻译：用于制备在2-位具有取代基的光学活性化合物的方法
公开(公告)号：US20060247458A1
公开(公告)日：2006-11-02
申请号：US10546823
申请日：2004-02-25
申请人： Shogo Yamamoto , Toshihiro Takeda , Yoshihide Fuse , Yasuyoshi Ueda
发明人： Shogo Yamamoto , Toshihiro Takeda , Yoshihide Fuse , Yasuyoshi Ueda
IPC分类号： C07C319/02
CPC分类号： C07B53/00 , C07B2200/07 , C07C51/363 , C07C319/14 , C07C57/58 , C07C323/56
摘要： The present invention provides a process for producing an optically active compound having a thio group at the 2-position important for manufacturing medicines. An optically active compound having a hydroxyl group at the 2-position is chlorinated with inversion of the configuration at the 2-position, and the resultant optically active compound having a chlorine atom at the 2-position is reacted with a metal thiolate to introduce a thio group with inversion of the configuration at the 2-position. This process is capable of minimizing racemization and producing an optically active compound having a thio group at the 2-position at low cost in high yield. When the optically active compound having a chlorine atom at the 2-position is reacted with the metal thiolate in coexistence with water in the reaction system, the optically active compound having a thio group at the 2-position with higher optical purity can be produced in higher yield. An optically active carboxylic acid having a thio group at the 2-position is crystallized in the presence of an aliphatic hydrocarbon solvent and/or a sulfur-containing solvent to effectively remove coexistent impurities such as an optical isomer and the like, thereby producing crystals of an optically active carboxylic acid having a thio group at the 2-position with higher purity.
摘要翻译：本发明提供了制造药物重要的2位具有硫基的光学活性化合物的方法。在2-位上具有羟基的光学活性化合物用2-位反转形式进行氯化，所得2-位上具有氯原子的光学活性化合物与金属硫醇盐反应，引入硫基与2-位配位反转。该方法能够使外消旋化最小化，并以高产率以低成本制备在2-位具有硫基的光学活性化合物。当反应体系中2-位上具有氯原子的光学活性化合物与金属硫醇盐在水中共存时，具有较高光学纯度的2位具有硫基的光学活性化合物可以在更高的产量。在脂肪族烃溶剂和/或含硫溶剂的存在下，在2-位具有硫基的光学活性羧酸结晶化，以有效除去共同的杂质如旋光异构体等，从而产生在2-位具有较高纯度的具有硫基的光学活性羧酸。

16. 发明授权

US07435567B2 Method for degradation of nucleic acids and use thereof 有权
标题翻译：核酸降解方法及其用途
公开(公告)号：US07435567B2
公开(公告)日：2008-10-14
申请号：US11070083
申请日：2005-03-03
申请人： Fumio Osakada , Yoshifumi Yanagida , Yasuyoshi Ueda
发明人： Fumio Osakada , Yoshifumi Yanagida , Yasuyoshi Ueda
IPC分类号： C12P7/62
CPC分类号： C12M47/06 , C12P7/62
摘要： The present invention provides a method to efficiently degrade nucleic acids, which result in a viscosity increase of the solution thereof on the occasion of decomposition or solubilization of microbial cells, in an easy and simple manner in the step of recovering various useful substance produced by a microorganism, and a use thereof. The product recovery method of the present invention make the product recovery from within microbial cells with ease under relatively mild conditions, because, by bringing living microbial cells into contact with a little amount of hypochlorous acid or a salt thereof, autodigestion of nucleic acids is induced and following decomposition of microbial cells or viscosity increase of the solution thereof after dissolution is inhibited. The method of the present invention is particularly preferred in recovering polyhydroxyalkanoates, which are biodegradable polymers, from microbial cells.
摘要翻译：本发明提供了一种在回收各种有用物质的步骤中以容易且简单的方式有效降解核酸的方法，其在微生物细胞的分解或溶解的情况下导致其溶液的粘度增加，微生物及其用途。本发明的产品回收方法使得在相对温和的条件下容易从微生物细胞中回收产物，因为通过使活的微生物细胞与少量的次氯酸或其盐接触，诱导了核酸的自身消化并且随着微生物细胞的分解或溶解后其溶液的粘度增加被抑制。本发明的方法特别优选从微生物细胞回收可生物降解的聚合物的聚羟基链烷酸酯。

17. 发明申请

US20050196827A1 Method for degradation of nucleic acids and use thereof 有权
标题翻译：核酸降解方法及其用途
公开(公告)号：US20050196827A1
公开(公告)日：2005-09-08
申请号：US11070083
申请日：2005-03-03
申请人： Fumio Osakada , Yoshifumi Yanagida , Yasuyoshi Ueda
发明人： Fumio Osakada , Yoshifumi Yanagida , Yasuyoshi Ueda
IPC分类号： C12P7/62
CPC分类号： C12M47/06 , C12P7/62
摘要： The present invention provides a method to efficiently degrade nucleic acids, which result in a viscosity increase of the solution thereof on the occasion of decomposition or solubilization of microbial cells, in an easy and simple manner in the step of recovering various useful substance produced by a microorganism, and a use thereof. The product recovery method of the present invention make the product recovery from within microbial cells with ease under relatively mild conditions, because, by bringing living microbial cells into contact with a little amount of hypochlorous acid or a salt thereof, autodigestion of nucleic acids is induced and following decomposition of microbial cells or viscosity increase of the solution thereof after dissolution is inhibited. The method of the present invention is particularly preferred in recovering polyhydroxyalkanoates, which are biodegradable polymers, from microbial cells.
摘要翻译：本发明提供了一种在回收各种有用物质的步骤中以容易且简单的方式有效降解核酸的方法，其在微生物细胞的分解或溶解的情况下导致其溶液的粘度增加，微生物及其用途。本发明的产品回收方法使得在相对温和的条件下容易从微生物细胞中回收产物，因为通过使活的微生物细胞与少量的次氯酸或其盐接触，诱导了核酸的自身消化并且随着微生物细胞的分解或溶解后其溶液的粘度增加被抑制。本发明的方法特别优选从微生物细胞回收可生物降解的聚合物的聚羟基链烷酸酯。

18. 发明申请

US20050222373A1 Method for producing polyhydroxyalkanoate crystal 失效
标题翻译：聚羟基链烷酸酯晶体的制备方法
公开(公告)号：US20050222373A1
公开(公告)日：2005-10-06
申请号：US10992132
申请日：2004-11-19
申请人： Koichi Kinoshita , Fumio Osakada , Yasuyoshi Ueda , Karunakaran Narasimhan , Angella Cearley , Kenneth Yee , Isao Noda
发明人： Koichi Kinoshita , Fumio Osakada , Yasuyoshi Ueda , Karunakaran Narasimhan , Angella Cearley , Kenneth Yee , Isao Noda
IPC分类号： C08G67/00
CPC分类号： C08G63/90 , C08G63/06
摘要： The present invention provides a method for easily obtaining a biodegradable polyhydroxyalkanoate by a solvent extraction method. A method for producing a polyhydroxyalkanoate crystal which comprises mixing a solution of a polyhydroxyalkanoate in a good solvent with a poor solvent at 50 to 130° C. to precipitate a polyhydroxyalkanoate.
摘要翻译：本发明提供了一种通过溶剂萃取方法容易地获得可生物降解的聚羟基链烷酸酯的方法。一种制备聚羟基链烷酸酯晶体的方法，其包括在50-130℃下将聚羟基链烷酸酯在良溶剂中的溶液与不良溶剂混合以沉淀聚羟基链烷酸酯。

19. 发明授权

US06320072B1 Method for isolation of n-protected s-phenylcysteine 失效
标题翻译：用于分离正保护的S-苯基半胱氨酸的方法
公开(公告)号：US06320072B1
公开(公告)日：2001-11-20
申请号：US09646702
申请日：2000-12-14
申请人： Yasuyoshi Ueda , Hiroshi Murao , Koki Yamashita , Koichi Kinoshita
发明人： Yasuyoshi Ueda , Hiroshi Murao , Koki Yamashita , Koichi Kinoshita
IPC分类号： C07C32100
CPC分类号： C07C319/28 , Y02P20/55 , C07C323/59
摘要： This invention provides a method of isolating N-protected-S-phenylcysteine (1) of high purity, expediently, efficiently and in good yield, which comprises causing said N-protected-S-phenylcysteine to be salted out in the form of a base salt in the presence of water. wherein R1 represents an amino-protecting group; R2 represents a hydrogen atom or, either independently of R1 or taken together with R1, represents an amino-protecting group.
摘要翻译：本发明提供了一种方法，有效和高效分离高纯度N-保护的S-苯基半胱氨酸（1）的方法，其包括使所述N-保护的S-苯基半胱氨酸以碱的形式盐析盐，其中R 1表示氨基保护基; R 2表示氢原子，或独立地为R 1或与R 1一起表示氨基保护基。

20. 发明申请

US20050228168A1 Method for producing polyhydroxyalkanoate crystal 有权
标题翻译：聚羟基链烷酸酯晶体的制备方法
公开(公告)号：US20050228168A1
公开(公告)日：2005-10-13
申请号：US10992133
申请日：2004-11-19
申请人： Koichi Kinoshita , Fumio Osakada , Yasuyoshi Ueda , Karunakaran Narasimhan , Angella Cearley , Kenneth Yee , Isao Noda
发明人： Koichi Kinoshita , Fumio Osakada , Yasuyoshi Ueda , Karunakaran Narasimhan , Angella Cearley , Kenneth Yee , Isao Noda
IPC分类号： C08F6/00 , C08G63/06 , C08G63/90 , C12P7/62
CPC分类号： C12P7/625 , C08G63/06 , C08G63/90
摘要： The present invention provides a method for conveniently obtaining a biodegradable polyhydroxyalkanoate by a solvent extraction method. A method for producing a polyhydroxyalkanoate crystal comprises precipitating a polyhydroxyalkanoate crystal using a monohydric alcohol having 4 to 10 carbon atoms as a extraction solvent, keeping a polyhydroxyalkanoate solution containing 0.1 to 10% by weight of water relative to the total amount of the solution warm at 70° C. or higher, and cooling the solution to below 70° C.
摘要翻译：本发明提供一种通过溶剂萃取方法方便地获得生物可降解的聚羟基链烷酸酯的方法。聚羟基链烷酸酯晶体的制造方法包括使用具有4〜10个碳原子的一元醇作为提取溶剂使聚羟基链烷酸酯晶体析出，保持含有0.1〜10重量％的水的聚羟基链烷酸酯溶液相对于温度为 70℃以上，将溶液冷却至70℃以下。

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