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11. 发明授权

US08717024B2 System and method for generating a magnetic resonance image using compressed sensing and parallel imaging 有权
标题翻译：使用压缩感测和并行成像产生磁共振图像的系统和方法
公开(公告)号：US08717024B2
公开(公告)日：2014-05-06
申请号：US13342857
申请日：2012-01-03
申请人： Kevin F. King , Dan Xu
发明人： Kevin F. King , Dan Xu
IPC分类号： G01R33/44
CPC分类号： G01R33/5611
摘要： A method for generating a magnetic resonance image includes acquiring a first k-space data set from each of a plurality of RF coils. The first k-space data set includes calibration data and randomly undersampled data. For each RF coil, a fully randomly sampled k-space data set is generated by removing a portion of the calibration data. A compressed sensing reconstruction technique is applied to the fully randomly sampled k-space data set to generate an aliased image, which is used to generate a uniformly undersampled k-space data set. A second k-space data set is generated by inserting the portion of the calibration data and a parallel imaging reconstruction technique is applied to the second k-space data set to synthesize unacquired data. The second k-space data set and the synthesized data are combined to generate a complete k-space data set for the RF coil.
摘要翻译：用于产生磁共振图像的方法包括从多个RF线圈中的每一个获取第一k空间数据集。第一个k空间数据集包括校准数据和随机欠采样数据。对于每个RF线圈，通过去除一部分校准数据来生成完全随机采样的k空间数据集。将压缩感测重构技术应用于完全随机采样的k空间数据集，以生成用于生成统一欠采样的k空间数据集的混叠图像。通过插入校准数据的一部分来生成第二k空间数据集，并且将并行成像重构技术应用于第二k空间数据集合以合成未查询的数据。第二k空间数据组和合成数据被组合以产生用于RF线圈的完整的k空间数据集。

12. 发明授权

US08680860B2 System and method for reducing localized signal fluctuation 有权
标题翻译：减少局部信号波动的系统和方法
公开(公告)号：US08680860B2
公开(公告)日：2014-03-25
申请号：US12962945
申请日：2010-12-08
申请人： Dan Xu , Jian Zhang , Richard Scott Hinks , Kevin F. King
发明人： Dan Xu , Jian Zhang , Richard Scott Hinks , Kevin F. King
IPC分类号： G01V3/00
CPC分类号： G01R33/4838 , G01R33/5607
摘要： A system and method is disclosed for eliminating localized fluctuation artifacts caused by fat signal contamination in MR images, the system includes a magnetic resonance imaging (MRI) system having a plurality of gradient coils positioned about a bore of a magnet, and an RF transceiver system and an RF switch controlled by a pulse module to transmit RF signals to an RF coil assembly to acquire MR images, and a computer programmed to apply a spectral-spatial fat saturation pulse, apply a slice selection gradient pulse, acquire imaging data of an imaging slice of interest, and generate an image.
摘要翻译：公开了一种用于消除由MR图像中的脂肪信号污染引起的局部波动伪影的系统和方法，该系统包括具有围绕磁体的孔定位的多个梯度线圈的磁共振成像（MRI）系统，以及RF收发器系统以及由脉冲模块控制的RF开关以将RF信号传输到RF线圈组件以获取MR图像，以及被编程为应用频谱 - 空间脂肪饱和脉冲的计算机，应用切片选择梯度脉冲，获取成像的成像数据切片感兴趣，并生成图像。

13. 发明申请

US20120271584A1 SYSTEM AND METHOD FOR PROSPECTIVE CORRECTION OF HIGH ORDER EDDY-CURRENT-INDUCED DISTORTION IN DIFFUSION-WEIGHTED ECHO PLANAR IMAGING 有权
标题翻译：用于扩展加权ECHO平面成像中高阶EDDY电流诱导失真的前瞻性校正的系统和方法
公开(公告)号：US20120271584A1
公开(公告)日：2012-10-25
申请号：US13364003
申请日：2012-02-01
申请人： Dan Xu , Joseph K. Maier , Kevin F. King , Bruce David Collick
发明人： Dan Xu , Joseph K. Maier , Kevin F. King , Bruce David Collick
IPC分类号： G01R35/00
CPC分类号： G01R33/56518 , G01R33/5616 , G01R33/56341
摘要： A computer is programmed to acquire calibration data from a calibration scan, the calibration data configured to characterize high order eddy current (HOEC) generated magnetic field error of an imaging system. The computer is also programmed to process the calibration data to generate a plurality of basis coefficients and a plurality of time constants and to calculate a plurality of basis correction coefficients based on the plurality of basis coefficients, the plurality of time constants, and gradient waveforms in a given pulse sequence. The computer is further programmed to execute a diffusion-weighted imaging scan that comprises application of a DW-EPI pulse sequence to acquire MR data from an imaging subject and reconstruction of an image based on the acquired MR data. The computer is also programmed to apply HOEC-generated magnetic field error correction during application of the DW-EPI pulse sequence configured to reduce HOEC-induced distortion in the reconstructed image.
摘要翻译：计算机被编程为从校准扫描获取校准数据，校准数据被配置为表征成像系统产生的高阶涡流（HOEC）产生的磁场误差。计算机还被编程为处理校准数据以产生多个基准系数和多个时间常数，并且基于多个基准系数，多个时间常数和梯度波形来计算多个基准校正系数给定的脉冲序列。计算机还被编程为执行扩散加权成像扫描，其包括应用DW-EPI脉冲序列以从成像对象获取MR数据并且基于所获取的MR数据重建图像。计算机还被编程为在应用DW-EPI脉冲序列期间应用HOEC产生的磁场误差校正，其被配置为减少重建图像中HOEC引起的失真。

14. 发明申请

US20100264926A1 SYSTEM AND METHOD FOR PHASE RELAXED RF PULSE DESIGN 有权
标题翻译：相位放大射频脉冲设计的系统与方法
公开(公告)号：US20100264926A1
公开(公告)日：2010-10-21
申请号：US12424797
申请日：2009-04-16
申请人： Dan Xu , Kevin F. King , Graeme C. McKinnon
发明人： Dan Xu , Kevin F. King , Graeme C. McKinnon
IPC分类号： G01R33/20
CPC分类号： G01R33/5612
摘要： Techniques for designing RF pulses may be configured to produce improved magnitude profiles of the resulting magnetization by relaxing the phase constraint and optimizing the phase profiles. In one embodiment, a spinor-based, optimal control, optimal phase technique may be used to design arbitrary-tip-angle (e.g., large and small tip angle) RF pulses (both parallel transmission and single channel). In another embodiment, small tip angle RF pulses (both parallel transmission and single channel) may be designed using a small-tip-angle (STA) pulse design without phase constraint that is formulated as a parameter optimization problem.
摘要翻译：用于设计RF脉冲的技术可以被配置为通过放松相位约束并优化相位曲线来产生所得到的磁化的改善的幅度分布。在一个实施例中，可以使用基于旋转器的最优控制最佳相位技术来设计任意尖角（例如，大和小尖角）RF脉冲（并行传输和单通道）。在另一个实施例中，可以使用没有相位约束的小尖角（STA）脉冲设计来设计小尖端角度RF脉冲（并行传输和单通道），其被配置为参数优化问题。

15. 发明授权

US07737690B2 System and method for amplitude reduction in RF pulse design 失效
标题翻译： RF脉冲设计幅度减小的系统和方法
公开(公告)号：US07737690B2
公开(公告)日：2010-06-15
申请号：US11750478
申请日：2007-05-18
申请人： Dan Xu , Kevin F. King
发明人： Dan Xu , Kevin F. King
IPC分类号： G01V3/00
CPC分类号： G01R33/4836 , A61B5/055 , G01R33/4824 , G01R33/4833
摘要： A system and method are provided for adjusting RF pulses and gradient waveforms to reduce B1 field magnitude in MR imaging sequences. When an RF pulse is presented which has a high amplitude segment that would exceed a maximum B1 magnitude, the system and method provided herein can apply a variable slew rate design technique. A slew rate of at least one gradient waveform can be varied to reduce a B1 field magnitude during transmission of the high amplitude segment of the RF pulse. By controlling the slew rate of gradient waveforms for non-Cartesian k-space trajectories according to a calculated maximum allowable slew rate function, embodiments of the system and method can, in effect, reduce gradient amplitude.
摘要翻译：提供了一种用于调整RF脉冲和梯度波形以减少MR成像序列中的B1场强的系统和方法。当提供具有超过最大B1幅度的高幅度段的RF脉冲时，本文提供的系统和方法可以应用可变转换速率设计技术。可以改变至少一个梯度波形的转换速率，以在RF脉冲的高幅度段的传输期间减小B1场幅度。通过根据计算出的最大允许转换速率函数控制非笛卡尔k空间轨迹的梯度波形的转换速率，该系统和方法的实施例实际上可以减小梯度幅度。

16. 发明授权

US09135728B2 System and method for multi-energy computed tomography imaging 有权
标题翻译：多能计算机断层成像系统和方法
公开(公告)号：US09135728B2
公开(公告)日：2015-09-15
申请号：US13439245
申请日：2012-04-04
申请人： Jiahua Fan , Jiang Hsieh , Naveen Chandra , Suresh Narayanan Narayanan , Dan Xu
发明人： Jiahua Fan , Jiang Hsieh , Naveen Chandra , Suresh Narayanan Narayanan , Dan Xu
IPC分类号： G06T11/00 , A61B6/06 , A61B6/00 , G21K1/02 , A61B6/03 , G21K1/10 , H01J35/26 , H01J35/30
CPC分类号： G06T11/005 , A61B6/032 , A61B6/06 , A61B6/4021 , A61B6/4035 , A61B6/4241 , A61B6/4291 , A61B6/482 , A61B6/582 , G06T2211/408 , G21K1/025 , G21K1/10 , H01J35/26 , H01J35/30
摘要： A CT system includes a gantry, an x-ray source, a detector, and a grating collimator that includes alternating first and second materials. The system includes a controller configured to emit a first beam of x-rays from a first focal spot and to a first detector pixel, wherein the first beam of x-rays passes along a ray and through one of the first materials of the grating collimator, and subsequently emit a second beam of x-rays from a second focal spot and to the first detector pixel, wherein the second beam of x-rays passes substantially along the ray and through one of the second materials of the grating collimator. The system includes a computer programmed to generate first and second kVp image datasets using data acquired from the first beam and second beams of x-rays, and reconstruct a basis material image of the object.
摘要翻译： CT系统包括台架，X射线源，检测器和包括交替的第一和第二材料的光栅准直器。该系统包括控制器，该控制器被配置为从第一焦点和第一检测器像素发射第一X射线束，其中第一射线束沿着光线并通过光栅准直器的第一材料之一并且随后从第二焦点和第一检测器像素发射第二射线束，其中所述第二光束X射线基本上沿着所述光线并通过所述光栅准直器的所述第二材料之一通过。该系统包括被编程为使用从第一光束和第二光束获得的数据来生成第一和第二kVp图像数据集的计算机，并重构对象的基础材料图像。

17. 发明申请

US20130266115A1 SYSTEM AND METHOD FOR MULTI-ENERGY COMPUTED TOMOGRAPHY IMAGING 有权
标题翻译：多功能计算机图像成像系统与方法
公开(公告)号：US20130266115A1
公开(公告)日：2013-10-10
申请号：US13439245
申请日：2012-04-04
申请人： Jiahua Fan , Jiang Hsieh , Naveen Chandra , Suresh Narayanan Narayanan , Dan Xu
发明人： Jiahua Fan , Jiang Hsieh , Naveen Chandra , Suresh Narayanan Narayanan , Dan Xu
IPC分类号： A61B6/08 , A61B6/03
CPC分类号： G06T11/005 , A61B6/032 , A61B6/06 , A61B6/4021 , A61B6/4035 , A61B6/4241 , A61B6/4291 , A61B6/482 , A61B6/582 , G06T2211/408 , G21K1/025 , G21K1/10 , H01J35/26 , H01J35/30
摘要： A CT system includes a gantry, an x-ray source, a detector, and a grating collimator that includes alternating first and second materials. The system includes a controller configured to emit a first beam of x-rays from a first focal spot and to a first detector pixel, wherein the first beam of x-rays passes along a ray and through one of the first materials of the grating collimator, and subsequently emit a second beam of x-rays from a second focal spot and to the first detector pixel, wherein the second beam of x-rays passes substantially along the ray and through one of the second materials of the grating collimator. The system includes a computer programmed to generate first and second kVp image datasets using data acquired from the first beam and second beams of x-rays, and reconstruct a basis material image of the object.
摘要翻译： CT系统包括台架，X射线源，检测器和包括交替的第一和第二材料的光栅准直器。该系统包括控制器，该控制器被配置为从第一焦点和第一检测器像素发射第一X射线束，其中第一射线束沿着光线并通过光栅准直器的第一材料之一并且随后从第二焦点和第一检测器像素发射第二射线束，其中所述第二光束X射线基本上沿着所述光线并通过所述光栅准直器的所述第二材料之一通过。该系统包括被编程为使用从第一光束和第二光束获得的数据来生成第一和第二kVp图像数据集的计算机，并重构对象的基础材料图像。

18. 发明申请

US20120134561A1 METHOD AND SYSTEM FOR CORRELATED NOISE SUPPRESSION IN DUAL ENERGY IMAGING 有权
标题翻译：双能量成像中相关噪声抑制的方法与系统
公开(公告)号：US20120134561A1
公开(公告)日：2012-05-31
申请号：US12955227
申请日：2010-11-29
申请人： Dan Xu , David Allen Langan , Xiaoye Wu , Jed Douglas Pack , Andrea Marie Schmitz
发明人： Dan Xu , David Allen Langan , Xiaoye Wu , Jed Douglas Pack , Andrea Marie Schmitz
IPC分类号： G06K9/00
CPC分类号： G06T11/008 , G06T5/002 , G06T5/50 , G06T2207/10081 , G06T2211/408
摘要： Methods and systems for correlated noise suppression are presented. The present correlated noise suppression technique estimates a correlation direction between noise values in a first and a second MD image corresponding to a first and a second basis material, respectively. The two MD images are diffused using the estimated correlation direction to generate a first and a second diffused image. Further, first and second noise masks are generated by subtracting the diffused image from the corresponding MD image. Edges in the first and the second MD images are processed with the first and second noise masks, respectively to generate a final first noise mask and a final second noise mask. The first MD image is then processed with the final second noise mask to generate a final first MD image and the second MD image is processed with the final first noise mask to generate a final second MD image.
摘要翻译：提出了相关噪声抑制的方法和系统。本相关噪声抑制技术分别估计与第一和第二基础材料对应的第一和第二MD图像中的噪声值之间的相关方向。使用估计的相关方向来扩散两个MD图像以生成第一和第二扩散图像。此外，通过从相应的MD图像中减去漫射图像来产生第一和第二噪声掩码。第一和第二MD图像中的边缘分别用第一和第二噪声掩模进行处理，以产生最终的第一噪声掩模和最终的第二噪声掩模。然后用最终的第二噪声掩码处理第一MD图像以产生最终的第一MD图像，并且用最终的第一噪声掩码处理第二MD图像以产生最终的第二MD图像。

19. 发明申请

US20120008842A1 SYSTEM AND METHOD OF IMAGE ARTIFACT REDUCTION USING SELF-NAVIGATED REAL-TIME PHASE CORRECTION IN ECHO PLANAR IMAGING 有权
标题翻译：使用自主导航的实时相位校正在ECHO平面图像中的图像艺术减少的系统和方法
公开(公告)号：US20120008842A1
公开(公告)日：2012-01-12
申请号：US12831562
申请日：2010-07-07
申请人： Richard Scott Hinks , Dan Xu
发明人： Richard Scott Hinks , Dan Xu
IPC分类号： G06K9/00 , G01R33/48
CPC分类号： G01R33/56554 , A61B5/055 , A61B5/7285 , G01R33/56563
摘要： An apparatus and method include a computer programmed to implement a scan sequence configured to elicit scan data, wherein the scan sequence comprises an echo planar imaging (EPI) sequence configured to elicit the image data and to acquire the scan data. The computer is also programmed to manipulate the scan data to determine a first plurality of phase errors in the image data responsible for a Nyquist ghost, wherein the manipulated scan data is free of navigator echo data, remove the first plurality of phase errors from the image data, and reconstruct an image based on the image data having the first plurality of phase errors removed therefrom.
摘要翻译：一种装置和方法包括被编程为实现被配置为引出扫描数据的扫描序列的计算机，其中扫描序列包括被配置为引出图像数据并获取扫描数据的回波平面成像（EPI）序列。计算机还被编程为操纵扫描数据以确定负责奈奎斯特幽灵的图像数据中的第一多个相位误差，其中所述被操纵的扫描数据没有导航回波数据，从图像中去除第一多个相位误差数据，并且基于从其中移除了第一多个相位误差的图像数据重建图像。

20. 发明申请

US20090082243A1 DETERGENT PARTICLE 审中-公开
标题翻译：洗涤颗粒
公开(公告)号：US20090082243A1
公开(公告)日：2009-03-26
申请号：US12211982
申请日：2008-09-17
申请人： Anju Deepali Massey Brooker , Alberto Martinez-Becares , David William York , Dan Xu , Gillian Margaret Hardy
发明人： Anju Deepali Massey Brooker , Alberto Martinez-Becares , David William York , Dan Xu , Gillian Margaret Hardy
IPC分类号： C11D7/02 , B32B1/00
CPC分类号： C11D3/126 , C11D17/06 , Y10T428/2982
摘要： A particle having a size of from about 50 to about 1,000 μm comprising a low-shear exfoliable nanoclay, the nanoclay having a primary particle size of from about 10 to about 300 nm. The invention also includes detergents comprising the particle and a process for making the particle.
摘要翻译：尺寸为约50至约1,000μm的颗粒包含低剪切可剥离的纳米粘土，所述纳米粘土具有约10至约300nm的初级粒度。本发明还包括包含颗粒的洗涤剂和制备颗粒的方法。

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