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11. 发明申请

US20050288297A1 Quinazoline derivatives as kinase inhibitors 失效
标题翻译：喹唑啉衍生物作为激酶抑制剂
公开(公告)号：US20050288297A1
公开(公告)日：2005-12-29
申请号：US11210028
申请日：2005-08-22
申请人： Anjali Pandey , Robert Scarborough , Kenji Matsuno , Michio Ichimura , Yuji Nomoto , Shinichi Ide , Eiji Tsukuda , Junko Sasaki , Shoji Oda
发明人： Anjali Pandey , Robert Scarborough , Kenji Matsuno , Michio Ichimura , Yuji Nomoto , Shinichi Ide , Eiji Tsukuda , Junko Sasaki , Shoji Oda
IPC分类号： A61K31/517 , A61K31/5377 , A61K31/541 , A61P9/08 , A61P9/10 , A61P13/12 , A61P35/00 , A61P43/00 , C07D239/94 , C07D401/12 , C07D403/12
CPC分类号： C07D239/94 , A61K31/517 , C07D401/12 , C07D403/12
摘要： The present invention relates to nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention is also related to a method of inhibiting kinases and treating disease states in a mammal by inhibiting the phosphorylation of kinases. In a particular aspect the present invention provides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which inhibit phosphorylation of a PDGF receptor to hinder abnormal cell growth and cell wandering, and a method for preventing or treating cell-proliferative diseases such as arteriosclerosis, vascular reobstruction, cancer and glomerulosclerosis.
摘要翻译：本发明涉及对抑制这种激酶活性的激酶磷酸化具有抑制活性的含氮杂环化合物及其药学上可接受的盐。本发明还涉及通过抑制激酶的磷酸化来抑制哺乳动物的激酶和治疗疾病状态的方法。在一个特定方面，本发明提供了抑制PDGF受体的磷酸化以阻止异常细胞生长和细胞游动的含氮杂环化合物及其药学上可接受的盐，以及预防或治疗细胞增殖性疾病如动脉硬化，血管重建，癌症和肾小球硬化症。

12. 发明申请

US20050101609A1 Quinazoline derivatives as kinase inhibitors 失效
标题翻译：喹唑啉衍生物作为激酶抑制剂
公开(公告)号：US20050101609A1
公开(公告)日：2005-05-12
申请号：US10344736
申请日：2001-08-17
申请人： Anjali Pandey , Robert Scarborough , Kenji Matsuno , Michio Ichimura , Yuji Nomoto , Shinichi Ide , Eiji Tsukuda , Junko Sasaki , Shoji Oda
发明人： Anjali Pandey , Robert Scarborough , Kenji Matsuno , Michio Ichimura , Yuji Nomoto , Shinichi Ide , Eiji Tsukuda , Junko Sasaki , Shoji Oda
IPC分类号： A61K31/517 , A61K31/5377 , A61K31/541 , A61P9/08 , A61P9/10 , A61P13/12 , A61P35/00 , A61P43/00 , C07D239/94 , C07D401/12 , C07D403/12 , C07D43/04 , C07D43/14
CPC分类号： C07D239/94 , A61K31/517 , C07D401/12 , C07D403/12
摘要： The present invention relates to nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention is also related to a method ol inhibiling kinascs and tre ating disease states in a mammal by inhibiting the phosphorylation of kinases. In a particular aspect the present invention prtvides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which inhibit phosphorylation of a of a PDGF receptor to hinder abnormal cell growth and cell wandering, and a method for preventing or treating cell-proliferative diseases such as arteriosclerosis, vascular reobstruction, cancer and glomerulosclerosis.
摘要翻译：本发明涉及对抑制这种激酶活性的激酶磷酸化具有抑制活性的含氮杂环化合物及其药学上可接受的盐。本发明还涉及一种通过抑制激酶的磷酸化来抑制哺乳动物抑制哺乳动物的疾病状态的方法。在一个特定方面，本发明提供了抑制PDGF受体的磷酸化阻碍异常细胞生长和细胞游动的含氮杂环化合物及其药学上可接受的盐，以及用于预防或治疗细胞增殖性疾病如动脉硬化的方法，血管重构，癌症和肾小球硬化症。

13. 发明授权

US08324205B2 Quinazoline derivatives as kinase inhibitors 失效
标题翻译：喹唑啉衍生物作为激酶抑制剂
公开(公告)号：US08324205B2
公开(公告)日：2012-12-04
申请号：US12471280
申请日：2009-05-22
申请人： Anjali Pandey , Robert M. Scarborough , Kenji Matsuno , Michio Ichimura , Yuji Nomoto , Shinichi Ide , Eiji Tsukuda , Junko Sasaki , Shoji Oda
发明人： Anjali Pandey , Robert M. Scarborough , Kenji Matsuno , Michio Ichimura , Yuji Nomoto , Shinichi Ide , Eiji Tsukuda , Junko Sasaki , Shoji Oda
IPC分类号： A61K31/535 , A61K31/497
CPC分类号： C07D239/94 , A61K31/517 , C07D401/12 , C07D403/12
摘要： The present invention relates to nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention is also related to a method of inhibiting kinases and treating disease states in a mammal by inhibiting the phosphorylation of kinases. In a particular aspect the present invention provides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which inhibit phosphorylation of a PDGF receptor to hinder abnormal cell growth and cell wandering, and a method for preventing or treating cell-proliferative diseases such as arteriosclerosis, vascular reobstruction, cancer and glomerulosclerosis.
摘要翻译：本发明涉及对抑制这种激酶活性的激酶磷酸化具有抑制活性的含氮杂环化合物及其药学上可接受的盐。本发明还涉及通过抑制激酶的磷酸化来抑制哺乳动物的激酶和治疗疾病状态的方法。在一个特定方面，本发明提供了抑制PDGF受体的磷酸化以阻止异常细胞生长和细胞游动的含氮杂环化合物及其药学上可接受的盐，以及预防或治疗细胞增殖性疾病如动脉硬化，血管重建，癌症和肾小球硬化症。

14. 发明授权

US06982266B2 Quinazoline derivatives as kinase inhibitors 失效
标题翻译：喹唑啉衍生物作为激酶抑制剂
公开(公告)号：US06982266B2
公开(公告)日：2006-01-03
申请号：US10344736
申请日：2001-08-17
申请人： Anjali Pandey , Robert M. Scarborough , Kenji Matsuno , Michio Ichimura , Yuji Nomoto , Shinichi Ide , Eiji Tsukuda , Junko Sasaki , Shoji Oda
发明人： Anjali Pandey , Robert M. Scarborough , Kenji Matsuno , Michio Ichimura , Yuji Nomoto , Shinichi Ide , Eiji Tsukuda , Junko Sasaki , Shoji Oda
IPC分类号： A01K31/675 , A01K31/517 , C07D43/02 , C07D239/72
CPC分类号： C07D239/94 , A61K31/517 , C07D401/12 , C07D403/12
摘要： The present invention relates to nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention is also related to a method of inhibiting kinases and treating disease states in a mammal by inhibiting the phosphorylation of kinases. In a particular aspect the present invention provides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which inhibit phosphorylation of a of a PDGF receptor to hinder abnormal cell growth and cell wandering, and a method for preventing or treating cell-proliferative diseases such as arteriosclerosis, vascular reobstruction, cancer and glomerulosclerosis.
摘要翻译：本发明涉及对抑制这种激酶活性的激酶磷酸化具有抑制活性的含氮杂环化合物及其药学上可接受的盐。本发明还涉及通过抑制激酶的磷酸化来抑制哺乳动物的激酶和治疗疾病状态的方法。在一个特定方面，本发明提供了抑制PDGF受体的磷酸化以阻止异常细胞生长和细胞游动的含氮杂环化合物及其药学上可接受的盐，以及用于预防或治疗细胞增殖性疾病如动脉硬化的方法，血管重构，癌症和肾小球硬化症。

15. 发明授权

US06956039B2 Nitrogenous heterocylic compounds 失效
标题翻译：含氮杂环化合物
公开(公告)号：US06956039B2
公开(公告)日：2005-10-18
申请号：US10344737
申请日：2001-08-17
申请人： Anjali Pandey , Robert M. Scarborough , Kenji Matsuno , Michio Ichimura , Yuji Nomoto , Shinichi Ide , Eiji Tsukuda , Junko Sasaki , Shoji Oda
发明人： Anjali Pandey , Robert M. Scarborough , Kenji Matsuno , Michio Ichimura , Yuji Nomoto , Shinichi Ide , Eiji Tsukuda , Junko Sasaki , Shoji Oda
IPC分类号： A61P35/00 , C07D239/94 , C07D401/12 , C07D403/12 , C07D487/00
CPC分类号： C07D401/12 , C07D239/94 , C07D403/12
摘要： The present invention relates to nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention is also related to a method of inhibiting kinases and treating disease states in a mammal by inhibiting the phosphorylation of kinases. In a particular aspect the present invention provides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which inhibit phosphorylation of a PDGF receptor to hinder abnormal cell growth and cell wandering, and a method for preventing or treating cell-proliferative diseases such as arteriosclerosis, vascular reobstruction, cancer and glomerulosclerosis.
摘要翻译：本发明涉及对抑制这种激酶活性的激酶磷酸化具有抑制活性的含氮杂环化合物及其药学上可接受的盐。本发明还涉及通过抑制激酶的磷酸化来抑制哺乳动物的激酶和治疗疾病状态的方法。在一个特定方面，本发明提供了抑制PDGF受体的磷酸化以阻止异常细胞生长和细胞游动的含氮杂环化合物及其药学上可接受的盐，以及预防或治疗细胞增殖性疾病如动脉硬化，血管重建，癌症和肾小球硬化症。

16. 发明授权

US08371885B2 Outboard motor 有权
标题翻译：舷外马达
公开(公告)号：US08371885B2
公开(公告)日：2013-02-12
申请号：US12626146
申请日：2009-11-25
申请人： Makoto Yazaki , Shinichi Ide , Shigekazu Sakata
发明人： Makoto Yazaki , Shinichi Ide , Shigekazu Sakata
IPC分类号： B63J2/00
CPC分类号： B63H20/28 , F02M35/10013 , F02M35/10078 , F02M35/168 , F02M37/007
摘要： An outboard motor has an internal combustion engine, an engine cover forming an engine compartment for holding the internal combustion engine therein, and a top cover covering the engine cover from above and provided with a carrying grip. An intermediate member is placed in a space between the engine cover and the top cover. First connecting parts for connecting the engine cover and the intermediate member are arranged in a space between the engine cover and the intermediate member, and second connecting parts for connecting the top cover and the intermediate cover are arranged in a space between the top cover and the intermediate cover. The connecting parts arranged in the spaces between the engine cover and the top cover ensure rigid connection, the degree of freedom of arranging the connecting parts is increased, and the engine cover can be manufactured at low cost.
摘要翻译：舷外马达具有内燃机，形成用于将内燃机保持在其中的发动机舱的发动机盖，以及从上方覆盖发动机罩的顶盖，并设置有携带把手。中间构件被放置在发动机盖和顶盖之间的空间中。用于连接发动机盖和中间构件的第一连接部分布置在发动机盖和中间构件之间的空间中，用于连接顶盖和中间盖的第二连接部分布置在顶盖和中间盖。配置在发动机盖和顶盖之间的空间中的连接部确保刚性连接，能够提高连接部的配置的自由度，能够低成本地制造发动机罩。

17. 发明授权

US08327978B2 Vertical power unit and outboard engine system 有权
标题翻译：垂直动力装置和舷外发动机系统
公开(公告)号：US08327978B2
公开(公告)日：2012-12-11
申请号：US11802577
申请日：2007-05-23
申请人： Shinichi Ide , Yoshiyuki Matsuda
发明人： Shinichi Ide , Yoshiyuki Matsuda
IPC分类号： F16H57/04 , B63H20/00 , B63H23/00
CPC分类号： F16H41/30 , B63H20/002 , B63H20/14 , B63H20/20 , B63H23/26 , B63H2023/305 , F16H41/04
摘要： A vertical power unit includes: an engine having a vertically arranged crankshaft; a vertically arranged output shaft provided below the crankshaft; and a torque converter providing a connection between the crankshaft and the output shaft. The torque converter is arranged so as to be offset from the crankshaft toward a cylinder block of the engine. A transmission device is provided between the crankshaft and the torque converter. The output shaft is arranged coaxially with the torque converter. Thus, the center of gravity of the vertical power unit is positioned as close as possible to the central portion of the engine, thereby minimizing bias of the center of gravity due to the weight of the torque converter and the output shaft to facilitate the handling of the vertical power unit.
摘要翻译：垂直动力单元包括：具有垂直布置的曲轴的发动机; 设置在曲轴下方的垂直排列的输出轴; 以及提供曲轴和输出轴之间的连接的变矩器。变矩器被布置成从曲轴向发动机的气缸体偏移。在曲轴和变矩器之间设置传动装置。输出轴与变矩器同轴设置。因此，垂直动力单元的重心定位为尽可能靠近发动机的中心部分，由此由于液力变矩器和输出轴的重量而使重心的偏差最小化，以便于处理垂直动力单元。

18. 发明授权

US07572159B2 Internal combustion engine installed in engine compartment 有权
标题翻译：内燃机安装在发动机舱内
公开(公告)号：US07572159B2
公开(公告)日：2009-08-11
申请号：US11904139
申请日：2007-09-26
申请人： Shinichi Ide , Koji Kasai , Tetsu Wada , Tetsuro Ikeno , Shoji Hasei , Hiroshi Takahashi
发明人： Shinichi Ide , Koji Kasai , Tetsu Wada , Tetsuro Ikeno , Shoji Hasei , Hiroshi Takahashi
IPC分类号： B63B35/73
CPC分类号： F02M35/168 , F02M35/10111 , F02M35/10144 , F02M35/10354
摘要： An outboard motor has an internal combustion engine installed in an engine compartment defined by an engine cover. The engine's intake air inlet is formed by an air intake duct, which communicates with an air intake space outside the engine compartment. The engine cover includes an upper cover with a receiving ring fitted on the air intake duct. The receiving ring and the intake duct form an overlapping part in which the ring and the duct overlap each other in the direction of flow of combustion air. The overlapping part has a sealing member therein which forms a seal between the air intake space and the interior space of the engine compartment. The sealing structure does not require high dimensional precision to form a required sealing property between the engine cover and the air inlet of the engine intake system. The sealing structure minimizes any influence of engine vibrations.
摘要翻译：舷外马达具有安装在由发动机罩限定的发动机舱中的内燃机。发动机的进气口由进气管形成，进气管与发动机室外的进气空间连通。发动机盖包括具有安装在进气管上的接收环的上盖。接收环和进气管形成重叠部分，其中环和管道在燃烧空气的流动方向上彼此重叠。重叠部分在其中具有密封构件，其在进气空间和发动机室的内部空间之间形成密封。密封结构不需要高尺寸精度，以在发动机盖和发动机进气系统的进气口之间形成所需的密封性。密封结构使发动机振动的任何影响最小化。

19. 发明授权

US07524224B2 Internal combustion engine and outboard motor provided with the same 有权
标题翻译：内燃机和舷外马达配备相同
公开(公告)号：US07524224B2
公开(公告)日：2009-04-28
申请号：US11904159
申请日：2007-09-26
申请人： Shinichi Ide , Koji Kasai , Tetsu Wada , Tetsuro Ikeno , Shoji Hasei , Hiroshi Takahashi
发明人： Shinichi Ide , Koji Kasai , Tetsu Wada , Tetsuro Ikeno , Shoji Hasei , Hiroshi Takahashi
IPC分类号： B63B35/73
CPC分类号： F02M35/10295 , F02M35/10111 , F02M35/10354 , F02M35/168
摘要： An internal combustion engine installed in an engine compartment 15 covered with an engine cover C is provided with an intake air passage P. The intake air passage P extends continuously from an intake air inlet Pi to intake air outlets Pe in the engine compartment 15 and has a first down passage 62, a reversing passage 63, an up passage 64 and a second down passage 67c arranged in the order in the flowing direction of combustion air. The combustion air taken through the intake air inlet Pi into the intake air passage P flows down through the first down passage 62, the reversing passage 63 reverses the flowing direction of the combustion air that has flowed down through the first down passage 62 such that the combustion air flows up, flows up through the up passage 64 to a position at a level higher than that of an uppermost intake air outlet Pe. Then, the combustion air flows down through the second down passage 67c and flows through the intake air outlets Pe into combustion chambers 30. Thus, an effect on preventing the flow of water into the combustion chamber 30 of the engine is improved.
摘要翻译：安装在被发动机盖C覆盖的发动机室15内的内燃机设置有进气通道P.进气通道P从进气入口Pi连续地延伸到发动机室15中的进气口Pe，并具有第一下降通道62，反向通道63，向上通道64和沿燃烧空气流动方向的顺序排列的第二下通道67c。通过进气入口Pi进入进气通道P的燃烧空气通过第一下通道62向下流动，反向通道63使已经沿着第一下通道62流下的燃烧空气的流动方向反转，燃烧空气向上流动，通过上部通道64向上流动到比最上面的进气出口Pe高的位置。然后，燃烧空气向下流过第二下通道67c，并且通过进气出口Pe流入燃烧室30.因此，提高了防止水流入发动机的燃烧室30的效果。

20. 发明授权

US07458867B2 Vertical fluid power transmission and outboard engine system 有权
标题翻译：垂直流体动力传动和舷外发动机系统
公开(公告)号：US07458867B2
公开(公告)日：2008-12-02
申请号：US11802578
申请日：2007-05-23
申请人： Yoshiyuki Matsuda , Shinichi Ide
发明人： Yoshiyuki Matsuda , Shinichi Ide
IPC分类号： B63H20/14
CPC分类号： F16H41/30 , B63H20/002 , B63H20/14 , B63H20/20 , B63H23/26 , B63H23/30 , B63H2023/305 , F16H57/04
摘要： A vertical fluid power transmission includes: a vertical crankshaft of an engine; a vertical output shaft; and a vertical torque converter disposed between the crankshaft and the output shaft. An oil supply passage is connected to one end of the circulation circuit of the vertical torque converter, and guides a stored oil that is drawn up from an oil tank and discharged by an oil pump. An oil return passage is connected to the other one end of the circulation circuit, and leads to the oil tank. A normally-closed pressure response valve is provided in the oil return passage. The pressure response valve is opened by an upstream pressure. Thus, the oil tank for storing a working oil of the torque converter is separated from the torque converter, thereby downsizing the torque converter, and the working oil is circulated between the oil tank and the circulation circuit of the torque converter, thereby promoting cooling of the working oil.
摘要翻译：垂直流体动力传递包括：发动机的竖直曲轴; 垂直输出轴; 以及设置在曲轴和输出轴之间的垂直变矩器。供油通道连接到垂直变矩器的循环回路的一端，并且引导从油箱抽出并被油泵排出的储油。回油通道连接到循环回路的另一端，并通向油箱。在回油通道中设置常闭压力响应阀。压力响应阀由上游压力打开。因此，用于储存变矩器的工作油的油箱与变矩器分离，从而使变矩器小型化，并且工作油在油箱与变矩器的循环回路之间循环，从而促进工作油。

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