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11. 发明授权

US06274709B1 Interferon-gamma (IFN-&ggr;) inducing factor (IGIF, IL-18) and peptide fragment thereof 有权
标题翻译：干扰素-γ（IFN-γ）诱导因子（IGIF，IL-18）及其肽片段
公开(公告)号：US06274709B1
公开(公告)日：2001-08-14
申请号：US09253523
申请日：1999-02-19
申请人： Haruki Okamura , Tadao Tanimoto , Kakuji Torigoe , Toshio Kunikata , Mutsuko Taniguchi , Keizo Kohno , Masashi Kurimoto
发明人： Haruki Okamura , Tadao Tanimoto , Kakuji Torigoe , Toshio Kunikata , Mutsuko Taniguchi , Keizo Kohno , Masashi Kurimoto
IPC分类号： C07K100
CPC分类号： C07K16/244 , A61K2039/505 , C07K14/52 , C07K16/24 , C07K2316/96 , C07K2317/76 , G01N33/6863 , G01N33/6866 , G01N33/6869 , G01N33/6872
摘要： A protein which induces the IFN-&ggr; production by immunocompetent cells and has a molecular weight of 19,000±5,000 daltons on SDS-PAGE or gel filtration method and a pI of 4.8±1.0 on chromatofocusing. The protein is isolated from mouse liver and can be purified by a monoclonal antibody specific to it. The monoclonal antibody can be also used for assaying the protein.
摘要翻译：通过免疫活性细胞诱导IFN-γ产生的蛋白质，并且在SDS-PAGE或凝胶过滤方法上具有19,000±5,000道尔顿的分子量，在色谱聚焦上的pI为4.8±1.0。蛋白质从小鼠肝脏中分离出来，可以通过特异性的单克隆抗体纯化。单克隆抗体也可用于测定蛋白质。

12. 发明授权

US5914253A Recombinant production of murine interferon--.gamma. (IFN-.gamma.) inducing factor (IGIF, IL-18) 失效
标题翻译：鼠干扰素-γ（IFN-γ）诱导因子（IGIF，IL-18）的重组产生
公开(公告)号：US5914253A
公开(公告)日：1999-06-22
申请号：US908005
申请日：1997-08-11
申请人： Haruki Okamura , Tadao Tanimoto , Kakuji Torigoe , Toshio Kunikata , Mutsuko Taniguchi , Keizo Kohno , Masashi Kurimoto
发明人： Haruki Okamura , Tadao Tanimoto , Kakuji Torigoe , Toshio Kunikata , Mutsuko Taniguchi , Keizo Kohno , Masashi Kurimoto
IPC分类号： C07K14/52 , C12N1/21 , C12N5/20 , C12N15/19 , C12N15/24 , G01N33/68 , A61K38/20 , C07K14/54
CPC分类号： C07K16/244 , C07K14/52 , C07K16/24 , G01N33/6863 , G01N33/6866 , G01N33/6869 , G01N33/6872 , A61K2039/505 , C07K2316/96
摘要： DNA encoding a murine protein capable of inducing the production of interferon-.gamma. by immunocompetent cells is described. The native protein from mouse liver has a molecular weight of 19.+-.5 kDa, a pI of 4.8.+-.1.0, and the amino acid sequence shown in SEQ ID NO: 2. Methods for producing the protein in recombinant expression systems including E. coli are provided.
摘要翻译：描述了编码能够通过免疫活性细胞诱导干扰素-γ产生的鼠蛋白的DNA。来自小鼠肝脏的天然蛋白质的分子量为19 +/- 5kDa，pI为4.8 +/- 1.0，氨基酸序列如SEQ ID NO：2所示。在重组表达系统中产生蛋白质的方法包括提供大肠杆菌。

13. 发明授权

US06207641B1 Pharmaceutical composition containing IFN-&ggr; inducing polypeptide or factor for treating and/or preventing IFN-&ggr; susceptive diseases 失效
标题翻译：含有IFN-γ诱导多肽或用于治疗和/或预防IFN-γ感染性疾病的因子的药物组合物
公开(公告)号：US06207641B1
公开(公告)日：2001-03-27
申请号：US08974469
申请日：1997-11-20
申请人： Kakuji Torigoe , Tadao Tanimoto , Shigeharu Fukuda , Masashi Kurimoto
发明人： Kakuji Torigoe , Tadao Tanimoto , Shigeharu Fukuda , Masashi Kurimoto
IPC分类号： A61K3817
CPC分类号： C07K16/244 , A61K38/00 , C07K14/52 , C07K14/54 , C07K16/24
摘要： An agent for susceptive diseases, which contains a polypeptide that has a molecular weight of 18,500±3,000 daltons on SDS-PAGE and a pI of 4.9±1.0 on chromatofocusing, strongly induces the IFN-&ggr; production by immunocompetent cells with only a small amount, and does not cause serious side effects even when administered to human at a relatively-high dose. The agent treats and/or prevents malignant tumors, viral diseases, bacterial infectious diseases, and immune diseases including atopies.
摘要翻译：在SDS-PAGE上含有分子量为18,500±3,000道尔顿且在色谱聚焦上为4.9±1.0的pI的多肽的感染性疾病药物强烈地诱导仅用少量的免疫活性细胞产生IFN-γ，即使以相当高的剂量施用于人，也不会引起严重的副作用。该药物治疗和/或预防恶性肿瘤，病毒性疾病，细菌感染性疾病和包括特应性的免疫疾病。

14. 发明申请

US20090075908A1 Agent For Strengthening Calcium Containing Tissue and Use Thereof 有权
标题翻译：代谢加强含钙组织及其用途
公开(公告)号：US20090075908A1
公开(公告)日：2009-03-19
申请号：US12210587
申请日：2008-09-15
申请人： Masaki Miyake , Shimpei Ushio , Kanso Iwaki , Masashi Kurimoto
发明人： Masaki Miyake , Shimpei Ushio , Kanso Iwaki , Masashi Kurimoto
IPC分类号： A61K31/70 , A61K31/352
CPC分类号： C07D311/30 , A23L33/105 , A23L33/11 , A23L33/15 , A23L33/16 , A61K8/4973 , A61K8/498 , A61K31/12 , A61K31/343 , A61K31/352 , A61Q11/00 , C07C49/796 , C07C49/83 , C07C49/835 , C07D307/83 , C07D311/32 , C07D311/62
摘要： The present invention has an object to provide an agent for strengthening calcium-containing tissues, which can be safely applied; and its use: The present invention solves the object by providing an agent for strengthening calcium-containing tissues, which comprises one or more flavones, flavonols, flavanones, flavanonols, anthocyanidins, flavanols, chalcones, and aurones.
摘要翻译：本发明的目的是提供一种可以安全应用的强化含钙组织的试剂。其用途：本发明通过提供一种强化含钙组织的试剂来解决该问题，其包含一种或多种黄酮，黄酮醇，黄酮酮，黄烷醇，花青素，黄烷醇，查耳酮和噢ones。

15. 发明授权

US07355014B2 Interferon-γ inducing polypeptide, pharmaceutical composition thereof, monoclonal antibody thereto, and methods of use 有权
标题翻译：干扰素-γ诱导多肽，其药物组合物，其单克隆抗体及其使用方法
公开(公告)号：US07355014B2
公开(公告)日：2008-04-08
申请号：US11580922
申请日：2006-10-16
申请人： Shimpei Ushio , Kakuji Torigoe , Todao Tanimoto , Haruki Okamura , Masashi Kurimoto , Shigeharu Fukuda , Toshio Kunikata , Mutsuko Taniguchi , Keizo Kohno
发明人： Shimpei Ushio , Kakuji Torigoe , Todao Tanimoto , Haruki Okamura , Masashi Kurimoto , Shigeharu Fukuda , Toshio Kunikata , Mutsuko Taniguchi , Keizo Kohno
IPC分类号： C07K16/00 , C07K16/18 , C07K16/24 , C12P21/08 , A61K38/00 , A61K38/19 , C07K14/00 , C07K14/54
CPC分类号： A61K38/2013 , A61K38/1709 , A61K38/208 , C07K16/18 , A61K2300/00
摘要： A human IFN-γ inducing polypeptide and its nucleotide sequence was isolated, purified and characterized. Pharmaceutical compositions containing this novel INF-γ inducing polypeptide or active fragments thereof are formulated and monoclonal antibodies are raised against this polypeptide or antigenic fragments thereof. The polypeptide can be used in a method for treating diseases susceptive to treatment with INF-γ, and methods for enhancing the cytotoxicity of NK cells or for inducing the formation of LAK cells, such as to treat tumors and malignant pathologies.
摘要翻译：分离，纯化和表征人IFN-γ诱导多肽及其核苷酸序列。配制含有该新型INF-γ诱导多肽或其活性片段的药物组合物，并针对该多肽或其抗原性片段产生单克隆抗体。该多肽可以用于治疗对用INF-γ进行治疗的疾病的方法，以及用于增强NK细胞的细胞毒性或诱导LAK细胞形成的方法，例如治疗肿瘤和恶性病变。

16. 发明申请

US20050048128A1 Process for producing collagen production enhancers and use thereof 审中-公开
标题翻译：生产胶原蛋白生产增强剂的方法及其用途
公开(公告)号：US20050048128A1
公开(公告)日：2005-03-03
申请号：US10491138
申请日：2002-08-08
申请人： Satomi Miyata , Shinpei Ushio , Masashi Kurimoto
发明人： Satomi Miyata , Shinpei Ushio , Masashi Kurimoto
IPC分类号： A23K1/18 , A23G9/32 , A23G9/36 , A23K1/16 , A23L1/076 , A23L1/30 , A23L1/302 , A23L2/38 , A61K8/06 , A61K8/34 , A61K8/67 , A61K8/96 , A61K8/98 , A61K31/341 , A61K31/375 , A61K35/64 , A61P17/00 , A61P43/00 , A61Q19/00 , A61Q19/08
CPC分类号： A23G9/366 , A23K20/10 , A23K20/174 , A23L2/38 , A23L21/20 , A23L33/15 , A23V2002/00 , A61K8/676 , A61K8/988 , A61K31/375 , A61K35/644 , A61Q19/00 , A61Q19/08 , A61K2300/00 , A23V2250/708 , A23V2250/636 , A23V2250/204 , A23V2250/2117 , A23V2250/6416
摘要： The object of the present invention is to provide a means which continuously exerts an action of enhancing the collagen production by L-ascorbic acid, and the object is solved by providing the collagen-production enhancer which comprises L-ascorbic acid and/or the like and royal jelly and/or the like.
摘要翻译：本发明的目的是提供一种连续发挥L-抗坏血酸增强胶原蛋白生成作用的方法，通过提供包含L-抗坏血酸等的胶原产生增强剂来解决该问题。和蜂王浆和/或类似物。

17. 发明授权

US06559298B1 Polypeptides that bind interleukin-18 (IL-18) 失效
标题翻译：结合白细胞介素-18（IL-18）
公开(公告)号：US06559298B1
公开(公告)日：2003-05-06
申请号：US09556972
申请日：2000-04-24
申请人： Kakuji Torigoe , Takanori Okura , Masashi Kurimoto
发明人： Kakuji Torigoe , Takanori Okura , Masashi Kurimoto
IPC分类号： C07H2104
CPC分类号： C07K14/7155 , A61K38/00
摘要： Disclosed are a polypeptide (including that in soluble form) as receptor for a novel cytokine, i.e., interleukin-18, a DNA encoding the polypeptide, and the uses of the polypeptide including pharmaceutical and neutralizer to interleukin-18. Pharmaceuticals with the polypeptide is useful to treat and prevent autoimmune and allergic disease because it suppresses and regulates excessive immunoreaction.
摘要翻译：公开了作为新型细胞因子（即白细胞介素-18），编码多肽的DNA的多肽（包括可溶形式的多肽）以及包括药物和中和剂在内的白细胞介素-18的多肽的用途。具有多肽的药物可用于治疗和预防自身免疫性和过敏性疾病，因为它抑制和调节过度的免疫反应。

18. 发明授权

US06274367B1 DNA coding for mammalian L-asparaginase 失效
标题翻译：编码哺乳动物L-天冬酰胺酶的DNA
公开(公告)号：US06274367B1
公开(公告)日：2001-08-14
申请号：US09309592
申请日：1999-05-11
申请人： Takeshi Ario , Madoka Taniai , Kakuji Torigoe , Masashi Kurimoto
发明人： Takeshi Ario , Madoka Taniai , Kakuji Torigoe , Masashi Kurimoto
IPC分类号： C12N982
CPC分类号： C12N9/82
摘要： Disclosed is a DNA coding for mammalian L-asparaginase. Transformants introduced with the DNA effectively produce desired amounts of mammalian L-asparaginase such as those from humans, guinea pigs, and mice. The DNA is also useful as a probe for screening a DNA coding for desired mammalian L-asparaginase.
摘要翻译：公开了编码哺乳动物L-天冬酰胺酶的DNA。用DNA引入的转化体有效地产生所需量的哺乳动物L-天冬酰胺酶，例如来自人，豚鼠和小鼠的那些。 DNA也可用作筛选编码所需哺乳动物L-天冬酰胺酶的DNA的探针。

19. 发明授权

US5874401A Cedar pollen protein and use thereof in treating, preventing, and diagnosing pollenosis 失效
标题翻译：雪松花粉蛋白及其用于治疗，预防和诊断花粉症的用途
公开(公告)号：US5874401A
公开(公告)日：1999-02-23
申请号：US773008
申请日：1996-12-24
申请人： Osamu Sanou , Katsuhiko Hino , Masashi Kurimoto
发明人： Osamu Sanou , Katsuhiko Hino , Masashi Kurimoto
IPC分类号： A61K39/36 , A61K38/00 , A61K39/385 , A61P37/00 , A61P37/08 , C07K1/22 , C07K7/08 , C07K14/415 , C07K14/76 , G01N33/487 , A61K38/16 , A61K49/00
CPC分类号： C07K14/415 , A61K38/00
摘要： A protein having a molecular weight of 44,000-54,000 daltons, isoelectric point of 8.5-9.2 and specific sugar chain is prepared from a cedar pollen. The protein induces pollenosis and can be suitably used as desensitization agent because it induces immunoglobulin antibody which is effective for desensitization, but does not substantially induce immunoglobulin E antibody, a major factor causative of side effects including anaphylaxis shock. Therefore, the protein can be advantageously used in the treatment, prevention and/or diagnosis of pollenosis.
摘要翻译：从雪松花粉中制备分子量为44,000-54,000道尔顿，等电点为8.5-9.2的蛋白质和特定的糖链。该蛋白质诱导花粉病，并且可以适当地用作脱敏剂，因为它诱导对脱敏有效的免疫球蛋白抗体，但基本上不诱导免疫球蛋白E抗体，其是副作用的主要因素，包括过敏性休克。因此，该蛋白质可有利地用于治疗，预防和/或诊断花粉症。

20. 发明授权

US5672692A Purification of human myelomonocyte interferon gamma with an immobilized antibody 失效
标题翻译：用固定化抗体纯化人类单核细胞干扰素γ
公开(公告)号：US5672692A
公开(公告)日：1997-09-30
申请号：US625369
申请日：1996-04-01
申请人： Masashi Kurimoto , Masakazu Mitsuhashi
发明人： Masashi Kurimoto , Masakazu Mitsuhashi
IPC分类号： A61K38/00 , A61K38/21 , C07K14/57 , C07K16/24 , C07K3/20 , C07K17/00 , C12P21/04 , G01N33/53
CPC分类号： A61K38/217 , A61K45/06 , C07K14/57 , C07K16/249
摘要： A human myelomonocyte interferon-gamma having a novel polypeptide and carbohydrate chain structure is produced by propagation of an established human myelomonocyte in vitro or after being implanted in a non-human warm-blooded animal or in a diffusion chamber placed inside or outside the body of the animal. The human myelomonocyte may be contacted with an inducer during propagation. A monoclonal antibody specific to the human myelomonocyte interferon-gamma is produced by immunizing a non-human warm-blooded animal with purified human myelomonocyte interferon-gamma as an antigen, recovering an antibody producing cell from the animal and fusing the cell with a myeloma cell to produce a hybrid capable of producing the monoclonal antibody. The human myelomonocyte interferon-gamma can be purified by chromatography with an immobilized anti-human myelomonocyte interferon-gamma antibody such as the monoclonal antibody. The human myelomonocyte interferon-gamma can be used as a prophylactic and therapeutic agent for human interferon-gamma susceptive diseases.
摘要翻译：具有新型多肽和碳水化合物链结构的人类单核细胞干扰素-γ通过体外建立的人骨髓单核细胞的繁殖或植入非人温血动物或置于体内或体外的扩散室中产生，这个动物。人类骨髓细胞在繁殖过程中可能与诱导物接触。通过用纯化的人骨髓单核细胞干扰素-γ作为抗原免疫非人温血动物，产生对人骨髓单核细胞干扰素-γ特异性的单克隆抗体，从动物中回收产生抗体的细胞并将细胞与骨髓瘤细胞融合以产生能够产生单克隆抗体的杂交体。可通过用固定化的抗人骨髓单核细胞干扰素-γ抗体如单克隆抗体进行色谱纯化人类单核细胞干扰素-γ。人类单核细胞干扰素-γ可用作人类干扰素-γ敏感性疾病的预防和治疗剂。

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