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11. 发明申请

US20060195024A1 Laser diode optical transducer assembly for non-invasive spectrophotometric blood oxygenation 有权
公开(公告)号：US20060195024A1
公开(公告)日：2006-08-31
申请号：US11384615
申请日：2006-03-20
申请人： Paul Benni
发明人： Paul Benni
IPC分类号： A61B5/00
CPC分类号： A61B5/14553 , A61B5/14552 , A61B5/6814 , A61B2560/0242
摘要： A non-invasive near infrared spectrophotometric monitoring transducer assembly includes a housing member, which is adhered directly on a patient's skin. The housing member contains a prism coupled to a flexible and lightweight single core optical light guide, which provides a means of transferring narrow spectral bandwidth light from multiple distant laser diodes of different wavelengths by use of a multi-fiber optic light combining assembly. Different wavelengths are needed to monitor the level of blood oxygenation in the patient. The assembly also contains a planar light guide mounted on the prism located in the housing member, which light guide contacts the patient's skin when the housing member is adhered to the patient's skin. The light guide controls the spacing between the prism and the patient's skin, and therefore controls the intensity of the area on the patient's skin which is illuminated by the laser light. The housing member contains a photodiode assembly, which detects the infrared light at a second location on the skin to determine light absorption. The photodiode assembly is preferably shielded from ambient electromagnetic interference (EMI) by an optically transparent EMI attenuating window. This rigid window placed over the photodiode also provides a planar interface between the assembly and the skin, improving optical coupling and stability as well as reducing the capacitive coupling between skin and the photodiode resulting in further EMI attenuation. The housing may be associated with a disposable sterile hydrogel coated adhesive envelope, or pad, which when applied to the patient's skin will adhere the housing to the patient's skin. The transducer assembly will thus be reusable, and skin-contacting part of the device, i.e., the envelope or pad can be discarded after a single use. The assembly also includes a laser safety interlock means, which is operable to turn off the laser light output in the event that the assembly accidentally becomes detached from the patient's skin.

12. 发明申请

US20060189861A1 Method for spectrophotometric blood oxygenation monitoring 有权
标题翻译：分光光度血氧监测方法
公开(公告)号：US20060189861A1
公开(公告)日：2006-08-24
申请号：US11376894
申请日：2006-03-16
申请人： Bo Chen , Paul Benni
发明人： Bo Chen , Paul Benni
IPC分类号： A61B5/00
CPC分类号： A61B5/14553
摘要： A method and apparatus for non-invasively determining the blood oxygenation within a subject's tissue is provided that utilizes a near infrared spectrophotometric (NIRS) sensor capable of transmitting a light signal into the tissue of a subject and sensing the light signal once it has passed through the tissue via transmittance or reflectance.
摘要翻译：提供了一种用于非侵入性地确定受试者组织内的血氧饱和的方法和装置，其利用能够将光信号传输到对象的组织中的近红外分光光度计（NIRS）传感器，并且一旦其通过就感测光信号组织通过透光率或反射率。

13. 发明授权

US08965472B2 Method and apparatus for spectrophotometric based oximetry 有权
标题翻译：基于分光光度法的血氧仪的方法和装置
公开(公告)号：US08965472B2
公开(公告)日：2015-02-24
申请号：US12090671
申请日：2006-10-18
申请人： Paul Benni
发明人： Paul Benni
IPC分类号： A61B5/00 , A61B5/1455
CPC分类号： A61B5/14553
摘要： A near infrared spectrophotometric (NIRS) sensor assembly for non-invasive monitoring of blood oxygenation levels in a subject's body is provided that includes a pad, at least one light source, a near light detector, a far light detector, and a cover. The light source is operative to emit near infrared light signals of a plurality of different wavelengths. The near light detector is separated from the light source by a first distance that is great enough to position the first light detector outside of an optical shunt field extending out from the light source. The far light detector is substantially linearly aligned with the near light detector and light source, and is separated from the near light detector by a second distance, wherein the second distance is greater than the first distance.
摘要翻译：提供了一种近红外分光光度计（NIRS）传感器组件，用于对受试者体内的血氧饱和度进行非侵入性监测，其包括垫，至少一个光源，近光检测器，远光检测器和盖。光源可操作地发射多个不同波长的近红外光信号。近光检测器与光源分离第一距离，其足够大以将第一光检测器定位在从光源延伸出的光分流场的外部。远光检测器与近光检测器和光源基本上线性对准，并且与近光检测器分离第二距离，其中第二距离大于第一距离。

14. 发明授权

US08396526B2 Method for spectrophotometric blood oxygenation monitoring 有权
标题翻译：分光光度血氧监测方法
公开(公告)号：US08396526B2
公开(公告)日：2013-03-12
申请号：US11914074
申请日：2006-05-10
申请人： Paul Benni
发明人： Paul Benni
IPC分类号： A61B5/00
CPC分类号： A61B5/14551 , A61B5/0205 , A61B5/0261 , A61B5/14546 , A61B5/14552 , A61B5/14553 , A61B5/1495 , A61B5/6814 , G01N21/359 , G01N21/49 , G01N2021/3144
摘要： According to the present invention, a method and apparatus for non-invasively determining the blood oxygen saturation level within a subject's tissue is provided. The method comprises the steps of: 1) providing a near infrared spectrophotometric sensor operable to transmit light along a plurality of wavelengths into the subject's tissue; 2) sensing the light transmitted into the subject's tissue using the sensor, and producing signal data representative of the light sensed from the subject's tissue; 3) processing the signal data to account for physical characteristics of the subject; and 4) determining the blood oxygen saturation level within the subject's tissue using a difference in attenuation between the wavelengths. The apparatus includes a sensor having a light source and at least one light detector, which sensor is operably connected to a processor. The sensor is operable to transmit light along a plurality of wavelengths into the subject's tissue, and produce signal data representative of the light sensed from the subject's tissue. The algorithm is operable to process the signal data to account for the physical characteristics of the subject being sensed.
摘要翻译：根据本发明，提供了用于非侵入性地确定受试者组织内的血氧饱和度水平的方法和装置。该方法包括以下步骤：1）提供近红外分光光度传感器，可操作以将多个波长的光透射到被检者的组织中; 2）使用传感器感测传播到被检者组织的光，并且产生代表从被检者组织感测的光的信号数据; 3）处理信号数据以解决被摄体的物理特征; 以及4）使用所述波长之间的衰减差来确定所述受试者组织内的血氧饱和度水平。该装置包括具有光源和至少一个光检测器的传感器，该传感器可操作地连接到处理器。传感器可操作以将多个波长的光传输到被检者的组织中，并且产生表示从受检者组织感测的光的信号数据。该算法可操作以处理信号数据以考虑被感测对象的物理特性。

15. 发明申请

US20090182209A1 METHOD AND APPARATUS FOR SPECTROPHOTOMETRIC BASED OXIMETRY 有权
标题翻译：用于分光光度计的方法和装置
公开(公告)号：US20090182209A1
公开(公告)日：2009-07-16
申请号：US12090671
申请日：2006-10-18
申请人： Paul Benni
发明人： Paul Benni
IPC分类号： A61B5/1455
CPC分类号： A61B5/14553
摘要： A near infrared spectrophotometric (NIRS) sensor assembly for non-invasive monitoring of blood oxygenation levels in a subject's body is provided that includes a pad, at least one light source, a near light detector, a far light detector, and a cover. The light source is operative to emit near infrared light signals of a plurality of different wavelengths. The near light detector is separated from the light source by a first distance that is great enough to position the first light detector outside of an optical shunt field extending out from the light source. The far light detector is substantially linearly aligned with the near light detector and light source, and is separated from the near light detector by a second distance, wherein the second distance is greater than the first distance.
摘要翻译：提供了一种近红外分光光度计（NIRS）传感器组件，用于对受试者体内的血氧饱和度进行非侵入性监测，其包括垫，至少一个光源，近光检测器，远光检测器和盖。光源可操作地发射多个不同波长的近红外光信号。近光检测器与光源分离第一距离，其足够大以将第一光检测器定位在从光源延伸出的光分流场的外部。远光检测器与近光检测器和光源基本上线性对准，并且与近光检测器分离第二距离，其中第二距离大于第一距离。

16. 发明申请

US20080300473A1 Stabilized Multi-Wavelength Laser System for Non-Invasive Spectrophotometric Monitoring 审中-公开
标题翻译：用于非侵入式分光光度监测的稳定的多波长激光系统
公开(公告)号：US20080300473A1
公开(公告)日：2008-12-04
申请号：US12097438
申请日：2006-12-14
申请人： Paul Benni
发明人： Paul Benni
IPC分类号： A61B5/1455
CPC分类号： G01N21/359 , A61B5/14553 , G01N2021/3144
摘要： A spectroscopy system that may be used for spectrophotometric oxygenation monitoring of tissue includes a monitor portion and a sensor portion. The sensor portion generally includes a light source and one or more light detectors. The sensor portion may attach to a human to sense light signals from the light source that have traversed biological tissue, the light signals ultimately being used by the system to determine biological tissue blood hemoglobin oxygenation levels. The monitor portion generally includes a processor and a visual display. A laser beam combiner may couple a plurality of laser diode output light signals into one optical fiber. To stabilize the output of each of the laser diodes, an optical fiber light stabilizer is coupled to the combined laser diode output. The optical fiber light stabilizer redistributes the modes in the optical fiber such that the higher-order modes are filled until an equilibrium mode distribution is established. A light sensor may also provide feedback with respect to the laser diode output, which allows for compensation of any laser diode light output instability independently of optical fiber related instabilities.
摘要翻译：可用于组织的分光光度氧合监测的光谱系统包括监测部分和传感器部分。传感器部分通常包括光源和一个或多个光检测器。传感器部分可以附着到人以感测来自已经穿过生物组织的光源的光信号，光信号最终被系统用于确定生物组织血红蛋白氧合水平。监视器部分通常包括处理器和视觉显示器。激光束组合器可以将多个激光二极管输出光信号耦合到一个光纤中。为了稳定每个激光二极管的输出，光纤光稳定器耦合到组合的激光二极管输出。光纤光稳定器重新分配光纤中的模式，使得高阶模式被填充直到建立平衡模式分布。光传感器还可以提供关于激光二极管输出的反馈，其允许补偿任何激光二极管光输出不稳定性，而与光纤相关的不稳定性无关。

17. 发明授权

US07313427B2 Laser diode optical transducer assembly for non-invasive spectrophotometric blood oxygenation 有权
公开(公告)号：US07313427B2
公开(公告)日：2007-12-25
申请号：US11384615
申请日：2006-03-20
申请人： Paul Benni
发明人： Paul Benni
IPC分类号： A61B5/00
CPC分类号： A61B5/14553 , A61B5/14552 , A61B5/6814 , A61B2560/0242
摘要： A non-invasive near infrared spectrophotometric monitoring transducer assembly includes a housing member, which is adhered directly on a patient's skin. The housing member contains a prism coupled to a flexible and lightweight single core optical light guide, which provides a means of transferring narrow spectral bandwidth light from multiple distant laser diodes of different wavelengths by use of a multi-fiber optic light combining assembly. Different wavelengths are needed to monitor the level of blood oxygenation in the patient. The assembly also contains a planar light guide mounted on the prism located in the housing member, which light guide contacts the patient's skin when the housing member is adhered to the patient's skin. The light guide controls the spacing between the prism and the patient's skin, and therefore controls the intensity of the area on the patient's skin which is illuminated by the laser light. The housing member contains a photodiode assembly, which detects the infrared light at a second location on the skin to determine light absorption. The photodiode assembly is preferably shielded from ambient electromagnetic interference (EMI) by an optically transparent EMI attenuating window. This rigid window placed over the photodiode also provides a planar interface between the assembly and the skin, improving optical coupling and stability as well as reducing the capacitive coupling between skin and the photodiode resulting in further EMI attenuation. The housing may be associated with a disposable sterile hydrogel coated adhesive envelope, or pad, which when applied to the patient's skin will adhere the housing to the patient's skin. The transducer assembly will thus be reusable, and skin-contacting part of the device, i.e., the envelope or pad can be discarded after a single use. The assembly also includes a laser safety interlock means, which is operable to turn off the laser light output in the event that the assembly accidentally becomes detached from the patient's skin.

18. 发明授权

US07047054B2 Laser diode optical transducer assembly for non-invasive spectrophotometric blood oxygenation monitoring 失效
公开(公告)号：US07047054B2
公开(公告)日：2006-05-16
申请号：US09951221
申请日：2001-09-14
申请人： Paul Benni
发明人： Paul Benni
IPC分类号： A61B5/00
CPC分类号： A61B5/14553 , A61B5/14552 , A61B5/6814 , A61B2560/0242
摘要： A non-invasive near infrared spectrophotometric monitoring transducer assembly includes a housing member, which is adhered directly on a patient's skin. The housing member contains a prism coupled to a flexible and lightweight single core optical light guide, which provides a means of transferring narrow spectral bandwidth light from multiple distant laser diodes of different wavelengths by use of a multi-fiber optic light combining assembly. Different wavelengths are needed to monitor the level of blood oxygenation in the patient. The assembly also contains a planar light guide mounted on the prism located in the housing member, which light guide contacts the patient's skin when the housing member is adhered to the patient's skin. The light guide controls the spacing between the prism and the patient's skin, and therefore controls the intensity of the area on the patient's skin which is illuminated by the laser light. The housing member contains a photodiode assembly, which detects the infrared light at a second location on the skin to determine light absorption. The photodiode assembly is preferably shielded from ambient electromagnetic interference (EMI) by an optically transparent EMI attenuating window. This rigid window placed over the photodiode also provides a planar interface between the assembly and the skin, improving optical coupling and stability as well as reducing the capacitive coupling between skin and the photodiode resulting in further EMI attenuation. The housing may be associated with a disposable sterile hydrogel coated adhesive envelope, or pad, which when applied to the patient's skin will adhere the housing to the patient's skin. The transducer assembly will thus be reusable, and skin-contacting part of the device, i.e., the envelope or pad can be discarded after a single use. The assembly also includes a laser safety interlock means, which is operable to turn off the laser light output in the event that the assembly accidentally becomes detached from the patient's skin.

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