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11. 发明申请

WO2007023430A1 SUBSTRATE MATERIAL FOR HANDLING AND ANALYSING SAMPLES 审中-公开
标题翻译：用于处理和分析样品的基材
公开(公告)号：WO2007023430A1
公开(公告)日：2007-03-01
申请号：PCT/IB2006/052842
申请日：2006-08-17
申请人： KONINKLIJKE PHILIPS ELECTRONICS N. V. , BROER, Dirk, Jan , PENTERMAN, Roel , PEETERS, Emiel , KURT, Ralph
发明人： BROER, Dirk, Jan , PENTERMAN, Roel , PEETERS, Emiel , KURT, Ralph
IPC分类号： C09K19/00 , C09K19/12 , G01N33/00 , G01N33/483
CPC分类号： B01L3/50273 , B01L3/5027 , B01L2300/0819 , B01L2300/0861 , B01L2300/089 , B01L2300/1822 , B01L2400/0677 , C09K19/00 , C09K19/12 , F16K99/0001 , F16K99/0032 , F16K99/0044 , F16K2099/0084
摘要： The invention relates to a substrate material for analyzing one or more fluid samples for the presence, amount or identity of one or more analytes in the samples, whereby the substrate material is adapted in that way that a flow of the sample or parts thereof in and/or with the substrate material is influenced and/or caused by phase transitions, preferably temperature-inducible phase transitions, in selected areas of the substrate material.
摘要翻译：本发明涉及一种用于分析一种或多种流体样品中用于样品中一种或多种分析物的存在，量或同一性的基底材料，由此基底材料以这种方式适应于样品或其部分的流动 /或衬底材料受到衬底材料的选定区域中的相变，优选温度诱导相变的影响和/或引起。

12. 发明申请

WO2007010432A1 SUBSTRATE MATERIAL FOR ANALYZING FLUIDS 审中-公开
标题翻译：用于分析流体的基材
公开(公告)号：WO2007010432A1
公开(公告)日：2007-01-25
申请号：PCT/IB2006/052327
申请日：2006-07-10
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N. V. , KURT, Ralph , STAPERT, Hendrik Roelof , JOHNSON, Mark Thomas , BROER, Dirk Jan , PENTERMAN, Roel , PEETERS, Emiel
发明人： KURT, Ralph , STAPERT, Hendrik Roelof , JOHNSON, Mark Thomas , BROER, Dirk Jan , PENTERMAN, Roel , PEETERS, Emiel
IPC分类号： G01N33/543 , G01N33/544 , G01N33/548
CPC分类号： B01L3/5023 , B01L3/5027 , B01L2300/123 , B01L2400/0406 , B01L2400/0481 , G01N33/54366 , G01N33/544 , G01N33/548 , Y10T428/249921
摘要： The invention relates to a substrate material for analyzing fluids which is elastic and allows radial lateral movement of sample within the substrate material upon application of pressure.
摘要翻译：本发明涉及一种用于分析流体的基底材料，该基底材料是弹性的并且在施加压力时允许样品在基底材料内的径向横向移动。

13. 发明申请

WO2006061783A1 MULTI-SPOT INVESTIGATION APPARATUS 审中-公开
标题翻译：多点调查装置
公开(公告)号：WO2006061783A1
公开(公告)日：2006-06-15
申请号：PCT/IB2005/054094
申请日：2005-12-07
申请人： KONINKLIJKE PHILIPS ELECTRONICS N. V. , KLUNDER, Derk Jan Wilfred , VAN HERPEN, Maarten , BALISTRERI, Marcello , LIEDENBAUM, Coen , PRINS, Menno , WIMBERGER-FRIEDL, Reinhold , KURT, Ralph
发明人： KLUNDER, Derk Jan Wilfred , VAN HERPEN, Maarten , BALISTRERI, Marcello , LIEDENBAUM, Coen , PRINS, Menno , WIMBERGER-FRIEDL, Reinhold , KURT, Ralph
IPC分类号： G01N21/55 , G01N21/64
CPC分类号： G01N21/6456 , G01N21/6452 , G01N21/648 , G01N2021/1772 , G01N2021/6463 , G01N2021/6478 , G01N2201/0461
摘要： The invention relates to a method and an apparatus for the investigation of a sample material by multiple sample light spots (501) generated by evanescent waves. An array of source light spots (510) is generated by a multi-spot generator, e.g. a multi-mode interferometer (106), and mapped onto sample light spots (501) in a sample layer (302) by (micro-)lenses (202, 203) or by the Talbot effect. The input light (504) of the source light spots (510) is shaped such that all of it is totally internally reflected at the interface between a transparent carrier plate (301) and the sample layer (302). Thus the sample light spots (501) consist of evanescent waves only and are restricted to a limited volume. In a preferred application, fluorescence stimulated in the sample light spots (501) is detected with spatial resolution by a CCD array (401).
摘要翻译：本发明涉及一种通过由ev逝波产生的多个样本光点（501）来研究样品材料的方法和装置。源光点阵列（510）由多点发生器产生，例如，多模干涉仪（106），并通过（微）透镜（202,203）或通过Talbot效应将样品层（302）中的样品光点（501）映射。源光点（510）的输入光（504）被成形为使得它们全部在内部被透明载体板（301）和样品层（302）之间的界面反射。因此，样本光点（501）仅由ev逝波组成，并被限制在有限的体积。在优选的应用中，通过CCD阵列（401）以空间分辨率检测样品光点（501）中刺激的荧光。

14. 发明申请

WO2010007549A1 PROCESS FOR PROVIDING AN ASSEMBLY OF CELL MICROCARRIERS 审中-公开
标题翻译：提供细胞培养基组装的方法
公开(公告)号：WO2010007549A1
公开(公告)日：2010-01-21
申请号：PCT/IB2009/052757
申请日：2009-06-26
申请人： KONINKLIJKE PHILIPS ELECTRONICS N. V. , HALTER, David , PEETERS, Emiel , PENTERMAN, Roel , KURT, Ralph , BROER, Dirk, J.
发明人： HALTER, David , PEETERS, Emiel , PENTERMAN, Roel , KURT, Ralph , BROER, Dirk, J.
IPC分类号： C12N5/00
CPC分类号： C12N5/0062 , C12N2531/00
摘要： The present invention is related to a process for providing an assembly of cell microcarriers, comprising the steps of providing planar, two-dimensional objects having two sides (“flakes”), wherein these objects comprise a material which, upon application of an extrinsic stimulus, is transferred from the planar state into a rolled state, providing cells on one side of said flakes (“cell-bearing side”), transferring the flakes from the planar state into a rolled state (“cell wrap”) by application of said extrinsic stimulus, and coupling at least one type of binding agent to the flakes.
摘要翻译：本发明涉及一种用于提供细胞微载体组件的方法，包括以下步骤：提供具有两侧（“薄片”）的平面二维物体，其中这些物体包括在应用外在刺激时从平面状态转移到卷绕状态，在所述片状物（“细胞承载侧”）的一侧提供细胞，通过施加所述片状物将片状物从平面状态转移到卷状态（“细胞包裹”）外部刺激，并将至少一种类型的结合剂偶联到片状物上。

15. 发明申请

WO2009074932A1 PATTERNED CELL SHEETS AND A METHOD FOR PRODUCTION OF THE SAME 审中-公开
标题翻译：图案细胞片及其生产方法
公开(公告)号：WO2009074932A1
公开(公告)日：2009-06-18
申请号：PCT/IB2008/055115
申请日：2008-12-05
申请人： KONINKLIJKE PHILIPS ELECTRONICS N. V. , PEETERS, Emiel , PENTERMAN, Roel , KURT, Ralph , BROER, Dirk, J. , DE KONING, Hendrik
发明人： PEETERS, Emiel , PENTERMAN, Roel , KURT, Ralph , BROER, Dirk, J. , DE KONING, Hendrik
IPC分类号： C12N5/00
CPC分类号： C12N5/0068 , C12N2535/10 , C12N2539/10
摘要： The present invention is related to a method for the production of cell sheets comprising at least two different cell types, said method comprising the steps of providing a continuous cell sheet which is disposed on a substrate comprising shape transition properties and/or alterable surface characteristics; exposing said continuous cell sheet to a releasing agent in a patterned fashion; washing the cell sheet after expo¬ sure to the releasing agent in order to remove cells which have been affected by the releasing agent, and repopulating the gaps remaining after the cells which have been affected by the releasing agent have been removed with a second cell type.
摘要翻译：本发明涉及生产包含至少两种不同细胞类型的细胞片的方法，所述方法包括以下步骤：提供设置在包含形状转变特性和/或可变表面特性的基底上的连续细胞片; 以图案方式将所述连续细胞片暴露于脱模剂; 在释放剂暴露后洗涤细胞片，以去除已经被脱模剂影响的细胞，并且在已经被脱模剂影响的细胞已经用第二细胞类型去除之后再填充剩余的间隙。

16. 发明申请

WO2008135899A1 BIO-RECOGNITION SENSOR WITH ACTUATION DEVICE 审中-公开
标题翻译：带致动装置的生物识别传感器
公开(公告)号：WO2008135899A1
公开(公告)日：2008-11-13
申请号：PCT/IB2008/051633
申请日：2008-04-28
申请人： KONINKLIJKE PHILIPS ELECTRONICS N. V. , PEETERS, Emiel , BROER, Dirk, J. , KURT, Ralph , PENTERMAN, Roel , DE KONING, Hendrik
发明人： PEETERS, Emiel , BROER, Dirk, J. , KURT, Ralph , PENTERMAN, Roel , DE KONING, Hendrik
IPC分类号： G01N33/537 , G01N33/543 , G01N33/542
CPC分类号： G01N33/5436 , G01N33/54373
摘要： The invention relates to a biochemical sensor having a gel-like first material and an actuation means which is capable of changing at least one of the physical properties of the first material.
摘要翻译：本发明涉及具有凝胶状第一材料的生物化学传感器和能够改变第一材料的至少一种物理性质的致动装置。

17. 发明申请

WO2008068678A1 BIOTECHNOLOGICAL DEVICE INCLUDING AN ACTUATION MEANS FOR CHANGING THE MOBILITY OF PRESELECTED BIOMOLECULES 审中-公开
标题翻译：生物技术设备，包括改变预选生物分子的移动性的手段
公开(公告)号：WO2008068678A1
公开(公告)日：2008-06-12
申请号：PCT/IB2007/054838
申请日：2007-11-29
申请人： KONINKLIJKE PHILIPS ELECTRONICS N. V. , KURT, Ralph , GILLIES, Murray, Fulton , PENTERMAN, Roel , CATTANEO, Stefano , BROER, Dirk, Jan , PEETERS, Emiel
发明人： KURT, Ralph , GILLIES, Murray, Fulton , PENTERMAN, Roel , CATTANEO, Stefano , BROER, Dirk, Jan , PEETERS, Emiel
IPC分类号： G01N33/543 , C12Q1/00 , C12Q1/68
CPC分类号： G01N33/54366 , C12Q1/002 , G01N33/54306
摘要： The present invention relates to a device for analyzing samples including mobility an actuation means for changing the ratio of the preselected biomolecules in the distance sample.
摘要翻译：本发明涉及一种用于分析包括移动性的样品的装置，该致动装置用于改变距离样品中的预选生物分子的比例。

18. 发明申请

WO2008010105A2 DEVICE FOR ANALYZING SAMPLES INCLUDING A GAS EVOLVING MEANS 审中-公开
标题翻译：用于分析样品的装置，包括气体发展手段
公开(公告)号：WO2008010105A2
公开(公告)日：2008-01-24
申请号：PCT/IB2007/050808
申请日：2007-03-12
申请人： KONINKLIJKE PHILIPS ELECTRONICS N. V. , GILLIES, Murray, Fulton , VOSSENAAR, Erik Robbert , JOHNSON, Mark Thomas , STAPERT, Hendrik Roelof , FISH, David Andrew , KURT, Ralph , PENTERMAN, Roel , CATTANEO, Stefano
发明人： GILLIES, Murray, Fulton , VOSSENAAR, Erik Robbert , JOHNSON, Mark Thomas , STAPERT, Hendrik Roelof , FISH, David Andrew , KURT, Ralph , PENTERMAN, Roel , CATTANEO, Stefano
IPC分类号： G01N33/543 , C12Q1/68
CPC分类号： G01N33/54366 , G01N33/54393
摘要： The invention relates to a device for analyzing one or more samples for the presence, amount or identity of one ore more target molecules in the samples, comprising one or more capture sites whereby the device comprises a gas evolving means. The gas evolved by the gas evolving means moves unbound target molecules away from the capture site and therefore helps to increase the efficacy of the analysis.
摘要翻译：本发明涉及一种用于分析一个或多个样品中用于样品中一个或多个靶分子的存在，数量或同一性的装置，其包括一个或多个捕获位点，由此该装置包括气体逸出装置。通过气体放出手段产生的气体将未结合的靶分子移离捕获位点，从而有助于提高分析的功效。

19. 发明申请

WO2007085980A1 DEVICE FOR ANALYZING FLUIDS 审中-公开
标题翻译：用于分析流体的装置
公开(公告)号：WO2007085980A1
公开(公告)日：2007-08-02
申请号：PCT/IB2007/050121
申请日：2007-01-15
申请人： KONINKLIJKE PHILIPS ELECTRONICS N. V. , PRINS, Menno Willem Jose , KURT, Ralph
发明人： PRINS, Menno Willem Jose , KURT, Ralph
IPC分类号： G01N35/00 , B01F13/08 , G01N27/40 , G01N33/543 , C12Q1/68
CPC分类号： G01N27/745 , B01F13/0809 , G01N35/0098 , Y10T436/143333 , Y10T436/25
摘要： It is an object of the invention to provide for an alternative for analyzing fluids. To this end a device for analyzing fluids comprising magnetic particles is provided, the device comprising magnetic means for generating a magnetic field designed for exerting a magnetic force to the magnetic particles creating a movement of the fluid comprising targets and a membrane with an array for moving the fluid through or along the array.
摘要翻译：本发明的目的是提供用于分析流体的替代方案。为此，提供了一种用于分析包含磁性颗粒的流体的装置，该装置包括磁性装置，用于产生设计用于向磁性颗粒施加磁力的磁场，该磁场产生包含靶的流体的运动和具有用于移动的阵列的膜流体通过或沿着阵列。

20. 发明申请

WO2006040717A1 COLOUR SWITCHING TEMPERATURE INDICATOR 审中-公开
标题翻译：彩色开关温度指示器
公开(公告)号：WO2006040717A1
公开(公告)日：2006-04-20
申请号：PCT/IB2005/053298
申请日：2005-10-07
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , MEIJER, Eduard, J. , WEGH, Rene, T. , KURT, Ralph
发明人： MEIJER, Eduard, J. , WEGH, Rene, T. , KURT, Ralph
IPC分类号： G01K11/12
CPC分类号： G01K11/12
摘要： A temperature indicator (101) is adapted to be provided on a surface (116) for providing a first type of light emission and a second type of light emission (L2). The temperature indicator (101) comprises a light-emitting diode (108) for providing said first type of light emission and a light-emitting electrochemical cell (109) for providing said second type of light emission (L2). The light-emitting electrochemical cell (109) has a first electrode (120), a second electrode (121) and a second light-emitting layer (113) being sandwiched between them and comprising a matrix and ions being movable in the matrix, the mobility of said ions in said matrix being temperature dependent. A power source (105) is adapted for driving the cell (109) with an AC voltage, the frequency of which is tuned in such a way that the cell (109) provides said second type of light emission (L2) when the surface temperature exceeds a certain level.
摘要翻译：温度指示器（101）适于设置在用于提供第一类型发光和第二类型发光（L2）的表面（116）上。温度指示器（101）包括用于提供所述第一类型发光的发光二极管（108）和用于提供所述第二类型发光（L2）的发光电化学电池（109）。发光电化学电池（109）具有第一电极（120），第二电极（121）和夹在它们之间的第二发光层（113），并且包括基质和可在基体中移动的离子，所述基质中所述离子的迁移率是温度依赖性的。电源（105）适于以交流电压驱动电池（109），其频率被调节为使得当电池（109）提供所述第二类型的发光（L2）时，表面温度超过一定水平。

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