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11. 发明申请

WO2007057806A3 DEVICE FOR IMAGING AN INTERIOR OF A TURBID MEDIUM 审中-公开
标题翻译：用于成像涡轮介质内部的装置
公开(公告)号：WO2007057806A3
公开(公告)日：2007-12-21
申请号：PCT/IB2006054061
申请日：2006-11-02
申请人： KONINKL PHILIPS ELECTRONICS NV , VAN BEEK MICHAEL C , VAN DER MARK MARTINUS B , BAKKER LEVINUS P
发明人： VAN BEEK MICHAEL C , VAN DER MARK MARTINUS B , BAKKER LEVINUS P
IPC分类号： A61B5/00 , G02B6/35
CPC分类号： A61B5/0059 , A61B5/0073 , A61B5/0091 , A61B5/4312
摘要： The invention relates to a device for imaging an interior of a turbid medium. Said device (1) comprises a measurement volume (15) for accommodating the turbid medium. Said measurement volume (15) comprises a number of sources capable of communicating light, said sources comprising a preferred source, capable of communicating preferred light and a further source, capable of communicating further light. Said device (1) further comprises a detection unit capable of detecting composed light comprising a preferred component comprising at least a part of the preferred light and a further component comprising at least a part of the further light. The device is adapted such that the negative effect said further component in the composed light may have on detecting the preferred component also present in the composed light is counteracted. According to the invention this object is realized in that the preferred source and the further source are located such that a path followed by the preferred component from the preferred source to the detector unit and a path followed by the further component from the further source to the detector unit are substantially the same.
摘要翻译：本发明涉及一种用于对浑浊介质内部进行成像的装置。所述装置（1）包括用于容纳混浊介质的测量体积（15）。所述测量体积（15）包括能够通信光的多个光源，所述光源包括能够传送更好的光的能够传送优选光的另一光源的优选光源。所述装置（1）还包括能够检测合成光的检测单元，其包括包含至少一部分优选光的优选组分和包含至少一部分光的另外组分。该装置适于使得组合光中所述另外的组分的负面影响可能在检测到组合光中也存在的优选组分时可能被抵消。根据本发明，该目的的实现是，优选的源和进一步的源被定位成使得从优选的源到检测器单元的优选组件之后的路径以及从另一个源到另一个源的另一个组件的路径检测器单元基本相同。

12. 发明申请

WO2007060596A3 A METHOD OF, SYSTEM FOR, AND MEDICAL IMAGE ACQUISITION SYSTEM FOR IMAGING AN INTERIOR OF A TURBID MEDIUM TAKING INTO ACCOUNT THE GEOMETRY OF THE TURBID MEDIUM 审中-公开
标题翻译：用于形成涡轮介质的内部的系统和用于摄像机的医疗图像采集系统的方法，用于涡轮介质的几何
公开(公告)号：WO2007060596A3
公开(公告)日：2007-09-07
申请号：PCT/IB2006054339
申请日：2006-11-20
申请人： KONINKL PHILIPS ELECTRONICS NV , VAN DER MARK MARTINUS B , VAN BEEK MICHAEL C , BAKKER LEVINUS P
发明人： VAN DER MARK MARTINUS B , VAN BEEK MICHAEL C , BAKKER LEVINUS P
IPC分类号： G01N21/49 , A61B5/00
CPC分类号： G01N21/4795 , G01N2021/1787 , G01N2021/4766 , G01N2021/6439
摘要： The invention relates to a method of imaging an interior of a turbid medium (45) comprising the following steps: accommodation of the turbid medium (45) inside a receiving volume (20); coupling transmission input light (65) from a transmission light source into the receiving volume (12), with said transmission input light (65) being chosen such that it is capable of propagating through the turbid medium (45) and with at least a part of said transmission input light (65) passing through a matching medium (50) in the receiving volume (12) , said matching medium (50) being chosen to reduce optical boundary effects at an interface between the turbid medium (45) and its surroundings; detection of transmission output light emanating from the receiving volume as a result of coupling transmission input light (65) from the transmission light source into the receiving volume (12) through use of a transmission photodetector unit. The invention also relates to a system for imaging an interior of a turbid medium (45) and a medical image acquisition system both using the method. According to the invention, the method, system for imaging an interior of a turbid medium (45), and medical image acquisition system are adapted such that data relating to the exterior of the turbid medium (45) can be obtained. This object is realized in that the method further comprises the following additional steps: coupling geometry input light (70, 75, 80) from a geometry light source into the receiving volume (12), with the receiving volume comprising the turbid medium (45), with the receiving volume (12) further comprising a geometry medium (60) for surrounding the turbid medium (45) during coupling of geometry input light (70, 75, 80) into the receiving volume (12), and with the combination of the geometry input light (70, 75, 80) , the geometry medium (60) , and the interface being chosen for creating a contrast between the turbid medium and its surroundings; - detection of the contrast between the turbid medium (45) and its surroundings; reconstructing an image of an interior of the turbid medium (45) using the detected contrast.
摘要翻译：本发明涉及一种对浑浊介质（45）内部进行成像的方法，包括以下步骤：在接收容积（20）内容纳混浊介质（45）; 将透射输入光（65）从透射光源耦合到接收体积（12）中，所述透射输入光（65）被选择为使得其能够传播通过混浊介质（45）并且具有至少一部分所述传输输入光（65）通过接收容积（12）中的匹配介质（50），所述匹配介质（50）被选择为减少混浊介质（45）与其周围环境之间的界面处的光学边界效应 ; 通过使用传输光电检测器单元将传输输入光（65）从传输光源耦合到接收容积（12）的结果，检测从接收卷发出的传输输出光。本发明还涉及一种用于使浑浊介质（45）的内部和医学图像采集系统成像的系统。根据本发明，用于对混浊介质（45）的内部进行成像的方法，医疗图像采集系统适于使得能够获得与混浊介质（45）的外部有关的数据。该目的的实现是，该方法还包括以下附加步骤：将几何输入光（70,75,80）从几何光源耦合到接收体积（12）中，其中接收体积包括混浊介质（45），接收体积（12）还包括几何介质（60），用于在将几何输入光（70,75,80）耦合到接收体积（12）期间围绕浑浊介质（45），并且与所述几何输入光（70,75,80），所述几何介质（60）和所述界面被选择用于在所述混浊介质及其周围环境之间产生对比度; - 检测混浊介质（45）与其周围环境之间的对比度; 使用检测到的对比度重建混浊介质（45）的内部的图像。

13. 发明申请

WO2010058339A3 IMAGING A TURBID MEDIUM 审中-公开
标题翻译：成像一个TURBID MEDIUM
公开(公告)号：WO2010058339A3
公开(公告)日：2010-07-22
申请号：PCT/IB2009055115
申请日：2009-11-17
申请人： KONINKL PHILIPS ELECTRONICS NV , BAKKER LEVINUS P , VAN DER MARK MARTINUS B , DECKERS JACOBUS A J M , VAN DER VOORT MARJOLEIN , LEPROUX ANAIS
发明人： BAKKER LEVINUS P , VAN DER MARK MARTINUS B , DECKERS JACOBUS A J M , VAN DER VOORT MARJOLEIN , LEPROUX ANAIS
IPC分类号： A61B5/00 , G01N21/47
CPC分类号： A61B5/411 , A61B5/0091 , A61B5/4312 , A61B2562/146 , G01N21/4795
摘要： An imaging system for imaging a turbid medium (1) comprises a holder (2) to receive the turbid medium. A fluid (22) surrounds at least part of the turbid medium. A pressure system (30) controls the hydrostatic pressure of the fluid. Notably, the imaging system of the invention images the turbid medium at different pressures applied to the turbid medium by the fluid. From a combination of the measured data or reconstructed images made at different pressures in the turbid medium, inhomogeneities are distinguished from a homogeneous surrounding. The fluid can be chosen to perform both the function of optical impedance matching between the turbid medium and its surroundings as well as the controlled application of hydrostatic pressure to the turbid medium.
摘要翻译：用于对混浊介质（1）成像的成像系统包括用于接收混浊介质的支架（2）。流体（22）包围混浊介质的至少一部分。压力系统（30）控制流体的静水压力。值得注意的是，本发明的成像系统在不同的压力下通过流体对混浊介质施加不同的压力来对混浊介质成像。根据混合介质中测量数据或不同压力下重建图像的组合，将不均匀性与均匀周围区分开来。可以选择流体来执行混浊介质与其周围环境之间的光阻抗匹配功能以及对混浊介质的流体静压力的受控应用。

14. 发明申请

WO2009060336A3 METHOD OF CONTROLLING A DEVICE FOR IMAGING THE INTERIOR OF TURBID MEDIA, DEVICE FOR IMAGING THE INTERIOR OF TURBID MEDIA AND COMPUTER PROGRAM PRODUCT 审中-公开
标题翻译：控制用于成像透明介质的内部装置的方法，用于成像透明介质和计算机程序产品的内部装置的方法
公开(公告)号：WO2009060336A3
公开(公告)日：2009-07-02
申请号：PCT/IB2008054439
申请日：2008-10-28
申请人： KONINKL PHILIPS ELECTRONICS NV , PHILIPS INTELLECTUAL PROPERTY , BAKKER LEVINUS P , BRENDEL BERNHARD J , HARBERS RIK , VAN DER MARK MARTINUS B
发明人： BAKKER LEVINUS P , BRENDEL BERNHARD J , HARBERS RIK , VAN DER MARK MARTINUS B
IPC分类号： G01N21/15 , A61B5/00 , G01N21/64
CPC分类号： G01N21/4795 , A61B5/0091 , A61B5/4312 , G01N21/15 , G01N2021/1787 , G01N2021/4719 , G01N2201/0826 , G01N2201/0833
摘要： A method of controlling a device for imaging the interior of turbid media is provided. The device comprises: a receiving portion (2) for receiving a turbid medium (1) tobe examined; at least one light source (6) optically connected to the receiving portion (2) for irradiating the interior of the receiving portion (2); and at least one detector (7) opticallyconnected to the receiving portion (2) for detecting light emanating from the interior ofthe receiving portion (2). The at least one light source (6) and the at least one detector (7) areoptically connected to the receivingportion (2) such that a plurality of differentsource- detector position combinationsare formedover a complete measurement. The different source-detector position combinations define different light paths through the receiving portion (2). The method comprises a fast-measurement step in which a reduced set of data corresponding to onlya part of the plurality of source-detector position combinations is generated for providing fast-information about the interior of the receiving portion (2).
摘要翻译：提供了一种控制用于对混浊介质的内部进行成像的设备的方法。该装置包括：用于接收待检查的混浊介质（1）的接收部分（2）至少一个光源（6），其光学连接至所述接收部分（2），用于照射所述接收部分（2）的内部; 和至少一个与接收部分（2）光学连接的检测器（7），用于检测从接收部分（2）内部发出的光。所述至少一个光源（6）和所述至少一个检测器（7）被光学地连接到所述接收部分（2），使得在完整的测量中形成多个不同的源 - 检测器位置组合。不同的源 - 检测器位置组合限定了通过接收部分（2）的不同光路。该方法包括快速测量步骤，其中产生与多个源 - 检测器位置组合的仅仅一部分相对应的简化数据集合，以提供关于接收部分（2）的内部的快速信息。

15. 发明申请

WO2009066253A2 MULTI-MODAL SPOT GENERATOR AND MULTI-MODAL MULTI-SPOT SCANNING MICROSCOPE 审中-公开
标题翻译：多模光斑发生器和多模多光斑扫描显微镜
公开(公告)号：WO2009066253A2
公开(公告)日：2009-05-28
申请号：PCT/IB2008054861
申请日：2008-11-19
申请人： KONINKL PHILIPS ELECTRONICS NV , STALLINGA SJOERD , VOSSEN DIRK L J , BAKKER LEVINUS P , HULSKEN BAS
发明人： STALLINGA SJOERD , VOSSEN DIRK L J , BAKKER LEVINUS P , HULSKEN BAS
IPC分类号： G02B3/00 , G02B5/18 , G02B21/00 , G02B27/00 , G02B27/09
CPC分类号： G02B21/0032 , G02B27/0087 , G02B27/0905
摘要： The invention relates to a spot generator (10) having: -an entrysurface (12) for receiving an incident light beam (20) and an exit surface (14) for transmitting the light beam, the entry surface defining an entryside (16) and the exit surface defining an exit side (18). According to the invention, the spot generator is designed to modulate the incident light beam to generate on the exit side a first plurality (22) and a second plurality (24) of separate light spots, each light spot belonging to the first plurality having a first angular spectrum and each light spot belonging to the second plurality having a second angular spectrum different than the first angular spectrum. Advantageously, the spot generator comprises a periodic binary phase structure. The invention further relates to a multi-spot scanning microscope and to a method of imaging a microscopic sample.
摘要翻译：本发明涉及一种点发生器（10），其具有： - 用于接收入射光束（20）的表面（12）和用于透射光束的出射表面（14），所述入射表面限定了农庄（16）;以及出口表面限定出口侧（18）。根据本发明，点发生器被设计为调制入射光束以在出射侧产生第一多个（22）和第二多个（24）分离的光点，属于第一多个的每个光点具有第一角谱和属于第二多个谱的每个光斑具有不同于第一角谱的第二角谱。有利地，点发生器包括周期性二元相位结构。本发明还涉及一种多点扫描显微镜和一种对显微镜样品成像的方法。

16. 发明申请

WO2008015604A3 MEASUREMENT WITH MULTIPLEXED DETECTION 审中-公开
标题翻译：多重检测的测量
公开(公告)号：WO2008015604A3
公开(公告)日：2008-04-03
申请号：PCT/IB2007052823
申请日：2007-07-16
申请人： KONINKL PHILIPS ELECTRONICS NV , BAKKER LEVINUS P
发明人： BAKKER LEVINUS P
IPC分类号： A61B5/00
CPC分类号： A61B5/4312 , A61B5/0073 , A61B5/0091
摘要： The invention relates to a device (1) for imaging an interior of a turbid medium (45) comprising: a) a measurement volume (15) for receiving the turbid medium (45); b) a light source (5) for irradiating the turbid medium (45); c) a photodetector unit (10) for detecting light emanating from exit positions (60) located on a boundary of the measurement volume (15) as a result of irradiating the turbid medium (45). The device (1) is adapted to collect light from spatially distinct beams of light emanating from a single exit position (60). The single exit position (60) may, for instance, come in the form of an optical channel (25b) or it may simply be an area of skin tissue from which light emanates. In one embodiment of the device (1) according to the invention multiple optical light guides (55) are optically coupled to the single exit position (60).
摘要翻译：本发明涉及一种用于对混浊介质（45）的内部进行成像的设备（1），包括：a）用于接收混浊介质（45）的测量容积（15）; b）用于照射混浊介质（45）的光源（5）; c）光检测器单元（10），用于检测作为照射混浊介质（45）的结果位于测量体积（15）的边界上的出口位置（60）发出的光。该装置（1）适于从单个出射位置（60）发出的空间上不同的光束收集光。单个出口位置（60）可以例如以光学通道（25b）的形式出现，或者其可以简单地是光从其发出的皮肤组织的区域。在根据本发明的设备（1）的一个实施例中，多个光学光导（55）光学耦合到单个出口位置（60）。

17. 发明申请

WO2006064458A3 METHOD OF ENCODING DATA ON AN INFORMATION CARRIER, SYSTEM FOR READING SUCH AN INFORMATION CARRIER. 审中-公开
标题翻译：在信息载体上编码数据的方法，用于读取这种信息载体的系统。
公开(公告)号：WO2006064458A3
公开(公告)日：2006-08-31
申请号：PCT/IB2005054199
申请日：2005-12-13
申请人： KONINKL PHILIPS ELECTRONICS NV , HENDRIKS ROBERT F M , BAKKER LEVINUS P
发明人： HENDRIKS ROBERT F M , BAKKER LEVINUS P
IPC分类号： G11B7/0065 , G11B7/125 , G11B7/24 , G11B7/24012 , G11C13/04
CPC分类号： G11B7/24012 , G11B7/005 , G11B7/128 , G11C13/04
摘要： The invention relates to a method of encoding a set of data on an information carrier comprising data areas each intended to store a data, each data area being characterized by a transmission coefficient and a phase-shift coefficient, said method comprising a step of calculating the transmission coefficient and phase-shift coefficient of said data areas so that an output light pattern corresponding to the intensity pattern of said set of data is generated at a given distance from the information carrier, via interference between light outputted by said data areas in response of an array of light spots periodically applied to non-adjacent data areas.
摘要翻译：本发明涉及一种在信息载体上编码数据集合的方法，该信息载体包括每个意图存储数据的数据区域，每个数据区域由传输系数和相移系数表征，所述方法包括以下步骤：传输系数和所述数据区域的相移系数，使得与所述数据组的强度模式相对应的输出光模式通过所述数据区域输出的光之间的干扰而从信息载体产生给定距离，以响应于周期性地应用于非相邻数据区的光点阵列。

18. 发明申请

WO2009066252A2 MULTI-FOCAL SPOT GENERATOR AND MULTI-FOCAL MULTI-SPOT SCANNING MICROSCOPE 审中-公开
标题翻译：多焦点发生器和多焦点多点扫描显微镜
公开(公告)号：WO2009066252A2
公开(公告)日：2009-05-28
申请号：PCT/IB2008054860
申请日：2008-11-19
申请人： KONINKL PHILIPS ELECTRONICS NV , STALLINGA SJOERD , BAKKER LEVINUS P , VOSSEN DIRK L J
发明人： STALLINGA SJOERD , BAKKER LEVINUS P , VOSSEN DIRK L J
IPC分类号： G02B3/00 , G02B21/00 , G02B27/00
CPC分类号： G02B27/0087 , G02B3/0006 , G02B21/004
摘要： The invention relates to a spot-generator (10) having: an entrance surface (12) for receiving an incident light beam (20) and an exit surface (14) for transmitting the light beam, the entrance surface defining an entrance side (16) and the exit surface defining an exit side (18), wherein the spot generator is designed to modulate the incident light beam to generate on the exit side a plurality of separate light spots. According to the invention, the plurality of light spots comprises a first light spot (22) generated in a first focal plane (24) and a second light spot (26) generated in a second focal plane (28), the first focal plane and the second focal plane being essentially perpendicular to the mean propagation direction of the exit light beam, and wherein the first light spot (22) differs from every other light spot generated on the exit side by the spot generator in the projection of its position on a plane essentially perpendicular to the mean propagation direction of the exit light beam. Advantageously, the light spots of the plurality of separate light spots have identical spectra. The invention further relates to a multi-spot scanning microscope and to a method of generating an image of a microscopic sample. Advantageously, the method comprises the step of generating a three- dimensional image of the sample.
摘要翻译：本发明涉及点光发生器（10），其具有：用于接收入射光束（20）的入射表面（12）和用于透射光束的出射表面（14），入射面限定入射侧（16 ）和所述出射表面限定出射侧（18），其中所述光斑发生器被设计成调制所述入射光束，以在所述出射侧产生多个单独的光斑。根据本发明，多个光点包括在第一焦平面（24）中产生的第一光点（22）和在第二焦平面（28）中产生的第二光点（26），第一焦平面和所述第二焦平面基本上垂直于所述出射光束的平均传播方向，并且其中所述第一光点（22）在其位置的投影中由所述光点发生器在出射侧产生的每隔一个光点不同平面基本上垂直于出射光束的平均传播方向。有利地，多个分开的光点中的光点具有相同的光谱。本发明还涉及多点扫描显微镜和产生微观样品图像的方法。有利地，该方法包括产生样本的三维图像的步骤。

19. 发明申请

WO2009060383A3 METHOD FOR CALIBRATING A DEVICE FOR IMAGING THE INTERIOR OF TURBID MEDIA AND METHOD FOR CORRECTING MEASURED INTENSITIES IN SUCH A DEVICE 审中-公开
标题翻译：用于校准用于成像涡轮介质的内部的装置的方法和用于校正这种装置中的测量强度的方法
公开(公告)号：WO2009060383A3
公开(公告)日：2009-07-30
申请号：PCT/IB2008054583
申请日：2008-11-04
申请人： KONINKL PHILIPS ELECTRONICS NV , PHILIPS INTELLECTUAL PROPERTY , KOEHLER THOMAS , NIELSEN TIM , BAKKER LEVINUS P
发明人： KOEHLER THOMAS , NIELSEN TIM , BAKKER LEVINUS P
IPC分类号： G01N21/47 , A61B5/00 , A61B6/00
CPC分类号： G01N21/4795 , A61B5/0091 , A61B5/4312 , A61B2560/0233
摘要： A method for calibrating a device for imaging the interior of turbid media is provided. The device for imaging the interior of turbid media uses a fluorescent contrast agent emitting fluorescence light and comprises a receptacle (2) for receiving a turbid medium (1 ) during examination; at least one light source optically connected to the receptacle (2) for irradiating the interior of the receptacle with light of a predetermined wavelength (?L); at least one detector optically connected to the receptacle (2) for detecting light emanating from the interior of the receptacle; and at least one filter introducible in the detection light path from the receptacle (2) to the at least one detector. The method for calibrating comprises the steps: - performing a first reference measurement with the receptacle (2) filled with an optically matching medium (4); - performing a second reference measurement with the receptacle (2) filled with a mixture of the optically matching medium and a fluorescent contrast agent; - calibrating the device based on the results of the first reference measurement and the second reference measurement.
摘要翻译：提供了一种用于校准用于对浑浊介质内部进行成像的装置的方法。用于对混浊介质内部进行成像的装置使用发射荧光的荧光对比剂，并且包括用于在检查期间接收混浊介质（1）的容器（2）至少一个光源，其光学连接到所述插座（2），用于用预定波长（λL）的光照射所述插座的内部; 至少一个检测器，其光学连接到所述容器（2），用于检测从所述容器的内部发出的光; 以及至少一个滤光器，其引导到从所述插座（2）到所述至少一个检测器的检测光路中。用于校准的方法包括以下步骤： - 用填充有光学匹配介质（4）的容器（2）执行第一参考测量; - 用所述光学匹配介质和荧光对比剂的混合物填充的所述容器（2）执行第二参考测量; - 根据第一个参考测量结果和第二个参考测量结果校准设备。

20. 发明专利

JP2007173805A System and method of detecting at least one contamination species in lithography device 有权
标题翻译：检测最小一次污染物种的系统和方法
公开(公告)号：JP2007173805A
公开(公告)日：2007-07-05
申请号：JP2006336392
申请日：2006-12-13
申请人： Asml Netherlands Bv , Koninkl Philips Electronics Nv , エーエスエムエルネザーランズビー.ブイ. , コーニンクレッカフィリップスエレクトロニクスエヌヴィ
发明人： BANINE VADIM YEVGENYEVICH , BAKKER LEVINUS P , KURT RALPH , JOSEPHINA MOORS JOHANNES HUBER , STEVENS LUCAS HENRICUS JOHANNE , ZALM PETER C
IPC分类号： H01L21/027 , G03F7/20
CPC分类号： G01N25/142 , G01N25/68 , Y10T436/25875
摘要： PROBLEM TO BE SOLVED: To provide an improved system and method for monitoring contamination in which the occurrence of the contamination is quickly detected using a comparatively easy and inexpensive monitoring device. SOLUTION: The system which detects at least one contamination species in the internal space of a lithography device includes at least one monitoring surface constituted as an internal space contact is carried out, a thermal controller configured so that the temperature on the monitoring surface may be controlled to at least one detection temperature, and at least one detector constituted so that the condensation of up to at least one monitoring surface of the contamination species might be detected. COPYRIGHT: (C)2007,JPO&INPIT

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