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11. 发明授权

US07741105B2 Biomolecule chip and fabrication method thereof 有权
标题翻译：生物分子芯片及其制造方法
公开(公告)号：US07741105B2
公开(公告)日：2010-06-22
申请号：US11329240
申请日：2006-01-10
申请人： Young-il Kim , Moon-chul Lee , Jung-ho Kang , Tae-sik Park
发明人： Young-il Kim , Moon-chul Lee , Jung-ho Kang , Tae-sik Park
IPC分类号： B81B7/04
CPC分类号： G01N33/544
摘要： Disclosed is a biomolecule chip and a fabrication method thereof. The biomolecule chip of the invention includes: a substrate; an insulating layer formed on the substrate; an adhesive layer formed on the insulating layer; a seed layer formed on the adhesive layer; an opening patterned at a predetermined location within the adhesive layer, the seed layer and the electroplating layer; and a biomolecule immobilized layer formed on the electroplating layer, the electroplating layer comprising a plasma-treated electroplating layer prior to the formation of the biomolecule immobilized layer. Accordingly, the immobilization of biomolecules onto the surface can be done more effectively by modifying the surface of the substrate in favor of biomolecules.
摘要翻译：公开了一种生物分子芯片及其制造方法。本发明的生物分子芯片包括：基材; 形成在所述基板上的绝缘层; 形成在所述绝缘层上的粘合剂层; 形成在粘合剂层上的种子层; 在粘合剂层内的预定位置图案化的开口，种子层和电镀层; 以及形成在所述电镀层上的生物分子固定层，所述电镀层在形成所述生物分子固定化层之前包含等离子体处理的电镀层。因此，通过改变基质表面有利于生物分子，可以更有效地进行生物分子固定在表面上。

12. 发明申请

US20060154242A1 Biomolecule chip and fabrication method thereof 有权
标题翻译：生物分子芯片及其制造方法
公开(公告)号：US20060154242A1
公开(公告)日：2006-07-13
申请号：US11329240
申请日：2006-01-10
申请人： Young-il Kim , Moon-chul Lee , Jung-ho Kang , Tae-sik Park
发明人： Young-il Kim , Moon-chul Lee , Jung-ho Kang , Tae-sik Park
IPC分类号： C12Q1/70 , C12Q1/68 , G01N33/53 , H01L21/00
CPC分类号： G01N33/544
摘要： Disclosed is a biomolecule chip and a fabrication method thereof The biomolecule chip of the invention includes: a substrate; an insulating layer formed on the substrate; an adhesive layer formed on the insulating layer; a seed layer formed on the adhesive layer; an opening patterned at a predetermined location within the adhesive layer, the seed layer and the electroplating layer; and a biomolecule immobilized layer formed on the electroplating layer, the electroplating layer comprising a plasma-treated electroplating layer prior to the formation of the biomolecule immobilized layer. Accordingly, the immobilization of biomolecules onto the surface can be done more effectively by modifying the surface of the substrate in favor of biomolecules.
摘要翻译：公开了一种生物分子芯片及其制造方法。本发明的生物分子芯片包括：基板; 形成在所述基板上的绝缘层; 形成在所述绝缘层上的粘合剂层; 形成在粘合剂层上的种子层; 在粘合剂层内的预定位置图案化的开口，种子层和电镀层; 以及形成在所述电镀层上的生物分子固定层，所述电镀层在形成所述生物分子固定化层之前包含等离子体处理的电镀层。因此，通过改变基质表面有利于生物分子，可以更有效地进行生物分子固定在表面上。

13. 发明授权

US07544472B2 Apparatus for detecting biomolecular bonding and a method thereof 有权
标题翻译：用于检测生物分子结合的装置及其方法
公开(公告)号：US07544472B2
公开(公告)日：2009-06-09
申请号：US11325056
申请日：2006-01-03
申请人： Tae-sik Park , Young-il Kim , Jung-ho Kang
发明人： Tae-sik Park , Young-il Kim , Jung-ho Kang
IPC分类号： C12Q1/68 , C12M1/36 , G01N15/06
CPC分类号： G01N33/542 , G01N29/036 , G01N33/54366 , G01N2291/0257
摘要： An apparatus and method for detecting biomolecular bonding are disclosed. The apparatus comprises a substrate; a rotation unit mounted on the substrate, a probe biomolecule immobilized on a surface of the rotation unit; an input port and an output port connected with the substrate. A frequency detector is connected with the output port to measure rotational frequency of the rotation unit. The presence or absence of molecular bonding is detected by measuring difference between the rotational frequencies before and after mixing the probe biomolecule with a sample biomolecule.
摘要翻译：公开了一种用于检测生物分子结合的装置和方法。该装置包括基板; 安装在所述基板上的旋转单元，固定在所述旋转单元的表面上的探针生物分子; 与基板连接的输入端口和输出端口。频率检测器与输出端口连接，以测量旋转单元的旋转频率。通过测量将探针生物分子与样品生物分子混合之前和之后的旋转频率之间的差异来检测分子键的存在或不存在。

14. 发明申请

US20060147972A1 Apparatus for detecting biomolecular bonding and a method thereof 有权
公开(公告)号：US20060147972A1
公开(公告)日：2006-07-06
申请号：US11325056
申请日：2006-01-03
申请人： Tae-sik Park , Young-il Kim , Jung-ho Kang
发明人： Tae-sik Park , Young-il Kim , Jung-ho Kang
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： G01N33/542 , G01N29/036 , G01N33/54366 , G01N2291/0257
摘要： An apparatus and method for detecting biomolecular bonding are disclosed. The apparatus comprises a substrate; a rotation unit mounted on the substrate, a probe biomolecule immobilized on a surface of the rotation unit; an input port and an output port connected with the substrate. A frequency detector is connected with the output port to measure rotational frequency of the rotation unit. The presence or absence of molecular bonding is detected by measuring difference between the rotational frequencies before and after mixing the probe biomolecule with a sample biomolecule.

15. 发明授权

US07933720B2 Biomolecule bonding detection apparatus using RF wireless energy transmission and method thereof 有权
标题翻译：使用RF无线能量传输的生物分子结合检测装置及其方法
公开(公告)号：US07933720B2
公开(公告)日：2011-04-26
申请号：US11315526
申请日：2005-12-21
申请人： Tae-sik Park , Young-il Kim , Jung-ho Kang
发明人： Tae-sik Park , Young-il Kim , Jung-ho Kang
IPC分类号： G01N33/48 , G01N31/00 , C12M1/00
CPC分类号： G01N27/3276 , G01N33/48785
摘要： An apparatus for detecting a biomolecule bonding using a radio frequency (RF) wireless energy transmission and a method thereof are disclosed. The method includes transmitting RF energy to a sensor module having one or more probe biomolecules immobilized thereon, and determining a first energy charging time of the sensor module, the first energy charging time representing the amount of time for the sensor to be completely charged by the transmitted RF energy, prior to mixing of the one or more probe biomolecules with one or more target sample biomolecules. A second energy charging time of the sensor module is determined, the second energy charging time representing the amount of time for the sensor to be completely charged by the transmitted RF energy, following mixing of the one or more probe biomolecules with one or more target biomolecule sample. A determination of whether biomolecule bonding has occurred is based on a variation of the first and second energy charging times.
摘要翻译：公开了一种使用射频（RF）无线能量传输检测生物分子结合的装置及其方法。该方法包括将RF能量传送到具有固定在其上的一个或多个探针生物分子的传感器模块，以及确定传感器模块的第一能量充电时间，第一能量充电时间表示传感器完全充电的时间量在将一种或多种探针生物分子与一种或多种靶样品生物分子混合之前，传输RF能量。确定传感器模块的第二能量充电时间，第二能量充电时间表示在将一个或多个探针生物分子与一个或多个靶生物分子混合之后传输的RF能量完全充电的传感器的时间量样品。是否发生生物分子结合的确定是基于第一和第二能量充电时间的变化。

16. 发明授权

US07815860B2 Biosensor, biosensor system and method of using thereof 有权
标题翻译：生物传感器，生物传感器系统及其使用方法
公开(公告)号：US07815860B2
公开(公告)日：2010-10-19
申请号：US11286030
申请日：2005-11-23
申请人： Young-il Kim , Jung-ho Kang , Tae-sik Park
发明人： Young-il Kim , Jung-ho Kang , Tae-sik Park
IPC分类号： G01N25/20 , G01N27/00 , G01N33/00 , G01N33/48 , G01N33/50 , G01N33/53
CPC分类号： G01N27/3271
摘要： A biosensor for detecting an analyte by using a variable voltage according to infrared radiation absorption is provided. The biosensor includes an infrared absorber having a variable resistance and bioreceptors immobilized onto the infrared absorber for selectively reacting and binding with an analyte, wherein an induced voltage at the infrared absorber varies depending on whether the bioreceptor reacts and binds with the analyte.
摘要翻译：提供了一种用于通过使用根据红外辐射吸收的可变电压来检测分析物的生物传感器。生物传感器包括具有可变电阻的红外吸收剂和固定在红外吸收器上的生物感应器，用于选择性地与分析物反应和结合，其中红外吸收剂处的感应电压根据生物受体是否与分析物反应而结合。

17. 发明授权

US08268552B2 Biomolecule detector and detection method using the same 有权
标题翻译：生物分子检测器和检测方法使用相同
公开(公告)号：US08268552B2
公开(公告)日：2012-09-18
申请号：US11323742
申请日：2005-12-30
申请人： Tae-sik Park , Young-il Kim , Jung-ho Kang
发明人： Tae-sik Park , Young-il Kim , Jung-ho Kang
IPC分类号： C12Q1/68 , C12M1/00 , C12M1/34 , C12M3/00
CPC分类号： G01N21/4788 , G01N21/45 , G01N33/54353 , G01N33/54366 , G01N33/6845
摘要： Disclosed is a biomolecule detector and a detection method using the same. The biomolecule detector includes a biomolecule chip having a substrate and a slit formed therein. Biomolecules are immobilized on at least a portion of the edges of the slit. A light source directs incident light toward the biomolecule chip, and a screen receives an image formed by a portion of the incident light passing through the slit. The biomolecule detector is small and portable, yet its capability for detecting a target biomolecule is quick, accurate and simple. The simple structural features of the biomolecule detector enable mass production.
摘要翻译：公开了一种生物分子检测器及其检测方法。生物分子检测器包括具有基板和形成在其中的狭缝的生物分子芯片。生物分子被固定在狭缝的至少一部分边缘上。光源将入射光引向生物分子芯片，并且屏幕接收由通过狭缝的入射光的一部分形成的图像。生物分子检测器小巧便携，检测目标生物分子的能力快速，准确，简单。生物分子检测器的简单结构特征使得能够批量生产。

18. 发明申请

US20060148067A1 Bio-bonding detection apparatus using ultrasonic waves and method thereof 审中-公开
标题翻译：使用超声波的生物接合检测装置及其方法
公开(公告)号：US20060148067A1
公开(公告)日：2006-07-06
申请号：US11282233
申请日：2005-11-17
申请人： Tae-sik Park , Young-il Kim , Jung-ho Kang , Nam-su Park
发明人： Tae-sik Park , Young-il Kim , Jung-ho Kang , Nam-su Park
IPC分类号： C12M1/34
CPC分类号： G01N29/022 , G01N29/2412 , G01N29/2437 , G01N2291/02466 , G01N2291/0256 , G01N2291/0423
摘要： An apparatus for detecting bio-bonding using ultrasonic waves and a method thereof are disclosed. The apparatus includes a generator for generating ultrasonic wave, a transformer, disposed in proximity to the generator, the transformer configured for vibration thereof by the generated ultrasonic wave. A probe biomolecule is immobilized on the transformer, and a metal plate is disposed in proximity to the transformer. An analyzer is configured for measuring the capacitance between the transformer and the metal plate. The bio-bonding detection apparatus conveniently determines whether bio-bonding is generated by detecting variation in capacitance or variation in a characteristic of the ultrasonic wave.
摘要翻译：公开了一种使用超声波检测生物粘合的装置及其方法。该装置包括用于产生超声波的发生器，设置在发电机附近的变压器，该变压器被配置为通过产生的超声波进行振动。探针生物分子固定在变压器上，金属板设置在变压器附近。分析器被配置为测量变压器和金属板之间的电容。生物粘合检测装置方便地确定通过检测电容的变化或超声波的特性的变化来生成生物结合。

19. 发明申请

US20060205060A1 Biosensor, biosensor system and method of using thereof 有权
标题翻译：生物传感器，生物传感器系统及其使用方法
公开(公告)号：US20060205060A1
公开(公告)日：2006-09-14
申请号：US11286030
申请日：2005-11-23
申请人： Young-il Kim , Jung-ho Kang , Tae-sik Park
发明人： Young-il Kim , Jung-ho Kang , Tae-sik Park
IPC分类号： C12M1/34
CPC分类号： G01N27/3271
摘要： A biosensor for detecting an analyte by using a variable voltage according to infrared radiation absorption is provided. The biosensor includes an infrared absorber having a variable resistance and bioreceptors immobilized onto the infrared absorber for selectively reacting and binding with an analyte, wherein an induced voltage at the infrared absorber varies depending on whether the bioreceptor reacts and binds with the analyte.
摘要翻译：提供了一种用于通过使用根据红外辐射吸收的可变电压来检测分析物的生物传感器。生物传感器包括具有可变电阻的红外吸收剂和固定在红外吸收器上的生物感应器，用于选择性地与分析物反应和结合，其中红外吸收剂处的感应电压根据生物受体是否与分析物反应而结合。

20. 发明申请

US20060154300A1 Biomolecule bonding detection apparatus using wireless antenna and method thereof 审中-公开
标题翻译：使用无线天线的生物分子接合检测装置及其方法
公开(公告)号：US20060154300A1
公开(公告)日：2006-07-13
申请号：US11327032
申请日：2006-01-05
申请人： Tae-sik Park , Young-il Kim , Jung-ho Kang
发明人： Tae-sik Park , Young-il Kim , Jung-ho Kang
IPC分类号： C12M1/34 , G01N33/53 , G08C19/04
CPC分类号： G01N33/54373
摘要： Disclosed is a biomolecule binding detection apparatus and a method thereof, which detects biomolecule bonding by measuring change in characteristics of a test signal transmitted by an antenna on which probe biomolecules are immobilized. The biomolecule bonding detection apparatus includes a transmitting unit on which probe biomolecules are immobilized, the probe biomolecules configured for detection of specific gene information included in sample biomolecules to be analyzed, the transmitting unit further configured for signal transmission. A receiving unit is configured for detecting biomolecule bonding by comparison of selected characteristics of a test signal transmitted from the transmitting unit before and after mixing of the probe biomolecules and the sample biomolecules.
摘要翻译：公开了一种生物分子结合检测装置及其方法，其通过测量由固定有探针生物分子的天线发射的测试信号的特性的变化来检测生物分子结合。所述生物分子结合检测装置包括固定有探针生物分子的发送单元，所述探针生物分子被配置为检测包含在待分析的样品生物分子中的特定基因信息，所述发送单元还被配置为进行信号传输。接收单元被配置为通过比较在探针生物分子和样品生物分子混合之前和之后从发送单元发送的测试信号的选定特征来检测生物分子结合。

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