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    • 13. 发明授权
    • Radioactive therapeutic seed having selective marker configuration
    • 具有选择标记物配置的放射性治疗种子
    • US06200258B1
    • 2001-03-13
    • US09371243
    • 1999-08-10
    • Charles R. SlaterThomas O. BalesKevin W. Smith
    • Charles R. SlaterThomas O. BalesKevin W. Smith
    • A61N500
    • A61N5/1027A61N2005/1024
    • Radioactive therapeutic seeds include a carrier structure bearing a radioactive isotope and a radiopaque marker. According to embodiments of the invention, the seeds include a central plug provided with an axial marker and a relatively transverse bore extending through the marker. A second marker may be positioned in the bore, thereby radiographically distinguishing a seed provided with the second marker relative to a seed not provided with the second marker. According to another embodiment of the invention, the isotope is deposited on the outer surface of a hollow radiolucent tube. A biologically-compatible, radiolucent, surface-sealing layer seals the external surface of the tube. A radiopaque marker wire of selected length is positioned in the hollow of the tube. Seeds may be radiographically distinguished from one another by providing seeds with marker wires of different lengths. Each embodiment permits at least two groups of seeds to be radiographically distinguished from one another by the use of differing marker configurations. Each embodiment is further capable of being selectively marked by the physician prior to implantation of the seeds, or by the manufacturer for delivery to the physician in radiographically distinguishable sets. As a result, seeds having different levels of radiation emission can be distinguished in vivo and their effect monitored by the physician.
    • 放射治疗种子包括具有放射性同位素和不透射线标记的载体结构。 根据本发明的实施例,种子包括设置有轴向标记的中心塞和延伸穿过标记的相对横向的孔。 可以将第二标记物定位在孔中,从而与提供有第二标记的种子相对于未设置有第二标记的种子进行射线照相。 根据本发明的另一个实施方案,同位素沉积在中空的射线可透管的外表面上。 生物相容的射线可透过的表面密封层密封管的外表面。 所选长度的不透射线标记线位于管的中空中。 种子可以通过向不同长度的标记线提供种子而被放射学地区分开。 每个实施例允许至少两组种子通过使用不同的标记物构造彼此放射学地区分开。 每个实施例还能够在植入种子之前被医生选择性地标记,或者由制造商在放射学可区分的组中递送给医师。 结果,具有不同水平的辐射发射的种子可以在体内被区分,并且其效果由医师监测。
    • 14. 发明授权
    • Endoscopic surgical methods utilizing a suction-irrigation instrument
with a port for endoscopic manipulating instruments
    • 内窥镜手术方法利用具有用于内窥镜操纵仪器的端口的吸入式装置
    • US5312332A
    • 1994-05-17
    • US51000
    • 1993-04-21
    • Thomas O. BalesCharles R. SlaterKevin W. Smith
    • Thomas O. BalesCharles R. SlaterKevin W. Smith
    • A61B10/00A61B10/06A61B17/00A61B17/34A61B18/14A61M1/00
    • A61B17/00234A61B10/06A61B17/3421A61B18/14A61B2090/0817A61B2217/005A61B2217/007
    • Methods of endoscopic surgery are disclosed. The methods utilize a suction/irrigation endoscopic instrument and a second endoscopic instrument. The suction/irrigation endoscopic instrument has a cannula, a fluid chamber in communication with the cannula, and an automatic valve at the proximal end of the fluid chamber. The second endoscopic instrument has end effectors and actuating means, and the end effectors of the second endoscopic instrument is inserted through the automatic valve, through the fluid chamber, and through the cannula. The methods involve inserting the suction/irrigation instrument through a trocar tube, and then inserting the second endoscopic instrument therethrough. The automatic valve insures that there is no leakage when the second instrument is inserted. The second endoscopic instrument may rotated inside, or may be partially withdrawn into the suction/irrigation instrument. Upon removing the second endoscopic instrument, the valve of the suction/irrigation instrument automatically closes so that there is no leakage. If desired, the suction/irrigation instrument may be provided with a cautery current at the cannula, and the second endoscopic instrument may be provided with a bump which contacts the cannula as a cautery pick-up.
    • 公开了内窥镜手术的方法。 该方法利用抽吸/灌洗内窥镜仪器和第二内窥镜仪器。 吸入/冲洗内窥镜器具具有插管,与插管连通的流体室,以及在流体室的近端处的自动阀。 第二内窥镜仪器具有末端执行器和致动装置,并且第二内窥镜器械的末端执行器通过自动阀,通过流体腔室并穿过套管插入。 所述方法包括通过套管针插入吸入/冲洗器械,然后将第二内窥镜器械插入其中。 自动阀确保插入第二台仪器时没有泄漏。 第二内窥镜器械可以在内部旋转,或者可以部分地抽吸到抽吸/冲洗仪器中。 在移除第二内窥镜仪器后,吸入/冲洗仪器的阀门自动关闭,因此不会有泄漏。 如果需要,吸入/冲洗器械可以在套管处设置有烧焦电流,并且第二内窥镜器械可以设置有作为灼烧拾取器接触套管的凸块。
    • 19. 发明授权
    • Radioactive therapeutic seeds
    • 放射治疗种子
    • US06273851B1
    • 2001-08-14
    • US09312215
    • 1999-05-14
    • Charles R. SlaterScott L. JahrmarktScott T. SmithThomas O. BalesKevin W. Smith
    • Charles R. SlaterScott L. JahrmarktScott T. SmithThomas O. BalesKevin W. Smith
    • A61M3600
    • A61N5/1027A61N2005/1005A61N2005/1023A61N2005/1024
    • Radioactive therapeutic seeds include a substantially radiotransparent cylindrical capsule containing a radioactive isotope and, in particular embodiments, a radiopaque or MRI-visible marker. Each of the embodiments is designed to provide a substantially isotropic distribution of radiation. In one embodiment, the isotope is deposited on the outer surface of a hollow radiolucent tube and a collar is provided about a central portion of the tube. The capsule comprises two tubular halves positioned over the tube with the open ends of the halves forming an interference fit with the collar and welded thereabout. In another embodiment, the isotope bearing structure is a plurality of radiolucent spheres provided with a thin coating of silver to facilitate the adhesion of the isotope thereto. The spheres are provided in two capsule halves which are welded closed about a plug have an axial radiopaque marker therein. In yet another embodiment, the isotope bearing structure is a pair of silver tubes having surfaces on which the isotope is provided. One tube is positioned in each half of the capsule, and the halves are then welded about a plug provided with a marker. In each embodiment, the closed ends of the capsule are provided with tissue engaging members or connectors which can be coupled to discrete spacing links.
    • 放射性治疗种子包括含有放射性同位素的基本上无辐射透明的圆柱形胶囊,特别是不透射线或MRI可见标记。 每个实施例被设计成提供基本上各向同性的辐射分布。 在一个实施例中,同位素沉积在中空的射线可透管的外表面上,并且围绕管的中心部分提供轴环。 胶囊包括位于管上方的两个管状半部,其半开口端形成与套环的过盈配合并在其周围焊接。 在另一个实施方案中,同位素承载结构是多个具有薄的银涂层的射线可透过球,以便于同位素与其粘附。 球体设置在两个胶囊半部中,其围绕塞子被焊接封闭,其中具有轴向不透射线的标记。 在另一个实施方案中,同位素承载结构是具有其上提供同位素的表面的一对银管。 一个管被定位在胶囊的每一半中,然后将半部焊接在设置有标记的塞子周围。 在每个实施例中,胶囊的封闭端部设置有组织接合构件或可连接到分立间隔连接件的连接器。