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11. 发明申请

US20110059090A1 AMINO ACID SEQUENCES DIRECTED AGAINST HER2 AND POLYPEPTIDES COMPRISING THE SAME FOR THE TREATMENT OF CANCERS AND/OR TUMORS 有权
标题翻译：指导针对HER2的氨基酸序列和包含癌症和/或肿瘤的治疗的多肽
公开(公告)号：US20110059090A1
公开(公告)日：2011-03-10
申请号：US12744991
申请日：2008-11-27
申请人： Hilde Adi Pierrette Revets , Carlo Boutton , Hendricus Renerus Jacobus Mattheus Hoogenboom
发明人： Hilde Adi Pierrette Revets , Carlo Boutton , Hendricus Renerus Jacobus Mattheus Hoogenboom
IPC分类号： A61K39/395 , C07K16/28 , C12N15/13 , C12N5/16 , C12P21/00 , C40B30/04 , A61P35/00
CPC分类号： C07K16/2863 , A61K39/3955 , A61K2039/505 , C07K16/3007 , C07K16/32 , C07K16/468 , C07K2317/22 , C07K2317/31 , C07K2317/32 , C07K2317/52 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/64 , C07K2317/76 , C07K2317/94 , C07K2319/00
摘要： The present invention relates to amino acid sequences and Nanobodies that are directed against Epidermal Growth Factor Receptor 2 (HER2), as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences.
摘要翻译：本发明涉及针对表皮生长因子受体2（HER2）的氨基酸序列和纳米抗体，以及包含或基本上由一个或多个这样的氨基酸组成的化合物或构建体，特别是蛋白质和多肽序列。

12. 发明授权

US08975382B2 Amino acid sequences directed against HER2 and polypeptides comprising the same for the treatment of cancers and/or tumors 有权
标题翻译：针对HER2的氨基酸序列和包含它们的多肽用于治疗癌症和/或肿瘤
公开(公告)号：US08975382B2
公开(公告)日：2015-03-10
申请号：US12744991
申请日：2008-11-27
申请人： Hilde Adi Pierrette Revets , Carlo Boutton , Hendricus Renerus Jacobus Mattheus Hoogenboom
发明人： Hilde Adi Pierrette Revets , Carlo Boutton , Hendricus Renerus Jacobus Mattheus Hoogenboom
IPC分类号： C07K16/30 , C07K16/32 , C07K16/46 , C07K16/28
CPC分类号： C07K16/2863 , A61K39/3955 , A61K2039/505 , C07K16/3007 , C07K16/32 , C07K16/468 , C07K2317/22 , C07K2317/31 , C07K2317/32 , C07K2317/52 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/64 , C07K2317/76 , C07K2317/94 , C07K2319/00
摘要： The present invention relates to amino acid sequences and Nanobodies that are directed against Epidermal Growth Factor Receptor 2 (HER2), as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences.
摘要翻译：本发明涉及针对表皮生长因子受体2（HER2）的氨基酸序列和纳米抗体，以及包含或基本上由一个或多个这样的氨基酸组成的化合物或构建体，特别是蛋白质和多肽序列。

13. 发明申请

US20130013279A1 APPARATUS AND METHOD FOR STRUCTURE-BASED PREDICTION OF AMINO ACID SEQUENCES 审中-公开
标题翻译：用于氨基酸序列的结构预测的装置和方法
公开(公告)号：US20130013279A1
公开(公告)日：2013-01-10
申请号：US13472080
申请日：2012-05-15
申请人： Johan Desmet , Ignace Lasters , Dominique Vlieghe , Carlo Boutton , Philippe Stas
发明人： Johan Desmet , Ignace Lasters , Dominique Vlieghe , Carlo Boutton , Philippe Stas
IPC分类号： G06F19/16 , G06G7/48
CPC分类号： G16B15/00
摘要： The present invention provides methods and apparatus for analyzing a protein structure.
摘要翻译：本发明提供了分析蛋白质结构的方法和装置。

14. 发明申请

US20120264917A1 BIPARATOPIC PROTEIN CONSTRUCTS DIRECTED AGAINST IL-23 审中-公开
标题翻译：针对IL-23指导的BIPARATOPIC蛋白质构建体
公开(公告)号：US20120264917A1
公开(公告)日：2012-10-18
申请号：US13321979
申请日：2010-05-27
申请人： Michael John Scott Saunders , Christophe Blanchetot , Carlo Boutton , Heidi Rommelaere , Johannes Joseph Wilhelmus De Haard , Veronique De Brabandere , Marc Jozef Lauwereys , Erika Morizzo , Ann Union , Gert Verheyden
发明人： Michael John Scott Saunders , Christophe Blanchetot , Carlo Boutton , Heidi Rommelaere , Johannes Joseph Wilhelmus De Haard , Veronique De Brabandere , Marc Jozef Lauwereys , Erika Morizzo , Ann Union , Gert Verheyden
IPC分类号： C07K16/46
CPC分类号： C07K16/244 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/32 , C07K2317/34 , C07K2317/569
摘要： Biparatopic protein constructs that are directed against IL-23, and in particular against the p19 subunit of IL-23. The constructs comprise at least a first binding domain or binding unit directed against a first defined epitope on p19 and at least a second binding domain or binding unit directed against a second defined epitope on p19 (or the p19/p40 interface). The binding domains or binding units may in particular be a domain antibody, a single domain antibody, a dAb or a Nanobody®. The constructs and pharmaceutical compositions comprising the same can be used for the prevention and/or treatment of diseases and disorders associated with IL-23 or IL-23 mediated signaling, such as inflammation and inflammatory disorders such as colitis, Crohn's disease and IBD, infectious diseases, psoriasis, cancer, autoimmune diseases, sarcoidosis, transplant rejection, cystic Fibrosis, asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, viral infection, and common variable immunodeficiency.
摘要翻译：针对IL-23，特别是针对IL-23的p19亚基的双比较性蛋白质构建体。所述构建体包含至少第一结合结构域或针对p19上的第一定义表位的结合单位，以及针对p19（或p19 / p40界面）上的第二定义表位的至少第二结合结构域或结合单位。结合域或结合单位特别可以是结构域抗体，单结构域抗体，dAb或纳米抗体。包含其的构建体和药物组合物可用于预防和/或治疗与IL-23或IL-23介导的信号传导相关的疾病和病症，例如炎症和炎症性疾病如结肠炎，克罗恩病和IBD，感染性疾病，牛皮癣，癌症，自身免疫疾病，结节病，移植排斥，囊性纤维化，哮喘，慢性阻塞性肺病，类风湿性关节炎，病毒感染和常见的免疫缺陷。

15. 发明申请

US20110137617A1 METHOD FOR GENERATING INFORMATION RELATED TO THE MOLECULAR STRUCTURE OF A BIOMOLECULE 有权
标题翻译：用于产生与生物分子的分子结构相关的信息的方法
公开(公告)号：US20110137617A1
公开(公告)日：2011-06-09
申请号：US12959224
申请日：2010-12-02
申请人： Johan DESMET , Ignace Lasters , Dominique Vlieghe , Carlo Boutton , Philippe Stas , Jan Spriet
发明人： Johan DESMET , Ignace Lasters , Dominique Vlieghe , Carlo Boutton , Philippe Stas , Jan Spriet
IPC分类号： G06F17/50
CPC分类号： G06F19/16 , B01J2219/00689 , B01J2219/00695 , B01J2219/007 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , C07K1/00 , C07K2299/00 , C40B40/06 , C40B40/10 , C40B40/12
摘要： A method for generating information related to the molecular structure of a biomolecule, comprising the steps of: (a) receiving a three-dimensional representation of said molecular structure, comprising a first set of residue portions and a template; and (b) modifying the representation of step (a) by at least one optimization cycle. Each optimization cycle comprises the steps of: (b1) perturbing a first representation of the molecular structure by modifying the structure of one or more of the first set of residue portions; (b2) relaxing the perturbed representation by optimizing the structure of one or more of the non-perturbed residue portions of the first set with respect to the one or more perturbed residue portions; (b3) evaluating the perturbed and relaxed representation of the molecular structure by using an energetic cost function and replacing the first representation by the perturbed and relaxed representation if the latter's global energy is more optimal than that of the first representation; and the method further comprises the steps of (c) terminating the optimization process according to step (b) when a predetermined termination criterion is reached; and (d) outputting to a storage medium or to a consecutive method a data structure comprising information extracted from step (b).
摘要翻译：一种用于产生与生物分子的分子结构相关的信息的方法，包括以下步骤：（a）接收所述分子结构的三维表示，包括第一组残基部分和模板; 和（b）通过至少一个优化周期来修改步骤（a）的表示。每个优化周期包括以下步骤：（b1）通过修改第一组残留部分中的一个或多个的结构扰乱分子结构的第一表示; （b2）通过相对于一个或多个扰动残余部分优化第一组的非扰动残余部分的一个或多个的结构来放松扰动表示; （b3）通过使用能量成本函数来评估分子结构的扰动和松弛表示，并且如果后者的全局能量比第一表示更为优化，则通过扰动和轻松表示来代替第一表示; 并且所述方法还包括以下步骤：（c）当达到预定的终止标准时，终止根据步骤（b）的优化过程; 以及（d）向存储介质或连续方法输出包括从步骤（b）提取的信息的数据结构。

16. 发明申请

US20110091462A1 NOVEL ANTIGEN BINDING DIMER-COMPLEXES, METHODS OF MAKING AND USES THEREOF 审中-公开
标题翻译：新型抗原结合二聚体复合物，其制备方法及其用途
公开(公告)号：US20110091462A1
公开(公告)日：2011-04-21
申请号：US12920862
申请日：2009-03-05
申请人： Peter Casteels , Marc Jozef Lauwereys , Patrick Stanssens , Christine Labeur , Carlo Boutton , Ann Brigé , Hendricus Renerus Jacobus M Hoogenboom , Els Anna Alice Beirnaert
发明人： Peter Casteels , Marc Jozef Lauwereys , Patrick Stanssens , Christine Labeur , Carlo Boutton , Ann Brigé , Hendricus Renerus Jacobus M Hoogenboom , Els Anna Alice Beirnaert
IPC分类号： C07K16/00 , A61K39/395
CPC分类号： C07K16/00 , C07K16/18 , C07K16/22 , C07K16/2866 , C07K16/36 , C07K2317/22 , C07K2317/569 , C07K2317/626
摘要： In a broad aspect the present invention generally relates to novel dimer-complexes (herein called “non-fused-dimers” or NFDs) comprising single variable domains, methods of making these complexes and uses thereof. These non-covalently bound dimer-complexes consist of two identical monomers that each comprises of one or more single variable domains (homodimers) or of two different monomers that each comprises on or more single variable domains (heterodimers). The subject NFDs have typically altered e.g. improved binding characteristics over their monomeric counterpart. The NFDs of the invention may further be engineered through linkage by a flexible peptide or cysteines in order to improve the stability. This invention also describes conditions under which such NFDs are formed and conditions under which the formation of such dimers can be avoided.
摘要翻译：在广泛的方面，本发明通常涉及包含单可变结构域的新型二聚体复合物（本文称为“非融合二聚体”或NFD），制备这些复合物的方法及其用途。这些非共价结合的二聚体复合物由两个相同的单体组成，每个单体包含一个或多个单个可变结构域（同源二聚体）或两个不同的单体，其各自包含或多个单个可变结构域（异源二聚体）。受试者NFD通常改变例如改善了其单体对应物的结合特性。本发明的NFD可进一步通过柔性肽或半胱氨酸的连接进行工程改造，以提高稳定性。本发明还描述了形成这种NFD的条件和可以避免形成这种二聚体的条件。

17. 发明授权

US08571806B2 Method for generating information related to the molecular structure of a biomolecule 有权
标题翻译：生成与生物分子的分子结构有关的信息的方法
公开(公告)号：US08571806B2
公开(公告)日：2013-10-29
申请号：US12959224
申请日：2010-12-02
申请人： Johan Desmet , Ignace Lasters , Dominique Vlieghe , Carlo Boutton , Philippe Stas , Jan Spriet
发明人： Johan Desmet , Ignace Lasters , Dominique Vlieghe , Carlo Boutton , Philippe Stas , Jan Spriet
IPC分类号： G01N33/48 , G06G7/48
CPC分类号： G06F19/16 , B01J2219/00689 , B01J2219/00695 , B01J2219/007 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , C07K1/00 , C07K2299/00 , C40B40/06 , C40B40/10 , C40B40/12
摘要： The present invention provides methods for generating information related to the molecular structure of a biomolecule.
摘要翻译：本发明提供了生成与生物分子的分子结构有关的信息的方法。

18. 发明授权

US08229721B1 Apparatus and method for structure-based prediction of amino acid sequences 有权
标题翻译：氨基酸序列结构预测的装置和方法
公开(公告)号：US08229721B1
公开(公告)日：2012-07-24
申请号：US10129513
申请日：2000-11-03
申请人： Johan Desmet , Ignace Lasters , Dominique Vlieghe , Carlo Boutton , Philippe Stas
发明人： Johan Desmet , Ignace Lasters , Dominique Vlieghe , Carlo Boutton , Philippe Stas
IPC分类号： G06G7/48 , G01N33/48 , G06F19/00
CPC分类号： G06F19/16
摘要： The invention provides methods and apparatus for analyzing a protein structure by A) receiving a reference structure (A) forming a three dimensional representation of a protein; B) substituting into the structure of (A) a pattern with amino-acids different from the one of the protein; C) optimizing the conformation of (A) substituted by pattern of (B); D) assessing the energetic compatibility (EC) of the pattern of (B) within the context of the structure of (A) being structurally optimized in (C) with respect to the pattern, by comparing the global energy of the substituted and optimized protein structure with the global energy of the non-substituted reference structure; and E) storing a value reflecting the EC of the pattern together with information related to the structure of the pattern in the form of an energetic compatibility object (ECO).
摘要翻译：本发明提供了通过A）接收形成蛋白质的三维表示的参考结构（A）来分析蛋白质结构的方法和装置; B）用不同于蛋白质的氨基酸取代（A）结构的结构; C）优化（A）由（B）的图案取代的构象; D）通过比较取代和优化的蛋白质的全球能量，评估在（A）的结构的上下文中（B）的模式的能量相容性（EC）在（C）中相对于模式在结构上优化具有非取代参考结构的全球能量结构; 以及E）将反映所述图案的EC的值与能量兼容对象（ECO）形式的与所述图案的结构有关的信息一起存储。

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