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11. 发明申请

US20120010541A1 Pulsed Cavitational Ultrasound Therapy 有权
标题翻译：脉冲式航空超声治疗
公开(公告)号：US20120010541A1
公开(公告)日：2012-01-12
申请号：US13241076
申请日：2011-09-22
申请人： Charles A. Cain , Zhen Xu , J. Brian Fowlkes , Timothy L. Hall , William W. Roberts
发明人： Charles A. Cain , Zhen Xu , J. Brian Fowlkes , Timothy L. Hall , William W. Roberts
IPC分类号： A61N7/00
CPC分类号： A61B17/22004 , A61B5/0536 , A61B5/055 , A61B8/00 , A61B8/08 , A61B8/4272 , A61B8/485 , A61B17/225 , A61B2017/00154 , A61B2017/00172 , A61B2017/22008 , A61B2017/22088 , A61B2017/22089 , A61B2090/378 , A61M37/0092
摘要： Therapy methods using pulsed cavitational ultrasound therapy can include the subprocesses of initiation, maintenance, therapy, and feedback of the histotripsy process, which involves the creation and maintenance of ensembles of microbubbles and the use of feedback in order to optimize the process based on observed spatial-temporal bubble cloud dynamics. The methods provide for the subdivision or erosion of tissue, liquification of tissue, and/or the enhanced delivery of therapeutic agents. Various feedback mechanisms allow variation of ultrasound parameters and provide control over the pulsed cavitational process, permitting the process to be tuned for a number of applications. Such applications can include specific tissue erosion, bulk tissue homogenization, and delivery of therapeutic agents across barriers.
摘要翻译：使用脉冲空化超声治疗的治疗方法可以包括组织过程的起始，维持，治疗和反馈的子过程，其涉及创建和维护微泡组合以及反馈的使用，以便基于观察到的空间来优化过程 - 时空泡云动力学。这些方法提供组织的细分或侵蚀，组织液化和/或治疗剂的增强递送。各种反馈机制允许超声参数的变化并且提供对脉冲空化过程的控制，允许该过程针对多个应用进行调整。这样的应用可以包括特定的组织侵蚀，本体组织均质化和跨越障碍物的治疗剂的递送。

12. 发明授权

US08057408B2 Pulsed cavitational ultrasound therapy 有权
标题翻译：脉冲空化超声治疗
公开(公告)号：US08057408B2
公开(公告)日：2011-11-15
申请号：US12121001
申请日：2008-05-15
申请人： Charles A. Cain , Zhen Xu , J. Brian Fowlkes , Timothy L. Hall , William W. Roberts
发明人： Charles A. Cain , Zhen Xu , J. Brian Fowlkes , Timothy L. Hall , William W. Roberts
IPC分类号： A61H1/00
CPC分类号： A61B17/22004 , A61B5/0536 , A61B5/055 , A61B8/00 , A61B8/08 , A61B8/4272 , A61B8/485 , A61B17/225 , A61B2017/00154 , A61B2017/00172 , A61B2017/22008 , A61B2017/22088 , A61B2017/22089 , A61B2090/378 , A61M37/0092
摘要： Therapy methods using pulsed cavitational ultrasound therapy can include the subprocesses of initiation, maintenance, therapy, and feedback of the histotripsy process, which involves the creation and maintenance of ensembles of microbubbles and the use of feedback in order to optimize the process based on observed spatial-temporal bubble cloud dynamics. The methods provide for the subdivision or erosion of tissue, liquification of tissue, and/or the enhanced delivery of therapeutic agents. Various feedback mechanisms allow variation of ultrasound parameters and provide control over the pulsed cavitational process, permitting the process to be tuned for a number of applications. Such applications can include specific tissue erosion, bulk tissue homogenization, and delivery of therapeutic agents across barriers.
摘要翻译：使用脉冲空化超声治疗的治疗方法可以包括组织过程的起始，维持，治疗和反馈的子过程，其涉及创建和维护微泡组合以及反馈的使用，以便基于观察到的空间来优化过程 - 时空泡云动力学。这些方法提供组织的细分或侵蚀，组织液化和/或治疗剂的增强递送。各种反馈机制允许超声参数的变化并且提供对脉冲空化过程的控制，允许该过程针对多个应用进行调整。这样的应用可以包括特定的组织侵蚀，本体组织均质化和跨越障碍物的治疗剂的递送。

13. 发明申请

US20080319356A1 PULSED CAVITATIONAL ULTRASOUND THERAPY 有权
标题翻译：脉冲超声治疗
公开(公告)号：US20080319356A1
公开(公告)日：2008-12-25
申请号：US12121001
申请日：2008-05-15
申请人： CHARLES A. CAIN , Zhen Xu , J. Brian Fowlkes , Timothy L. Hall , William W. Roberts
发明人： CHARLES A. CAIN , Zhen Xu , J. Brian Fowlkes , Timothy L. Hall , William W. Roberts
IPC分类号： A61G1/00 , A61B19/00 , A61B5/00
CPC分类号： A61B17/22004 , A61B5/0536 , A61B5/055 , A61B8/00 , A61B8/08 , A61B8/4272 , A61B8/485 , A61B17/225 , A61B2017/00154 , A61B2017/00172 , A61B2017/22008 , A61B2017/22088 , A61B2017/22089 , A61B2090/378 , A61M37/0092
摘要： Therapy methods using pulsed cavitational ultrasound therapy can include the subprocesses of initiation, maintenance, therapy, and feedback of the histotripsy process, which involves the creation and maintenance of ensembles of microbubbles and the use of feedback in order to optimize the process based on observed spatial-temporal bubble cloud dynamics. The methods provide for the subdivision or erosion of tissue, liquification of tissue, and/or the enhanced delivery of therapeutic agents. Various feedback mechanisms allow variation of ultrasound parameters and provide control over the pulsed cavitational process, permitting the process to be tuned for a number of applications. Such applications can include specific tissue erosion, bulk tissue homogenization, and delivery of therapeutic agents across barriers.
摘要翻译：使用脉冲空化超声治疗的治疗方法可以包括组织过程的起始，维持，治疗和反馈的子过程，其涉及创建和维护微泡组合以及反馈的使用，以便基于观察到的空间来优化过程 - 时空泡云动力学。这些方法提供组织的细分或侵蚀，组织液化和/或治疗剂的增强递送。各种反馈机制允许超声参数的变化并且提供对脉冲空化过程的控制，允许该过程针对多个应用进行调整。这样的应用可以包括特定的组织侵蚀，本体组织均质化和跨越障碍物的治疗剂的递送。

14. 发明授权

US06413216B1 Method and assembly for performing ultrasound surgery using cavitation 有权
标题翻译：使用气穴进行超声手术的方法和装配
公开(公告)号：US06413216B1
公开(公告)日：2002-07-02
申请号：US09470644
申请日：1999-12-22
申请人： Charles A. Cain , J. Brian Fowlkes
发明人： Charles A. Cain , J. Brian Fowlkes
IPC分类号： A61B800
CPC分类号： A61B17/22004 , A61B2017/22008 , A61B2017/22089 , A61M37/0092
摘要： A method and assembly are provided which use cavitation induced by an ultrasound beam for creating a controlled surgical lesion in a selected treatment volume of a patient, such as an internal body cavity or organ. First, a plurality of microbubbles are provided in the treatment volume. Preferably, the threshold for cavitation of microbubbles in the treatment volume is lowered compared with the threshold for cavitation in surrounding tissues. The expected location of the surgical lesion within the treatment volume may be previewed, and then the microbubbles in the treatment volume are cavitated with the ultrasound beam to create the controlled surgical lesion. In addition, substances can be associated with the microbubbles such that cavitation of the microbubbles delivers the substances to the treatment volume. Preferably, the creation of the surgical lesion at the expected lesion location is then verified. Using the method and assembly of the present invention, the cavitation threshold within the treatment volume is made predictable, and a low frequency ultrasound beam may be used to cavitate the microbubbles within the treatment volume without causing damage to surrounding tissues.
摘要翻译：提供了一种方法和组件，其使用由超声波束引起的空化，以在患者（例如内部体腔或器官）的选定治疗体积中产生受控手术病变。首先，在处理容积中设置多个微泡。优选地，与周围组织中的空化阈值相比，治疗体积中的微泡气蚀阈值降低。手术病变在治疗体积内的预期位置可以预览，然后治疗体积中的微泡被超声波束气蚀，以产生受控的手术病变。此外，物质可以与微泡相关联，使得微泡的空化将物质输送到治疗体积。优选地，验证在预期的病变位置处的手术损伤的产生。使用本发明的方法和装配，可以预测处理体积内的气蚀阈值，并且可以使用低频超声波束来对治疗体积内的微泡进行空化，而不会对周围组织造成损伤。

15. 发明申请

US20110054363A1 DEVICES AND METHODS FOR USING CONTROLLED BUBBLE CLOUD CAVITATION IN FRACTIONATING URINARY STONES 有权
标题翻译：在爆炸性裂缝中使用受控气泡的装置和方法
公开(公告)号：US20110054363A1
公开(公告)日：2011-03-03
申请号：US12868775
申请日：2010-08-26
申请人： Charles A. Cain , Timothy L. Hall , William W. Roberts , Zhen Xu , J. Brian Fowlkes , Thomas W. Davison
发明人： Charles A. Cain , Timothy L. Hall , William W. Roberts , Zhen Xu , J. Brian Fowlkes , Thomas W. Davison
IPC分类号： A61B17/225
CPC分类号： A61N7/00 , A61B8/00 , A61B17/225 , A61B17/2256 , A61B2017/00172 , A61B2017/22008 , A61B2090/378
摘要： A medical imaging and therapy device is provided that may include any of a number of features. One feature of the device is that it can deliver Lithotripsy therapy to a patient, so as to fractionate urinary stones. Another feature of the device is that it can deliver Histotripsy therapy to a patient, so as to erode urinary stones. In some embodiments, the medical imaging and therapy device is configured to target and track urinary stones in the patient during therapy. Methods associated with use of the medical imaging and therapy device are also covered.
摘要翻译：提供了可以包括许多特征中的任何一个的医学成像和治疗装置。该装置的一个特征是它可以向病人提供Lithotripsy治疗，以便分泌尿石。该装置的另一个特征是可以将Histotripsy治疗方法提供给患者，以便侵蚀尿石。在一些实施例中，医学成像和治疗装置被配置为在治疗期间靶向和跟踪患者的尿石。还涉及与使用医学成像和治疗装置相关的方法。

16. 发明申请

US20080287799A1 Method and apparatus for measuring volumetric flow 审中-公开
标题翻译：测量体积流量的方法和装置
公开(公告)号：US20080287799A1
公开(公告)日：2008-11-20
申请号：US11803966
申请日：2007-05-16
申请人： Anne Lindsay Hall , Jonathan Matthews Rubin , J. Brian Fowlkes , Oliver Daniel Kripfgans , Paul L. Carson
发明人： Anne Lindsay Hall , Jonathan Matthews Rubin , J. Brian Fowlkes , Oliver Daniel Kripfgans , Paul L. Carson
IPC分类号： A61B8/06
CPC分类号： A61B8/469 , A61B8/06 , A61B8/13
摘要： An ultrasound system comprises an ultrasound probe, a user interface and a processor. The ultrasound probe comprises a transducer face emitting ultrasound beams into a patient. The probe acquires a volume of ultrasound data comprising a blood vessel. The user interface defines a surface on an image that is based on the volume. The surface bisects the blood vessel and further comprises a plurality of points where at least some of the points are located at unequal distances with respect to the transducer face. The processor is configured to steer a subset of the ultrasound beams to intersect the surface at a 90 degree angle and calculate volumetric flow information through the blood vessel based on the ultrasound data corresponding to the surface.
摘要翻译：超声系统包括超声探头，用户接口和处理器。超声波探头包括将超声波束发射到患者体内的换能器面。探头获取包括血管的一定体积的超声数据。用户界面定义基于卷的图像上的曲面。所述表面将血管平分，并且还包括多个点，其中至少一些点相对于换能器表面位于不相等的距离处。处理器被配置为引导超声波束的子集以90度角相交，并且基于对应于表面的超声数据计算通过血管的体积流量信息。

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