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11. 发明申请

US20060257452A1 Ocular therapy using alpha-2 adrenergic receptor anterior compounds having enhanced clearance rates 有权
标题翻译：使用具有增强的清除率的α-2肾上腺素能受体前体化合物进行眼部治疗
公开(公告)号：US20060257452A1
公开(公告)日：2006-11-16
申请号：US11416929
申请日：2006-05-02
申请人： Patrick Hughes , James Burke , Joan-En Chang-Lin
发明人： Patrick Hughes , James Burke , Joan-En Chang-Lin
IPC分类号： A61F2/02
CPC分类号： A61K9/0051 , A61K9/0048 , A61K9/1647
摘要： Ophthalmically therapeutic materials, such as liquid-containing compositions and polymeric drug delivery systems, include a therapeutic component which includes an alpha 2 adrenergic receptor agonist that is cleared from the anterior segment of an individual's eye to which the material is administered. The alpha 2 adrenergic receptor agonist may have a vitreal half-life greater than about three hours. The present materials are effective in treating an ocular condition(s) that affect the anterior segment of an eye, or the anterior and posterior segment of the eye. The materials are suitable for intravitreal or periocular administration and can provide prolonged drug delivery and therapeutic benefits to patients to which the materials have been administered. The alpha 2 adrenergic receptor agonists can be provided in liquid-containing formulations and/or bioerodible and/or non-bioerodible polymeric implants and microparticles. Methods of making and using the present materials are also described.
摘要翻译：眼科治疗材料，例如含液组合物和聚合物药物递送系统，包括治疗成分，其包括α2肾上腺素能受体激动剂，其从施用该物质的个体眼睛的前段清除。 α2肾上腺素能受体激动剂可具有大于约3小时的玻璃体半衰期。本发明的材料可有效治疗影响眼前段或眼部前段和后段的眼睛状况。这些材料适用于玻璃体内或眼周内给药，并且可以为已经施用材料的患者提供延长的药物递送和治疗益处。 α2肾上腺素能受体激动剂可以在含液制剂和/或生物可侵蚀和/或非生物可侵蚀的聚合物植入物和微粒中提供。还描述了制备和使用本发明材料的方法。

12. 发明申请

US20050244463A1 Sustained release intraocular implants and methods for treating ocular vasculopathies 审中-公开
标题翻译：持续释放眼内植入物和治疗眼血管病变的方法
公开(公告)号：US20050244463A1
公开(公告)日：2005-11-03
申请号：US10836911
申请日：2004-04-30
申请人： Glenn Huang , Brittany Jackson , James Burke , Ton Lin , Patrick Hughes , Larry Wheeler , Rosy Donn
发明人： Glenn Huang , Brittany Jackson , James Burke , Ton Lin , Patrick Hughes , Larry Wheeler , Rosy Donn
IPC分类号： A61K9/00 , A61K31/498
CPC分类号： A61L31/148 , A61K9/0051 , A61K9/204 , A61K31/498 , A61K47/34 , A61L27/58 , A61L31/06 , A61L31/16 , A61L2300/436 , A61L2300/604 , C08L67/04 , Y02A50/401
摘要： Biocompatible intraocular implants include an alpha-2 adrenergic receptor agonist and a polymer associated with the alpha-2 adrenergic receptor agonist to facilitate release of the alpha-2 adrenergic receptor agonist into an eye for an extended period of time. The alpha-2 adrenergic receptor agonist may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. The implants may be placed in an eye to treat one or more ocular conditions, such as an ocular vasculopathy or glaucoma, among others.
摘要翻译：生物相容性眼内植入物包括α-2肾上腺素能受体激动剂和与α-2肾上腺素能受体激动剂相关的聚合物，以促进α-2肾上腺素能受体激动剂延长一段时间的眼睛释放。 α-2肾上腺素能受体激动剂可以与可生物降解的聚合物基质例如两种可生物降解的聚合物的基质相关联。植入物可以放置在眼睛中以治疗一种或多种眼部病症，例如眼睛血管病变或青光眼等。

13. 发明申请

US20050224035A1 Vehicle with switched supplemental energy storage system for engine cranking 有权
标题翻译：具有用于发动机起动的开关式补充能量存储系统的车辆
公开(公告)号：US20050224035A1
公开(公告)日：2005-10-13
申请号：US11029659
申请日：2005-01-05
申请人： James Burke , Dean Solberg
发明人： James Burke , Dean Solberg
IPC分类号： F02N11/08
CPC分类号： F02N11/0866
摘要： An engine cranking system includes an engine, a cranking motor coupled to the engine, a battery coupled to the cranking motor and to a system ground and a capacitor. First and second electrical paths interconnect the capacitor with the cranking motor and the system ground. The system further includes first and second switches and a first relay included in one of the first or second electrical paths. The first relay is moveable between at least a closed-circuit position, wherein the first relay completes one of the first and second electrical paths, and an open-circuit position, wherein the first relay interrupts one of the first and second electrical paths. The first switch is coupled between the first relay and the capacitor. A second relay is coupled to the second switch and is moveable between at least a closed-circuit position, wherein the second relay completes a third electrical path activating the cranking motor, and an open-circuit position, wherein the second relay interrupts the third electrical path preventing cranking of the cranking motor.
摘要翻译：发动机起动系统包括发动机，联接到发动机的起动马达，耦合到起动马达的电池以及系统地和电容器。第一和第二电路将电容器与起动马达和系统接地互连。该系统还包括第一和第二开关以及包括在第一或第二电路之一中的第一继电器。第一继电器可在至少一个闭路位置之间移动，其中第一继电器完成第一和第二电路之一以及开路位置，其中第一继电器中断第一和第二电路之一。第一开关耦合在第一继电器和电容器之间。第二继电器耦合到第二开关，并且可在至少闭路位置之间移动，其中第二继电器完成启动起动马达的第三电路和开路位置，其中第二继电器中断第三电防止启动电机起动的路径。

14. 外观设计

USD464355S1 Transaction card 失效
标题翻译：交易卡
公开(公告)号：USD464355S1
公开(公告)日：2002-10-15
申请号：US29128135
申请日：2000-08-18
申请人： James Burke
设计人： James Burke

15. 发明授权

US5862391A Power management control system 失效
标题翻译：电源管理控制系统
公开(公告)号：US5862391A
公开(公告)日：1999-01-19
申请号：US626102
申请日：1996-04-03
申请人： Patrick G. Salas , Donald R. Brown , Jose Bscheider , Thomas A. Murphy , Grady W. Broadnax, Jr. , Edgar Yee , Mary A. Doddy , Veronica Kertesz , Indrajit Purkayastha , Sara Uecker , James Burke , Dana Foster , John S. Vandevanter , Wolfgang Meyer-Haack
发明人： Patrick G. Salas , Donald R. Brown , Jose Bscheider , Thomas A. Murphy , Grady W. Broadnax, Jr. , Edgar Yee , Mary A. Doddy , Veronica Kertesz , Indrajit Purkayastha , Sara Uecker , James Burke , Dana Foster , John S. Vandevanter , Wolfgang Meyer-Haack
IPC分类号： G06F17/60
CPC分类号： G01D4/002 , Y02B90/241 , Y04S20/32
摘要： The power management control system comprises a computer having standard RS485 interface cards and adapters installed in its I/O slots defining multiple industry standard Modbus RTU networks. The computer contains software for monitoring and controlling selected aspects of power usage/consumption, as described in more detail hereinafter. The Modbus RTU protocol is a well known industry standard. Devices with a Modbus RTU interface can be connected directly to the Modbus and other devices which communicate on the Commnet protocol require a Modbus concentrator. The Modbus concentrator provides an interface between the Modbus RTU protocol and the Commnet protocol, whereby these other devices can communicate through the Modbus concentrator over the Modbus. Alternatively, standard Ethernet interface cards and adapters are installed in the computer's I/O slots defining multiple standard Ethernet TCP/IP networks. The Ethernet TCP/IP protocol is a well known standard, which would allow a user of the power management control system of the present invention to use its existing LAN. Ethernet gateways are connected to the Ethernet TCP/IP networks to provide an interface between the Ethernet TCP/IP protocol and the Modbus RTU protocol.
摘要翻译：电源管理控制系统包括具有标准RS485接口卡和安装在其定义多个工业标准Modbus RTU网络的I / O插槽中的适配器的计算机。计算机包含用于监视和控制功率使用/消耗的所选方面的软件，如下文更详细描述的。 Modbus RTU协议是众所周知的行业标准。具有Modbus RTU接口的设备可以直接连接到Modbus和其他通过Commnet协议进行通信的设备需要Modbus集线器的设备。 Modbus集中器提供Modbus RTU协议和Commnet协议之间的接口，这些其他设备可以通过Modbus通过Modbus集中器进行通信。或者，标准以太网接口卡和适配器安装在计算机的定义多个标准以太网TCP / IP网络的I / O插槽中。以太网TCP / IP协议是众所周知的标准，其允许本发明的电力管理控制系统的用户使用其现有的LAN。以太网网关连接到以太网TCP / IP网络，以提供以太网TCP / IP协议和Modbus RTU协议之间的接口。

16. 发明申请

US20130213336A1 SUPPLEMENTARY ENERGY STARTING SYSTEM INCORPORATING A TIMING CIRCUIT 有权
标题翻译：补充能源启动系统并入时序电路
公开(公告)号：US20130213336A1
公开(公告)日：2013-08-22
申请号：US13400254
申请日：2012-02-20
申请人： Dean Solberg , James Burke
发明人： Dean Solberg , James Burke
IPC分类号： F02N11/08
CPC分类号： F02N11/0866
摘要： An engine cranking system and a method of cranking an engine are provided. The engine cranking system comprises an engine, cranking motor, and capacitor. The engine cranking system further comprises an electrical path interconnecting the cranking motor or a battery to the capacitor. The engine cranking system further comprises a control circuit coupled to the capacitor. The control circuit comprises a timer operative to track temporal information. The control circuit is operative to apply a control voltage that varies in response to the tracked temporal information. The control circuit further comprises a relay included in the electrical path. The relay is operative to switch, in response to the control voltage, between an open-circuit condition, in which the relay interrupts the electrical path, and a closed-circuit condition.
摘要翻译：提供一种发动机起动系统和起动发动机的方法。发动机起动系统包括发动机，起动马达和电容器。发动机起动系统还包括将起动马达或电池互连到电容器的电气路径。发动机起动系统还包括耦合到电容器的控制电路。控制电路包括用于跟踪时间信息的定时器。控制电路可操作以施加响应于跟踪的时间信息而变化的控制电压。控制电路还包括包含在电路径中的继电器。继电器可操作以响应于控制电压在继电器中断电路径的开路状态与闭路状态之间切换。

17. 发明授权

US08293210B2 Sustained release intraocular implants and methods for preventing retinal dysfunction 有权
标题翻译：持续释放眼内植入物和预防视网膜功能障碍的方法
公开(公告)号：US08293210B2
公开(公告)日：2012-10-23
申请号：US11927615
申请日：2007-10-29
申请人： Glenn T. Huang , James Burke , Patrick M. Hughes , Kai-Ming Zhang , Ton Lin , Larry A. Wheeler , Rosy Sheng Donn
发明人： Glenn T. Huang , James Burke , Patrick M. Hughes , Kai-Ming Zhang , Ton Lin , Larry A. Wheeler , Rosy Sheng Donn
IPC分类号： A61K31/498 , A61P27/16
CPC分类号： A61K31/498 , A61K9/0051 , A61K47/34
摘要： Biocompatible intraocular implants include an alpha-2 adrenergic receptor agonist and a polymer associated with the alpha-2 adrenergic receptor agonist to facilitate release of the alpha-2 adrenergic receptor agonist into an eye for an extended period of time. The alpha-2 adrenergic receptor agonist may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. The implants may be placed in an eye to prevent the occurrence of one or more ocular conditions, or to reduce one or more symptoms of an ocular condition, such as an ocular neurosensory disorder and the like.
摘要翻译：生物相容性眼内植入物包括α-2肾上腺素能受体激动剂和与α-2肾上腺素能受体激动剂相关的聚合物，以促进α-2肾上腺素能受体激动剂延长一段时间的眼睛释放。 α-2肾上腺素能受体激动剂可以与可生物降解的聚合物基质例如两种可生物降解的聚合物的基质相关联。植入物可以放置在眼睛中以防止发生一种或多种眼部病症，或者减少眼部疾病如眼睛神经感觉障碍等的一种或多种症状。

18. 发明申请

US20110251201A1 Sustained release intraocular implants and methods for preventing retinal dysfunction 审中-公开
标题翻译：持续释放眼内植入物和预防视网膜功能障碍的方法
公开(公告)号：US20110251201A1
公开(公告)日：2011-10-13
申请号：US13154079
申请日：2011-06-06
申请人： Glenn T. Huang , James Burke , Patrick M. Hughes , Kai-Ming Zhang , Ton Lin , Larry A. Wheeler , Rosy Sheng Donn
发明人： Glenn T. Huang , James Burke , Patrick M. Hughes , Kai-Ming Zhang , Ton Lin , Larry A. Wheeler , Rosy Sheng Donn
IPC分类号： A61K31/498 , A61P27/02
CPC分类号： A61K31/498 , A61K9/0051 , A61K47/34
摘要： Biocompatible intraocular implants include an alpha-2 adrenergic receptor agonist and a polymer associated with the alpha-2 adrenergic receptor agonist to facilitate release of the alpha-2 adrenergic receptor agonist into an eye for an extended period of time. The alpha-2 adrenergic receptor agonist may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. The implants may be placed in an eye to prevent the occurrence of one or more ocular conditions, or to reduce one or more symptoms of an ocular condition, such as an ocular neurosensory disorder and the like.
摘要翻译：生物相容性眼内植入物包括α-2肾上腺素能受体激动剂和与α-2肾上腺素能受体激动剂相关的聚合物，以促进α-2肾上腺素能受体激动剂延长一段时间的眼睛释放。 α-2肾上腺素能受体激动剂可以与可生物降解的聚合物基质例如两种可生物降解的聚合物的基质相关联。植入物可以放置在眼睛中以防止发生一种或多种眼部病症，或者减少眼部疾病如眼睛神经感觉障碍等的一种或多种症状。

19. 发明授权

US07771589B2 Screen blockage measurement and flow performance optimization system 有权
标题翻译：屏障测量和流量性能优化系统
公开(公告)号：US07771589B2
公开(公告)日：2010-08-10
申请号：US12144178
申请日：2008-06-23
申请人： Scott Kelly , Kenneth Oyler , James Burke
发明人： Scott Kelly , Kenneth Oyler , James Burke
IPC分类号： B01D33/46 , B01D33/50 , E02B5/08
CPC分类号： B01D33/04 , B01D33/333 , B01D33/807 , C02F2209/001 , C02F2209/003 , C02F2209/005 , C02F2209/42 , C02F2303/24
摘要： An apparatus and method are provided that enable the control of a screening operation based on a calculated screen blockage percentage and the velocity throughput of the screen. The apparatus includes an upstream level detector, a downstream level detector and a flow determining device which determines the volumetric flow through the screen. The apparatus may further include a blockage determination unit which determines the percent screen blockage based on the flow level upstream of the screen, the flow level downstream of the screen and the volumetric flow.
摘要翻译：提供了一种装置和方法，其能够基于计算的屏幕阻塞百分比和屏幕的速度吞吐量来控制筛选操作。该装置包括上游水平检测器，下游水平检测器和确定通过筛网的体积流量的流量确定装置。该装置还可以包括阻塞确定单元，其基于屏幕上游的流量水平，屏幕下游的流量水平和体积流量来确定屏幕的堵塞百分比。

20. 发明授权

US07657002B2 Cathode head having filament protection features 失效
标题翻译：阴极头具有灯丝保护功能
公开(公告)号：US07657002B2
公开(公告)日：2010-02-02
申请号：US11343599
申请日：2006-01-31
申请人： James Burke , Charles Lynn Chidester , Bruce A Cain , Rob Treseder , James Boye , Ray Daly , Ricky Smith , Paul Gene Christean
发明人： James Burke , Charles Lynn Chidester , Bruce A Cain , Rob Treseder , James Boye , Ray Daly , Ricky Smith , Paul Gene Christean
IPC分类号： H01J35/06
CPC分类号： H01J35/06 , H01J2235/06 , H01J2235/1026 , H01J2235/1216
摘要： A cathode assembly including certain features designed to protect the integrity of a filament contained therein is disclosed. In particular, the cathode assembly is configured to prevent damage to the filament should it inadvertently contact another portion of the cathode assembly. In an example embodiment, an x-ray tube incorporating features of the present invention is disclosed. The x-ray tube includes an evacuated enclosure containing a cathode assembly and an anode. The cathode assembly includes a head portion having a head surface. A slot is defined on the head surface and an electron-emitting filament is included in the slot. A protective surface is defined on the head surface proximate to a central portion of the filament. The protective surface in one embodiment is composed of tungsten and is configure to prevent fusing of the filament to the protective surface should the filament inadvertently contact the protective surface.
摘要翻译：公开了一种阴极组件，其包括设计成保护其中所包含的细丝的完整性的某些特征。特别地，阴极组件被构造成如果它不经意地接触阴极组件的另一部分，则防止对细丝的损坏。在示例性实施例中，公开了包含本发明的特征的X射线管。 x射线管包括一个包含阴极组件和一个阳极的真空外壳。阴极组件包括具有头表面的头部部分。在头表面上限定狭缝，并且在槽中包括电子发射丝。保护表面限定在靠近灯丝中心部分的头表面上。一个实施例中的保护表面由钨组成，并且被配置为当灯丝不经意地接触保护表面时防止灯丝熔合到保护表面。

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