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11. 发明申请

US20070020708A1 PAAD domain-containing polypeptides, encoding nucleic acids, and methods of use 失效
标题翻译：含PAAD结构域的多肽，编码核酸和使用方法
公开(公告)号：US20070020708A1
公开(公告)日：2007-01-25
申请号：US11496017
申请日：2006-07-27
申请人： John Reed , Adam Godzik
发明人： John Reed , Adam Godzik
IPC分类号： G01N33/574 , C07H21/04 , C12P21/06 , C07K14/82 , C07K16/30
CPC分类号： C07H21/04 , C07K14/4747 , Y10T436/143333
摘要： The invention provides isolated nucleic acid molecules encoding PAAD-domain containing polypeptides and functional fragments thereof, including fragments containing PAAD domains, NACHT domains and ARED domains, encoded polypeptides, and antibodies. Also provided are methods of identifying polypeptides and agents that associate with a PAAD-domain containing polypeptide or fragment thereof, or that alter an association of a PAAD domain-containing polypeptides. Further provided are methods of identifying agents that modulate PAAD domain-mediated inhibition of NFκB activity, or modulate an activity of a NACHT domain of a PAAD domain-containing polypeptide. Also provided are methods of modulating NFκB transcriptional activity in a cell, and methods of altering expression of a PAAD domain-containing polypeptide in a cell.
摘要翻译：本发明提供编码含有PAAD结构域的多肽及其功能片段的分离的核酸分子，包括含有PAAD结构域，NACHT结构域和ARED结构域，编码多肽和抗体的片段。还提供了鉴定与含PAAD结构域的多肽或其片段缔合的多肽和试剂的方法，或改变含PAAD结构域的多肽的缔合。还提供了鉴定调节PAAD结构域介导的NFκB活性抑制或调节含有PAAD结构域的多肽的NACHT结构域的活性的试剂的方法。还提供了调节细胞中NFκB转录活性的方法，以及改变细胞中含有PAAD结构域的多肽的表达的方法。

12. 发明授权

US07638324B2 Bcl-G polypeptides, encoding nucleic acids and methods of use 失效
标题翻译： Bcl-G多肽，编码核酸和使用方法
公开(公告)号：US07638324B2
公开(公告)日：2009-12-29
申请号：US09738396
申请日：2000-12-14
申请人： John C. Reed , Adam Godzik , Bin Guo
发明人： John C. Reed , Adam Godzik , Bin Guo
IPC分类号： C07H21/02 , C07H21/04 , C12Q1/68 , C12N5/00 , A61K31/70
CPC分类号： C07K7/08 , C07K7/06 , C07K14/4747 , C07K2319/00
摘要： The invention provides Bcl-G polypeptides and encoding nucleic acids. Bcl-G polypeptides include Bcl-GL and Bcl-GS. The invention also provides mouse Bcl-G. The invention also provides vectors containing Bcl-G nucleic acids, host cells containing such vectors, Bcl-G anti-sense nucleic acids and related compositions. The invention additionally provides Bcl-G oligonucleotides that can be used to hybridize to or amplify a Bcl-G nucleic acid. Anti-Bcl-G specific antibodies are also provided. Further provided are kits containing Bcl-G nucleic acids or Bcl-G specific antibodies. Such kits and reagents can be used to diagnose cancer, monitor response to therapy, or predict the prognosis of a cancer patient. The invention additionally provides methods of modulating apoptosis using Bcl-G polypeptides, encoding nucleic acids, or compounds that modulate the activity or expression of Bcl-G polypeptides. The methods for modulating apoptosis can be used to treat diseases such as cancer.
摘要翻译：本发明提供了Bcl-G多肽和编码核酸。 Bcl-G多肽包括Bcl-GL和Bcl-GS。本发明还提供了小鼠Bcl-G。本发明还提供含有Bcl-G核酸的载体，含有这些载体的宿主细胞，Bcl-G反义核酸和相关组合物。本发明另外提供可用于与Bcl-G核酸杂交或扩增的Bcl-G寡核苷酸。还提供抗Bcl-G特异性抗体。还提供了含有Bcl-G核酸或Bcl-G特异性抗体的试剂盒。这样的试剂盒和试剂可用于诊断癌症，监测对治疗的反应或预测癌症患者的预后。本发明另外提供了使用调节Bcl-G多肽的活性或表达的Bcl-G多肽，编码核酸或化合物来调节凋亡的方法。调节凋亡的方法可用于治疗癌症等疾病。

13. 发明申请

US20090049046A1 Annotation and Publication Framework 失效
标题翻译：注释和出版框架
公开(公告)号：US20090049046A1
公开(公告)日：2009-02-19
申请号：US11838829
申请日：2007-08-14
申请人： Adam Godzik , Sri Krishna Subramanian , Dana Grace Weekes
发明人： Adam Godzik , Sri Krishna Subramanian , Dana Grace Weekes
IPC分类号： G06F17/30
CPC分类号： G06F17/241 , G06F17/3089
摘要： A hybrid annotation and publication system is disclosed that can access content in a scalable manner from databases, allow for its editing and publication via wiki-style programs, while at the same time allowing for peer-review of such content via peer-review programs. This system balances the wiki-style programs, the peer-review programs, and any database store accesses in a manner appropriate to the need at hand according to various heuristics. For instance, the system can be accessed via a web browser, and data provided from various databases can be edited. Such data can be stored in the system in a hierarchical manner. Once the content is annotated, it can be reviewed (at various levels, ranging from expert to novice). Upon review, such content can be published using the wiki programs, so that the content is ready for public and/or private consumption.
摘要翻译：公开了一种混合注释和发布系统，可以从数据库以可扩展的方式访问内容，允许通过wiki样式程序进行编辑和发布，同时允许通过同行评审程序对这些内容进行同行评审。该系统根据各种启发式，以适合于需要的方式平衡维基样式程序，对等审查程序和任何数据库存储访问。例如，可以通过Web浏览器访问系统，并且可以编辑从各种数据库提供的数据。这样的数据可以以分层方式存储在系统中。一旦内容被注释，可以对其进行评估（在各个级别，从专家到新手）。审查后，可以使用wiki程序发布此类内容，以便内容准备用于公共和/或私人消费。

14. 发明申请

US20080233638A1 PAAD domain-containing polypeptides, encoding nucleic acids, and methods of use 审中-公开
标题翻译：含PAAD结构域的多肽，编码核酸和使用方法
公开(公告)号：US20080233638A1
公开(公告)日：2008-09-25
申请号：US11977647
申请日：2007-10-24
申请人： John C. Reed , Adam Godzik
发明人： John C. Reed , Adam Godzik
IPC分类号： C12N5/06 , C07H21/04 , C12N15/00 , C12N5/00 , C07K14/435 , C07K16/18
CPC分类号： C07H21/04 , C07K14/4747 , Y10T436/143333
摘要： The invention provides isolated nucleic acid molecules encoding PAAD-domain containing polypeptides and functional fragments thereof, including fragments containing PAAD domains, NACHT domains and ARED domains, encoded polypeptides, and antibodies. Also provided are methods of identifying polypeptides and agents that associate with a PAAD-domain containing polypeptide or fragment thereof, or that alter an association of a PAAD domain-containing polypeptides. Further provided are methods of identifying agents that modulate PAAD domain-mediated inhibition of NFκB activity, or modulate an activity of a NACHT domain of a PAAD domain-containing polypeptide. Also provided are methods of modulating NFκB transcriptional activity in a cell, and methods of altering expression of a PAAD domain-containing polypeptide in a cell.
摘要翻译：本发明提供编码含有PAAD结构域的多肽及其功能片段的分离的核酸分子，包括含有PAAD结构域，NACHT结构域和ARED结构域，编码多肽和抗体的片段。还提供了鉴定与含PAAD结构域的多肽或其片段缔合的多肽和试剂的方法，或改变含PAAD结构域的多肽的缔合。还提供了鉴定调节PAAD结构域介导的NFκB活性抑制或调节含有PAAD结构域的多肽的NACHT结构域的活性的试剂的方法。还提供了调节细胞中NFκB转录活性的方法，以及改变细胞中含有PAAD结构域的多肽的表达的方法。

15. 发明申请

US20050276818A1 Uncharacterized ORF3 in SARS-coronavirus is a cyclic-AMP-dependent kinase and a target for SARS therapy 失效
标题翻译： SARS冠状病毒中的未表征的ORF3是环AMP-依赖性激酶和SARS治疗的靶标
公开(公告)号：US20050276818A1
公开(公告)日：2005-12-15
申请号：US11132142
申请日：2005-05-17
申请人： Adam Godzik , Sergey Sikora
发明人： Adam Godzik , Sergey Sikora
IPC分类号： A61K39/215 , C07K14/165 , C12N1/18 , C12Q1/70 , G01N33/569
CPC分类号： C07K14/005 , C12N15/1086 , C12N2770/20022 , G01N33/56983 , G01N2333/165 , G01N2500/00
摘要： The present invention relates to novel methods for identifying antiviral agents which selectively interfere with viral proteins that cause the unique infectivity activity of the SARS-coronavirus in comparison to other non-SARS strains of coronavirus. In particular, the present invention relates to screening assays that identify agents which selectively inhibit cyclic-AMP dependent protein kinase activity of the SARS-coronavirus ORF3. The present invention also relates to screening assays that identify agents which selectively inhibit the interaction between SARS-coronavirus cyclic-AMP dependent protein kinase and a calcium dependent targeting molecule. Therefore the agents identified using the assays of the invention may have utility as antiviral agents. The present invention also relates to treatments for sever acute respiratory syndrome caused by a coronavirus, and particularly to treatments that affect the infectivity activity of the SARS-coronavirus. The present invention also relates to diagnostic assays for identifying and characterizing a strain of coronavirus as being one causing severe acute respiratory syndrome.
摘要翻译：本发明涉及用于鉴定抗病毒剂的新方法，其与冠状病毒的其它非SARS菌株相比选择性干扰导致SARS冠状病毒的独特感染性活性的病毒蛋白质。特别地，本发明涉及鉴定选择性抑制SARS冠状病毒ORF3的环AMP依赖性蛋白激酶活性的试剂的筛选试验。本发明还涉及鉴定选择性抑制SARS-冠状病毒环AMP依赖性蛋白激酶与钙依赖性靶向分子之间相互作用的试剂的筛选试验。因此，使用本发明的测定法鉴定的药剂可以用作抗病毒剂。本发明还涉及由冠状病毒引起的急性呼吸综合征治疗，特别涉及影响SARS冠状病毒感染性活性的治疗。本发明还涉及用于鉴定和表征冠状病毒株作为引起严重急性呼吸综合征的病毒的诊断测定法。

16. 发明申请

US20130224182A1 BCL-G POLYPEPTIDES, ENCODING NUCLEIC ACIDS AND METHODS OF USE 审中-公开
标题翻译： BCL-G多肽，编码核酸和使用方法
公开(公告)号：US20130224182A1
公开(公告)日：2013-08-29
申请号：US13247882
申请日：2011-09-28
申请人： John C. Reed , Adam Godzik
发明人： John C. Reed , Adam Godzik
IPC分类号： C07K7/08 , C07K7/06
CPC分类号： C07K7/08 , C07K7/06 , C07K14/4747 , C07K2319/00
摘要： The invention provides Bcl-G polypeptides and encoding nucleic acids. Bcl-G polypeptides include Bcl-GL and Bcl-GS. The invention also provides mouse Bcl-G. The invention also provides vectors containing Bcl-G nucleic acids, host cells containing such vectors, Bcl-G anti-sense nucleic acids and related compositions. The invention additionally provides Bcl-G oligonucleotides that can be used to hybridize to or amplify a Bcl-G nucleic acid. Anti-Bcl-G specific antibodies are also provided. Further provided are kits containing Bcl-G nucleic acids or Bcl-G specific antibodies. Such kits and reagents can be used to diagnose cancer, monitor response to therapy, or predict the prognosis of a cancer patient. The invention additionally provides methods of modulating apoptosis using Bcl-G polypeptides, encoding nucleic acids, or compounds that modulate the activity or expression of Bcl-G polypeptides. The methods for modulating apoptosis can be used to treat diseases such as cancer.
摘要翻译：本发明提供了Bcl-G多肽和编码核酸。 Bcl-G多肽包括Bcl-GL和Bcl-GS。本发明还提供了小鼠Bcl-G。本发明还提供含有Bcl-G核酸的载体，含有这些载体的宿主细胞，Bcl-G反义核酸和相关组合物。本发明另外提供可用于与Bcl-G核酸杂交或扩增的Bcl-G寡核苷酸。还提供抗Bcl-G特异性抗体。还提供了含有Bcl-G核酸或Bcl-G特异性抗体的试剂盒。这样的试剂盒和试剂可用于诊断癌症，监测对治疗的反应或预测癌症患者的预后。本发明另外提供了使用调节Bcl-G多肽的活性或表达的Bcl-G多肽，编码核酸或化合物来调节凋亡的方法。调节凋亡的方法可用于治疗癌症等疾病。

17. 发明申请

US20110071213A1 CARD-DOMAIN CONTAINING POLYPEPTIDES, ENCODING NUCLEIC ACIDS, AND METHODS OF USE 审中-公开
标题翻译：含有多核苷酸的多核苷酸，编码核酸的方法和使用方法
公开(公告)号：US20110071213A1
公开(公告)日：2011-03-24
申请号：US12917295
申请日：2010-11-01
申请人： Krzysztof Pawlowski , John C. Reed , Adam Godzik
发明人： Krzysztof Pawlowski , John C. Reed , Adam Godzik
IPC分类号： A61K31/7088 , C07H21/04 , C07H21/02 , C07K14/00 , C07K16/00 , C12N15/63 , C12N5/10 , C12P21/06 , C12N5/07 , G01N33/566 , C12N5/02
CPC分类号： C07K14/4702 , A01K2217/05 , A01K2227/105 , A61K38/00
摘要： The invention provides caspase recruitment domain (CARD)-containing polypeptides and functional fragments thereof, encoding nucleic acid molecules, and specific antibodies. Also provided are screening methods for identifying CARD-associated polypeptides (CAPs), and for identifying agents that alter the association of a CARD-containing polypeptide with itself or with a CAP. Further provided are methods of altering a biochemical process modulated by a CARD-containing polypeptide, and methods of diagnosing a pathology characterized by an increased or decreased level of a CARD-containing polypeptide.
摘要翻译：本发明提供了含有胱天蛋白酶募集区（CARD）的多肽及其功能片段，编码核酸分子和特异性抗体。还提供了用于鉴定CARD相关多肽（CAP）的筛选方法，以及用于鉴定改变含CARD的多肽与其自身或与CAP的缔合的试剂。还提供了改变由含CARD的多肽调节的生物化学过程的方法，以及诊断特征在于含CARD的多肽的水平升高或降低的病理学的方法。

18. 发明授权

US07671183B2 PAAD domain-containing polypeptides, encoding nucleic acids, and methods of use 失效
标题翻译：含PAAD结构域的多肽，编码核酸和使用方法
公开(公告)号：US07671183B2
公开(公告)日：2010-03-02
申请号：US11496017
申请日：2006-07-27
申请人： John C. Reed , Adam Godzik
发明人： John C. Reed , Adam Godzik
IPC分类号： C07H21/02
CPC分类号： C07H21/04 , C07K14/4747 , Y10T436/143333
摘要： The invention provides isolated nucleic acid molecules encoding PAAD-domain containing polypeptides and functional fragments thereof, including fragments containing PAAD domains, NACHT domains and ARED domains, encoded polypeptides, and antibodies. Also provided are methods of identifying polypeptides and agents that associate with a PAAD-domain containing polypeptide or fragment thereof, or that alter an association of a PAAD domain-containing polypeptides. Further provided are methods of identifying agents that modulate PAAD domain-mediated inhibition of NFKB activity, or modulate an activity of a NACHT domain of a PAAD domain-containing polypeptide. Also provided are methods of modulating NFKB transcriptional activity in a cell, and methods of altering expression of a PAAD domain-containing polypeptide in a cell.
摘要翻译：本发明提供编码含有PAAD结构域的多肽及其功能片段的分离的核酸分子，包括含有PAAD结构域，NACHT结构域和ARED结构域，编码多肽和抗体的片段。还提供了鉴定与含PAAD结构域的多肽或其片段缔合的多肽和试剂的方法，或改变含PAAD结构域的多肽的缔合。还提供了鉴定调节PAAD结构域介导的NFκB活性抑制或调节含有PAAD结构域的多肽的NACHT结构域的活性的试剂的方法。还提供了调节细胞中NFκB转录活性的方法，以及改变细胞中含有PAAD结构域的多肽表达的方法。

19. 发明授权

US08037094B2 Annotation and publication framework 失效
标题翻译：注释和出版框架
公开(公告)号：US08037094B2
公开(公告)日：2011-10-11
申请号：US11838829
申请日：2007-08-14
申请人： Adam Godzik , Sri Krishna Subramanian , Dana Grace Weekes
发明人： Adam Godzik , Sri Krishna Subramanian , Dana Grace Weekes
IPC分类号： G06F7/00 , G06F17/30
CPC分类号： G06F17/241 , G06F17/3089
摘要： A hybrid annotation and publication system can access content in a scalable manner from databases, allowing for its editing and publication via wiki-style programs, while at the same time allowing for peer-review of such content via peer-review programs. This system balances the wiki-style programs, the peer-review programs, and any database store accesses in a manner appropriate to the need at hand according to various heuristics. For instance, the system can be accessed via a web browser, and data provided from various databases can be edited. Such data can be stored in the system in a hierarchical manner. Once the content is annotated, it can be reviewed (at various levels, ranging from expert to novice). Upon review, such content can be published using the wiki programs, so that the content is ready for public and/or private consumption.
摘要翻译：混合注释和发布系统可以从数据库以可扩展的方式访问内容，允许通过wiki样式程序进行编辑和发布，同时允许通过同行评审程序对这些内容进行同行评审。该系统根据各种启发式，以适合于需要的方式平衡维基样式程序，对等审查程序和任何数据库存储访问。例如，可以通过Web浏览器访问系统，并且可以编辑从各种数据库提供的数据。这样的数据可以以分层方式存储在系统中。一旦内容被注释，可以对其进行评估（在各个级别，从专家到新手）。审查后，可以使用wiki程序发布此类内容，以便内容准备用于公共和/或私人消费。

20. 发明授权

US08034901B2 Bcl-G polypeptides, encoding nucleic acids and methods of use 失效
标题翻译： Bcl-G多肽，编码核酸和使用方法
公开(公告)号：US08034901B2
公开(公告)日：2011-10-11
申请号：US12646747
申请日：2009-12-23
申请人： John C. Reed , Adam Godzik
发明人： John C. Reed , Adam Godzik
IPC分类号： C07K5/00 , C07K14/00 , A61K38/00
CPC分类号： C07K7/08 , C07K7/06 , C07K14/4747 , C07K2319/00
摘要： The invention provides Bcl-G polypeptides and encoding nucleic acids. Bcl-G polypeptides include Bcl-GL and Bcl-GS. The invention also provides mouse Bcl-G. The invention also provides vectors containing Bcl-G nucleic acids, host cells containing such vectors, Bcl-G anti-sense nucleic acids and related compositions. The invention additionally provides Bcl-G oligonucleotides that can be used to hybridize to or amplify a Bcl-G nucleic acid. Anti-Bcl-G specific antibodies are also provided. Further provided are kits containing Bcl-G nucleic acids or Bcl-G specific antibodies. Such kits and reagents can be used to diagnose cancer, monitor response to therapy, or predict the prognosis of a cancer patient. The invention additionally provides methods of modulating apoptosis using Bcl-G polypeptides, encoding nucleic acids, or compounds that modulate the activity or expression of Bcl-G polypeptides. The methods for modulating apoptosis can be used to treat diseases such as cancer.
摘要翻译：本发明提供了Bcl-G多肽和编码核酸。 Bcl-G多肽包括Bcl-GL和Bcl-GS。本发明还提供了小鼠Bcl-G。本发明还提供含有Bcl-G核酸的载体，含有这些载体的宿主细胞，Bcl-G反义核酸和相关组合物。本发明另外提供可用于与Bcl-G核酸杂交或扩增的Bcl-G寡核苷酸。还提供抗Bcl-G特异性抗体。还提供了含有Bcl-G核酸或Bcl-G特异性抗体的试剂盒。这样的试剂盒和试剂可用于诊断癌症，监测对治疗的反应或预测癌症患者的预后。本发明另外提供了使用调节Bcl-G多肽的活性或表达的Bcl-G多肽，编码核酸或化合物来调节凋亡的方法。调节凋亡的方法可用于治疗癌症等疾病。

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