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11. 发明授权

US06955681B2 Transmyocardial revascularization system and method of use 失效
标题翻译：心肌血运重建系统及其使用方法
公开(公告)号：US06955681B2
公开(公告)日：2005-10-18
申请号：US10301007
申请日：2002-11-21
申请人： Douglas G. Evans , John E. Nash
发明人： Douglas G. Evans , John E. Nash
IPC分类号： A61B17/00 , A61F2/02 , A61F2/82 , A61B17/34
CPC分类号： A61F2/82 , A61B2017/00247 , A61B2018/00392 , A61F2/2493
摘要： A transmyocardial revascularization system including a plurality of inserts formed of a material to elicit a healing response in tissue of the myocardium and deployment instruments and associated components for deploying the inserts into the wall of the myocardium. The inserts are arranged to be disposed within respective lumens or channels in the wall of the myocardium. The inserts can take various forms, e.g., be solid members, tubular members, or porous members, and may be resorbable, partially resorbable or non-resorbable. In some embodiments the inserts are arranged to be left in place within the channels in the wall of the myocardium to result in plural lumens which enable blood to flow therethrough and into contiguous capillaries. The deployment instruments are arranged to pierce the tissue of the myocardium from either the endocardium or the epicardium to insert the inserts into the myocardium, depending on the particular deployment instrument used. The deployment instruments may make use of a stabilizing device to stabilize them during the procedure of inserting the inserts into the myocardium. A controller may also be provided as part of the system to coordinate the operation of the deployment instrument with the cardiac cycle. The formation of the lumens can be achieved either by the inserts or by some other means, such as a piercing tip or an energy applicator forming a portion of the instrument. The inserts may include one or more of pharmaceuticals, biologically active agents, radiopaque materials, etc.
摘要翻译：一种经心肌血运重建系统，其包括由材料组成的多个插入物，以在心肌的组织中引发愈合反应，以及用于将插入物部署到心肌壁上的相关组件。插入件布置成设置在心肌壁中相应的腔或通道内。插入件可以采取各种形式，例如是实心构件，管状构件或多孔构件，并且可以是可再吸收的，部分可再吸收的或不可再吸收的。在一些实施例中，插入物被布置成在心肌壁中的通道内留在适当的位置，以产生多个流明，使得血液能够流过并流入相邻的毛细血管。根据所使用的特定部署仪器，这些展开装置被设置成从心内膜或心外膜刺穿心肌的组织以将插入物插入心肌。在将插入物插入心肌的过程中，展开装置可以利用稳定装置来稳定它们。还可以提供控制器作为系统的一部分，以协调部署仪器与心动周期的操作。腔的形成可以通过插入件或通过其它手段实现，例如刺穿尖端或形成器械的一部分的能量施加器。插入物可以包括一种或多种药物，生物活性剂，不透射线材料等。

12. 发明授权

US06517518B2 Tool for facilitating the connecting of a catheter or other tubular member onto a guide-wire without access to the ends of the guide-wire 有权
公开(公告)号：US06517518B2
公开(公告)日：2003-02-11
申请号：US09861728
申请日：2001-05-21
申请人： John E. Nash , Gregory Walters , Douglas G. Evans , David Szabo , Michael Paris
发明人： John E. Nash , Gregory Walters , Douglas G. Evans , David Szabo , Michael Paris
IPC分类号： A61M5178
CPC分类号： A61M25/0169 , A61M25/00 , A61M25/0068 , A61M25/007 , A61M25/0074 , A61M25/09041 , A61M29/02 , A61M2025/0177 , A61M2025/018 , A61M2025/0186 , A61M2025/09008 , A61M2025/09125 , A61M2025/1056 , A61M2025/1095
摘要： An attachment tool to facilitate the attachment of a catheter or similar elongated instrument to a guide-wire or other elongated guide member, without requiring access to either end of said wire or member. Said tool providing repeatable and reliable alignment of components to be attached, while being operated with a single hand. The tool further facilitates the attachment of a plurality of catheters or instruments to a single wire or member.

13. 发明授权

US06350280B1 Surgical connector systems and methods of use 有权
标题翻译：手术连接器系统和使用方法
公开(公告)号：US06350280B1
公开(公告)日：2002-02-26
申请号：US09497274
申请日：2000-02-03
申请人： John E. Nash , Douglas G. Evans , David M. Hoganson
发明人： John E. Nash , Douglas G. Evans , David M. Hoganson
IPC分类号： A61F200
CPC分类号： A61B17/11 , A61B17/0057 , A61B17/06 , A61B17/12009 , A61B2017/00004 , A61B2017/00243 , A61B2017/1107 , A61B2017/1135
摘要： A system and method of use for effecting the bypass or other anastomosis of a portion of a native blood vessel, duct, lumen or other tubular organ within the body of a living being. The system includes a connector assembly and a deployment instrument for carrying the device to the desired position within the vessel, duct, lumen or tubular organ. The system includes a piercer-dilator instrument to form an opening in the wall of the vessel, duct, lumen or tubular organ into which the connector assembly is deployed by the deployment instrument. The connector assembly is at least partially formed of a resorbable material and includes movable members for securing it to the tissue of the vessel, duct, lumen or tubular organ contiguous with the opening. Other components may be included in the device for expediting the anastomosis procedure, with or without the use of sutures.
摘要翻译：一种用于实现生物体内的天然血管，导管，内腔或其他管状器官的一部分的旁路或其它吻合的系统和方法。该系统包括连接器组件和用于将装置运送到容器，管道，管腔或管状器官内所需位置的展开仪器。该系统包括穿孔器 - 扩张仪器，以在容器，管道，管腔或管状器官的壁中形成开口，连接器组件通过展开器械展开。连接器组件至少部分地由可吸收材料形成，并且包括可移动构件，用于将其固定到与开口相邻的容器，管道，管腔或管状器官的组织。在使用或不使用缝合线的情况下，可以在装置中包括用于加速吻合程序的其它部件。

14. 发明授权

US6090130A Hemostatic puncture closure system including blood vessel locator and method of use 失效
标题翻译：止血性穿刺闭合系统，包括血管定位器和使用方法
公开(公告)号：US6090130A
公开(公告)日：2000-07-18
申请号：US104321
申请日：1998-06-25
申请人： John E. Nash , Douglas G. Evans , Kenneth Kensey
发明人： John E. Nash , Douglas G. Evans , Kenneth Kensey
IPC分类号： A61B17/00 , A61B17/04 , A61B17/12 , A61B19/00 , F16G11/04 , F16G11/10 , A61B17/08
CPC分类号： A61B17/0057 , F16G11/108 , A61B2017/00004 , A61B2017/00637 , A61B2017/00654 , A61B2017/00659 , A61B2017/00672 , A61B2017/0496 , A61B2090/032 , A61B2090/0811 , A61B90/03 , A61B90/39 , Y10S604/90
摘要： A system for sealing a percutaneous puncture in a blood vessel in a living being and method of use thereof. The system includes a hemostatic closure, a blood vessel locator device for determining the position of the blood vessel via the percutaneous puncture, and a deployment instrument for deploying the closure within the puncture to seal the puncture. The vessel locator includes means for enabling blood from the vessel to flow therethrough so that the position of the vessel can be rapidly determined. Once the vessel has been located the deployment instrument, which includes a tubular carrier storing the closure, is extended into the puncture to deploy the closure. The closure basically comprises a radiopaque rigid anchor for location within the blood vessel, a compressed collagen plug for location within the puncture tract leading to the vessel, and a thin filament connecting the two in a pulley-like arrangement. The deployment instrument also includes a tamper which is used to mechanically deform the plug within the tract. Once the closure is positioned hemostasis occurs rapidly, thereby locking the closure in place.
摘要翻译：一种用于密封生物体内的血管中的经皮穿刺的系统及其使用方法。该系统包括止血闭合件，用于通过经皮穿刺确定血管位置的血管定位器装置，以及用于在穿刺部内展开封闭物以密封穿刺的展开装置。容器定位器包括用于使来自血管的血液流过其中的装置，使得能够快速确定容器的位置。一旦容器已经定位，包括容纳封闭件的管状载体的展开器械延伸到穿刺部分中以展开闭合件。闭合件基本上包括用于定位在血管内的不透射线的刚性锚固件，用于定位在穿过血管的穿刺道内的压缩胶原塞，以及以滑轮状布置连接两者的细丝。部署仪器还包括用于将管塞内的插头机械地变形的篡改。一旦闭合物被定位，止血就快速发生，从而将闭合件锁定就位。

15. 发明授权

US6017352A Systems for intravascular procedures and methods of use 失效
标题翻译：血管内手术系统和使用方法
公开(公告)号：US6017352A
公开(公告)日：2000-01-25
申请号：US008266
申请日：1998-01-16
申请人： John E. Nash , Douglas G. Evans
发明人： John E. Nash , Douglas G. Evans
IPC分类号： A61B17/00 , A61B17/06 , A61B17/08 , A61B17/11 , A61B17/12
CPC分类号： A61B17/0057 , A61B17/11 , A61B17/06 , A61B17/12009 , A61B2017/00004 , A61B2017/00243 , A61B2017/1107 , A61B2017/1135
摘要： A system and method of use for effecting the bypass or other anastomosis of a portion of a native blood vessel, duct, lumen or other tubular organ within the body of a living being. The system includes a connector assembly and a deployment instrument for carrying the device to the desired position within the vessel, duct, lumen or tubular organ. The system includes a piercerdilator instrument to form an opening in the wall of the vessel, duct, lumen or tubular organ into which the connector assembly is deployed by the deployment instrument. The connector assembly is at least partially formed of a resorbable material and includes movable members for securing it to the tissue of the vessel, duct, lumen or tubular organ contiguous with the opening. Other components may be included in the device for expediting the anastomosis procedure, with or without the use of sutures. Moreover, the system can be used to bypass of at least two coronary arteries by a common connection with the aorta utilizing at least two bypass grafts and plural connectors for securement to the aorta and the coronary arteries.
摘要翻译：一种用于实现生物体内的天然血管，导管，内腔或其他管状器官的一部分的旁路或其它吻合的系统和方法。该系统包括连接器组件和用于将装置运送到容器，管道，管腔或管状器官内所需位置的展开仪器。该系统包括穿孔器器械，以在容器，管道，管腔或管状器官的壁中形成开口，连接器组件通过展开器械展开。连接器组件至少部分地由可吸收材料形成，并且包括可移动构件，用于将其固定到与开口相邻的容器，管道，管腔或管状器官的组织。在使用或不使用缝合线的情况下，可以在装置中包括用于加速吻合程序的其它部件。此外，该系统可以用于通过与主动脉的共同连接来绕过至少两个冠状动脉，利用至少两个旁路移植物和用于固定到主动脉和冠状动脉的多个连接器。

16. 发明授权

US08911406B2 Guide wire exchange catheter system 有权
标题翻译：导丝交换导管系统
公开(公告)号：US08911406B2
公开(公告)日：2014-12-16
申请号：US11457147
申请日：2006-07-12
申请人： Douglas G. Evans , John E. Nash , Steven J. Link
发明人： Douglas G. Evans , John E. Nash , Steven J. Link
IPC分类号： A61M5/178 , A61M25/09 , A61M25/01
CPC分类号： A61M25/09041 , A61M25/0172 , A61M2025/018 , A61M2025/0183
摘要： A guide wire exchange system including an elongate, flexible, guide wire exchange catheter capable exchanging one guide wire for another in a safe, efficient, and secured manner, where a primary guide wire, after having been advanced through the body, is to be replaced with a secondary guide wire that is to be securely advanced through the body to the target site by the advancement of the exchange catheter over the path of the primary wire. The exchange catheter may include a securement element in order to releasably secure at least one guide wire to the exchange catheter at or near the distal end of the exchange catheter. Once secured, both the exchange catheter and the secured guide wire(s) may be advanced or retracted in a synchronous manner, without the possibility of divergence at the distal ends of the secured components as they are being manipulated by an operator.
摘要翻译：引导线交换系统，其包括细长的，柔性的导丝线交换导管，其能够以安全，有效和固定的方式交换一根导丝，其中主导丝在被推进穿过身体之后被更换其中次级导丝将通过在主线路的路径上的交换导管的前进而牢固地推进到身体到达目标位置。交换导管可以包括固定元件，以便在交换导管的远端处或附近将至少一根导丝可释放地固定到交换导管。一旦固定，交换导管和固定的导丝线可以以同步方式前进或缩回，而不会在被操作者操纵的情况下在固定部件的远端发散。

17. 发明申请

US20100094196A1 Systems and methods for delivering agents into targeted tissue of a living being 审中-公开
标题翻译：将药剂递送到生活目标组织中的系统和方法
公开(公告)号：US20100094196A1
公开(公告)日：2010-04-15
申请号：US12567592
申请日：2009-09-25
申请人： John E. Nash , Douglas G. Evans , David M. Hoganson
发明人： John E. Nash , Douglas G. Evans , David M. Hoganson
IPC分类号： A61M25/00 , A61M5/307 , A61F2/84 , A61B17/32 , A61N1/00
CPC分类号： A61B17/32037 , A61B17/320758 , A61B17/3478 , A61B18/14 , A61B18/1492 , A61B2017/00247 , A61B2017/003 , A61B2017/22038 , A61B2018/00208 , A61B2018/00291 , A61B2018/00392 , A61B2018/00839 , A61B2018/1861 , A61B2018/2005
摘要： The systems basically comprise a delivery system for accessing the targeted tissue within the living being and introduction of at least one agent at select locations in the into the myocardium and other select tissues. The delivery systems are arranged to access the tissues of the heart. One or more of the systems can be utilized during transluminal, transthoracic and direct surgical access procedures. Where appropriate, for example in the case of intraventricular access, portions of the system are steerable to properly orient the device. The instruments may pierce the heart tissue and create channels extending from the endocardium, the epicardium, or the cardiac vessels. When tissue penetration is utilized, the device may include a feature to control the depth of penetration. To minimize bleeding through the channels the device can dilate small initial punctures that later contract down after device removal. When the formation of channels is required, this can be achieved, by way of example, with a rotary-tipped device, pressurized fluid jet devices, vibratory instruments and piercing needle-like tip devices. The system may utilize some form of mechanical action or application of energy (e.g. electrical, sonic, thermal, optical, pressurized fluid, radio frequency (RF), nuclear) in the process. The mechanical action or energy application may affect the surroundings tissues at a distance from the device. The agent delivered to the tissue may include one or more of pharmaceuticals, biologically active agents, radiopaque materials, etc.
摘要翻译：该系统基本上包括用于进入生命体内的目标组织的递送系统，以及在心肌和其它选择组织中的选定位置处引入至少一种药剂。输送系统被布置成进入心脏的组织。可以在经腔，经胸和直接手术进入程序中使用一个或多个系统。在适当的情况下，例如在心室内进入的情况下，系统的部分可操纵以适当地定向装置。仪器可以刺穿心脏组织并产生从心内膜，心外膜或心脏血管延伸的通道。当使用组织穿透时，该装置可以包括控制穿透深度的特征。为了最大程度地减少通道通道的流出，设备可以扩大小的初始穿刺，后来在设备移除后收缩。当需要形成通道时，可以通过例如旋转尖端装置，加压流体喷射装置，振动器械和刺穿针状尖端装置来实现。该系统可以在该过程中利用某种形式的机械作用或能量的应用（例如电，声，热，光，加压流体，射频（RF），核）。机械作用或能量施加可能会影响距离设备一定距离的周围组织。递送到组织的药剂可以包括一种或多种药物，生物活性剂，不透射线材料等。

18. 发明申请

US20080082049A1 GUIDE WIRE EXCHANGE CATHETER SYSTEM 有权
标题翻译：指导式交流电源系统
公开(公告)号：US20080082049A1
公开(公告)日：2008-04-03
申请号：US11457147
申请日：2006-07-12
申请人： Douglas G. Evans , John E. Nash , Steven J. Link
发明人： Douglas G. Evans , John E. Nash , Steven J. Link
IPC分类号： A61M5/178
CPC分类号： A61M25/09041 , A61M25/0172 , A61M2025/018 , A61M2025/0183
摘要： A guide wire exchange system including an elongate, flexible, guide wire exchange catheter capable exchanging one guide wire for another in a safe, efficient, and secured manner, where a primary guide wire, after having been advanced through the body, is to be replaced with a secondary guide wire that is to be securely advanced through the body to the target site by the advancement of the exchange catheter over the path, of the primary wire. The exchange catheter may include a securement element in order to releasably secure at least one guide wire to the exchange catheter at or near the distal end of the exchange catheter. Once secured, both the exchange catheter and the secured guide wire(s) may be advanced or retracted in a synchronous manner, without the possibility of divergence at the distal ends of the secured components as they are being manipulated by an operator.
摘要翻译：引导线交换系统，其包括细长的，柔性的导丝线交换导管，其能够以安全，有效和固定的方式交换一根导丝，其中主导丝在被推进穿过身体之后被更换其中次级导丝将通过主导线的路径上的交换导管的前进而被牢固地推进到身体到达目标位置。交换导管可以包括固定元件，以便在交换导管的远端处或附近将至少一根导丝可释放地固定到交换导管。一旦固定，交换导管和固定的导丝线可以以同步方式前进或缩回，而不会在被操作者操纵的情况下在固定部件的远端发散。

19. 发明授权

US6056762A Anastomosis system and method of use 失效
标题翻译：吻合系统及使用方法
公开(公告)号：US6056762A
公开(公告)日：2000-05-02
申请号：US861584
申请日：1997-05-22
申请人： John E. Nash , Douglas G. Evans
发明人： John E. Nash , Douglas G. Evans
IPC分类号： A61B17/00 , A61B17/11 , A61F2/06
CPC分类号： A61B17/11 , A61F2/064 , A61B2017/00004 , A61B2017/1107 , A61B2017/1135 , A61F2002/065
摘要： A system and method of use for effecting the bypass or other anastomosis of a portion of a native blood vessel, duct, lumen or other tubular organ within the body of a living being. The system includes an anastomosis connector device and a deployment instrument for carrying the device to the desired position within the vessel, duct, lumen or tubular organ. The deployment device may include a dilator to facilitate the placement of the anastomosis device within the interior of the vessel, duct, lumen or other tubular organ. The anastomosis device is preferably formed of a resorbable material and is configured to minimize blood or other fluid turbulence therethrough. The device may include snap-connectors or other components for securing it to the tissue of the vessel, duct, lumen or tubular organ and hemostasis-inducing sealing rings to prevent blood leakage. Other components may be included in the device for expediting the anastomosis procedure, with or without the use of sutures.
摘要翻译：用于实现生物体内的天然血管，管道，管腔或其他管状器官的一部分的旁路或其它吻合的系统和方法。该系统包括吻合连接器装置和用于将装置运送到血管，管道，管腔或管状器官内所需位置的展开装置。展开装置可以包括扩张器，以便于将吻合装置放置在血管，管道，管腔或其它管状器官的内部。吻合装置优选地由可再吸收的材料形成并且被构造成使通过其中的血液或其它流体湍流最小化。该装置可以包括卡扣连接器或其它部件，用于将其固定到血管，管道，管腔或管状器官的组织，以及止血诱导密封环以防止血液渗漏。在使用或不使用缝合线的情况下，可以在装置中包括用于加速吻合程序的其它部件。

20. 发明授权

US6036705A Anastomosis connection system and method of use 有权
公开(公告)号：US6036705A
公开(公告)日：2000-03-14
申请号：US323193
申请日：1999-06-01
申请人： John E. Nash , Douglas G. Evans
发明人： John E. Nash , Douglas G. Evans
IPC分类号： A61B17/00 , A61B17/11 , A61F2/06
CPC分类号： A61B17/11 , A61F2/064 , A61B2017/00004 , A61B2017/1107 , A61B2017/1135 , A61F2002/065
摘要： A system and method of use for effecting the bypass or other anastomosis of a portion of a native blood vessel, duct, lumen or other tubular organ within the body of a living being. The system includes an anastomosis connector device and a deployment instrument for carrying the device to the desired position within the vessel, duct, lumen or tubular organ. The deployment device may include a dilator to facilitate the placement of the anastomosis device within the interior of the vessel, duct, lumen or other tubular organ. The anastomosis device is preferably formed of a resorbable material and is configured to minimize blood or other fluid turbulence therethrough. The device may include snap-connectors or other components for securing it to the tissue of the vessel, duct, lumen or tubular organ and hemostasis-inducing sealing rings to prevent blood leakage. Other components may be included in the device for expediting the anastomosis procedure, with or without the use of sutures.

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