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11. 发明授权

US06015828A Chemical modification of chloride channels as a treatment for cystic fibrosis and other diseases 失效
标题翻译：氯化物通道的化学修饰作为囊性纤维化等疾病的治疗
公开(公告)号：US06015828A
公开(公告)日：2000-01-18
申请号：US863102
申请日：1997-05-23
申请人： John Cuppoletti
发明人： John Cuppoletti
IPC分类号： A61K45/06 , A01N43/50 , A01N33/02 , A61K31/415 , A61K31/13
CPC分类号： A61K45/06 , Y10S514/851
摘要： This invention relates generally to medical treatment methods. Specifically, the invention relates to methodology for the correction of defective chloride transport by activation of chloride channels of the lung and other epithelia using genetic or chemical modification. These methods relate to the treatment of epithelia with compounds which cause activation of the channel as measured by increased probability (Po) of opening of the channel at physiologically relevant holding potentials. These methods also relate to the treatment of epithelia with gene therapy to introduce chloride channels genes with site mutations which cause activation of the channel as measured by increased probability (Po) of opening of the channel at physiologically relevant holding potentials. These treatments will reduce life-threatening complications frequently found in diseases such as cystic fibrosis. These methods of activation of chloride channels also comprise treatment of chloride channels with amidation reactions.
摘要翻译：本发明一般涉及医疗方法。具体地，本发明涉及通过使用遗传或化学修饰激活肺和其他上皮的氯化物通道来校正有缺陷的氯转运的方法。这些方法涉及用生理相关保持电位增加通道开放概率（Po）测量的引起通道活化的化合物来治疗上皮细胞。这些方法还涉及通过基因治疗来治疗上皮细胞以将氯化物通道基因引入位点突变，所述位点引起通道的激活，其通过在生理相关的保持电位下通道开放的概率（Po）来测量。这些治疗可以减少在诸如囊性纤维化等疾病中经常发现的危及生命的并发症。这些氯化物通道的活化方法还包括用酰胺化反应处理氯化物通道。

12. 发明申请

US20130122605A1 Methods for Ionophorically Screening Pore Forming Bacterial Protein Toxins and Receptors 有权
标题翻译：离子色谱筛选形成细菌蛋白质毒素和受体的孔的方法
公开(公告)号：US20130122605A1
公开(公告)日：2013-05-16
申请号：US13721425
申请日：2012-12-20
申请人： John Cuppoletti
发明人： John Cuppoletti
IPC分类号： G01N33/68
CPC分类号： G01N27/447 , G01N33/56911 , G01N33/68 , G01N2400/50 , G01N2500/20 , Y10S435/975 , Y10T428/249953
摘要： A method for determining the amount of live pore forming bacterial toxin protein in a sample is provided, the method including the steps of a) forming a membrane comprising a lipid bilayer and a receptor, b) contacting the membrane with an ion solution and the sample, c) measuring ion flow through the membrane, d) comparing the ion flow through the membrane to a standard curve, and e) determining the amount of pore forming bacterial toxin protein in the sample. A kit for determining the amount of live pore forming bacterial toxin protein present in the sample is also provided.
摘要翻译：提供了一种用于确定样品中活细菌形成细菌毒素蛋白质的量的方法，所述方法包括以下步骤：a）形成包含脂质双层和受体的膜，b）使膜与离子溶液和样品接触 c）测量通过膜的离子流，d）将通过膜的离子流与标准曲线进行比较，e）确定样品中形成细菌毒素蛋白的量。还提供了用于确定样品中存在的活细孔形成细菌毒素蛋白的量的试剂盒。

13. 发明授权

US07829185B2 Selectively permeable film supported membrane 有权
标题翻译：选择性透膜支撑膜
公开(公告)号：US07829185B2
公开(公告)日：2010-11-09
申请号：US10569694
申请日：2004-08-26
申请人： John Cuppoletti
发明人： John Cuppoletti
IPC分类号： B32B3/26 , C12Q1/70
CPC分类号： B01D71/74 , A62D5/00 , B01D69/02 , B01D69/10 , B01D69/122 , B01D69/141 , G01N27/40 , H01M8/0289 , H01M8/1023 , H01M8/1039 , H01M8/1053 , H01M2300/0094 , Y10T428/249953 , Y10T428/31504 , Y10T428/31544 , Y10T428/31855 , Y10T428/31938
摘要： A selectively permeable film supported membrane comprises a selectively permeable film comprising at least one ionomer; a bilayer formed on the film; and at least one transport substance incorporated into the bilayer. Methods for forming a selectively permeable film supported membrane comprise the steps of forming a bilayer on a selectively permeable film comprising at least one ionomer and incorporating at least one transport substance into the bilayer. Fuel cells, toxins detectors and protective devices comprise a selectively permeable film supported membrane.
摘要翻译：选择性渗透膜支撑膜包括选择性渗透膜，其包含至少一种离聚物; 在电影上形成一个双层; 以及并入双层中的至少一种运输物质。形成选择性渗透膜负载膜的方法包括以下步骤：在包含至少一种离子交联聚合物的选择性渗透膜上形成双层并将至少一种输送物质并入双层中。燃料电池，毒素检测器和保护装置包括选择性渗透膜支撑膜。

14. 发明申请

US20100267832A1 METHOD FOR TREATING MACULAR DEGENERATION 失效
标题翻译：处理微粒变形的方法
公开(公告)号：US20100267832A1
公开(公告)日：2010-10-21
申请号：US12758550
申请日：2010-04-12
申请人： Ryuji Ueno , John Cuppoletti
发明人： Ryuji Ueno , John Cuppoletti
IPC分类号： A61K31/5575 , A61P27/02
CPC分类号： A61K31/20 , A61K9/0048 , A61K31/557 , A61K31/5575 , A61K47/14 , A61K47/26
摘要： Disclosed is a method for treating macular degeneration in a mammalian subject, which comprises administering to the subject in need thereof an effective amount of a 15-keto-prostaglandin compound such as 13,14-dihydro-15-keto-20-ethyl-prostaglandin F2α isopropyl ester.
摘要翻译：公开了一种治疗哺乳动物受试者黄斑变性的方法，其包括向有需要的受试者施用有效量的15-酮 - 前列腺素化合物，例如13,14-二氢-15-酮-20-乙基 - 前列腺素 F2α异丙酯。

15. 发明申请

US20080138839A1 Methods for Ionophorically Screening Pore Forming Bacterial Protein Toxins and Receptors 有权
标题翻译：离子色谱筛选形成细菌蛋白质毒素和受体的孔的方法
公开(公告)号：US20080138839A1
公开(公告)日：2008-06-12
申请号：US11832868
申请日：2007-08-02
申请人： John Cuppoletti
发明人： John Cuppoletti
IPC分类号： G01N33/554 , G01N33/566
CPC分类号： G01N27/447 , G01N33/56911 , G01N33/68 , G01N2400/50 , G01N2500/20 , Y10S435/975 , Y10T428/249953
摘要： One embodiment of the present invention is directed to methods for ionophorically screening pore forming bacterial protein toxins and receptors. The method includes: a) forming a membrane comprising a lipid and a receptor, b) contacting the membrane with the pore forming bacterial protein toxin and an ion solution, and c) measuring ion flow through the membrane.
摘要翻译：本发明的一个实施方案涉及用于离子色谱筛选造孔细菌蛋白质毒素和受体的方法。该方法包括：a）形成包含脂质和受体的膜，b）使所述膜与形成孔的细菌蛋白质毒素和离子溶液接触，以及c）测量通过膜的离子流。

16. 发明授权

US6159968A Activation of chloride channels for correction of defective chloride transport 有权
标题翻译：氯化物通道的激活用于纠正氯化物运输缺陷
公开(公告)号：US6159968A
公开(公告)日：2000-12-12
申请号：US231760
申请日：1999-01-15
申请人： John Cuppoletti
发明人： John Cuppoletti
IPC分类号： A61K31/4439 , A61K31/542 , A61K31/535 , A61K31/445
CPC分类号： A61K31/542 , A61K31/4439
摘要： This invention provides a method for increasing the permeability of epithelial cells to a chloride ion in a subject comprising administering a permeability enhancing amount of a composition comprising a specifically-defined nontoxic, benzimidazole or benzimidazole derivative. The invention also relates to a method of treating cystic fibrosis comprising administering an epithelial cell chloride permeability enhancing amount of a composition comprising a specifically-defined nontoxic, benzimidazole or benzimidazole derivative. The benzimidazole compound having chloride channel activation activity for use in this invention includes a 2-[(pyridyl)-methylsulfinyl or -methylthio]benzimidazole derivatives and salts thereof, for instance. Specifically, these include the compounds omeprazole, lansoprazole, thimoprazole and pantoprazole. When appropriately applied, these compounds can correct detective chloride transport, increasing the salt and water flux in diseased tissues to levels closer to those of normal tissues thus reducing life-threatening complications.
摘要翻译：本发明提供了增加受试者中上皮细胞对氯离子的渗透性的方法，包括给予渗透性提高量的包含特异性无毒的苯并咪唑或苯并咪唑衍生物的组合物。本发明还涉及一种治疗囊性纤维化的方法，包括施用上皮细胞氯化物渗透性增加量的包含特异性定义的无毒苯并咪唑或苯并咪唑衍生物的组合物。具有用于本发明的氯化物通道活化活性的苯并咪唑化合物包括例如2 - [（吡啶基） - 甲基亚磺酰基或 - 甲硫基]苯并咪唑衍生物及其盐。具体地，这些包括化合物奥美拉唑，兰索拉唑，噻喹酮和泮托拉唑。当适当应用时，这些化合物可以纠正检测氯转运，将病变组织中的盐和水通量增加到更接近于正常组织的水平，从而减少危及生命的并发症。

17. 发明授权

US08609729B2 Method for treating macular degeneration 失效
标题翻译：治疗黄斑变性的方法
公开(公告)号：US08609729B2
公开(公告)日：2013-12-17
申请号：US12758550
申请日：2010-04-12
申请人： Ryuji Ueno , John Cuppoletti
发明人： Ryuji Ueno , John Cuppoletti
IPC分类号： A01N37/08 , A01N53/00 , A01N35/00 , A01N27/00 , A61K31/19 , A61K31/557 , A61K31/12 , A61K31/015
CPC分类号： A61K31/20 , A61K9/0048 , A61K31/557 , A61K31/5575 , A61K47/14 , A61K47/26
摘要： Disclosed is a method for treating macular degeneration in a mammalian subject, which comprises administering to the subject in need thereof an effective amount of a 15-keto-prostaglandin compound such as 13,14-dihydro-15-keto-20-ethyl-prostaglandin F2α isopropyl ester.
摘要翻译：公开了一种治疗哺乳动物受试者黄斑变性的方法，其包括向有需要的受试者施用有效量的15-酮 - 前列腺素化合物，例如13,14-二氢-15-酮-20-乙基 - 前列腺素 F2alpha异丙酯。

18. 发明申请

US20120142044A1 METHODS FOR IONOPHORICALLY SCREENING PORE FORMING BACTERIAL PROTEIN TOXINS AND RECEPTORS 有权
标题翻译：方法筛选形成细菌蛋白毒素和受体的孔
公开(公告)号：US20120142044A1
公开(公告)日：2012-06-07
申请号：US13368861
申请日：2012-02-08
申请人： John Cuppoletti
发明人： John Cuppoletti
IPC分类号： G01N27/00 , G01N21/75 , C12Q1/02 , G01N33/68
CPC分类号： G01N27/447 , G01N33/56911 , G01N33/68 , G01N2400/50 , G01N2500/20 , Y10S435/975 , Y10T428/249953
摘要： One embodiment of the present invention is directed to methods for ionophorically screening pore forming bacterial protein toxins and receptors for insect toxicity. The method includes: a) forming a membrane comprising a lipid and an insect receptor, b) contacting the membrane with the pore forming bacterial protein toxin and an ion solution, and c) measuring ion flow through the membrane. Also provided are a method and kit for determining the amount of live pore forming bacterial toxin protein in a sample.
摘要翻译：本发明的一个实施方案涉及用于电离屏蔽成孔细菌蛋白质毒素和昆虫毒性的受体的方法。该方法包括：a）形成包含脂质和昆虫受体的膜，b）使所述膜与形成孔的细菌蛋白质毒素和离子溶液接触，以及c）测量通过膜的离子流。还提供了用于测定样品中活细孔形成细菌毒素蛋白的量的方法和试剂盒。

19. 发明授权

US08148172B2 Methods for ionophorically screening pore forming bacterial protein toxins and receptors 有权
标题翻译：用于离子色谱筛选形成细菌的细菌蛋白毒素和受体的方法
公开(公告)号：US08148172B2
公开(公告)日：2012-04-03
申请号：US11832868
申请日：2007-08-02
申请人： John Cuppoletti
发明人： John Cuppoletti
IPC分类号： C12M1/00 , C12M1/34 , G01N33/543
CPC分类号： G01N27/447 , G01N33/56911 , G01N33/68 , G01N2400/50 , G01N2500/20 , Y10S435/975 , Y10T428/249953
摘要： One embodiment of the present invention is directed to methods for ionophorically screening pore forming bacterial protein toxins and receptors. The method includes: a) forming a membrane comprising a lipid and a receptor, b) contacting the membrane with the pore forming bacterial protein toxin and an ion solution, and c) measuring ion flow through the membrane.
摘要翻译：本发明的一个实施方案涉及用于离子色谱筛选造孔细菌蛋白质毒素和受体的方法。该方法包括：a）形成包含脂质和受体的膜，b）使所述膜与形成孔的细菌蛋白质毒素和离子溶液接触，以及c）测量通过膜的离子流。

20. 发明申请

US20070116610A1 Selectively permeable membranes on porous substrates 有权
标题翻译：多孔基材上的选择性渗透膜
公开(公告)号：US20070116610A1
公开(公告)日：2007-05-24
申请号：US11454569
申请日：2006-06-16
申请人： John Cuppoletti
发明人： John Cuppoletti
IPC分类号： B01L11/00
CPC分类号： B01D69/10 , B01D69/144 , B01D71/06 , H01B1/122 , H01M8/16 , H01M2300/0082 , H01M2300/0094 , Y02E60/527 , Y02P70/56 , Y10T428/249953
摘要： Functional biological synthetic composite (BSC) membranes comprising phospholipids, biological membrane proteins and porous supports or membranes are provided. Lipid bilayers are formed on porous polycarbonate (PC), polyethylene terephthalate (PETE) and poly (I-lactic acid) (PLLA) membranes and in laser-drilled pores in a multi-well plastic plate as measured by increased resistance or decreased currents. BSC's comprising functional reconstituted Kv 1.5 K channel and/or H/K ATPase transport proteins are also provided c inhibitor), methods of manufacture, and high throughput screening assays employing the inventive membranes are also provided.
摘要翻译：提供了包含磷脂，生物膜蛋白质和多孔载体或膜的功能性生物合成复合物（BSC）膜。在多孔聚碳酸酯（PC），聚对苯二甲酸乙二醇酯（PETE）和聚（l-乳酸）（PLLA）膜上形成脂质双层，并在多孔塑料板中的激光钻孔中形成电阻增加或电流降低测量。还提供了包含功能重构的Kv 1.5K通道和/或H / K ATP酶转运蛋白的BSC，c抑制剂），使用本发明的膜的制备方法和高通量筛选测定。

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