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11. 发明授权

US5122373A Immunoglobulin-G-containing fraction 失效
$Immunoglobulin-G-containing fraction$
标题翻译：含有免疫球蛋白的G含量
公开(公告)号：US5122373A
公开(公告)日：1992-06-16
申请号：US569535
申请日：1990-08-20
申请人： Johann Eibl , Yendra Linnau , Otto Schwarz
发明人： Johann Eibl , Yendra Linnau , Otto Schwarz
IPC分类号： A61K39/395 , A61K38/00 , C07K16/06
CPC分类号： C07K16/065 , A61K38/00
摘要： An immunoglobulin-G-containing fraction from human or animal plasma comprising monomeric IgG molecules as well as at least 70% gammaglobulins, destined for intravenous application.The fraction has a low anticomplementary activity and is substantially free of vasoactive and leucopenically active as well as bronchospastic substances.
摘要翻译：来自人或动物血浆的含有免疫球蛋白G的级分包含单体IgG分子以及至少70％的用于静脉内应用的丙种球蛋白。所述级分具有低抗补体活性，并且基本上不含血管活性和有丝分裂活性物质以及支气管痉挛物质。

12. 发明授权

US4904641A Method of inactivating reproducible filterable pathogens in blood plasma products 失效
标题翻译：灭活血浆中可再生可过滤病原体的方法
公开(公告)号：US4904641A
公开(公告)日：1990-02-27
申请号：US293085
申请日：1989-01-03
申请人： Johann Eibl , Otto Schwarz , Fritz Elsinger , Gunter Wober , Anton Philapitsch , Yendra Linnau , Friedrich Dorner , Karl Trambauer , Wolfgang Frechinger
发明人： Johann Eibl , Otto Schwarz , Fritz Elsinger , Gunter Wober , Anton Philapitsch , Yendra Linnau , Friedrich Dorner , Karl Trambauer , Wolfgang Frechinger
IPC分类号： A61K35/14 , A61L2/00
CPC分类号： A61L2/0023
摘要： There is disclosed a method of inactivating reproducible filterable pathogens in blood plasma products by applying elevated temperatures. The blood plasma products are heat treated in a solid state in a closed inactivation container in the presence of specific amounts of water and organic compounds, provided that the water substantially remains physically bound to the blood plasma products, while the organic compound is present in a gaseous form in the atmosphere. The water content of the blood plasma products is 0.08 to 0.40. The concentration of the organic compounds in the gaseous phase is 0.01 to 10 g per liter of container volume.
摘要翻译：公开了通过施加升高的温度来灭活血浆产品中可再现的可过滤病原体的方法。在特定量的水和有机化合物的存在下，在封闭的灭活容器中将血浆产物以固态热处理，条件是水基本上保持与血浆产物的物理结合，而有机化合物存在于气体形式在大气中。血浆产品的含水量为0.08〜0.40。气相中有机化合物的浓度为每升容器体积0.01至10g。

13. 发明授权

US06307032B1 Highly purified factor VIII complex 有权
标题翻译：高纯度因子VIII复合物
公开(公告)号：US06307032B1
公开(公告)日：2001-10-23
申请号：US09171121
申请日：1998-11-18
申请人： Wolfgang Schönhofer , Johann Eibl , Alfred Weber , Yendra Linnau
发明人： Wolfgang Schönhofer , Johann Eibl , Alfred Weber , Yendra Linnau
IPC分类号： C07K100
CPC分类号： C07K14/755 , A61K38/00
摘要： There is disclosed a highly purified complex comprising the components factor VIII and vWF having a specific activity of at least 70, preferably 100 to 300 U factor VIII:C/mg, a stable pharmaceutical preparation containing this complex as well as a method of producing the same.
摘要翻译：公开了一种高纯度复合物，其包含具有至少70，优选100至300U因子VIII：C / mg的比活性的组分因子VIII和vWF，包含该复合物的稳定药物制剂以及制备相同。

14. 发明授权

US5410022A Method of producing a factor VIII preparation 失效
标题翻译：生产因子VIII制剂的方法
公开(公告)号：US5410022A
公开(公告)日：1995-04-25
申请号：US49585
申请日：1993-04-20
申请人： Johann Eibl , Friedrich Elsinger , Herbert Gritsch , Yendra Linnau , Otto Schwarz , Peter Turecek , Gunther Wober
发明人： Johann Eibl , Friedrich Elsinger , Herbert Gritsch , Yendra Linnau , Otto Schwarz , Peter Turecek , Gunther Wober
IPC分类号： A61K38/43 , A61K38/00 , A61K38/37 , A61L2/04 , A61L2/16 , A61L2/18 , A61P7/04 , C07K1/14 , C07K1/16 , C07K14/435 , C07K14/745 , C07K14/755 , C12N9/74 , C07K3/20 , C07K15/06
CPC分类号： C07K14/755 , A61K38/00 , Y10S530/83 , Y10S530/831
摘要： The invention relates to a method of producing virus-safe highly purified factor VIII. The method includes a combination of the following measures:a) chromatographic purification of a factor VIII-containing fraction,b) tenside treatment of factor VIII in an aqueous solution at a tenside/protein ratio of from 1:1 to 1000:1, andc) heat treatment of the factor VIII preparation in the solid state.
摘要翻译：本发明涉及一种生产病毒安全高度纯化因子VIII的方法。该方法包括以下措施的组合：a）含有因子VIII的级分的色谱纯化，b）在表面活性剂/蛋白质比例为1:1至1000:1的水溶液中进行因子VIII的表面活性剂处理，以及 c）在固体状态下热处理VIII因子制剂。

15. 发明授权

US4510084A Method of producing an antithrombin III-heparin concentrate or antithrombin III-heparinoid concentrate 失效
标题翻译：生产抗凝血酶III-肝素浓缩物或抗凝血酶III-类肝素浓缩物的方法
公开(公告)号：US4510084A
公开(公告)日：1985-04-09
申请号：US611639
申请日：1984-05-18
申请人： Johann Eibl , Ernst Hetzl , Yendra Linnau
发明人： Johann Eibl , Ernst Hetzl , Yendra Linnau
IPC分类号： A61K35/16 , A61K31/715 , A61K35/14 , A61K38/00 , A61K38/16 , A61K38/55 , A61P7/00 , A61P7/02 , C07K1/14 , C07K1/18 , C07K14/435 , C07K14/745 , C07K14/81 , C08B37/10 , C07G7/00 , A61K31/725 , A61K37/64
CPC分类号： A61K31/715 , C07K14/8128 , C08B37/0075 , A61K38/00 , Y10S530/83
摘要： In a method of producing an antithrombin III-heparin or an antithrombin III-heparinoid concentrate, heparin or heparinoid is added to human plasma or to antithrombin III containing plasma fractions to form an antithrombin III-heparin or antithrombin III-heparinoid complex, the complex thus formed is adsorbed on an anion exchanger, and eluted with a salt solution; then the antithrombin III-heparin or antithrombin III-heparinoid complex contained in the eluate is separated from salts and undesired proteins, and the resulting product is loyphilized.
摘要翻译：在制备抗凝血酶III-肝素或抗凝血酶III-类肝素浓缩物的方法中，将肝素或类肝素添加到人血浆或含有血浆级分的抗凝血酶III以形成抗凝血酶III-肝素或抗凝血酶III-类肝素复合物，因此复合物形成的吸附在阴离子交换剂上，并用盐溶液洗脱; 然后将洗脱液中含有的抗凝血酶III-肝素或抗凝血酶III-类肝素复合物与盐和不需要的蛋白质分离，并将所得产物刺激。

16. 发明授权

US4388232A Method of producing plasma fractions free of side-effects using fast-reacting antithrombin 失效
$Method of producing plasma fractions free of side-effects using fast-reacting antithrombin$
标题翻译：使用快速反应的抗凝血酶产生不含副作用的血浆级分的方法
公开(公告)号：US4388232A
公开(公告)日：1983-06-14
申请号：US375044
申请日：1982-05-05
申请人： Johann Eibl , Fritz Elsinger , Yendra Linnau
发明人： Johann Eibl , Fritz Elsinger , Yendra Linnau
IPC分类号： A61K35/16 , A61K38/16 , A61K38/43 , A61K38/48 , A61K38/55 , C12Q1/56 , G01N33/86 , C07G7/00
CPC分类号： C12Q1/56 , A61K35/16 , G01N33/86 , G01N2333/8128 , G01N2333/9108 , G01N2333/91085 , G01N2400/40 , Y10S530/83
摘要： In a method of producing plasma fractions free of side-effects by purification and step-wise enrichment of plasma proteins in the presence of calcium-binding anticoagulants, also fast reactive (avid) antithrombin is present, wherein a concentration of the fast reacting (avid) antithrombin of 0.05 to 50 units per ml of the respective solution is maintained during all fractionation process steps.
摘要翻译：在通过在钙结合抗凝剂的存在下纯化和逐步浓缩血浆蛋白质来产生没有副作用的血浆级分的方法中，还存在快速反应性（抗生素）抗凝血酶，其中快速反应的浓度）抗凝血酶的浓度为0.05〜50单位/ ml的各溶液。

17. 发明授权

US4814435A Method of producing a factor VIII (AHF) containing fraction 失效
$Method of producing a factor VIII (AHF) containing fraction$
标题翻译：制备含有因子VIII（AHF）的级分的方法
公开(公告)号：US4814435A
公开(公告)日：1989-03-21
申请号：US108458
申请日：1987-10-15
申请人： Otto Schwarz , Yendra Linnau
发明人： Otto Schwarz , Yendra Linnau
IPC分类号： A61K35/14 , A61K38/00 , A61K38/43 , A61P7/04 , C07K1/30 , C07K14/435 , C07K14/745 , C07K14/755 , A61K35/16 , C07K15/14
CPC分类号： C07K14/755 , A61K38/00 , Y10S530/83
摘要： There is disclosed a method of producing a Factor VIII (AHF) containing fraction having a specific activity of at least 2.5 units of Factor VIII/mg protein as well as a portion of immunoglobulin G (IgG) of 10 mg/1000 units of Factor VIII at the most. Its risk of transmission of viral or bacterial infections is to be avoided or largely reduced. The method consists in that undesired proteins are at first precipitated from a Factor VIII (AHF) containing plasma fraction in the presence of SPS. The purified Factor VIII containing solution is treated with suitable salts or salt mixtures in order to obtain a Factor VIII containing precipitate. This precipitate is dissolved, lyophilized and finally heat-treated.
摘要翻译：公开了一种生产含有至少2.5单位因子VIII / mg蛋白的比活性的因子VIII（AHF）的部分以及10mg / 1000单位因子VIII的免疫球蛋白G（IgG）的一部分的方法至多，最多。其传播病毒或细菌感染的风险是要避免或大大降低。该方法包括在SPS存在下首先从含有血浆级分的因子VIII（AHF）沉淀不需要的蛋白质。用合适的盐或盐混合物处理纯化的含Ⅷ因子的溶液，以获得含Ⅷ因子的沉淀物。将该沉淀溶解，冻干，最后进行热处理。

18. 发明授权

US4404131A Method of producing a factor-VIII(AHF)-high-concentrate 失效
标题翻译：生产因子VIII（AHF） - 高浓缩物的方法
公开(公告)号：US4404131A
公开(公告)日：1983-09-13
申请号：US287912
申请日：1981-07-29
申请人： Otto Schwarz , Yendra Linnau
发明人： Otto Schwarz , Yendra Linnau
IPC分类号： C07K14/745 , A61K35/14 , A61K38/00 , A61K38/16 , A61K38/43 , C07K14/435 , C07K14/755 , C07G7/00
CPC分类号： C07K14/755 , A61K38/00 , Y10S530/83 , Y10S530/831
摘要： In a method of producing a factor-VIII(AHF)-high-concentrate having a specific activity of at least 2.5 units AHF and a fibrinogen content of less than 0.25 mg/mg protein from human or animal plasma, the plasma is subjected to a multi-step fractionation. The fraction purified by these fractionation measures and enriched in factor VIII (AHF) is subjected to a cryoalcohol precipitation and the resulting precipitate is processed into a stable form.
摘要翻译：在生产具有至少2.5单位AHF的比活性和来自人或动物血浆的纤维蛋白原含量小于0.25mg / mg蛋白质的因子VIII（AHF） - 高浓缩物的方法中，将等离子体进行多步分馏。通过这些分级测量纯化并富集因子VIII（AHF）的级分进行冷冻醇沉淀，并将所得沉淀物加工成稳定的形式。

19. 发明授权

US5393666A Method of activating prothrombin 失效
标题翻译：激活凝血酶原的方法
公开(公告)号：US5393666A
公开(公告)日：1995-02-28
申请号：US34778
申请日：1993-03-19
申请人： Yendra Linnau
发明人： Yendra Linnau
IPC分类号： C12N9/74 , C12N9/64 , C12N9/76 , C12N11/00 , C12N9/00 , C12N11/16 , A61K37/547
CPC分类号： C12N9/6429 , C12N9/6427 , C12N9/647 , C12Y304/21005
摘要： There is disclosed a method of activating prothrombin by means of trypsin, wherein the prothrombin is recovered from a blood or plasma fraction, treated with trypsin immobilized on a water-insoluble carrier, and separated from the immobilized trypsin after activation.
摘要翻译：公开了一种通过胰蛋白酶激活凝血酶原的方法，其中从固定在水不溶性载体上的胰蛋白酶处理的血液或血浆级分中回收凝血酶原，并在活化后与固定的胰蛋白酶分离。

20. 发明授权

US5371007A Method of producing lys-plasminogen 失效
标题翻译：产生溶酶原纤溶酶原的方法
公开(公告)号：US5371007A
公开(公告)日：1994-12-06
申请号：US41332
申请日：1993-04-01
申请人： Yendra Linnau , Ernst Hetzl
发明人： Yendra Linnau , Ernst Hetzl
IPC分类号： A61K38/46 , A61P7/02 , C12N9/68 , C12S3/14 , C12P21/00 , C12N9/00
CPC分类号： C12N9/6435 , C12Y304/21007
摘要： To produce lys-plasminogen having a specific activity of at least 17.5 caseinolytic units/mg protein and at least 50 mymoles/g protein nitrogen as well as an electrophoretic purity of at least 90%, plasminogen from plasma, a plasminogen-containing fraction or a tissue culture is adsorbed on immobilized lysine for the purpose of purification, is eluted and is recovered from the eluate by a protein precipitating agent. A solution of the thus purified plasminogen is adjusted to a plasmin activity ranging between 0.005 and 0.2 mymoles/ml min relative to chromogenic substrate H-D-valyl-L-leucyl-L-lysine-p-nitroanilide dihydrochloride, is maintained at a temperature of from +1.degree. C. to +20.degree. C. for a period of from 6 to 60 hours in order to provoke an enzymatic-proteolytic conversion of plasminogen into lys-plasminogen, whereupon the enzymatic action is interrupted and lys-plasminogen is isolated.
摘要翻译：为了产生具有至少17.5个酪蛋白分解单位/ mg蛋白和至少50 mymoles / g蛋白质氮的比活性以及至少90％的电泳纯度的溶血纤溶酶原，血浆中的纤溶酶原，含纤溶酶原的级分或组织培养物被吸附在固定的赖氨酸上用于纯化，被洗脱并通过蛋白质沉淀剂从洗脱液中回收。将如此纯化的纤溶酶原的溶液调节至相对于显色底物HD-缬氨酰-L-亮氨酰-L-赖氨酸 - 对硝基苯胺二盐酸盐在0.005至0.2 mymoles / ml min范围内的纤溶酶活性维持在 +1℃至+ 20℃，时间为6至60小时，以引起纤溶酶原转化为溶酶原纤维蛋白溶酶原的酶 - 蛋白水解转化，由此中断酶促作用并分离裂解纤溶酶原。

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