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11. 发明授权

US06673897B1 Inhibitors of NF-&kgr;B Activation 失效
标题翻译： NF-κB激活抑制剂
公开(公告)号：US06673897B1
公开(公告)日：2004-01-06
申请号：US09702953
申请日：2000-10-31
申请人： Rudi Beyaert , Karen Heyninck , Walter Fiers
发明人： Rudi Beyaert , Karen Heyninck , Walter Fiers
IPC分类号： C07K100
CPC分类号： C07K14/4702 , A61K38/00
摘要： The present invention relates to novel inhibitors of the Nuclear factor kappa B (NF-&kgr;B) activating pathway useful in the treatment of NF-&kgr;B related diseases and/or in the improvement of anti-tumor treatments. These inhibitors interfere early in the TRAF induced signaling pathway and are therefore more specific than I&kgr;B.
摘要翻译：本发明涉及可用于治疗NF-κB相关疾病和/或改善抗肿瘤治疗的核因子κB（NF-κB）激活途径的新型抑制剂。这些抑制剂在TRAF诱导的信号传导途径中早期干扰，因此比IkappaB更具体。

12. 发明授权

US09409973B2 Respiratory syncytial virus vaccine 有权
标题翻译：呼吸道合胞病毒疫苗
公开(公告)号：US09409973B2
公开(公告)日：2016-08-09
申请号：US13885388
申请日：2011-11-15
申请人： Xavier Saelens , Bert Schepens , Walter Fiers
发明人： Xavier Saelens , Bert Schepens , Walter Fiers
IPC分类号： A61K39/155 , C07K16/10 , A61K39/12 , C12N7/02 , C07K7/06 , C07K14/005 , C07K14/78 , A61K39/385 , A61K39/00
CPC分类号： A61K39/155 , A61K39/12 , A61K39/385 , A61K2039/5258 , A61K2039/543 , A61K2039/55505 , A61K2039/55544 , A61K2039/55566 , A61K2039/575 , A61K2039/6031 , A61K2039/6075 , A61K2039/6081 , A61K2039/645 , C07K7/06 , C07K14/005 , C07K14/78 , C07K16/1027 , C07K2317/10 , C07K2317/76 , C12N7/00 , C12N7/02 , C12N2760/18522 , C12N2760/18534 , C12N2760/18571
摘要： Described is a vaccine against Respiratory Syncytial Virus (RSV). More specifically, described is a recombinant subunit vaccine comprising the ectodomain of the RSV-encoded Small Hydrophobic (SH) protein. The ectodomain of SH is referred to as SHe. The ectodomain is typically presented as an oligomer, or a pentamer. Further described are antibodies, raised against the ectodomain or specific for the ectodomain, and their use for protecting a subject against RSV infection and/or for treatment of an infected subject.
摘要翻译：描述了一种针对呼吸道合胞病毒（RSV）的疫苗。更具体地，描述了包含RSV编码的小疏水（SH）蛋白的胞外域的重组亚单位疫苗。 SH的胞外域被称为SHe。胞外域通常表现为低聚物或五聚体。还描述了针对胞外结构域或针对胞外结构域特异性的抗体，以及它们用于保护受试者免受RSV感染和/或用于感染受试者治疗的用途。

13. 发明申请

US20130315916A1 RESPIRATORY SYNCYTIAL VIRUS VACCINE 有权
标题翻译：呼吸道同类病毒疫苗
公开(公告)号：US20130315916A1
公开(公告)日：2013-11-28
申请号：US13885388
申请日：2011-11-15
申请人： Xavier Saelens , Bert Schepens , Walter Fiers
发明人： Xavier Saelens , Bert Schepens , Walter Fiers
IPC分类号： C07K16/10 , C07K14/78 , C07K7/06 , C07K14/005
CPC分类号： A61K39/155 , A61K39/12 , A61K39/385 , A61K2039/5258 , A61K2039/543 , A61K2039/55505 , A61K2039/55544 , A61K2039/55566 , A61K2039/575 , A61K2039/6031 , A61K2039/6075 , A61K2039/6081 , A61K2039/645 , C07K7/06 , C07K14/005 , C07K14/78 , C07K16/1027 , C07K2317/10 , C07K2317/76 , C12N7/00 , C12N7/02 , C12N2760/18522 , C12N2760/18534 , C12N2760/18571
摘要： Described is a vaccine against Respiratory Syncytial Virus (RSV). More specifically, described is a recombinant subunit vaccine comprising the ectodomain of the RSV-encoded Small Hydrophobic (SH) protein. The ectodomain of SH is referred to as SHe. The ectodomain is typically presented as an oligomer, or a pentamer. Further described are antibodies, raised against the ectodomain or specific for the ectodomain, and their use for protecting a subject against RSV infection and/or for treatment of an infected subject.
摘要翻译：描述了一种针对呼吸道合胞病毒（RSV）的疫苗。更具体地，描述了包含RSV编码的小疏水（SH）蛋白的胞外域的重组亚单位疫苗。 SH的胞外域被称为SHe。胞外域通常表现为低聚物或五聚体。还描述了针对胞外结构域或针对胞外结构域特异性的抗体，以及它们用于保护受试者免受RSV感染和/或用于感染受试者治疗的用途。

14. 发明授权

US07732130B2 Immunoprotective influenza antigen and its use in vaccination 有权
标题翻译：免疫保护性流感抗原及其在疫苗接种中的应用
公开(公告)号：US07732130B2
公开(公告)日：2010-06-08
申请号：US11374922
申请日：2006-03-14
申请人： Sabine Neirynck , Willy Min Jou , Walter Fiers
发明人： Sabine Neirynck , Willy Min Jou , Walter Fiers
IPC分类号： C12Q1/70 , A61K39/00 , A61K39/145
CPC分类号： C07K14/005 , A61K38/00 , C07K14/472 , C07K2319/00 , C07K2319/02 , C12N2730/10122 , C12N2760/16122
摘要： The present invention relates to an influenza antigen, comprising a fusion product of at least the extracellular part of a conserved influenza membrane protein or a functional fragment thereof and a presenting carrier, which may be a presenting (poly)peptide or a non-peptidic structure, such as glycans, peptide mimetics, synthetic polymers. The invention further relates to a vaccine against influenza, comprising at least an antigen of the invention, optionally in the presence of one or more excipients. The invention also relates to use of the antigen, a method for preparing the antigen and acceptor cells expressing the antigen.
摘要翻译：本发明涉及流感抗原，其包含至少保守的流感病毒膜蛋白的细胞外部分或其功能片段和呈递载体的融合产物，其可以是呈递（多）肽或非肽结构，如聚糖，肽模拟物，合成聚合物。本发明进一步涉及抗流感疫苗，其中至少包含本发明的抗原，任选地在一种或多种赋形剂的存在下。本发明还涉及抗原的用途，制备抗原的方法和表达抗原的受体细胞。

15. 发明授权

US07414026B2 Inhibitors of NF-kappaB activation 失效
标题翻译： NF-κB活化抑制剂
公开(公告)号：US07414026B2
公开(公告)日：2008-08-19
申请号：US10680998
申请日：2003-10-08
申请人： Rudi Beyaert , Karen Heyninck , Walter Fiers
发明人： Rudi Beyaert , Karen Heyninck , Walter Fiers
IPC分类号： A61K38/00
CPC分类号： C07K14/4702 , A61K38/00
摘要： The present invention relates to novel inhibitors of the Nuclear factor kappa B (NF-κB) activating pathway useful in the treatment of NF-κB related diseases and/or in the improvement of anti-tumor treatments. These inhibitors interfere early in the TRAF induced signaling pathway and are therefore more specific than IκB.
摘要翻译：本发明涉及可用于治疗NF-κB相关疾病和/或改善抗肿瘤治疗的核因子κB（NF-κB）激活途径的新型抑制剂。这些抑制剂在TRAF诱导的信号传导途径中早期干扰，因此比IkappaB更具体。

16. 发明授权

US5422104A TNF-muteins 失效
标题翻译： TNF-突变蛋白
公开(公告)号：US5422104A
公开(公告)日：1995-06-06
申请号：US794400
申请日：1991-11-20
申请人： Walter Fiers , Jan Tavernier , Xaveer Van Ostade
发明人： Walter Fiers , Jan Tavernier , Xaveer Van Ostade
IPC分类号： A61K38/00 , A61P35/00 , C07K14/52 , C07K14/525 , C12N1/21 , C12N15/09 , C12N15/28 , C12P21/02 , C12R1/19 , A61K45/05 , C12P21/06
CPC分类号： C07K14/525 , A61K38/00
摘要： It is an object of this invention to provide a human Tumor Necrosis Factor mutein or a pharmaceutically acceptable salt thereof characterized in that the TNF sequence is changed by a deletion, insertion, substitution or combinations thereof, of one or more amino acids so that the mutein shows a significant difference between its binding affinity to the human p75-Tumor-Necrosis-Factor-Receptor and to the human p55-Tumor-Necrosis-Factor-Receptor. The invention also includes DNA sequences coding for such muteins, vectors comprising such DNA sequences, host cells transformed with such vectors and a process for the production of such muteins employing such transformed host cells and pharmaceutical compositions containing such muteins and their use for the treatment of illnesses, for example cancer.
摘要翻译：本发明的目的是提供一种人肿瘤坏死因子突变蛋白或其药学上可接受的盐，其特征在于通过其一个或多个氨基酸的缺失，插入，取代或组合改变TNF序列，使得突变蛋白显示其与人p75-肿瘤坏死因子受体和人p55-肿瘤坏死因子受体的结合亲和力之间的显着差异。本发明还包括编码这种突变蛋白的DNA序列，包含这种DNA序列的载体，用这种载体转化的宿主细胞和使用这种转化的宿主细胞产生这种突变蛋白的方法和含有这种突变蛋白的药物组合物及其用于治疗疾病，例如癌症。

17. 发明授权

US5332571A Products containing a lithium salt and a tumor necrosis factor 失效
标题翻译：含有锂盐和肿瘤坏死因子的产品
公开(公告)号：US5332571A
公开(公告)日：1994-07-26
申请号：US613518
申请日：1990-11-02
申请人： Joachim Kempeni , Michael Kluge , Walter Fiers
发明人： Joachim Kempeni , Michael Kluge , Walter Fiers
IPC分类号： A61K38/00 , A61K33/00 , A61K38/19 , A61P35/00 , A61K45/06 , A61K37/02
CPC分类号： A61K38/191
摘要： The enhancement of the antitumor action of tumor necrosis factor by lithium salts is described.
摘要翻译： PCT No.PCT / EP90 / 00324 Sec。 371日期1990年11月2日 102（e）1990年11月2日日期PCT提交1990年2月27日PCT公布。出版物WO90 / 10455 1990年9月20日。描述了锂盐对肿瘤坏死因子的抗肿瘤作用的增强。

18. 发明授权

US07731972B1 Immunoprotective influenza antigen and its use in vaccination 有权
标题翻译：免疫保护性流感抗原及其在疫苗接种中的应用
公开(公告)号：US07731972B1
公开(公告)日：2010-06-08
申请号：US09498046
申请日：2000-02-04
申请人： Sabine Neirynck , Willy Min Jou , Walter Fiers
发明人： Sabine Neirynck , Willy Min Jou , Walter Fiers
IPC分类号： A61K39/00 , A61K39/145
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/523 , A61K2039/53 , A61K2039/543 , A61K2039/55566 , A61K2039/55572 , C07K2319/00 , C12N2710/14143 , C12N2730/10122 , C12N2760/16122
摘要： The present invention relates to an influenza antigen, comprising a fusion product of at least (1) the extracellular part of a conserved influenza membrane protein (e.g., M2) or a functional equivalent thereof and (2) a presenting carrier. The presenting carrier may be a (poly)peptide or a non-peptidic structure such as glycans, peptide mimetics, and synthetic polymers. The invention further relates to methods of making and using the antigen, and to influenza vaccines comprising the antigen and optionally one or more excipients.
摘要翻译：本发明涉及流感抗原，其包含至少（1）保守流感病毒膜蛋白（例如M2）的细胞外部分或其功能等同物的融合产物和（2）呈递载体。呈递载体可以是（多）肽或非肽结构，例如聚糖，肽模拟物和合成聚合物。本发明还涉及制备和使用抗原的方法，以及包含抗原和任选的一种或多种赋形剂的流感疫苗的方法。

19. 发明授权

US07361352B2 Influenza immunogen and vaccine 失效
标题翻译：流感免疫原和疫苗
公开(公告)号：US07361352B2
公开(公告)日：2008-04-22
申请号：US10787734
申请日：2004-02-26
申请人： Ashley J. Birkett , Walter Fiers
发明人： Ashley J. Birkett , Walter Fiers
IPC分类号： A61K39/29 , A61K39/00
CPC分类号： A61K39/145 , A61K39/12 , A61K39/292 , A61K2039/5256 , A61K2039/5258 , A61K2039/543 , A61K2039/55505 , A61K2039/55572 , A61K2039/70 , C07K14/005 , C07K2319/00 , C12N7/00 , C12N2730/10122 , C12N2730/10123 , C12N2730/10134 , C12N2760/16122 , C12N2760/16134 , Y02A50/484
摘要： A chimeric, carboxy-terminal truncated hepatitis B virus nucleocapsid (HBc) protein is disclosed that contains an immunogen for inducing the production of antibodies to the influenza M2 protein. An immunogenic influenza sequence in two to four copies is preferably expressed at or near the N-terminus or in the HBc immunogenic loop sequence. The HBc chimer preferably contains an influenza-specific T cell epitope and is preferably engineered for both enhanced stability of self-assembled particles and enhanced yield of those chimeric particles. Methods of making and using the chimers are also disclosed.
摘要翻译：公开了一种嵌合的羧基末端截短的乙型肝炎病毒核衣壳蛋白（HBc），其包含用于诱导产生针对流感M2蛋白的抗体的免疫原。 2至4个拷贝中的免疫原性流感病毒序列优选在N末端或HBc免疫原性环序列中或附近表达。 HBc嵌合体优选含有流感特异性T细胞表位，并且优选地被设计用于增强自组装颗粒的稳定性和提高那些嵌合颗粒的产量。还公开了制造和使用这种开发者的方法。

20. 发明申请

US20060246092A1 Immunoprotective influenza antigen and its use in vaccination 有权
标题翻译：免疫保护性流感抗原及其在疫苗接种中的应用
公开(公告)号：US20060246092A1
公开(公告)日：2006-11-02
申请号：US11374922
申请日：2006-03-14
申请人： Sabine Neirynck , Willy Min Jou , Walter Fiers
发明人： Sabine Neirynck , Willy Min Jou , Walter Fiers
IPC分类号： A61K39/145 , C12N15/86 , C12N1/21
CPC分类号： C07K14/005 , A61K38/00 , C07K14/472 , C07K2319/00 , C07K2319/02 , C12N2730/10122 , C12N2760/16122
摘要： The present invention relates to an influenza antigen, comprising a fusion product of at least the extracellular part of a conserved influenza membrane protein or a functional fragment thereof and a presenting carrier, which may be a presenting (poly)peptide or a non-peptidic structure, such as glycans, peptide mimetics, synthetic polymers. The invention further relates to a vaccine against influenza, comprising at least an antigen of the invention, optionally in the presence of one or more excipients. The invention also relates to use of the antigen, a method for preparing the antigen and acceptor cells expressing the antigen.
摘要翻译：本发明涉及流感抗原，其包含至少保守的流感病毒膜蛋白的细胞外部分或其功能片段和呈递载体的融合产物，其可以是呈递（多）肽或非肽结构，如聚糖，肽模拟物，合成聚合物。本发明进一步涉及抗流感疫苗，其中至少包含本发明的抗原，任选地在一种或多种赋形剂的存在下。本发明还涉及抗原的用途，制备抗原的方法和表达抗原的受体细胞。

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