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11. 发明申请

US20110025333A1 SHEAR MODE PRESSURE-ACTIVATED DRIVER FOR MAGNETIC RESONANCE ELASTOGRAPHY 有权
标题翻译：用于磁共振ELASTOGRAPHY的剪切模式压力驱动器
公开(公告)号：US20110025333A1
公开(公告)日：2011-02-03
申请号：US12847712
申请日：2010-07-30
申请人： Eric C. Ehman , Kiaran P. McGee , Richard L. Ehman
发明人： Eric C. Ehman , Kiaran P. McGee , Richard L. Ehman
IPC分类号： G01R33/20
CPC分类号： G01R33/56358
摘要： A magnetic resonance elastography (“MRE”) driver that can produce shear waves in a subject without relying on mode conversion of longitudinal waves is disclosed. More specifically, the MRE driver includes a pneumatic driver located remotely from a magnetic resonance imaging (“MRI”) system which is operable in response to an applied electrical current to oscillate, a pressure-activated driver that is positioned on a subject in the MRI system, and a tube that is in fluid communication, at one end, with the pneumatic driver. The pressure-activated driver includes a base plate and a driver plate having a region between them that receives the tube. Oscillations of the pneumatic driver produce a pressure wave in the tube that causes the driver plate to vibrate. The driver plate rests against the subject of interest to apply a corresponding shear oscillatory force to the subject during the MRE examination.
摘要翻译：公开了一种能够在不依赖纵波的模式转换的情况下在受试者中产生剪切波的磁共振弹性成像（“MRE”）驱动器。更具体地说，MRE驱动器包括一个位于远离磁共振成像（“MRI”）系统的气动驱动器，该系统可响应所施加的电流振荡而操作，压力激活的驱动器位于MRI中的受试者身上系统和一个管，其一端与气动驱动器流体连通。压力驱动的驱动器包括基板和驱动板，驱动板在它们之间具有容纳管的区域。气动驱动器的振动在管中产生压力波，导致驱动器板振动。驾驶员座椅抵靠感兴趣的主题，以在MRE检查期间向对象施加相应的剪切振荡力。

12. 发明申请

US20140107467A1 System And Method For Improved Efficiency In Magnetic Resonance Elastography 有权
标题翻译：在磁共振弹性成像中提高效率的系统和方法
公开(公告)号：US20140107467A1
公开(公告)日：2014-04-17
申请号：US14049632
申请日：2013-10-09
申请人： Joel P. Felmlee , Richard L. Ehman , Matthew C. Murphy
发明人： Joel P. Felmlee , Richard L. Ehman , Matthew C. Murphy
IPC分类号： G01R33/48 , A61B5/055 , A61B5/00 , A61B8/08
CPC分类号： G01R33/4814 , A61B5/0035 , A61B5/055 , A61B5/725 , A61B5/7278 , A61B8/485 , G01R33/56358
摘要： A system and method for generating a magnetic resonance elastography (MRE) report includes a) acquiring MRE data from a subject including positively motion encoded medical imaging data and negatively motion encoded medical imaging data and b) deriving uncorrected difference medical imaging data from the MRE data for a given slice. The method also includes c) filtering the uncorrected difference medical imaging data to create filtered medical imaging data corrected for errors associated with phase ramps occurring during gradient switching used to derive the positively motion encoded medical imaging data and negatively motion encoded medical imaging data, d) generating a corrected difference image for the given slice from the filtered medical imaging data and the uncorrected difference medical imaging data, e) repeating steps b) through d) for each slice reflected in the MRE data, and f) generating a report of elastic properties of the subject from the corrected difference image.
摘要翻译：用于产生磁共振弹性成像（MRE）报告的系统和方法包括：a）从主体获取MRE数据，包括正运动编码的医学成像数据和负运动编码的医学成像数据，以及b）从MRE数据导出未校正的差分医学成像数据对于给定的切片。该方法还包括：c）对未校正的差分医学成像数据进行滤波，以产生针对与用于导出正运动编码的医学成像数据和负运动编码的医学成像数据的梯形切换期间发生的相位斜坡相关的误差校正的滤波的医学成像数据，d）从经滤波的医学成像数据和未校正的差分医学成像数据生成针对给定切片的校正差分图像，e）对在MRE数据中反映的每个切片重复步骤b）至d），以及f）生成弹性特性报告从修正后的差分图像中获取。

13. 发明授权

US4715383A Method for reducing artifacts in NMR images 失效
标题翻译：减少核磁共振图像中伪像的方法
公开(公告)号：US4715383A
公开(公告)日：1987-12-29
申请号：US928504
申请日：1986-11-10
申请人： Richard L. Ehman , Joel P. Felmlee
发明人： Richard L. Ehman , Joel P. Felmlee
IPC分类号： G01R33/483 , G01R33/561 , G01R33/565 , G01R33/567 , A61B5/05
CPC分类号： G01R33/56509 , G01R33/561 , G01R33/4838 , G01R33/56545
摘要： A method for eliminating flow, motion and aliasing artifacts includes a series of saturation pulse sequences which are interleaved with the NMR pulse sequences used to acquire the data needed to reconstruct the desired image. Whereas, the NMR pulse sequences extract data from the volume of interest to be imaged, the saturation pulse sequences excite and saturate spins in the adjacent regions.
摘要翻译：用于消除流动，运动和混叠伪像的方法包括一系列饱和脉冲序列，其与用于获取重建所需图像所需的数据的NMR脉冲序列交错。然而，NMR脉冲序列从要成像的感兴趣体积中提取数据，饱和脉冲序列激发并使相邻区域中的自旋饱和。

14. 发明授权

US6037774A Inertial driver device for MR elastography 失效
标题翻译：用于MR弹性成像的惯性驱动装置
公开(公告)号：US6037774A
公开(公告)日：2000-03-14
申请号：US57405
申请日：1998-04-08
申请人： Joel P. Felmlee , Richard L. Ehman
发明人： Joel P. Felmlee , Richard L. Ehman
IPC分类号： A61B5/055 , G01R33/28 , G01R33/563 , G01V3/00
CPC分类号： G01R33/56358 , A61B5/0051 , A61B5/055 , A61B5/407 , G01R33/563
摘要： Devices for producing an oscillatory shear stress within an object positioned in a polarizing magnetic field of an NMR imaging system are used to perform MR elastography. In one embodiment shear stress is produced within the brain by vibrating the entire skull with a transducer that is gripped by the patient's teeth.
摘要翻译：用于在位于NMR成像系统的偏振磁场内的物体内产生振荡剪切应力的装置用于执行MR弹性成像。在一个实施例中，通过用患者的牙齿夹住的换能器振动整个头骨，在脑内产生剪切应力。

15. 发明授权

US4968935A Selective rephasing of NMR signals to suppress motion artifacts 失效
标题翻译： NMR信号的选择性重新定位以抑制运动伪影
公开(公告)号：US4968935A
公开(公告)日：1990-11-06
申请号：US405892
申请日：1989-09-11
申请人： Richard L. Ehman , Joel P. Felmlee
发明人： Richard L. Ehman , Joel P. Felmlee
IPC分类号： G01R33/567
CPC分类号： G01R33/56509
摘要： Motion artifacts are selectively suppressed in an image by correcting only the NMR data in the central views. The peripheral views are not corrected with the result that motion artifacts produced by large objects in the image are suppressed while motion artifacts produced by small objects are not. Consequently, the interior of small blood vessels remain darker in the reconstructed image.
摘要翻译：通过仅校正中央视图中的NMR数据，在图像中选择性地抑制运动伪像。周边视图不被校正，结果是由图像中的大对象产生的运动伪影被抑制，而由小对象产生的运动伪影不是。因此，重建图像中小血管内部保持较暗。

16. 发明授权

US4937526A Adaptive method for reducing motion and flow artifacts in NMR images 失效
标题翻译：用于减少NMR图像中的运动和流动伪影的自适应方法
公开(公告)号：US4937526A
公开(公告)日：1990-06-26
申请号：US365632
申请日：1989-06-13
申请人： Richard L. Ehman , Joel P. Felmlee
发明人： Richard L. Ehman , Joel P. Felmlee
IPC分类号： A61B5/055 , G01R33/48 , G01R33/54 , G01R33/567
CPC分类号： G01R33/5676
摘要： An NMR data set which is acquired with applied phase encoding and read-out gradients is corrected to reduce motion artifacts and increase image sharpness. The acquired NMR data set is examined to detect bulk displacements of the object being imaged and phase displacements caused by motion. This information is employed to produce correction operators which are applied to the NMR image data set. One or more navigator signals may also be acquired during the scan to produce an NMR data set from which the corrective operators can more readily be derived.
摘要翻译：校正采用施加的相位编码和读出梯度获得的NMR数据集，以减少运动伪影并增加图像清晰度。检查获取的NMR数据集以检测被成像物体的体积位移和由运动引起的相位位移。该信息用于产生应用于NMR图像数据集的校正算子。也可以在扫描期间获取一个或多个导航信号以产生NMR数据集，校正操作者可从该数据集更容易地导出。

17. 发明授权

US09134393B2 System and method for improved efficiency in magnetic resonance elastography 有权
标题翻译：提高磁共振弹性成像效率的系统和方法
公开(公告)号：US09134393B2
公开(公告)日：2015-09-15
申请号：US14049632
申请日：2013-10-09
申请人： Joel P. Felmlee , Richard L. Ehman , Matthew C. Murphy
发明人： Joel P. Felmlee , Richard L. Ehman , Matthew C. Murphy
IPC分类号： A61B5/055 , G01R33/48 , A61B8/08 , A61B5/00 , G01R33/563
CPC分类号： G01R33/4814 , A61B5/0035 , A61B5/055 , A61B5/725 , A61B5/7278 , A61B8/485 , G01R33/56358
摘要： A system and method for generating a magnetic resonance elastography (MRE) report includes a) acquiring MRE data from a subject including positively motion encoded medical imaging data and negatively motion encoded medical imaging data and b) deriving uncorrected difference medical imaging data from the MRE data for a given slice. The method also includes c) filtering the uncorrected difference medical imaging data to create filtered medical imaging data corrected for errors associated with phase ramps occurring during gradient switching used to derive the positively motion encoded medical imaging data and negatively motion encoded medical imaging data, d) generating a corrected difference image for the given slice from the filtered medical imaging data and the uncorrected difference medical imaging data, e) repeating steps b) through d) for each slice reflected in the MRE data, and f) generating a report of elastic properties of the subject from the corrected difference image.
摘要翻译：用于产生磁共振弹性成像（MRE）报告的系统和方法包括：a）从主体获取MRE数据，包括正运动编码的医学成像数据和负运动编码的医学成像数据，以及b）从MRE数据导出未校正的差分医学成像数据对于给定的切片。该方法还包括：c）对未校正的差分医学成像数据进行滤波，以产生针对与用于导出正运动编码的医学成像数据和负运动编码的医学成像数据的梯形切换期间发生的相位斜坡相关的误差校正的滤波的医学成像数据，d）从经滤波的医学成像数据和未校正的差分医学成像数据生成针对给定切片的校正差分图像，e）对在MRE数据中反映的每个切片重复步骤b）至d），以及f）生成弹性特性报告从修正后的差分图像中获取。

18. 发明授权

US08727998B2 Portal vein pressure measurement using elastography 有权
标题翻译：门静脉压力测量使用弹性成像
公开(公告)号：US08727998B2
公开(公告)日：2014-05-20
申请号：US12599721
申请日：2008-05-15
申请人： Meng Yin , Jayant A. Talwalkar , Anthony J. Romano , Armando Manduca , Richard L. Ehman
发明人： Meng Yin , Jayant A. Talwalkar , Anthony J. Romano , Armando Manduca , Richard L. Ehman
IPC分类号： A61B5/02
CPC分类号： A61B5/055 , A61B5/416 , A61B8/08 , A61B8/485
摘要： The shear stiffness of a subject's spleen is measured using elastography techniques such as ultrasound elastography or a magnetic resonance elastography (MRE) acquisition with an MRI system. A relationship between splenic shear stiffness and portal venous blood pressure is modeled and is used to calculate portal venous blood pressure non-invasively from the measured splenic shear stiffness.
摘要翻译：使用弹性成像技术测量受试者脾脏的剪切刚度，例如使用MRI系统进行超声弹性成像或磁共振弹性成像（MRE）采集。模拟了剪切刚度和门静脉血压之间的关系，并用于从测量的脾剪切刚度非侵入地计算门静脉血压。

19. 发明授权

US06329819B1 Autocorrection of MR images for motion artifacts 有权
标题翻译：用于运动伪像的MR图像的自动校正
公开(公告)号：US06329819B1
公开(公告)日：2001-12-11
申请号：US09673489
申请日：2000-10-16
申请人： Armando Manduca , Richard L. Ehman
发明人： Armando Manduca , Richard L. Ehman
IPC分类号： G01V300
CPC分类号： G06T11/008 , G06T2211/412 , G06T2211/424
摘要： An MRI image is corrected for motion artifacts using an iterative, autocorrection process in which corrections are tried and the quality of the resulting reconstructed image is measured. Metrics based on the gradient of the reconstructed image are employed to measure image quality.
摘要翻译：使用迭代自动校正过程来校正MRI图像，以进行修正，并测量所得到的重建图像的质量。采用基于重建图像的梯度的度量来测量图像质量。

20. 发明申请

US20100241012A1 Portal Vein Pressure Measurement Using Elastography 有权
标题翻译：门静脉压力测量使用弹性成像
公开(公告)号：US20100241012A1
公开(公告)日：2010-09-23
申请号：US12599721
申请日：2008-05-15
申请人： Meng Yin , Jayant A. Talwalkar , Anthony J. Romano , Armando Manduca , Richard L. Ehman
发明人： Meng Yin , Jayant A. Talwalkar , Anthony J. Romano , Armando Manduca , Richard L. Ehman
IPC分类号： A61B5/021
CPC分类号： A61B5/055 , A61B5/416 , A61B8/08 , A61B8/485
摘要： The shear stiffness of a subject's spleen is measured using elastography techniques such as ultrasound elastography or a magnetic resonance elastography (MRE) acquisition with an MRI system. A relationship between splenic shear stiffness and portal venous blood pressure is modeled and is used to calculate portal venous blood pressure non-invasively from the measured splenic shear stiffness.
摘要翻译：使用弹性成像技术测量受试者脾脏的剪切刚度，例如使用MRI系统进行超声弹性成像或磁共振弹性成像（MRE）采集。模拟了剪切刚度和门静脉血压之间的关系，并用于从测量的脾剪切刚度非侵入地计算门静脉血压。

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