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11. 发明授权

US08759396B2 Use of aminolevulinic acid and derivatives thereof 有权
标题翻译：氨基乙酰丙酸及其衍生物的应用
公开(公告)号：US08759396B2
公开(公告)日：2014-06-24
申请号：US12523048
申请日：2008-01-11
申请人： Hans Christian Wulf , Aslak Godal , Jo Klaveness
发明人： Hans Christian Wulf , Aslak Godal , Jo Klaveness
IPC分类号： A01N37/12 , A61N1/30
CPC分类号： A61K41/0061 , A61K31/221 , A61N5/062
摘要： The invention provides the use of a photosensitizer which is 5-aminolevulinic acid (5-ALA) or a derivative (e.g. an ester) of 5-ALA, or a pharmaceutically acceptable salt thereof, in the manufacture of a composition for use in methods of photodynamic therapy (PDT) on an animal, wherein said PDT comprises: (a) administering to said animal a composition comprising said photosensitizer; and (b) photoactivating said photosensitizer, and wherein side-effects (e.g. pain and/or erythema) of said PDT are prevented or reduced by use of one or more of (i)-(iv): (i) said composition comprises said photosensitizer in a concentration of less than 10% wt (e.g. 0.5 to 8% wt), (ii) said composition is administered for less than 2 hours (e.g. 30 minutes to 90 minutes) prior to said photoactivation, (iii) said photoactivation is carried out with a light source having a fluence rate of less than 50 mW/cm2 (e.g. 5 to 40 mW/cm2), (iv) said photoactivation is carried out with sunlight. Preferably, side-effects of PDT are prevented or reduced by using (iii) or (iv) in combination with (i) and/or (ii).
摘要翻译：本发明提供了5-氨基乙酰丙酸（5-ALA）或5-ALA衍生物（例如酯）或其药学上可接受的盐的光敏剂在制备用于光动力疗法（PDT），其中所述PDT包括：（a）向所述动物施用包含所述光敏剂的组合物; 和（b）光活化所述光敏剂，并且其中通过使用（i） - （iv）中的一种或多种来防止或减少所述PDT的副作用（例如疼痛和/或红斑）：（i）所述组合物包含浓度小于10％wt（例如0.5至8％wt）的光敏剂，（ii）所述组合物在所述光活化之前施用少于2小时（例如30分钟至90分钟），（iii）所述光活化是用光通量小于50mW / cm2（例如5〜40mW / cm2）的光源进行，（iv）所述的光活化是在太阳光下进行的。优选地，通过使用（iii）或（iv）与（i）和/或（ii）组合来防止或减少PDT的副作用。

12. 发明申请

US20050002865A1 Diagnostic/therapeutic agents 审中-公开
标题翻译：诊断/治疗剂
公开(公告)号：US20050002865A1
公开(公告)日：2005-01-06
申请号：US10734730
申请日：2003-12-15
申请人： Jo Klaveness , Pal Rongved , Anders Hogset , Helge Tolleshaug , Alan Cuthbertson , Aslak Godal , Lars Hoff , Geir Gogstad , Klaus Bryn , Anne Naevestad , Dagfinn Lovhaug , Halldis Hellebust , Magne Solbakken
发明人： Jo Klaveness , Pal Rongved , Anders Hogset , Helge Tolleshaug , Alan Cuthbertson , Aslak Godal , Lars Hoff , Geir Gogstad , Klaus Bryn , Anne Naevestad , Dagfinn Lovhaug , Halldis Hellebust , Magne Solbakken
IPC分类号： A61K47/48 , A61K49/00 , A61K49/08 , A61K49/18 , A61K49/22 , A61K51/04 , A61K51/08 , A61K51/12
CPC分类号： A61K51/1255 , A61K47/542 , A61K47/62 , A61K47/6925 , A61K49/0002 , A61K49/0043 , A61K49/0047 , A61K49/0054 , A61K49/0056 , A61K49/0058 , A61K49/0091 , A61K49/223 , A61K51/065 , A61K51/1227 , Y10S977/928 , Y10S977/929 , Y10S977/93
摘要： Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.
摘要翻译：靶向诊断和/或治疗活性剂，例如超声造影剂，其包含在包含含气体或气体产生材料的报道分子的含水载体液体中的悬浮液，所述试剂能够与靶形成至少两种结合对。

13. 发明授权

US06680047B2 Diagnostic/therapeutic agents 失效
标题翻译：诊断/治疗剂
公开(公告)号：US06680047B2
公开(公告)日：2004-01-20
申请号：US09925715
申请日：2001-08-10
申请人： Jo Klaveness , Pål Rongved , Anders Høgset , Helge Tolleshaug , Alan Cuthbertson , Aslak Godal , Lars Hoff , Geir Gogstad , Klaus Bryn , Anne Nævestad , Dagfinn Løvhaug , Halldis Hellebust , Magne Solbakken
发明人： Jo Klaveness , Pål Rongved , Anders Høgset , Helge Tolleshaug , Alan Cuthbertson , Aslak Godal , Lars Hoff , Geir Gogstad , Klaus Bryn , Anne Nævestad , Dagfinn Løvhaug , Halldis Hellebust , Magne Solbakken
IPC分类号： A61B800
CPC分类号： A61K51/1255 , A61K47/542 , A61K47/62 , A61K47/6925 , A61K49/0002 , A61K49/0043 , A61K49/0047 , A61K49/0054 , A61K49/0056 , A61K49/0058 , A61K49/0091 , A61K49/223 , A61K51/065 , A61K51/1227 , Y10S977/928 , Y10S977/929 , Y10S977/93
摘要： Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.
摘要翻译：靶向诊断和/或治疗活性剂，例如超声造影剂，其包含在包含含气体或气体产生材料的报道分子的含水载体液体中的悬浮液，所述试剂能够与靶形成至少两种结合对。

14. 发明申请

US20110293528A1 ENEMA PREPARATIONS AND THEIR USE 审中-公开
标题翻译： ENEMA制剂及其使用
公开(公告)号：US20110293528A1
公开(公告)日：2011-12-01
申请号：US13141919
申请日：2009-12-23
申请人： Aslak Godal , Jo Klaveness
发明人： Aslak Godal , Jo Klaveness
IPC分类号： A61K49/06 , A61K31/221 , A61K49/04 , A61P1/00 , A61P1/04 , A61P31/00 , A61K31/197 , A61P35/00
CPC分类号： A61K9/0031 , A61K41/0061 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/18 , A61K47/20 , A61K47/34 , A61K47/38
摘要： This invention relates to improved methods of photodynamic treatment and diagnosis of cancer and non-cancerous conditions, and in particular to improved enema preparations for use in such methods, said enema preparations comprising a photosensitiser which is 5-aminolevulinic acid (5-ALA) or a precursor or derivative thereof, e.g. a 5-ALA ester. Such preparations may further comprise one or more viscosity enhancing agents, mucoadhesive or mucolytic agents, penetration enhancers or chelating agents. The methods and preparations herein described are particularly suitable for use in photodynamic methods of treating and/or diagnosing cancer and non-cancerous conditions in the colon and/or rectum.
摘要翻译：本发明涉及光动力学治疗和诊断癌症和非癌症病症的改进方法，特别是涉及用于这些方法的改善的灌肠剂制剂，所述灌肠制剂包含5-氨基乙酰丙酸（5-ALA）的光敏剂或其前体或衍生物，例如一种5-ALA酯。这样的制剂还可以包含一种或多种粘度增强剂，粘膜粘附或粘液溶解剂，渗透增强剂或螯合剂。本文所述的方法和制剂特别适用于治疗和/或诊断结肠和/或直肠癌和非癌症病症的光动力学方法。

15. 发明申请

US20080188558A1 Treatment of Acne Using Derivatives of 5-Aminolevulinic Acid 审中-公开
标题翻译：使用5-氨基乙酰丙酸衍生物治疗痤疮
公开(公告)号：US20080188558A1
公开(公告)日：2008-08-07
申请号：US11667504
申请日：2005-11-04
申请人： Aslak Godal , Jo Klaveness , Hilde Morris
发明人： Aslak Godal , Jo Klaveness , Hilde Morris
IPC分类号： A61K31/215 , A61K31/19 , A61P17/10
CPC分类号： A61N5/0616 , A61K31/197 , A61K41/0061
摘要： The invention provides use of a photosensitiser, which is a derivative (e.g. an ester) of 5-aminolevulinic acid (5-ALA) or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for use in the prevention or treatment of acne.
摘要翻译：本发明提供了在制备用于预防或治疗痤疮的药物中使用作为5-氨基乙酰丙酸（5-ALA）的衍生物（例如酯）或其药学上可接受的盐的光敏剂的用途。

16. 发明申请

US20130211215A1 HYPEROSMOTIC PREPARATIONS COMPRISING 5-AMINOLEVULINIC ACID OR DERIVATIVE AS PHOTOSENSITIZING AGENT 审中-公开
标题翻译：包含5-氨基酸或衍生物作为光敏剂的高效制剂
公开(公告)号：US20130211215A1
公开(公告)日：2013-08-15
申请号：US13806578
申请日：2011-06-23
申请人： Inger Ferner Heglund , Aslak Godal , Jo Klaveness
发明人： Inger Ferner Heglund , Aslak Godal , Jo Klaveness
IPC分类号： A61K41/00 , A61B5/00
CPC分类号： A61K41/0061 , A61B5/0071 , A61B5/0084 , A61K9/0031 , A61K47/10 , A61K47/26
摘要： Provided herein are improved methods of photodynamic treatment and diagnosis of cancer and non-cancerous conditions in the gastrointestinal tract, e.g. in the colon, and in particular hyperosmotic enema preparations for use in such methods. The enema preparations comprise a photosensitizer which is 5-aminolevulinic acid (5-ALA) or a precursor or derivative thereof, e.g. a 5-ALA ester, in combination with at least one hyperosmotic agent. The methods and preparations herein described are particularly suitable for use in photodynamic methods of treating and/or diagnosing colorectal cancer.
摘要翻译：本文提供了光动力学治疗和诊断胃肠道中的癌症和非癌性病症的改进方法，例如。在结肠中，特别是用于这些方法的高渗灌肠剂。灌肠制剂包含5-氨基乙酰丙酸（5-ALA）或其前体或衍生物的光敏剂，例如5-氨基乙酰丙酸。 5-ALA酯，与至少一种高渗剂组合。本文描述的方法和制剂特别适用于治疗和/或诊断结肠直肠癌的光动力学方法。

17. 发明申请

US20100137439A1 USE OF AMINOLEVULINIC ACID AND DERIVATIVES THEREOF 有权
标题翻译：氨基酸及其衍生物的使用
公开(公告)号：US20100137439A1
公开(公告)日：2010-06-03
申请号：US12523048
申请日：2008-01-11
申请人： Hans Christian Wulf , Aslak Godal , Jo Klaveness
发明人： Hans Christian Wulf , Aslak Godal , Jo Klaveness
IPC分类号： A61K31/195 , A61P35/00
CPC分类号： A61K41/0061 , A61K31/221 , A61N5/062
摘要： The invention provides the use of a photosensitiser which is 5-aminolevulinic acid (5-ALA) or a derivative (e.g. an ester) of 5-ALA, or a pharmaceutically acceptable salt thereof, in the manufacture of a composition for use in methods of photodynamic therapy (PDT) on an animal, wherein said PDT comprises: (a) administering to said animal a composition comprising said photosensitiser; and (b) photoactivating said photosensitiser, and wherein side-effects (e.g. pain and/or erythema) of said PDT are prevented or reduced by use of one or more of (i)-(iv): (i) said composition comprises said photosensitiser in a concentration of less than 10% wt (e.g. 0.5 to 8% wt), (ii) said composition is administered for less than 2 hours (e.g. 30 minutes to 90 minutes) prior to said photoactivation, (iii) said photoactivation is carried out with a light source having a fluence rate of less than 50 mW/cm2 (e.g. 5 to 40 mW/cm2), (iv) said photoactivation is carried out with sunlight. Preferably, side-effects of PDT are prevented or reduced by using (iii) or (iv) in combination with (i) and/or (ii).
摘要翻译：本发明提供了5-氨基乙酰丙酸（5-ALA）或5-ALA衍生物（例如酯）或其药学上可接受的盐的光敏剂在制备用于光动力疗法（PDT），其中所述PDT包括：（a）向所述动物施用包含所述光敏剂的组合物; 和（b）光活化所述光敏剂，并且其中通过使用（i） - （iv）中的一种或多种来防止或减少所述PDT的副作用（例如疼痛和/或红斑）：（i）所述组合物包含浓度小于10％wt（例如0.5至8％wt）的光敏剂，（ii）所述组合物在所述光活化前施用少于2小时（例如30分钟至90分钟），（iii）所述光活化是用光通量小于50mW / cm2（例如5〜40mW / cm2）的光源进行，（iv）所述的光活化是在太阳光下进行的。优选地，通过使用（iii）或（iv）与（i）和/或（ii）组合来防止或减少PDT的副作用。

18. 发明授权

US08992954B2 Compositions comprising a derivative of 5-aminolevulinic acid 有权
标题翻译：包含5-氨基乙酰丙酸衍生物的组合物
公开(公告)号：US08992954B2
公开(公告)日：2015-03-31
申请号：US13038305
申请日：2011-03-01
申请人： Oddveig Sellæg Helland , Stig Ove Johnsen , Enrique Alabata , Anja J. Jentoft , Aslak Godal
发明人： Oddveig Sellæg Helland , Stig Ove Johnsen , Enrique Alabata , Anja J. Jentoft , Aslak Godal
IPC分类号： A61K8/02 , A61K9/00 , A61K31/19 , A61K8/44 , A61K8/06 , A61K8/92 , A61Q17/04 , A61Q19/08
CPC分类号： A61K8/44 , A61K8/06 , A61K8/92 , A61K2800/522 , A61K2800/88 , A61Q17/04 , A61Q19/08
摘要： The present invention relates to compositions comprising a derivative of 5-aminolevulinic acid (5-ALA), e.g. an ester of 5-ALA or a skin compatible salt thereof. Further, the invention relates to use of such compositions in methods of cosmetic treatment, particularly in methods of improving or otherwise enhancing the appearance of the skin.
摘要翻译：本发明涉及包含5-氨基乙酰丙酸（5-ALA）衍生物的组合物，例如 5-ALA的酯或其与皮肤相容的盐。此外，本发明涉及这种组合物在美容治疗方法中的用途，特别是在改善或以其它方式增强皮肤外观的方法中。

19. 发明申请

US20070036722A1 Separation processes 审中-公开
标题翻译：分离过程
公开(公告)号：US20070036722A1
公开(公告)日：2007-02-15
申请号：US11498651
申请日：2006-08-03
申请人： Pal Rongved , Dagfinn Loevhaug , Hege Fjerdingstad , Magne Solbakken , Aslak Godal , Alan Cuthbertson
发明人： Pal Rongved , Dagfinn Loevhaug , Hege Fjerdingstad , Magne Solbakken , Aslak Godal , Alan Cuthbertson
IPC分类号： A61K49/00 , C12Q1/70 , C12Q1/68 , G01N33/574 , A61K39/395 , A61K39/42 , A61M31/00
CPC分类号： G01N33/5306 , G01N33/5432
摘要： Separation of target material from a liquid sample is achieved by coupling the target to targetable encapsulated gas microbubbles, allowing the microbubbles and coupled target to float to the surface of the sample to form a floating microbubble/target layer, and separating this layer from the sample. In a positive separation process the microbubbles are then removed from the target, e.g. by bursting. In a negative separation process target-free sample material is recovered following separation of the floating layer. The method may also be used diagnostically to detect the presence of a disease marker in a sample. Novel separation apparatus is also described.
摘要翻译：目标材料与液体样品的分离是通过将目标物与可靶向包封的气体微泡耦合来实现的，允许微泡和偶联的目标物漂浮到样品表面以形成浮动微泡/目标层，并将该层与样品分离。在正分离过程中，然后从目标物中除去微泡。通过爆裂。在负分离过程中，在浮选层分离后回收无目标样品材料。该方法也可以在诊断上用于检测样品中疾病标志物的存在。还描述了新颖的分离装置。

20. 发明授权

US06806045B2 Method for the identification of a receptor 失效
标题翻译：识别受体的方法
公开(公告)号：US06806045B2
公开(公告)日：2004-10-19
申请号：US10052299
申请日：2002-01-18
申请人： Mari Ann Kulseth , Dagfinn Lovhaug , Aslak Godal
发明人： Mari Ann Kulseth , Dagfinn Lovhaug , Aslak Godal
IPC分类号： C12Q170
CPC分类号： C12N15/1082 , C12N15/1034 , G01N33/5005 , G01N33/566
摘要： A method for the identification and characterization of a receptor in target tissue for which a selected vector has affinity, wherein a transfected cell line expressing the receptor is added to a suspension of encapsulated microbubbles to which the selected vector is coupled and allowing the microbubbles and cells coupled thereto to float to the surface of the suspension. Upon isolating the microbubble-bound cells at the surface, these may be cultured to study the receptor, or cells may be lysed, amplifying the receptor-encoding cDNA and sequencing the cDNA.
摘要翻译：用于鉴定和表征所选载体具有亲和力的靶组织中的受体的方法，其中将表达受体的转染细胞系加入到所选载体偶联的包封的微泡的悬浮液中，并允许微泡和细胞联接到其上以漂浮到悬架的表面。在分离表面的微泡结合细胞时，可以培养这些细胞以研究受体，或者可以裂解细胞，扩增受体编码的cDNA并测序cDNA。

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