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11. 发明申请

US20160304555A1 PSMA Imaging Agents 有权
标题翻译： PSMA成像剂
公开(公告)号：US20160304555A1
公开(公告)日：2016-10-20
申请号：US14917127
申请日：2012-08-21
申请人： Eric WANG , Hartmuth C. KOLB , Anna Katrin INGS , Changhui LIU , Joseph C. WALSH , Gang CHEN , Anjana SINHA , Dhanalakshmi KASI , Chul YU , Umesh B. GANGADHARMATH , Wei ZHANG , Tieming ZHAO , Vani P. MOCHARLA
发明人： Eric Wang , Hartmuth C. Kolb , Anna Katrin Szardenings , Changhui Liu , Joseph C. Walsh , Gang Chen , Anjana Sinha , Dhanalakshmi Kasi , Chul Yu , Umesh B. Gangadharmath , Wei Zhang , Tieming Zhao , Vani P. Mocharla
IPC分类号： C07K5/02 , A61K51/04 , A61K51/08 , C07D249/06 , C07D249/04
CPC分类号： C07K5/0215 , A61K38/00 , A61K51/0453 , A61K51/088 , C07D207/16 , C07D209/48 , C07D213/81 , C07D213/82 , C07D233/78 , C07D233/96 , C07D239/60 , C07D249/04 , C07D249/06 , C07D251/30 , C07D263/34 , C07D277/56 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07K5/06026 , C07K5/06113
摘要： Compounds for targeting and agents for imaging, Prostate-specific membrane antigen (PSMA) are disclosed. Methods of synthesizing compounds and imaging agents, as well as methods for imaging PSMA are also disclosed. The imaging agents disclosed are suitable for PET and SPECT imaging.
摘要翻译：公开了靶向化合物和成像剂，前列腺特异性膜抗原（PSMA）。还公开了合成化合物和成像剂的方法以及PSMA成像方法。所公开的成像剂适用于PET和SPECT成像。

12. 发明授权

US09002333B1 Mobile device reputation system 有权
标题翻译：移动设备信誉系统
公开(公告)号：US09002333B1
公开(公告)日：2015-04-07
申请号：US12189580
申请日：2008-08-11
申请人： Ning Tong , Gang Chen
发明人： Ning Tong , Gang Chen
IPC分类号： H04M3/42
CPC分类号： H04M3/4211 , H04L63/126 , H04L65/1079 , H04L65/1096 , H04M3/436 , H04W12/12
摘要： A reputation system aids in the prevention of unwanted spam or malicious communications from being sent to a mobile device, such as a cell phone. A collaborative process is used to determine ratings for a collection of source identifications of the communications. The source identifications are caller identifications (IDs) of a corresponding voice or SMS communication. A collection of opinions is maintained regarding the caller IDs. The reputation system then uses a method of making automatic predictions about the caller IDs by collecting caller ID information from many users to populate the database of maintained opinions. As such, caller IDs of users who have sent spam or malicious messages can be blocked by using collaborative information from many users, as opposed to relying on individual users to block unwanted communications.
摘要翻译：信誉系统有助于防止不想要的垃圾邮件或恶意通信被发送到诸如手机的移动设备。协作过程用于确定通信的源标识集合的等级。源标识是对应的语音或SMS通信的呼叫者标识（ID）。维护有关呼叫者ID的意见集。信誉系统然后使用通过从许多用户收集呼叫者ID信息来填充维护意见的数据库来对呼叫者ID进行自动预测的方法。因此，通过使用来自许多用户的协作信息，可以阻止发送垃圾邮件或恶意邮件的用户的呼叫者ID，而不是依赖于个人用户来阻止不必要的通信。

13. 发明申请

US20140049240A1 MULTI-PHASE POWER SUPPLY CONTROLLER AND METHOD THEREFOR 有权
标题翻译：多相电源控制器及其方法
公开(公告)号：US20140049240A1
公开(公告)日：2014-02-20
申请号：US13958429
申请日：2013-08-02
申请人： Gang Chen , Gabor Reizik , Paul J. Harriman , KISUN LEE
发明人： Gang Chen , Gabor Reizik , Paul J. Harriman , KISUN LEE
IPC分类号： G05F1/10
CPC分类号： G05F1/10 , H02M3/156 , H02M3/158 , H02M3/1588 , H02M2001/0032 , H02M2003/1586 , Y02B70/1466 , Y02B70/16
摘要： In one embodiment, a method of forming a multi-channel power supply controller includes forming a plurality of channels configured to regulate an output voltage between first and second values, configuring the controller to select a channel that has a lowest current value and initiate forming a drive signal for that channel responsively to the output voltage having a value that is less than the first value, configuring a reset circuit for each channel to terminate the respective drive signal responsively to at least the output voltage having a value greater than the first value.
摘要翻译：在一个实施例中，形成多通道电源控制器的方法包括形成多个通道，其配置成调节第一和第二值之间的输出电压，配置控制器以选择具有最低电流值的通道，并启动形成响应于具有小于第一值的值的输出电压的该通道的驱动信号，配置每个通道的复位电路以响应于至少具有大于第一值的值的输出电压终止相应的驱动信号。

14. 发明申请

US20140048897A1 PIXEL WITH NEGATIVELY-CHARGED SHALLOW TRENCH ISOLATION (STI) LINER 审中-公开
标题翻译： PIXEL带负电荷的浅层隔离（STI）衬垫
公开(公告)号：US20140048897A1
公开(公告)日：2014-02-20
申请号：US13587811
申请日：2012-08-16
申请人： Yin Qian , Hsin-Chih Tai , Gang Chen , Duli Mao , Vincent Venezia , Howard E. Rhodes
发明人： Yin Qian , Hsin-Chih Tai , Gang Chen , Duli Mao , Vincent Venezia , Howard E. Rhodes
IPC分类号： H01L31/02 , H01L31/18
CPC分类号： H01L27/1463 , H01L27/14689
摘要： Embodiments of a pixel including a substrate having a front surface and a photosensitive region formed in or near the front surface of the substrate. An isolation trench is formed in the front surface of the substrate adjacent to the photosensitive region. The isolation trench includes a trench having a bottom and sidewalls, a passivation layer formed on the bottom and the sidewalls, and a filler to fill the portion of the trench not filled by the passivation layer.
摘要翻译：包括具有形成在基板的表面中或附近的前表面和感光区域的基板的像素的实施例。在与感光区域相邻的基板的前表面中形成隔离沟槽。隔离沟槽包括具有底部和侧壁的沟槽，形成在底部和侧壁上的钝化层，以及用于填充未被钝化层填充的沟槽部分的填料。

15. 发明授权

US08643349B2 Power supply controller and method 有权
标题翻译：电源控制器及方法
公开(公告)号：US08643349B2
公开(公告)日：2014-02-04
申请号：US12614532
申请日：2009-11-09
申请人： Gang Chen , Xin Zhang , Weiyun Chen
发明人： Gang Chen , Xin Zhang , Weiyun Chen
IPC分类号： G05F1/00
CPC分类号： H02M3/156
摘要： A power supply controller and method for improving the transient response of the power supply controller. The power supply controller includes a pulse width modulation control module connected to a feedback network. The feedback network is composed of an amplifier having an inverting input terminal, a non-inverting input terminal, and an output terminal. A compensation network is coupled between the inverting input terminal and the output terminal of the amplifier and a reference voltage is coupled to the non-inverting input terminal of the amplifier. A switch is coupled between the output terminal of the amplifier and an input terminal of the compensation network. The transient response of the controller is improved by operating the controller in a closed loop compensation configuration during a continuously pulsing operating mode and in an open loop compensation configuration during a pulse skip operating mode.
摘要翻译：一种用于改善电源控制器的瞬态响应的电源控制器和方法。电源控制器包括连接到反馈网络的脉宽调制控制模块。反馈网络由具有反相输入端子，非反相输入端子和输出端子的放大器组成。补偿网络耦合在反相输入端和放大器的输出端之间，参考电压耦合到放大器的非反相输入端。开关耦合在放大器的输出端和补偿网络的输入端之间。通过在脉冲跳过操作模式期间在连续脉冲操作模式和开环补偿配置期间操作控制器处于闭环补偿配置来改善控制器的瞬态响应。

16. 发明授权

US08643132B2 In-pixel high dynamic range imaging 有权
标题翻译：像素高动态范围成像
公开(公告)号：US08643132B2
公开(公告)日：2014-02-04
申请号：US13155969
申请日：2011-06-08
申请人： Gang Chen , Duli Mao , Hsin-Chih Tai , Howard E. Rhodes
发明人： Gang Chen , Duli Mao , Hsin-Chih Tai , Howard E. Rhodes
IPC分类号： H01L31/06 , H01L31/062 , H01L31/113
CPC分类号： H01L27/14616 , H01L27/14612 , H01L27/14643
摘要： Embodiments of the invention describe providing high dynamic range imaging (HDRI or simply HDR) to an imaging pixel by coupling a floating diffusion node of the imaging pixel to a plurality of metal-oxide semiconductor (MOS) capacitance regions. It is understood that a MOS capacitance region only turns “on” (i.e., changes the overall capacitance of the floating diffusion node) when the voltage at the floating diffusion node (or a voltage difference between a gate node and the floating diffusion node) is greater than its threshold voltage; before the MOS capacitance region is “on” it does not contribute to the overall capacitance or conversion gain of the floating diffusion node.Each of the MOS capacitance regions will have different threshold voltages, thereby turning “on” at different illumination conditions. This increases the dynamic range of the imaging pixel, thereby providing HDR for the host imaging system.
摘要翻译：本发明的实施例描述了通过将成像像素的浮动扩散节点耦合到多个金属氧化物半导体（MOS）电容区域来向成像像素提供高动态范围成像（HDRI或简单的HDR）。可以理解，当浮动扩散节点处的电压（或者栅极节点和浮动扩散节点之间的电压差）为（...）时，MOS电容区域只会变为“导通”（即，改变浮动扩散节点的整体电容）大于其阈值电压; 在MOS电容区域“接通”之前，它不会对浮动扩散节点的整体电容或转换增益有贡献。每个MOS电容区域将具有不同的阈值电压，从而在不同的照明条件下“打开”。这增加了成像像素的动态范围，从而为主机成像系统提供HDR。

17. 发明授权

US08599323B2 Battery low-voltage warning apparatus for auto-darkening filter for welding helmet 有权
标题翻译：用于焊接头盔的自动变暗过滤器的电池低压警告装置
公开(公告)号：US08599323B2
公开(公告)日：2013-12-03
申请号：US12498113
申请日：2009-07-06
申请人： Gang Chen
发明人： Gang Chen
IPC分类号： G02F1/1335
CPC分类号： A61F9/065 , G01R19/16542 , G01R31/3689
摘要： An apparatus for annunciating low-voltage in a battery supplying electricity to an auto-darkening optical filter system (10) for a welding helmet (not shown). Low voltage is annunciated by changing, for example strobing, the opacity of the optical filter system (10).
摘要翻译：一种用于向供给用于焊接头盔（未示出）的自动变暗光学滤光器系统（10）的电池供给电池的低电压的装置。通过改变（例如选通）光学滤波器系统（10）的不透明度来报告低电压。

18. 发明授权

US08568721B2 Method of treating rheumatoid arthritis with an anti-IL-6R antibody 有权
标题翻译：用抗IL-6R抗体治疗类风湿性关节炎的方法
公开(公告)号：US08568721B2
公开(公告)日：2013-10-29
申请号：US13462938
申请日：2012-05-03
申请人： Allen Radin , Sean Stevens , Tammy T. Huang , Joel H. Martin , Jeanette L. Fairhurst , Ashique Rafique , Eric Smith , Kevin J. Pobursky , Nicholas J. Papadopoulos , James P. Fandl , Gang Chen , Margaret Karow
发明人： Allen Radin , Sean Stevens , Tammy T. Huang , Joel H. Martin , Jeanette L. Fairhurst , Ashique Rafique , Eric Smith , Kevin J. Pobursky , Nicholas J. Papadopoulos , James P. Fandl , Gang Chen , Margaret Karow
IPC分类号： A61K39/395
CPC分类号： A61K39/3955 , A61K31/4706 , A61K31/519 , A61K31/655 , A61K38/191 , A61K39/39541 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/248 , C07K16/2866 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , Y10S514/885 , A61K2300/00
摘要： The present invention provides methods of preventing or treating rheumatoid arthritis using a fully human antibody or antigen-binding fragment thereof that specifically binds human interleukin-6 receptor (hIL-6R). The methods of the present invention may include administration of a second therapeutic agent, such as one or more of a non-steroidal anti-inflammatory drug (NSAID), a glucocorticoid, a disease-modifying anti-rheumatic drug (DMARD), or a TNF-alpha antagonist, T-cell blocker, anti-CD20 antibody, an IL-1, JAK or IL-17 antagonist, or any combination thereof.
摘要翻译：本发明提供使用特异性结合人白细胞介素-6受体（hIL-6R）的完全人抗体或其抗原结合片段预防或治疗类风湿性关节炎的方法。本发明的方法可以包括施用第二治疗剂，例如非甾体抗炎药（NSAID），糖皮质激素，疾病缓解性抗风湿药（DMARD）中的一种或多种，或 TNF-α拮抗剂，T细胞阻断剂，抗CD20抗体，IL-1，JAK或IL-17拮抗剂或其任何组合。

19. 发明申请

US20130205035A1 METHOD AND DEVICE FOR NETWORK COMMUNICATIONS 审中-公开
标题翻译：网络通信的方法和设备
公开(公告)号：US20130205035A1
公开(公告)日：2013-08-08
申请号：US13812012
申请日：2011-07-25
申请人： Gang Chen
发明人： Gang Chen
IPC分类号： H04L29/12
CPC分类号： H04L61/251 , H04L61/1511
摘要： The present invention provides a method and a device for network communication. The method comprises the steps of translating, by a terminal, IPv6 information into IPv4 information when receiving the IPv6 information from an IPv6 application, and transmitting an IPv6 application request carrying the IPv4 information; and receiving, by the terminal, an IPv6 application response corresponding to the IPv6 application request. The present invention enables free communication between IPv6 applications and services of the other IP address families within an IPv4 network.
摘要翻译：本发明提供一种网络通信的方法和装置。该方法包括以下步骤：当从IPv6应用接收IPv6信息时，通过终端将IPv6信息转换为IPv4信息，以及发送携带IPv4信息的IPv6应用请求; 以及由所述终端接收对应于所述IPv6应用请求的IPv6应用响应。本发明实现IPv6应用与IPv4网络内的其他IP地址族的业务之间的自由通信。

20. 发明授权

US08486372B2 Cyclic azapeptides as integrin markers and methods of using 有权
标题翻译：循环azapeptides作为整合素标记和使用方法
公开(公告)号：US08486372B2
公开(公告)日：2013-07-16
申请号：US13113580
申请日：2011-05-23
申请人： Hartmuth C. Kolb , Kai Chen , Joseph C. Walsh , Dhanalakshmi Kasi , Vani P. Mocharla , Gang Chen , Qianwa Liang , Tieming Zhao
发明人： Hartmuth C. Kolb , Kai Chen , Joseph C. Walsh , Dhanalakshmi Kasi , Vani P. Mocharla , Gang Chen , Qianwa Liang , Tieming Zhao
IPC分类号： A61B5/055
CPC分类号： A61K51/08 , A61K38/00 , A61K47/60 , A61K51/082 , C07K5/021 , C07K7/54 , C07K7/64
摘要： The present application is directed to radiolabeled cyclic polyazapeptides, pharmaceutical compositions comprising radiolabeled cyclic polyazapeptides, and methods of using the radiolabeled cyclic polyazapeptides. Such polyazapeptides can be used in imaging studies, such as Positron Emitting Tomography (PET) or Single Photon Emission Computed Tomography (SPECT).
摘要翻译：本申请涉及放射性标记的环状多氮杂肽，包含放射性标记的环状多氮杂肽的药物组合物，以及使用放射性标记的环状多氮杂肽的方法。这种多分子肽可用于成像研究，如正电子发射断层扫描（PET）或单光子发射计算机断层扫描（SPECT）。

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