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11. 发明授权

US06329169B1 Nucleic acid molecules encoding cytostatin II 失效
标题翻译：编码细胞抑素II的核酸分子
公开(公告)号：US06329169B1
公开(公告)日：2001-12-11
申请号：US09043646
申请日：1998-09-09
申请人： Jian Ni , Guo-Liang Yu , Reiner L. Gentz
发明人： Jian Ni , Guo-Liang Yu , Reiner L. Gentz
IPC分类号： C12P2102
CPC分类号： G01N33/57415 , A61K38/00 , C07K14/475
摘要： The invention relates to cytostatin II growth modulatory peptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications which are related, in part, to research, diagnostic and clinical arts.
摘要翻译：本发明涉及细胞抑制素II生长调节肽，编码多肽的多核苷酸，特别是通过表达多核苷酸产生多肽的方法，多肽的激动剂和拮抗剂。本发明还涉及利用这些多核苷酸，多肽，激动剂和拮抗剂用于部分与研究，诊断和临床领域有关的应用的方法。

12. 发明授权

US06300477B1 Antibodies to human cystatin E 有权
标题翻译：人类半胱氨酸蛋白酶抑制剂E的抗体
公开(公告)号：US06300477B1
公开(公告)日：2001-10-09
申请号：US09241376
申请日：1999-02-02
申请人： Jian Ni , Reiner L. Gentz , Guo-Liang Yu , Craig A. Rosen
发明人： Jian Ni , Reiner L. Gentz , Guo-Liang Yu , Craig A. Rosen
IPC分类号： C07K1618
CPC分类号： C07K14/8139 , A61K38/00
摘要： Disclosed are antibodies and antibody fragments that bind to novel human CysE polypeptides. Also provided are methods for producing the antibodies. Also disclosed are methods for utilizing such antibodies and antibody fragments for the purification and analysis of CysE polypeptides, as well as the diagnosis and treatment of CysE polypeptide associated diseases.
摘要翻译：公开了结合新的人CysE多肽的抗体和抗体片段。还提供了用于产生抗体的方法。还公开了利用这些抗体和抗体片段来纯化和分析CysE多肽的方法，以及CysE多肽相关疾病的诊断和治疗。

13. 发明授权

US5919658A Human cystatin F 失效
标题翻译：人类半胱氨酸蛋白酶抑制剂F
公开(公告)号：US5919658A
公开(公告)日：1999-07-06
申请号：US832535
申请日：1997-04-03
申请人： Jian Ni , Haodong Li , Guo-Liang Yu , Reiner L. Gentz
发明人： Jian Ni , Haodong Li , Guo-Liang Yu , Reiner L. Gentz
IPC分类号： A61K38/00 , C07K14/81 , C12P21/06 , C07H21/04 , C12N5/00 , C12N15/00
CPC分类号： C07K14/8139 , A61K38/00 , C07K2319/00
摘要： The invention relates to cystatin F polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
摘要翻译：本发明涉及半胱氨酸蛋白酶抑制剂F多肽，编码多肽的多核苷酸，产生多肽的方法，特别是通过表达多核苷酸，多肽的激动剂和拮抗剂。本发明还涉及用于应用的这些多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床领域。

14. 发明授权

US07803615B1 Death domain containing receptor 5 失效
标题翻译：含有受体5的死亡域
公开(公告)号：US07803615B1
公开(公告)日：2010-09-28
申请号：US09042583
申请日：1998-03-17
申请人： Jian Ni , Reiner L. Gentz , Guo-Liang Yu , Jeffrey Y. Su , Craig A. Rosen
发明人： Jian Ni , Reiner L. Gentz , Guo-Liang Yu , Jeffrey Y. Su , Craig A. Rosen
IPC分类号： C07K14/705 , C12N5/10 , C12N15/12 , C12N15/62 , C12N15/63
CPC分类号： C07K14/7151 , A61K38/00 , C07K2319/00
摘要： The present invention relates to novel Death Domain Containing Receptor-5 (DR5) proteins which are members of the tumor necrosis factor (TNF) receptor family, and have now been shown to bind TRAIL. In particular, isolated nucleic acid molecules are provided encoding the human DR5 proteins. DR5 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying antagonists and antagonists of DR5 activity.
摘要翻译：本发明涉及作为肿瘤坏死因子（TNF）受体家族的成员的新的含有死亡域的受体-5（DR5）蛋白，现在已经显示结合TRAIL。特别地，提供编码人DR5蛋白的分离的核酸分子。还提供了DR5多肽，载体，宿主细胞以及用于制备它们的重组方法。本发明还涉及用于鉴定DR5活性的拮抗剂和拮抗剂的筛选方法。

15. 发明申请

US20090062510A1 Human Chemotactic Cytokine I Polypeptides 审中-公开
标题翻译：人类趋化细胞因子I多肽
公开(公告)号：US20090062510A1
公开(公告)日：2009-03-05
申请号：US11737622
申请日：2007-04-19
申请人： Jian Ni , Guo-Liang Yu , Pedro Alfonso , Reiner L. Gentz , Jeffrey Y. Su
发明人： Jian Ni , Guo-Liang Yu , Pedro Alfonso , Reiner L. Gentz , Jeffrey Y. Su
IPC分类号： C07K14/52
CPC分类号： C07K14/52 , C07H21/04
摘要： Human chemotactic cytokine I polypeptides and DNA (RNA) encoding such chemotactic cytokines and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemotactic cytokines for the treatment of leukemia, tumors, chronic infections, auto-immune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemotactic cytokines and their use as a therapeutic to treat rheumatoid arthritis, auto-immune and chronic and acute inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the chemotactic cytokines and for detecting altered levels of the polypeptide in a host.
摘要翻译：公开了人类趋化性细胞因子I多肽和编码这种趋化性细胞因子的DNA（RNA）以及通过重组技术产生此类多肽的方法。还公开了利用这种趋化性细胞因子治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。还公开了抗这种趋化性细胞因子的拮抗剂及其作为治疗类风湿性关节炎，自身免疫，慢性和急性炎性和感染性疾病，过敏反应，前列腺素不依赖性发烧和骨髓衰竭的治疗剂的用途。还公开了用于检测与核酸序列中的突变和多肽的改变的浓度相关的疾病的诊断测定。还公开了用于检测编码趋化性细胞因子的多核苷酸中的突变并用于检测宿主中多肽的改变水平的诊断测定。

16. 发明授权

US06872568B1 Death domain containing receptor 5 antibodies 有权
标题翻译：含有受体5抗体的死亡域
公开(公告)号：US06872568B1
公开(公告)日：2005-03-29
申请号：US09565009
申请日：2000-05-04
申请人： Jian Ni , Reiner L. Gentz , Guo-Liang Yu , Craig A. Rosen
发明人： Jian Ni , Reiner L. Gentz , Guo-Liang Yu , Craig A. Rosen
IPC分类号： A61K38/00 , A61K39/395 , C07K14/705 , C07K14/715 , C12N15/12 , C07K16/28 , C07K16/30 , G01N33/53
CPC分类号： C07K14/7151 , A61K38/00 , A61K39/395 , C07K14/70578 , C07K2319/00 , C07K2319/30 , A61K2300/00
摘要： The present invention relates to novel Death Domain Containing Receptor-5 (DR5) proteins which are members of the tumor necrosis factor (TNF) receptor family, and have now been shown to bind TRAIL. In particular, isolated nucleic acid molecules are provided encoding the human DR5 proteins. DR5 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying antagonists and antagonists of DR5 activity.
摘要翻译：本发明涉及作为肿瘤坏死因子（TNF）受体家族的成员的新的含有死亡域的受体-5（DR5）蛋白，现在已经显示结合TRAIL。特别地，提供编码人DR5蛋白的分离的核酸分子。还提供了DR5多肽，载体，宿主细胞以及用于制备它们的重组方法。本发明还涉及用于鉴定DR5活性的拮抗剂和拮抗剂的筛选方法。

17. 发明授权

US06759513B2 Death domain containing receptors 有权
公开(公告)号：US06759513B2
公开(公告)日：2004-07-06
申请号：US09333966
申请日：1999-06-16
申请人： Guo-Liang Yu , Jian Ni , Reiner L. Gentz , Patrick J. Dillon
发明人： Guo-Liang Yu , Jian Ni , Reiner L. Gentz , Patrick J. Dillon
IPC分类号： C07K14705
CPC分类号： C07K14/70578 , A61K38/00
摘要： The present invention relates to novel Death Domain Containing Receptor (DR3 and DR3-V1) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR3 and DR3-V1 proteins. DR3 and DR3-V1 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR3 and DR3-V1 activity.

18. 发明授权

US06541224B2 Tumor necrosis factor delta polypeptides 有权
标题翻译：肿瘤坏死因子δ多肽
公开(公告)号：US06541224B2
公开(公告)日：2003-04-01
申请号：US09879919
申请日：2001-06-14
申请人： Guo-Liang Yu , Jian Ni , Reiner L. Gentz , Patrick J. Dillon
发明人： Guo-Liang Yu , Jian Ni , Reiner L. Gentz , Patrick J. Dillon
IPC分类号： C12N1500
CPC分类号： A61K49/0004 , A61K47/6849 , A61K2039/505 , C07K14/52 , C07K14/70575 , C07K16/2875 , C07K2317/21 , C07K2317/622 , C07K2317/74 , G01N33/564 , G01N33/6863 , G01N2333/525
摘要： The invention relates to human TNF delta and TNF epsilon polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
摘要翻译：本发明涉及人TNFδ和TNFε多肽，编码多肽的多核苷酸，产生多肽的方法，特别是通过表达多核苷酸，多肽的激动剂和拮抗剂。本发明还涉及用于应用的这些多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床领域。

19. 发明授权

US06482922B2 Mammary transforming protein 失效
标题翻译：乳腺转化蛋白
公开(公告)号：US06482922B2
公开(公告)日：2002-11-19
申请号：US09263811
申请日：1999-03-08
申请人： Jian Ni , Guo-Liang Yu , Reiner L. Gentz
发明人： Jian Ni , Guo-Liang Yu , Reiner L. Gentz
IPC分类号： C07K100
CPC分类号： C07K14/82 , A61K38/00 , A61K48/00 , C12N2799/026 , C12Q1/6886 , C12Q2600/136
摘要： A human mammary transforming protein and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for inhibiting such polypeptide for preventing and/or treating neoplasia. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.
摘要翻译：公开了一种编码这种多肽的人类乳腺转化蛋白和DNA（RNA），以及通过重组技术产生这种多肽的方法。还公开了抑制这种多肽以预防和/或治疗瘤形成的方法。还公开了用于鉴定编码本发明多肽的核酸序列中的突变并用于检测用于检测疾病例如癌症的本发明多肽的改变水平的诊断测定法。

20. 发明申请

US20100266533A1 Death Domain Containing Receptors 有权
标题翻译：死亡域包含受体
公开(公告)号：US20100266533A1
公开(公告)日：2010-10-21
申请号：US12771910
申请日：2010-04-30
申请人： Guo-Liang Yu , Jian Ni , Reiner L. Gentz , Patrick J. Dillon
发明人： Guo-Liang Yu , Jian Ni , Reiner L. Gentz , Patrick J. Dillon
IPC分类号： A61K39/395 , C07K16/18 , A61K38/20 , A61K38/21 , C07K14/435 , A61K38/17 , A61P35/00 , A61P37/00 , A61P37/06 , A61P29/00
CPC分类号： C07K14/4747 , A61K38/00 , A61K48/00 , C07K14/705 , C07K14/70578 , C07K16/2878 , C07K2317/21 , C12N2799/026
摘要： The present invention relates to novel Death Domain Containing Receptor (DR3 and DR3-V1) proteins that are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR3 and DR3-V1 proteins. DR3 and DR3-V1 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Also provided are antibodies and fragments thereof that bind to polypeptides of the invention. The invention further relates to screening methods for identifying agonists and antagonists of DR3 and DR3-V1 activity.
摘要翻译：本发明涉及作为肿瘤坏死因子（TNF）受体家族成员的新型死亡域含有受体（DR3和DR3-V1）蛋白。特别地，提供编码人DR3和DR3-V1蛋白的分离的核酸分子。还提供DR3和DR3-V1多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。还提供了结合本发明多肽的抗体及其片段。本发明还涉及用于鉴定DR3和DR3-V1活性的激动剂和拮抗剂的筛选方法。

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