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11. 发明授权

US5776493A Oral osmotic device for delivery of nystatin with hydrogel driving member 失效
标题翻译：口服渗透装置用于用水凝胶驱动构件递送制霉菌素
公开(公告)号：US5776493A
公开(公告)日：1998-07-07
申请号：US171875
申请日：1993-12-22
申请人： Brian L. Barclay , Jerry D. Childers , Jeri Wright , Virgil A. Place , Patrick S.-L. Wong
发明人： Brian L. Barclay , Jerry D. Childers , Jeri Wright , Virgil A. Place , Patrick S.-L. Wong
IPC分类号： A61K9/00 , A61K9/52 , A61K9/24
CPC分类号： A61K9/0004
摘要： An osmotic device (10) for delivering a beneficial drug, such as an anti-fungal, into the mouth of a human patient is disclosed. The device (10) has a size and shape adapting it to be comfortably retained in the mouth for extended periods of time. The device (10) comprises a wall (12) surrounding a compartment (13) housing a layer of an agent (14) that is insoluble to very soluble in aqueous biological fluids, e.g., saliva, and a layer (16) of a fluid swellable, hydrophilic polymer. A passageway (17) in the wall (12) connects the agent (14) with the exterior of the device (10). The wall (12) is permeable to the passage of aqueous biological fluid but substantially impermeable to the passage of the hydrophilic polymer (16). In one embodiment the beneficial agent (14) has a different color than the hydrophilic polymer (16). The wall (12) is sufficiently translucent to permit the patient to see the amount of drug/beneficial agent (14) remaining to be delivered. Marking lines (19) may be provided on the wall (12) indicating the amount of drug/agent (14) which has been delivered and/or the amount remaining to be delivered.
摘要翻译：公开了一种用于将有益药物（例如抗真菌）递送到人类患者的口中的渗透装置（10）。装置（10）具有适应其舒适地保持在口中长时间的尺寸和形状。装置（10）包括围绕隔室（13）的壁（12），该隔室（13）容纳不溶于非常可溶于水生物流体（例如唾液）的试剂（14）层，以及流体层可溶胀的亲水性聚合物。壁（12）中的通道（17）将试剂（14）与装置（10）的外部连接。所述壁（12）对于水性生物流体的通道是可渗透的，但是对于亲水性聚合物（16）的通过基本上是不透水的。在一个实施方案中，有益剂（14）具有与亲水性聚合物（16）不同的颜色。壁（12）是足够半透明的，以允许患者看到待传送的药物/有益剂（14）的量。标记线（19）可以设置在壁（12）上，指示已经被输送的药物/试剂（14）的量和/或剩余的待传送量。

12. 发明授权

US5897878A Method for administering steroid 失效
标题翻译：施用类固醇的方法
公开(公告)号：US5897878A
公开(公告)日：1999-04-27
申请号：US963967
申请日：1992-10-21
申请人： Liang C. Dong , Michael H. Dealey , Terry L. Burkoth , Patrick S.-L. Wong , Jerry D. Childers , Brian L. Barclay
发明人： Liang C. Dong , Michael H. Dealey , Terry L. Burkoth , Patrick S.-L. Wong , Jerry D. Childers , Brian L. Barclay
IPC分类号： A61K9/00 , A61K9/24
CPC分类号： A61K9/0004
摘要： A dosage form is disclosed comprising means for lessening the tackiness and/or irritation of the components of the dosage form to mucosal tissue. The dosage form provides means for forming in the dosage form a floc comprising a drug, which floc, when delivered from the dosage form, lessens the tackiness and/or irritation of the mucosal tissue of a warm-blooded recipient.
摘要翻译：公开了一种剂型，其包括用于减轻剂型组分对粘膜组织的粘性和/或刺激性的方法。剂型提供了用于在剂型中形成包含药物的絮凝物，当从剂型递送时，该絮凝剂减轻温血接受者的粘膜组织的粘性和/或刺激性。

13. 发明授权

US5906832A Method for treating epilepsies 失效
标题翻译：治疗癫痫的方法
公开(公告)号：US5906832A
公开(公告)日：1999-05-25
申请号：US439914
申请日：1995-05-12
申请人： Frank Jao , Patrick S.-L. Wong , Evangeline Cruz , Eduardo C. Sy , Anthony L. Kuczynski
发明人： Frank Jao , Patrick S.-L. Wong , Evangeline Cruz , Eduardo C. Sy , Anthony L. Kuczynski
IPC分类号： A61K9/00 , A61K9/22 , A61K9/52 , A61K31/165 , A61K31/17 , A61K31/195 , A61K31/27 , A61K31/4015 , A61K31/4166 , A61K31/421 , A61K31/426 , A61K31/4535 , A61K31/495 , A61K31/513 , A61K31/515 , A61K31/53 , A61K31/54 , A61K31/551 , A61K31/5513 , A61K31/635 , A61K45/06 , A61K47/34 , A61K9/20
CPC分类号： A61K31/00 , A61K31/165 , A61K31/17 , A61K31/195 , A61K31/27 , A61K31/4015 , A61K31/4166 , A61K31/421 , A61K31/426 , A61K31/4535 , A61K31/495 , A61K31/513 , A61K31/515 , A61K31/53 , A61K31/54 , A61K31/551 , A61K31/5513 , A61K31/635 , A61K45/06 , A61K9/0004 , Y10S514/964
摘要： A dosage form is disclosed for delivering an antiepileptic drug, which dosage form comprises for maintaining the integrity of the dosage form and of the antiepileptic drug.
摘要翻译：公开了用于递送抗癫痫药物的剂型，该剂型包括用于维持剂型和抗癫痫药物的完整性。

14. 发明授权

US5785994A Method for administering drug to gastrointestinal tract 失效
标题翻译：向胃肠道给药的方法
公开(公告)号：US5785994A
公开(公告)日：1998-07-28
申请号：US862665
申请日：1992-04-01
申请人： Patrick S.-L. Wong , Felix Theeuwes , Atul Devdatt Ayer , Anthony L. Kuczynski
发明人： Patrick S.-L. Wong , Felix Theeuwes , Atul Devdatt Ayer , Anthony L. Kuczynski
IPC分类号： A61K9/00 , A61K9/22 , A61K31/155 , A61K31/275 , A61K31/435 , A61K31/55 , A61K9/24
CPC分类号： A61K9/0004
摘要： A dosage form is disclosed that comprises means inside the dosage form for providing a substantially drug-free interval before the dosage form delivers a drug from inside the dosage form. The dosage form in an embodiment comprises a drug on the exterior of the dosage form, which drug is available for immediate delivery.
摘要翻译：公开了一种剂型，其包含剂型内的装置，用于在剂型从剂型内部递送药物之前提供基本上无药物的间隔。在一个实施方案中的剂型包含在剂型外部的药物，该药物可用于立即递送。

15. 发明授权

US5591454A Method for lowering blood glucose 失效
标题翻译：降低血糖的方法
公开(公告)号：US5591454A
公开(公告)日：1997-01-07
申请号：US442040
申请日：1995-05-16
申请人： Anthony L. Kuczynski , Atul D. Ayer , Patrick S.-L. Wong
发明人： Anthony L. Kuczynski , Atul D. Ayer , Patrick S.-L. Wong
IPC分类号： A61K9/00 , A61K9/20 , A61K9/22 , A61K9/26 , A61K31/64 , A61P3/10 , A61K9/10 , A61K9/16 , A61K9/24 , A61K47/32
CPC分类号： A61K31/64 , A61K9/0004 , A61K9/2027 , A61K9/2031 , A61K9/2054 , Y10S514/866
摘要： The invention disclosed comprises a method for administering the antidiabetic drug glipizide to a patient in need of glipizide in need of antidiabetic therapy.
摘要翻译：所公开的发明包括将抗糖尿病药物格列吡嗪给予需要需要抗糖尿病治疗的格列吡嗪的患者的方法。

16. 发明授权

US5024843A Oral hypoglycemic glipizide granulation 失效
标题翻译：口服降糖吡吡嗪颗粒
公开(公告)号：US5024843A
公开(公告)日：1991-06-18
申请号：US402314
申请日：1989-09-05
申请人： Anthony L. Kuczynski , Atul D. Ayer , Patrick S.-L. Wong
发明人： Anthony L. Kuczynski , Atul D. Ayer , Patrick S.-L. Wong
IPC分类号： A61K9/00 , A61K9/20 , A61K9/22 , A61K31/64 , A61K47/32 , A61K47/38
CPC分类号： A61K31/64 , A61K9/0004 , A61K9/2027 , A61K9/2031 , A61K9/2054 , Y10S514/866
摘要： A dosage form is disclosed comprising the antidiabetic drug glipizide for administering to a patient in need of glipizide therapy.
摘要翻译：公开了一种剂型，其包含用于给予需要格列吡嗪治疗的患者的抗糖尿病药物格列吡嗪。

17. 发明授权

US5876750A Effective therapy for epilepsies 失效
标题翻译：有效治疗癫痫
公开(公告)号：US5876750A
公开(公告)日：1999-03-02
申请号：US871075
申请日：1997-06-09
申请人： Frank Jao , Patrick S.-L. Wong , Evangeline Cruz , Eduardo C. Sy , Anthony L. Kuczynski
发明人： Frank Jao , Patrick S.-L. Wong , Evangeline Cruz , Eduardo C. Sy , Anthony L. Kuczynski
IPC分类号： A61K9/00 , A61K9/22 , A61K9/52 , A61K31/165 , A61K31/17 , A61K31/195 , A61K31/27 , A61K31/4015 , A61K31/4166 , A61K31/421 , A61K31/426 , A61K31/4535 , A61K31/495 , A61K31/513 , A61K31/515 , A61K31/53 , A61K31/54 , A61K31/551 , A61K31/5513 , A61K31/635 , A61K45/06 , A61K47/34 , A61K9/20 , A61K9/24 , A61K31/415
CPC分类号： A61K31/00 , A61K31/165 , A61K31/17 , A61K31/195 , A61K31/27 , A61K31/4015 , A61K31/4166 , A61K31/421 , A61K31/426 , A61K31/4535 , A61K31/495 , A61K31/513 , A61K31/515 , A61K31/53 , A61K31/54 , A61K31/551 , A61K31/5513 , A61K31/635 , A61K45/06 , A61K9/0004 , Y10S514/964
摘要： A dosage form is disclosed for delivering an antiepileptic drug, which dosage form comprises a laminated wall for maintaining the integrity of the dosage form and of the antiepileptic drug.
摘要翻译：公开了用于递送抗癫痫药物的剂型，该剂型包括用于维持剂型和抗癫痫药物的完整性的层压壁。

18. 发明授权

US5863558A Effective therapy for epilepsies 失效
公开(公告)号：US5863558A
公开(公告)日：1999-01-26
申请号：US955445
申请日：1997-10-21
申请人： Frank Jao , Patrick S.-L. Wong , Evangeline Cruz , Eduardo C. Sy , Anthony L. Kuczynski
发明人： Frank Jao , Patrick S.-L. Wong , Evangeline Cruz , Eduardo C. Sy , Anthony L. Kuczynski
IPC分类号： A61K9/00 , A61K9/22 , A61K9/52 , A61K31/165 , A61K31/17 , A61K31/195 , A61K31/27 , A61K31/4015 , A61K31/4166 , A61K31/421 , A61K31/426 , A61K31/4535 , A61K31/495 , A61K31/513 , A61K31/515 , A61K31/53 , A61K31/54 , A61K31/551 , A61K31/5513 , A61K31/635 , A61K45/06 , A61K47/34 , A61K9/20 , A61K9/24
CPC分类号： A61K31/00 , A61K31/165 , A61K31/17 , A61K31/195 , A61K31/27 , A61K31/4015 , A61K31/4166 , A61K31/421 , A61K31/426 , A61K31/4535 , A61K31/495 , A61K31/513 , A61K31/515 , A61K31/53 , A61K31/54 , A61K31/551 , A61K31/5513 , A61K31/635 , A61K45/06 , A61K9/0004 , Y10S514/964
摘要： A dosage form is disclosed for delivering an antiepileptic drug, which dosage form comprises a laminated wall for maintaining the integrity of the dosage form and of the antiepileptic drug.

19. 发明授权

US08524277B2 Extended release dosage form 有权
标题翻译：延长释放剂型
公开(公告)号：US08524277B2
公开(公告)日：2013-09-03
申请号：US11673066
申请日：2007-02-09
申请人： David E. Edgren , Patrick S.-L. Wong , Gurdish K. Bhatti , Shu Li , Robert R. Skluzacek
发明人： David E. Edgren , Patrick S.-L. Wong , Gurdish K. Bhatti , Shu Li , Robert R. Skluzacek
IPC分类号： A61K9/22 , A61K9/30 , A61K9/32 , A01N43/42 , A01N37/18
CPC分类号： A61K9/0004 , A61K9/2027 , A61K9/2031 , A61K9/2866 , A61K9/2886
摘要： A membrane system comprising an interior wall, a fluid-permeable exterior wall surrounding the interior wall and an internal compartment defined by the membrane system, wherein fluid permeability of the interior wall is responsive to osmolarity of an osmotic core within the internal compartment are disclosed. A controlled release dosage form comprising the membrane system and a process for delivering an osmotically active formulation from an osmotic pump over an extended period of time are also disclosed.
摘要翻译：公开了一种膜系统，其包括内壁，围绕内壁的流体可渗透的外壁和由膜系统限定的内部隔室，其中内壁的流体渗透性响应于内部隔室内的渗透性芯的渗透压。还公开了一种包含膜系统的控释剂型，以及用于在延长的时间段内从渗透泵输送渗透活性制剂的方法。

20. 发明授权

US06365183B1 Method of fabricating a banded prolonged release active agent dosage form 失效
公开(公告)号：US06365183B1
公开(公告)日：2002-04-02
申请号：US09274648
申请日：1999-03-23
申请人： David E. Edgren , Patrick S.-L. Wong , Francisco Jao , Yolanda M. Puga
发明人： David E. Edgren , Patrick S.-L. Wong , Francisco Jao , Yolanda M. Puga
IPC分类号： A61K922
CPC分类号： A61K9/2072 , A61K9/2095 , A61K9/2893
摘要： The present invention is directed to an active agent dosage form and methods of its fabrication which is useful for the prolonged delivery of an active agent formulation to a fluid environment of use. The active agent dosage form is a matrix that has on its surface one or more insoluble bands located in complementary grooves. The invention is also directed to articles of manufacture, methods and systems for fabricating the active agent dosage form.

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