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11. 发明申请

US20120294831A1 USE OF THIAZOLIDE COMPOUNDS FOR THE PREVENTION AND TREATMENT OF VIRAL DISEASES, CANCER AND DISEASES CAUSED BY INTRACELLULAR INFECTIONS 审中-公开
标题翻译：用于预防和治疗由细菌感染引起的病毒，癌症和疾病的噻唑化合物的使用
公开(公告)号：US20120294831A1
公开(公告)日：2012-11-22
申请号：US13471948
申请日：2012-05-15
申请人： Jean-Francois Rossignol
发明人： Jean-Francois Rossignol
IPC分类号： A61K31/426 , A61P37/04 , A61K31/4745 , A61K38/47 , A61P31/12 , A61P31/16 , A61P31/20 , A61P35/00 , A61P35/02 , A61K31/7068 , A61K33/24 , A61K38/14 , A61K31/475 , A61K31/704 , A61K31/44 , A61K38/21 , A61P33/02 , A61K31/506 , A61K31/7056 , A61K31/473 , A61P31/04 , A61P31/06 , A61K39/39
摘要： The invention provides for the use of pharmaceutical compositions comprising a thiazolide in the stimulation of the immune system in a subject in need thereof, thereby preventing and/or treating viral diseases, cancer and diseases caused by intracellular protozoan infections
摘要翻译：本发明提供了包含噻唑烷在有需要的受试者中刺激免疫系统的药物组合物的用途，从而预防和/或治疗由细胞内原生动物感染引起的病毒性疾病，癌症和疾病

12. 发明申请

US20120122939A1 ALKYLSULFONYL-SUBSTITUTED THIAZOLIDE COMPOUNDS 有权
标题翻译：烷基取代的噻唑化合物
公开(公告)号：US20120122939A1
公开(公告)日：2012-05-17
申请号：US13353686
申请日：2012-01-19
申请人： Jean-Francois Rossignol , J. Edward Semple
发明人： Jean-Francois Rossignol , J. Edward Semple
IPC分类号： A61K31/426 , C07D277/54 , A61P31/14 , C07D277/42
CPC分类号： C07D277/46 , C07D417/12
摘要： A new class of alkylsulfonyl-substituted thiazolide compounds is described. These compounds show strong activity against hepatitis virus.
摘要翻译：描述了一类新的烷基磺酰基取代的噻唑烷化合物。这些化合物对肝炎病毒表现出强烈的活性。

13. 发明申请

US20120108592A1 PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE OF SALICYLANILIDES FOR TREATMENT OF HEPATITIS VIRUSES 审中-公开
标题翻译：药物组合物及其用于治疗乙型肝炎病毒的方法
公开(公告)号：US20120108592A1
公开(公告)日：2012-05-03
申请号：US13284232
申请日：2011-10-28
申请人： J. Edward Semple , Jean-Francois Rossignol
发明人： J. Edward Semple , Jean-Francois Rossignol
IPC分类号： A61K31/5375 , A61K31/196 , A61K31/365 , A61K31/366 , A61K31/222 , A61K31/24 , A61K31/404 , A61K31/37 , A61K31/4025 , A61K31/4965 , A61K31/50 , A61K31/4164 , A61K31/4409 , A61K31/4406 , A61K31/4458 , A61K31/4462 , A61K31/4465 , A61K31/495 , A61P31/14 , A61P31/20 , A61K31/245 , A61K31/265 , A61K31/4245 , A61K31/41 , A61K31/167
CPC分类号： A61K31/167 , A61K31/216 , A61K31/357 , A61K31/36 , A61K31/366 , A61K31/4025 , A61K31/404 , A61K31/4164 , A61K31/4409 , A61K31/4465 , A61K31/4965 , A61K31/50 , A61K31/609
摘要： A new class of salicylanilides is described. These compounds show strong activity against hepatitis viruses.
摘要翻译：描述了一类新的水杨酰苯胺。这些化合物对肝炎病毒表现出很强的活性。

14. 发明申请

US20120108591A1 ALKYLSULFINYL-SUBSTITUTED THIAZOLIDE COMPOUNDS 有权
标题翻译：烷基磺酰脲取代的噻唑化合物
公开(公告)号：US20120108591A1
公开(公告)日：2012-05-03
申请号：US13284242
申请日：2011-10-28
申请人： J. Edward Semple , Jean-Francois Rossignol
发明人： J. Edward Semple , Jean-Francois Rossignol
IPC分类号： A61K31/5377 , A61K31/426 , C07D417/12 , A61K31/496 , A61K31/427 , A61K31/506 , C07D513/04 , A61K31/429 , A61P31/14 , C07D277/54 , A61K31/4439
CPC分类号： C07D277/54 , C07D417/12
摘要： A new class of alkylsulfinyl thiazolides is described. These compounds show strong activity against hepatitis viruses.
摘要翻译：描述了一类新的烷基亚磺酰基噻唑烷。这些化合物对肝炎病毒表现出很强的活性。

15. 发明申请

US20090036467A1 ALKYLSULFONYL-SUBSTITUTED THIAZOLIDE COMPOUNDS 有权
标题翻译：烷基取代的噻唑化合物
公开(公告)号：US20090036467A1
公开(公告)日：2009-02-05
申请号：US12184760
申请日：2008-08-01
申请人： Jean-Francois Rossignol , J. Edward Semple
发明人： Jean-Francois Rossignol , J. Edward Semple
IPC分类号： A61K31/427 , C07D277/54 , C07D277/38 , A61K31/496 , A61K31/4439 , A61P31/12 , A61K31/426 , A61K31/506 , C07D417/14 , C07D417/12
CPC分类号： C07D277/46 , C07D417/12
摘要： A new class of alkylsulfonyl-substituted thiazolide compounds is described. These compounds show strong activity against hepatitis virus.
摘要翻译：描述了一类新的烷基磺酰基取代的噻唑烷化合物。这些化合物对肝炎病毒表现出强烈的活性。

16. 发明授权

US5578621A Benzamide derivatives 失效
标题翻译：苯甲酰胺衍生物
公开(公告)号：US5578621A
公开(公告)日：1996-11-26
申请号：US301407
申请日：1994-09-08
申请人： Jean-Francois Rossignol
发明人： Jean-Francois Rossignol
IPC分类号： A61K31/425 , A61K31/426 , C07D277/58
CPC分类号： C07D277/58 , A61K31/425 , A61K31/426
摘要： The present invention relates to a new compound of formula I ##STR1## with one of the symbols R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 representing OH, whereas the remaining symbols represent H; to a pharmaceutical composition containing the said compound, and to the use of said compound as anti-parasital, anti-bacterial, anti-fungal agent.The Prior ArtNitrothiazole compound PH 5776 (2-(acetolyloxy)-N-(5-nitro 2-thiazolyl) benzamide) is a compound of formula II ##STR2## in which R.sub.1 =O--COCH3 R.sub.2 =R.sub.3 =R.sub.4 =R.sub.5 =HThe preparation and uses of this compound are disclosed in U.S. Pat. No. 3,950,351, as well as in publication made by Applicant.In U.S. Pat. No. 3,950,351, the compound of formula II is prepared by reacting ##STR3## This reaction is not suitable for the preparation of pure compound of formula I ##STR4## in which one of the symbols R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 represent OH, whereas the remaining symbols represent H.Moreover, contrary to what could be expected from the prior art, i.e. that the presence of an acyloxy group was necessary for rendering the compound active and efficient against bacteria, parasites, . . . , it has now been found that the compound of formula I ##STR5## with one of the symbols R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 representing OH, whereas the remaining symbols represent H; had an excellent efficiency against parasites, bacteria, fungus although it does not contain an acyloxy group.The compound of formula I had a substantially immediate action against parasite, fungus, bacteria.
摘要翻译：本发明涉及一种新的式I化合物，其中符号R1，R2，R3，R4和R5之一代表OH，而其余符号代表H; 涉及含有所述化合物的药物组合物，以及所述化合物作为抗寄生虫，抗菌，抗真菌剂的用途。现有技术硝基噻唑化合物PH5776（2-（乙酰基氧基）-N-（5-硝基2-噻唑基）苯甲酰胺）是式II化合物，其中R1 = O-COCH3R2 = R3 = R4 = R5 = 该化合物的制备和用途在美国专利No. 3,950,351号以及申请人出版的刊物。在美国专利式3,950,351中，式II化合物通过反应制备，该反应不适用于制备纯化合物Ⅰ“IMAGE”，其中R1，R2，R3，R4和R5之一代表OH 而其余符号代表H.此外，与现有技术可以预期的相反，即，需要存在酰氧基以使化合物对细菌，寄生虫有效和有效。。。现在已经发现，具有代表OH的符号R1，R2，R3，R4和R5之一的式I化合物，而其余的符号代表H; 尽管它不含有酰氧基，但对寄生虫，细菌，真菌具有极好的效力。式I的化合物对寄生虫，真菌，细菌具有基本上立即的作用。

17. 发明授权

US5387598A Composition and galenic formulation suitable for combatting affections of the lower abdomen 失效
标题翻译：组合物和盖仑制剂适用于对抗下腹部的感染
公开(公告)号：US5387598A
公开(公告)日：1995-02-07
申请号：US227033
申请日：1994-04-13
申请人： Jean-Francois Rossignol
发明人： Jean-Francois Rossignol
IPC分类号： A61K9/16 , A61K31/425 , C07D277/44 , C07D277/58
CPC分类号： A61K9/1635 , A61K31/425 , A61K9/1652
摘要： The present invention relates to a composition and a galenic formulation suitable for combatting affections of the lower abdomen, for example intestinal conditions such as diarrhea, said composition or formulation containing:(a) an effective amount of a compound of formula I ##STR1## (b) at least one wetting agent, and preferably (c) a starch derivative.
摘要翻译：本发明涉及一种适用于对抗下腹部感染的组合物和盖仑制剂，例如肠状况如腹泻，所述组合物或制剂含有：（a）有效量的式I化合物（IMAGE） I）（b）至少一种润湿剂，优选（c）淀粉衍生物。

18. 发明授权

US3950351A New derivatives of 2-benzamido-5-nitro thiazoles 失效
标题翻译： 2-苄氧基-5-硝基噻唑的新衍生物
公开(公告)号：US3950351A
公开(公告)日：1976-04-13
申请号：US495749
申请日：1974-08-08
申请人： Jean-Francois Rossignol , Raymond Cavier
发明人： Jean-Francois Rossignol , Raymond Cavier
IPC分类号： A01N43/78 , C07D277/20 , C07D277/46 , C07D277/58 , C07D277/44
CPC分类号： C07D277/46 , C07D277/58
摘要： The new derivatives of 2-benzamido-5-nitro-thiazole represented by the formula: ##SPC1##In which at least one of the symbols R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 represents an acyloxy group, preferably an acetoxy or propionoxy group, whereas the remaining symbols represent hydrogen or one of said remaining symbols represents an alkoxy group, such as the methoxy group, or a halogen atom, such as a chlorine or bromine atom, are interesting parasiticides, fungistatic and molluscicidal agents.

19. 发明授权

US08895752B2 Alkylsulfonyl-substituted thiazolide compounds 有权
标题翻译：烷基磺酰基取代的噻唑烷化合物
公开(公告)号：US08895752B2
公开(公告)日：2014-11-25
申请号：US13353686
申请日：2012-01-19
申请人： Jean-Francois Rossignol , J. Edward Semple
发明人： Jean-Francois Rossignol , J. Edward Semple
IPC分类号： C07D277/00 , A61K31/425 , C07D417/12 , C07D277/46
CPC分类号： C07D277/46 , C07D417/12
摘要： A new class of alkylsulfonyl-substituted thiazolide compounds is described. These compounds show strong activity against hepatitis virus.
摘要翻译：描述了一类新的烷基磺酰基取代的噻唑烷化合物。这些化合物对肝炎病毒表现出强烈的活性。

20. 发明授权

US08846727B2 Haloalkyl heteroaryl benzamide compounds 有权
标题翻译：卤代烷基杂芳基苯甲酰胺化合物
公开(公告)号：US08846727B2
公开(公告)日：2014-09-30
申请号：US12777383
申请日：2010-05-11
申请人： Jean-Francois Rossignol , J. Edward Semple
发明人： Jean-Francois Rossignol , J. Edward Semple
IPC分类号： A61K31/415 , A61K31/4168 , A61K31/4196 , A61K31/421 , A61K31/4245 , A61K31/427 , A61K31/433 , C07D231/38 , C07D233/38 , C07D249/14 , C07D261/14 , C07D263/48 , C07D271/07 , C07D285/125 , C07D275/03 , C07D277/38 , C07D277/46 , C07D285/135 , C07D403/12 , C07D277/56 , C07D233/90 , C07D231/40 , C07D233/88 , C07D417/12 , C07D271/113 , C07D413/12 , C07D231/44 , C07D285/08 , C07D409/06 , C07D403/06 , C07D417/06 , C07D405/12
CPC分类号： C07D417/12 , A61K31/4196 , A61K31/4245 , A61K31/427 , A61K31/433 , A61K31/454 , A61K31/497 , A61K31/506 , A61K45/06 , C07D231/40 , C07D231/44 , C07D233/88 , C07D233/90 , C07D249/14 , C07D261/14 , C07D263/48 , C07D271/07 , C07D271/113 , C07D275/03 , C07D277/46 , C07D277/56 , C07D285/08 , C07D285/135 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/06 , C07D413/12 , C07D417/06
摘要： A new class of haloalkyl heteroaryl benzamides is described. These compounds show strong activity against hepatitis viruses.
摘要翻译：描述了一类新的卤代烷基杂芳基苯甲酰胺。这些化合物对肝炎病毒表现出很强的活性。

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