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11. 发明授权

US5147878A Aminoalkoxyphenyl derivatives, process of preparation and compositions containing the same 失效
标题翻译：氨基烷基衍生物，其制备方法及其组合物
公开(公告)号：US5147878A
公开(公告)日：1992-09-15
申请号：US511095
申请日：1990-04-19
申请人： Jean Gubin , Pierre Chatelain
发明人： Jean Gubin , Pierre Chatelain
IPC分类号： A61K31/435 , A61K31/44 , A61P3/00 , A61P9/00 , A61P9/06 , A61P9/08 , A61P9/10 , A61P9/12 , A61P25/02 , A61P35/00 , C07D207/36 , C07D213/26 , C07D471/04
CPC分类号： C07D471/04 , Y10S514/913
摘要： Aminoalkoxyphenyl derivatives useful in the treatment of certain pathological syndromes of the cardiovascular system of formula: ##STR1## in which: B represents a --S, --SO--, or --SO.sub.2 -- group,R.sub.1 and R.sub.2, which are identical or different, each denote hydrogen, a methyl or ethyl radical or a halogen such as chlorine, bromine or iodine, A denotes a straight- or branched-alkylene radical having from 2 to 5 carbon atoms or a 2-hydroxypropylene radical in which the hydroxy is optionally substituted by a lower alkyl radical, Ar represents a group ##STR2## R.sub.4 denotes hydrogen or an alkyl radical and Cy represents a cyclic group.

12. 发明授权

US5565484A Benzenesulphonylindole derivatives for the preparation of medicines 失效
标题翻译：苯磺酰吲哚衍生物用于制备药物
公开(公告)号：US5565484A
公开(公告)日：1996-10-15
申请号：US282288
申请日：1994-07-29
申请人： Jean-Marc Herbert , Pierre Chatelain
发明人： Jean-Marc Herbert , Pierre Chatelain
IPC分类号： C07D401/12 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/47 , A61P9/00 , A61P9/08 , A61P9/10 , C07D209/30 , A61K31/435 , C07D213/70
CPC分类号： C07D209/30
摘要： The invention relates to use of at least one indole derivative of general formula: ##STR1## or of one of the pharmaceutically acceptable salts thereof, in which: Am is selected from radical (a) and (b) defined as follows: ##STR2## R is a C.sub.1 -C.sub.6 alkyl or C.sub.3 -C.sub.6 cycloalkyl radical R.sub.1 represents hydrogen or a C.sub.1 -C.sub.4 alkyl radicalR.sub.2 and R.sub.3, which may be identical or different, represent hydrogen, the methyl or ethyl radical or a halogenR.sub.4, R.sub.5 and R.sub.6, which may be identical or different, represent hydrogen, a C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkoxy radical or a halogenR.sub.7 represents hydrogen or a halogenR.sub.8 represents hydrogen or a C.sub.1 -C.sub.4 alkyl radicalR.sub.9 represents hydrogen or, when R.sub.8 and R.sub.9 are taken together, form the methylene radicalm represents 1 or 2n represents 2, 3 or 4for preventing or treating diseases involving a proliferation of smooth muscle cells.
摘要翻译：本发明涉及至少一种通式如下的吲哚衍生物或其药学上可接受的盐之一：其中：Am选自如下定义的基团（a）和（b）：（a）（a）（b）R是C 1 -C 6烷基或C 3 -C 6环烷基，R 1表示氢或C 1 -C 4烷基，R 2和R 3可以相同或不同，表示氢，甲基或乙基基或卤素可以相同或不同的R 4，R 5和R 6表示氢，C 1 -C 4烷基或C 1 -C 4烷氧基或卤素R 7表示氢或卤素R 8表示氢或C 1 -C 4烷基 R9表示氢，或当R8和R9一起形成亚甲基时m表示1或2 n表示2,3或4，用于预防或治疗涉及平滑肌细胞增殖的疾病。

13. 发明授权

US06451801B1 Compounds and methods for treatment of asthma, allergy and inflammatory disorders 失效
标题翻译：用于治疗哮喘，过敏和炎性疾病的化合物和方法
公开(公告)号：US06451801B1
公开(公告)日：2002-09-17
申请号：US09534947
申请日：2000-03-24
申请人： Ralph Scannell , Pierre Chatelain , Anna Toy-Palmer , Edmond Differding , James Ellis , Marie-Agnes Lassoie , Xiong Cai , Sajjat Hussoin , Gurmit Grewal , Timothy Lewis
发明人： Ralph Scannell , Pierre Chatelain , Anna Toy-Palmer , Edmond Differding , James Ellis , Marie-Agnes Lassoie , Xiong Cai , Sajjat Hussoin , Gurmit Grewal , Timothy Lewis
IPC分类号： A61K31495
CPC分类号： C07D295/096 , C07D295/084 , C07D295/088 , C07D295/125 , C07D295/13 , C07D295/135 , C07D295/15 , C07D307/14 , C07D307/52 , C07D401/04
摘要： The present invention provides 1,4 substituted piperazines, 1,4 substituted piperidines, and 1-substituted, 4-alkylidenyl peperidines compounds. The compounds of the invention are dual acting molecules having both leukotriene inhibition properties as well as antihistaminergic properties. The compounds of the invention are useful for treating conditions in which there is likely to be a histamine and/or leukotriene component. These conditions include preferable asthma, seasonal and perennial allergic rhinitis, sinusitus, conjunctivitis, food allergy, scombroid poisoning, psoriasis, urticaria, pruritus, eczema, rheumatoid arthritis, inflammatory bowel disease, chronic obstructive pulmonary disease, thrombotic disease and otitis media. Also provided are methods of treating asthma and rhinitis by administering an effective asthma and rhinitis-relieving amount of the compounds to a subject in need thereof.
摘要翻译：本发明提供了1,4取代的哌嗪，1,4-取代的哌啶和1-取代的4-亚烷基哌啶化合物。本发明的化合物是具有白细胞三烯抑制性质以及抗组胺能性质的双作用分子。本发明的化合物可用于治疗可能存在组胺和/或白三烯组分的病症。这些病症包括优选的哮喘，季节性和常年性变态反应性鼻炎，窦炎，结膜炎，食物过敏，偶发性中毒，牛皮癣，荨麻疹，瘙痒，湿疹，类风湿性关节炎，炎性肠病，慢性阻塞性肺病，血栓性疾病和中耳炎。还提供了通过向有需要的受试者施用有效的哮喘和减轻炎症的量的化合物来治疗哮喘和鼻炎的方法。

14. 发明申请

US20130336910A1 OLFACTORY RECEPTORS INVOLVED IN THE PERCEPTION OF SWEAT CARBOXYLIC ACIDS AND THE USE THEREOF 有权
标题翻译：涉及甜菜羧酸的影响的老年受体及其用途
公开(公告)号：US20130336910A1
公开(公告)日：2013-12-19
申请号：US13916282
申请日：2013-06-12
申请人： Pierre Chatelain , Alex Veithen
发明人： Pierre Chatelain , Alex Veithen
IPC分类号： G01N33/566
CPC分类号： G01N33/566 , G01N2500/04
摘要： The invention relates to the identification of carboxylic acids, present in human sweat, as natural ligands of a specific subgroup of seven olfactory receptor (OR) belonging to class 1 within the OR classification. The invention encompasses the use of the interaction of OR polypeptides and carboxylic acids as the basis of screening assays for agents that specifically modulate the activity of the seven ORs of the invention.
摘要翻译：本发明涉及作为OR分类中属于1类的七个嗅觉受体（OR）的特定亚组的天然配体，存在于人类汗液中的羧酸的鉴定。本发明包括使用OR多肽和羧酸的相互作用作为特异性调节本发明的七个OR的活性的试剂的筛选测定的基础。

15. 发明授权

US06894059B1 Compounds and methods for treatment of asthma, allergy and inflammatory disorders 失效
标题翻译：用于治疗哮喘，过敏和炎性疾病的化合物和方法
公开(公告)号：US06894059B1
公开(公告)日：2005-05-17
申请号：US09937667
申请日：2000-03-23
申请人： Ralph Scannell , Pierre Chatelain , Anna Toy-Palmer , Edmund Differding , James Ellis , Marie-Agnes Lassoie , Michelle Young , Xiong Cai , Sajjat Hussoin , Gurmit Grewal , Timothy Lewis
发明人： Ralph Scannell , Pierre Chatelain , Anna Toy-Palmer , Edmund Differding , James Ellis , Marie-Agnes Lassoie , Michelle Young , Xiong Cai , Sajjat Hussoin , Gurmit Grewal , Timothy Lewis
IPC分类号： C07D295/084 , C07D295/088 , C07D295/092 , C07D295/096 , C07D295/125 , C07D295/13 , C07D295/135 , C07D295/15 , C07D307/52 , A61K31/44 , A61K31/445
CPC分类号： C07D295/096 , C07D295/084 , C07D295/088 , C07D295/125 , C07D295/13 , C07D295/135 , C07D295/15 , C07D307/52
摘要： The present invention provides 1,4 substituted piperazines, 1,4 substituted piperidines, and 1-substituted, 4-alkylidenyl piperidines compounds. The compounds of the invention are dual acting molecules having both leukotriene inhibition properties as well as antihistaminergic properties. The compounds of the invention are useful for treating conditions in which there is likely to be a histamine and/or leukotriene component. These conditions include preferably asthma, seasonal and perennial allergic rhinitis, sinusitus, conjunctivitis, food allergy, scombroid poisoning, psoriasis, urticaria, pruritus, eczema, rheumatoid arthritis, inflammatory bowel disease, chronic obsructive pulmonary disease, thrombotic disease and otitis media. Also provided are methods of treating asthma and rhinitis by administering an effective asthma and rhinitis-relieving amount of the compounds to a subject in need thereof.
摘要翻译：本发明提供了1,4取代的哌嗪，1,4-取代的哌啶和1-取代的4-亚烷基哌啶化合物。本发明的化合物是具有白细胞三烯抑制性质以及抗组胺能性质的双作用分子。本发明的化合物可用于治疗可能存在组胺和/或白三烯组分的病症。这些病症优选包括哮喘，季节性和常年性过敏性鼻炎，窦炎，结膜炎，食物过敏，鲭鱼中毒，牛皮癣，荨麻疹，瘙痒，湿疹，类风湿性关节炎，炎性肠病，慢性损伤性肺病，血栓性疾病和中耳炎。还提供了通过向有需要的受试者施用有效的哮喘和减轻炎症的量的化合物来治疗哮喘和鼻炎的方法。

16. 发明授权

US6003457A Boat powered by means of a kite via a hinged arm 失效
标题翻译：船借由铰接臂的风筝供电
公开(公告)号：US6003457A
公开(公告)日：1999-12-21
申请号：US67994
申请日：1998-04-01
申请人： Pierre Chatelain
发明人： Pierre Chatelain
IPC分类号： B63H9/06 , B63B35/00
CPC分类号： B63H9/0685
摘要： Apparatus for powering a boat by a kite so as to use wind as a prime mover and without generating significant rolling and yawing moments, having, in combination with the boat, an arm hinged at one extremity to the boat with means for controlling the position of the arm in inclination and in orientation, and provided at its free end with means for holding kite connection lines from the boat to the kite, with the free end serving as a kite-pulling traction point; the controlling means enabling the development of a straight traction line for the kite lines to pass close to the center board of the boat as the inclination of the arm is lowered and raised and the orientation in azimuth is varied with respect to the direction of the kite lines.
摘要翻译：用于通过风筝为船舶提供动力的装置，以便使用风力作为原动机并且不产生显着的滚动和偏转力矩，其具有与所述船一起组合的臂，所述臂以一端铰接到所述船上，所述手臂用于控制所述船的位置臂的倾斜和取向，并且在其自由端设置有用于将风筝连接线从船上放置到风筝的装置，其自由端用作风筝牵引点; 随着臂的倾斜度降低和升高，使得风筝线的直线牵引线的发展能够靠近船的中心板的控制装置，并且方位角方向相对于风筝的方向变化线条。

17. 发明授权

US08637259B1 Methods of identifying modulators of olfactory receptors involved in the perception of sweat carboxylic acids 有权
标题翻译：鉴定涉及汗羧酸感觉的嗅觉受体调节剂的方法
公开(公告)号：US08637259B1
公开(公告)日：2014-01-28
申请号：US13024325
申请日：2011-02-09
申请人： Pierre Chatelain , Alex Veithen
发明人： Pierre Chatelain , Alex Veithen
IPC分类号： G01N33/53 , G01N33/567
CPC分类号： G01N33/566 , G01N2500/04
摘要： The invention relates to the identification of carboxylic acids, present in human sweat, as natural ligands of a specific subgroup of seven olfactory receptor (OR) belonging to class 1 within the OR classification. The invention encompasses the use of the interaction of OR polypeptides and carboxylic acids as the basis of screening assays for agents that specifically modulate the activity of the seven ORs of the invention.
摘要翻译：本发明涉及作为OR分类中属于1类的七个嗅觉受体（OR）的特定亚组的天然配体，存在于人类汗液中的羧酸的鉴定。本发明包括使用OR多肽和羧酸的相互作用作为特异性调节本发明的七个OR的活性的试剂的筛选测定的基础。

18. 发明授权

US06797713B2 Compounds and methods for treatment of asthma, allergy and inflammatory disorders 失效
标题翻译：用于治疗哮喘，过敏和炎性疾病的化合物和方法
公开(公告)号：US06797713B2
公开(公告)日：2004-09-28
申请号：US10242346
申请日：2002-09-12
申请人： Ralph Scannell , Pierre Chatelain , Anna Toy-Palmer , Edmond Differding , James Ellis , Marie-Agnes Lassoie , Michelle Young , Xiong Cai , Sajjat Hussoin , Gurmit Grewal , Timothy Lewis
发明人： Ralph Scannell , Pierre Chatelain , Anna Toy-Palmer , Edmond Differding , James Ellis , Marie-Agnes Lassoie , Michelle Young , Xiong Cai , Sajjat Hussoin , Gurmit Grewal , Timothy Lewis
IPC分类号： A61K31495
CPC分类号： C07D295/096 , C07D295/084 , C07D295/088 , C07D295/125 , C07D295/13 , C07D295/135 , C07D295/15 , C07D307/14 , C07D307/52 , C07D401/04
摘要： The present invention provides 1,4 substituted piperazines, 1,4 substituted piperidines, and 1-substituted, 4-alkylidenyl piperidines compounds. The compounds of the invention are dual acting molecules having both leukotriene inhibition properties as well as antihistaminergic properties. The compounds of the invention are useful for treating conditions in which there is likely to be a histamine and/or leukotriene component. These conditions include preferably asthma, seasonal and perennial allergic rhinitis, sinusitus, conjunctivitis, food allergy, scombroid poisoning, psoriasis, urticaria, pruritus, eczema, rheumatoid arthritis, inflammatory bowel disease, chronic obstructive pulmonary disease, thrombotic disease and otitis media. Also provided are methods of treating asthma and rhinitis by administering an effective asthma and rhinitis-relieving amount of the compounds to a subject in need thereof.
摘要翻译：本发明提供了1,4取代的哌嗪，1,4-取代的哌啶和1-取代的4-亚烷基哌啶化合物。本发明的化合物是具有白细胞三烯抑制性质以及抗组胺能性质的双作用分子。本发明的化合物可用于治疗可能存在组胺和/或白三烯组分的病症。这些病症优选包括哮喘，季节性和常年性过敏性鼻炎，鼻窦炎，结膜炎，食物过敏症，偶发性中毒，牛皮癣，荨麻疹，瘙痒，湿疹，类风湿性关节炎，炎性肠病，慢性阻塞性肺病，血栓性疾病和中耳炎。还提供了通过向有需要的受试者施用有效的哮喘和减轻炎症的量的化合物来治疗哮喘和鼻炎的方法。

19. 发明授权

US06369065B1 CD40 signal blocking agent 失效
标题翻译： CD40信号阻断剂
公开(公告)号：US06369065B1
公开(公告)日：2002-04-09
申请号：US09711620
申请日：2000-11-13
申请人： Pierre Chatelain , Anne Mignot , Mark Taubman , Michel Goldman
发明人： Pierre Chatelain , Anne Mignot , Mark Taubman , Michel Goldman
IPC分类号： A61K31505
CPC分类号： A61K31/519
摘要： A CD40 signal blocking agent comprising, as an active ingredient, s-triazolo[1,5-a]pyrimidine derivative represented by the following formula (1) or a pharmaceutically acceptable salt thereof, is disclosed
摘要翻译：公开了一种CD40信号阻断剂，其包含作为活性成分的由下式（1）表示的三唑并[1,5-a]嘧啶衍生物或其药学上可接受的盐

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