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11. 发明授权

US06178355B1 Intracardiac defibrillation leads 失效
标题翻译：心脏除颤引导
公开(公告)号：US06178355B1
公开(公告)日：2001-01-23
申请号：US09216293
申请日：1998-12-18
申请人： Terrell M. Williams , Peter M. J. Mulier , John G. Keimel , Timothy G. Laske , Gregory A. Boser , Mary M. Morris , Xiaoyi Min
发明人： Terrell M. Williams , Peter M. J. Mulier , John G. Keimel , Timothy G. Laske , Gregory A. Boser , Mary M. Morris , Xiaoyi Min
IPC分类号： A61N105
CPC分类号： A61N1/0565 , A61N1/0563
摘要： A lead and a lead system for dispersion of a cardioversion/defibrillation electrode formed of one or more small diameter defibrillation electrodes in a heart chamber and for attaching a pace/sense electrode in contact with the heart. The small diameter defibrillation electrode or electrodes extend distally from the distal end of the lead body. If multiple electrodes are employed, they are preferably biased to spread apart when unrestrained and have a cross-section size small enough to be inserted into interstices of trabeculae in the ventricular chamber. The distal ends of the defibrillation electrodes may be free of attachment to the lead body or may be attached by a weak bond to the distal portion of the lead.
摘要翻译：一种用于在心室中由一个或多个小直径除颤电极形成的复律/除颤电极的分散的引线和引导系统，并且用于附接与心脏接触的步调/感测电极。小直径除颤电极或电极从引线体的远端向远端延伸。如果使用多个电极，则它们优选地被偏置以在不受限制的情况下展开，并且具有足够小的横截面尺寸以插入心室中的小梁的间隙中。除颤电极的远端可以没有附着到引线体，或者可以通过弱接合附着到引线的远端部分。

12. 发明授权

US5374286A Torque indicator for fixed screw leads 失效
标题翻译：用于固定螺钉的转矩指示器
公开(公告)号：US5374286A
公开(公告)日：1994-12-20
申请号：US40735
申请日：1993-03-31
申请人： Mary M. Morris
发明人： Mary M. Morris
IPC分类号： A61N1/05 , A61N1/362 , A61N1/02
CPC分类号： A61N1/056 , Y10T29/49117
摘要： A body-implantable lead (10) for use in cardiac pacing having a proximal end and a distal end, the proximal end connected to a medical device, an active fixation device such as a helix electrode (330) having a distal end and a proximal end, the tissue securing means extending from the lead body distal end, an electrical conductor (15) extending between the proximal and distal ends of the lead, and a longitudinally extending radiopaque marker (35 or 335) affixed to the lead body (10) proximal to the tissue securing means, the radiopaque marker (35 or 335) showing rotational movement or distortion of the radiopaque marker (35 or 335) under fluoroscopy.
摘要翻译：一种用于心脏起搏的体动植入式导线（10），其具有近端和远端，所述近端连接到医疗装置，主动固定装置，例如螺旋电极（330），其具有远端和近端从引线体远端延伸的组织固定装置，在引线的近端和远端之间延伸的电导体（15）和固定到引线体（10）的纵向延伸的不透射线的标记（35或335）靠近组织固定装置，在透视下显示不透射线标记物（35或335）的旋转运动或变形的不透射线标记（35或335）。

13. 发明授权

US08784800B2 Method of delivering cell therapy to a target site 有权
标题翻译：将细胞治疗递送到目标部位的方法
公开(公告)号：US08784800B2
公开(公告)日：2014-07-22
申请号：US12400059
申请日：2009-03-09
申请人： Mary M. Morris , Kenneth Gardeski , Laurent Verard , Kevin Thomas Wu , Michael R. Neidert
发明人： Mary M. Morris , Kenneth Gardeski , Laurent Verard , Kevin Thomas Wu , Michael R. Neidert
IPC分类号： A61K35/12 , A61K35/00 , A61K49/04 , A61K49/06 , A61K35/28 , A61K35/32
CPC分类号： A61K35/28 , A61B5/06 , A61B5/7285 , A61B6/12 , A61B6/481 , A61B6/487 , A61B6/541 , A61K35/39 , A61K49/0017 , A61K49/06
摘要： A method of delivering therapy to a target site. The method includes (a) obtaining a base image of the target site, (b) injecting a dose of a mix of a therapeutic agent and a contrast agent into a first injection location at the target site via a needle passing through a catheter, (c) collecting sequential fluoroscopic images of a contrast agent dispersion cloud at the first injection location, (d) determining a contrast agent dispersion area from the sequential fluoroscopic images, (e) determining a therapeutic agent dispersion area from the contrast agent dispersion area, (f) marking the therapeutic agent dispersion area on the base image of the target site, and (g) repeating (b) through (f) until the target site is substantially covered with overlapping therapeutic agent dispersion areas corresponding to a plurality of injections at a plurality of injection locations at the target site.
摘要翻译：将治疗递送到目标部位的方法。该方法包括（a）获得目标部位的基础图像，（b）通过穿过导管的针将目标部位的剂量的治疗剂和造影剂的剂量注射到目标部位的第一注射位置（ c）在第一注射位置处收集造影剂分散云的顺序透视图像，（d）从顺序透视图像确定造影剂分散区域，（e）从造影剂分散区域确定治疗剂分散区域（ f）在目标部位的基础图像上标记治疗剂分散区域，和（g）重复（b）到（f）直到目标部位基本上覆盖有与多个注射相对应的重叠治疗剂分散区域在目标地点的多个注射位置。

14. 发明授权

US08672917B2 Pressure monitoring to control delivery of therapeutic agent 有权
公开(公告)号：US08672917B2
公开(公告)日：2014-03-18
申请号：US12767224
申请日：2010-04-26
申请人： Daniel C. Sigg , Prasanga D. Hiniduma-Lokuge , Mary M. Morris
发明人： Daniel C. Sigg , Prasanga D. Hiniduma-Lokuge , Mary M. Morris
IPC分类号： A61M31/00
CPC分类号： A61B5/036 , A61B5/0031 , A61B5/0215 , A61B5/4839 , A61M5/14276 , A61M5/16854 , A61M5/1723 , A61M2005/1726 , A61M2205/3331 , A61M2205/3334
摘要： A method for adjusting delivery of a therapeutic fluid to a patient suffering from or at risk of pulmonary arterial hypertension includes introducing the therapeutic fluid to a patient via a catheter at a predetermined rate. The catheter is positioned to deliver the fluid to the right ventricle or the pulmonary artery. The catheter a one-way valve configured to allow the fluid to flow from the catheter to the target location. The method further includes monitoring pressure of the target location by monitoring internal catheter pressure, and adjusting the rate at which the therapeutic fluid is introduced to the catheter based on the monitored pressure. The rate at which the fluid is introduced to the catheter is increased if internal catheter pressure increases, and the rate at which the fluid is introduced to the catheter is decreased if the internal catheter pressure decreases.

15. 发明授权

US08369965B2 Expandable systems for medical electrical stimulation 有权
标题翻译：用于医疗电刺激的可扩展系统
公开(公告)号：US08369965B2
公开(公告)日：2013-02-05
申请号：US12846547
申请日：2010-07-29
申请人： Sean P. Skubitz , Stephen L. Bolea , Paula M. Kaplan , Mary M. Morris
发明人： Sean P. Skubitz , Stephen L. Bolea , Paula M. Kaplan , Mary M. Morris
IPC分类号： A61N1/05
CPC分类号： A61N1/0553 , A61N1/0558
摘要： A medical system for electrical stimulation includes a first column of electrodes, a second column of electrodes, an expandable member disposed between first and second columns, and an expansion mechanism adapted to transmit an externally applied pressure to the expandable member. The pressure expands the expandable member in order to force the first column of electrodes apart from the second column of electrodes. The first and second columns, disposed side-by-side, may be inserted through a percutaneous needle and into a epidural space, alongside a spinal cord; after insertion, the first column may be forced apart from the second column by applying the pressure to the expandable member.
摘要翻译：用于电刺激的医疗系统包括第一列电极，第二电极列，设置在第一和第二列之间的可扩张构件以及适于将外部施加的压力传递到可扩张构件的膨胀机构。压力使可膨胀构件膨胀，以迫使第一列电极与第二列电极分开。并排设置的第一和第二列可以穿过经皮针插入到与脊髓一起的硬膜外腔中; 在插入之后，通过向可膨胀构件施加压力，第一柱可以被迫离开第二柱。

16. 发明授权

US07925358B2 Radiopaque marking of lead electrode zone in a continuous conductor construction 失效
标题翻译：连续导体结构中铅电极区的不透射线标记
公开(公告)号：US07925358B2
公开(公告)日：2011-04-12
申请号：US11846774
申请日：2007-08-29
申请人： Elisabeth L. Belden , Mary M. Morris
发明人： Elisabeth L. Belden , Mary M. Morris
IPC分类号： A61N1/06
CPC分类号： A61N1/0563
摘要： A cardiac transvenous defibrillation lead has a continuous coil conductor within a layer of insulation. A portion of the coil conductor is exposed as a defibrillation electrode. In order to enhance fluoroscopic visualization of the exposed electrode during implant, the end of the exposed electrode is marked with a radiopaque element. The element may be in the form of an adhesive filled with radiopaque material that is used to backfill under the layer of insulation. Alternatively, a tube made of radiopaque material may be installed between the layer of insulation and the coil conductor.
摘要翻译：心脏静脉除颤引线在绝缘层内具有连续的线圈导体。线圈导体的一部分作为除颤电极露出。为了在植入期间增强暴露电极的荧光透视可视化，暴露电极的端部用不透射线的元件标记。元件可以是填充有不透射线材料的粘合剂的形式，其用于在绝缘层下方回填。或者，由不透射线材料制成的管可以安装在绝缘层和线圈导体之间。

17. 发明申请

US20090276025A1 TECHNIQUES FOR PLACING MEDICAL LEADS FOR ELECTRICAL STIMULATION OF NERVE TISSUE 有权
公开(公告)号：US20090276025A1
公开(公告)日：2009-11-05
申请号：US12433768
申请日：2009-04-30
申请人： John E. Burnes , Mary M. Morris , Michael R.S. Hill , Avram Scheiner , Ruth N. Klepfer , Matthew D. Bonner
发明人： John E. Burnes , Mary M. Morris , Michael R.S. Hill , Avram Scheiner , Ruth N. Klepfer , Matthew D. Bonner
IPC分类号： A61N1/05
CPC分类号： A61N1/36053 , A61M25/09 , A61N1/05 , A61N1/0551 , A61N1/0558 , A61N1/057 , A61N1/36085 , A61N1/36114 , A61N1/36125 , A61N1/36128
摘要： This disclosure is directed to extra, intra, and transvascular medical lead placement techniques for arranging medical leads and electrical stimulation and/or sensing electrodes proximate nerve tissue within a patient.

18. 发明授权

US07500949B2 Multilumen catheter 有权
标题翻译：多元导管
公开(公告)号：US07500949B2
公开(公告)日：2009-03-10
申请号：US10331949
申请日：2002-12-30
申请人： Rebecca Gottlieb , Rajiv Shah , Mary M. Morris , Victor Giron , Michael E. Miller , Bradley J. Enegren
发明人： Rebecca Gottlieb , Rajiv Shah , Mary M. Morris , Victor Giron , Michael E. Miller , Bradley J. Enegren
IPC分类号： A61B5/00 , A61B5/05 , A61M5/00 , A61M35/00
CPC分类号： A61M25/0032 , A61B5/028 , A61B5/14532 , A61B5/1486 , A61B5/415 , A61M5/14244 , A61M5/1723 , A61M25/0017 , A61M25/0023 , A61M2025/0003 , A61M2025/0046 , A61M2230/201 , Y10T29/49826
摘要： A multilumen catheter having tubings extending into lumens within the catheter. The lumens may be used for blood, drugs or other medicants. The lumens may also be used for sensors. The junction element, external to the patient, connects the tubings to the lumens. The tubings, also external to the patient, connect to infusion members, to which one or more infusion systems may be connected to deliver blood, drugs and other medicants to the patient. A sensor having a sensing element may extend through the sensor lumen and be positioned internal to the patient for physiological parameter sensing. An external portion of the sensor may be connected to associated electronics to provide automatic monitoring of the physiological parameters and automatic delivery and control of the infusants. Also, a central line catheter for delivering fluids directly into a main artery or vein near the heart, which contains a first lumen to deliver a fluid through the central line catheter and a second lumen containing a sensor capable indicating a characteristic level in blood. The first lumen delivers the fluid downstream of the sensor to prevent any interference between the fluid delivery and the sensor readings. In other versions, the central line catheter can have additional lumens for additional purposes. In addition, the central line catheter can further include a flush sleeve to remove debris around the sensor.
摘要翻译：一种多管导管，其具有延伸到导管内腔内的管道。流明可用于血液，药物或其他药物。流明也可用于传感器。患者外部的连接元件将管道连接到管腔。也在患者外部的管连接到输注构件，一个或多个输注系统可以连接到输注构件，以向患者输送血液，药物和其他药剂。具有感测元件的传感器可以延伸穿过传感器内腔并且位于患者的内部以用于生理参数感测。传感器的外部部分可以连接到相关联的电子设备，以提供对生理参数的自动监测以及对输入的自动传送和控制。另外，一种用于将流体直接输送到心脏附近的主动脉或静脉的中心线导管，其包含用于通过中心线导管输送流体的第一内腔和包含能够指示血液中的特征水平的传感器的第二腔。第一个内腔在传感器的下游传送流体，以防止流体输送和传感器读数之间的任何干扰。在其他版本中，中心线导管可以具有另外的流明用于其他目的。此外，中心线导管还可以包括冲洗套筒以去除传感器周围的碎屑。

19. 发明授权

US07413564B2 Slit valve catheters 有权
标题翻译：狭缝阀导管
公开(公告)号：US07413564B2
公开(公告)日：2008-08-19
申请号：US10382948
申请日：2003-03-06
申请人： Mary M. Morris , Timothy G. Laske , Kenneth T. Heruth , Michael R. Ujhelyi , Jesus W. Casas-Bejar
发明人： Mary M. Morris , Timothy G. Laske , Kenneth T. Heruth , Michael R. Ujhelyi , Jesus W. Casas-Bejar
IPC分类号： A61M25/16 , A61M25/18
CPC分类号： A61M25/0075
摘要： An external surface of a catheter body includes a pressure responsive slit formed in an indentation wherein a wall thickness of the catheter body within the indentation is less than a wall thickness of a major portion of the catheter body. Material exits a lumen of the catheter body, via the pressure responsive slit, when a pressure inside the lumen exceeds an external pressure.
摘要翻译：导管体的外表面包括形成在凹陷中的压力响应狭缝，其中压痕内导管体的壁厚小于导管主体的主要部分的壁厚。当内腔内的压力超过外部压力时，材料通过压力响应狭缝离开导管主体的内腔。

20. 发明授权

US07031777B2 Cardiac vein lead with flexible anode and method for forming same 有权
标题翻译：具有柔性阳极的心静脉导线及其形成方法
公开(公告)号：US07031777B2
公开(公告)日：2006-04-18
申请号：US10256353
申请日：2002-09-27
申请人： Douglas S. Hine , John L. Sommer , Wayne R. Bass , Mary M. Morris , Peter B. McIntyre , Carla C. Pfeiffer , Roger Lafond , Patricia K. Peterson
发明人： Douglas S. Hine , John L. Sommer , Wayne R. Bass , Mary M. Morris , Peter B. McIntyre , Carla C. Pfeiffer , Roger Lafond , Patricia K. Peterson
IPC分类号： A61N1/05
CPC分类号： A61N1/056 , A61N2001/0585
摘要： A bipolar cardiac vein lead and method of assembly is provided wherein the lead includes a flexible coil anode electrode such that the lead may be advanced through a tortuous pathway. The coil electrode is coupled to a conductor using a method of assembly that minimizes or eliminates rigid components, maintaining flexibility of the distal lead end. Multi-polar cardiac vein leads may include multiple flexible coil electrodes to achieve pacing and/or sensing in the left atrium and the left ventricle or at multiple left heart sites.
摘要翻译：提供了一种双极心静脉引线和组装方法，其中引线包括柔性线圈阳极电极，使得引线可以通过曲折的通路前进。线圈电极使用最小化或消除刚性部件的组装方法联接到导体，保持远端引线端的柔性。多极心静脉引线可以包括多个柔性线圈电极，以实现左心房和左心室或多个左心脏部位的起搏和/或感测。

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