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11. 发明申请

US20130087467A1 HIGH-PERFORMANCE ANALYTICAL INSTRUMENT AND METHOD 审中-公开
标题翻译：高性能分析仪器和方法
公开(公告)号：US20130087467A1
公开(公告)日：2013-04-11
申请号：US13532772
申请日：2012-06-25
申请人： Hongjun Yang
发明人： Hongjun Yang
IPC分类号： G01N27/28
CPC分类号： G01N27/28 , G01N21/76
摘要： Apparatus and methods are provided for improving sensitivity, throughput, and efficiency of multi-analyte analytical testing. Specifically, an improved Electrochemiluminescence (ECL) analytical apparatus is provided for analytical chemistry, diagnostics, and environmental applications. The ECL apparatus comprises a 96 or more-well plate, where a microarray of working electrodes is placed in each well for high throughput and multi-analyte testing. The microarray of working electrodes connects with a counter electrode forming a two-electrode electrochemical system. Each well is electrically addressable, thereby controlling ECL reactions in flexible modes. The ECL apparatus further comprises a detector of ECL signals, and the detector employs a CCD-chip assembling matrix. Also provided are methods for high-throughput multi-analyte testing. The methods according to this disclosure are applied in various embodiments to test a broad range of analytes, including chemical compounds, proteins, peptides, DNAs, RNAs, antigens, antibodies, pathogens, contaminants, and derivatives thereof.
摘要翻译：提供了设备和方法来提高多分析物分析测试的灵敏度，产量和效率。具体来说，提供改进的电化学发光（ECL）分析仪器用于分析化学，诊断和环境应用。 ECL装置包括96孔或更多孔板，其中工作电极的微阵列放置在每个孔中用于高通量和多分析物测试。工作电极的微阵列与形成双电极电化学系统的对电极连接。每个井都是电可寻址的，从而以灵活的模式控制ECL反应。 ECL装置还包括ECL信号的检测器，并且检测器采用CCD芯片组装矩阵。还提供了用于高通量多分析物测试的方法。根据本公开的方法应用于各种实施方案中以测试广泛的分析物，包括化合物，蛋白质，肽，DNA，RNA，抗原，抗体，病原体，污染物及其衍生物。

12. 发明申请

US20050176055A1 Electrochemiluminescence of rare earth metal chelates 失效
标题翻译：稀土金属螯合物的电化学发光
公开(公告)号：US20050176055A1
公开(公告)日：2005-08-11
申请号：US11077076
申请日：2005-03-11
申请人： Hongjun Yang , Nicholas Cairns
发明人： Hongjun Yang , Nicholas Cairns
IPC分类号： C07F5/00 , G01N33/58 , C12Q1/68 , C07K14/79 , G01N33/53
CPC分类号： C07F5/003 , G01N33/582 , Y10S436/806 , Y10T436/13
摘要： Luminescent chemical reagents that include complexes of rare earth metals with ligands such as aromatic heterocyclic nitrogen-containing compounds and semi-aromatic oxygen-containing compounds are used to detect small quantities of complex substances such as pharmaceuticals, metabolites, and microorganisms in complex sample mixtures.
摘要翻译：包括稀土金属络合物与芳族杂环含氮化合物和半芳族含氧化合物等配体的发光化学试剂用于检测复杂样品混合物中的少量复合物质，如药物，代谢物和微生物。

13. 发明授权

US5858676A Electrochemiluminescence of rare earth metal chelates 失效
公开(公告)号：US5858676A
公开(公告)日：1999-01-12
申请号：US891337
申请日：1997-07-10
申请人： Hongjun Yang , Nicholas Cairns
发明人： Hongjun Yang , Nicholas Cairns
IPC分类号： C07F5/00 , G01N33/58 , G01N33/53
CPC分类号： C07F5/003 , G01N33/582 , Y10S436/806 , Y10T436/13
摘要： Luminescent chemical reagents that include complexes of rare earth metals with ligands such as aromatic heterocyclic nitrogen-containing compounds and semi-aromatic oxygen-containing compounds are used to detect small quantities of complex substances such as pharmaceuticals, metabolites, and microorganisms in complex sample mixtures.

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