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11. 发明申请

US20100285146A1 PEPTIDES AND METHODS FOR THE TREATMENT OF SYSTEMIC LUPUS ERYTHEMATOSUS 审中-公开
标题翻译：用于治疗系统性红斑狼疮的肽和方法
公开(公告)号：US20100285146A1
公开(公告)日：2010-11-11
申请号：US12601261
申请日：2008-05-22
申请人： Yaakov Naparstek
发明人： Yaakov Naparstek
IPC分类号： A61K35/16 , B01J20/22 , B01D15/08
CPC分类号： C07K16/44 , A61K38/00 , A61M1/0023 , A61M1/3472 , A61M1/3679
摘要： A method is disclosed for treating systemic lupus erythematosus in a mammalian subject, comprising administering to said subject an effective dose of at least one laminin peptide, or an analog or a derivative thereof. In one exemplary embodiment, the laminin peptide is selected from the group consisting of R38 (SEQ. ID. NO. 1), and claimed R38 analogs and derivatives thereof including 5200 (SEQ. ID. NO. 10), 5104 (SEQ. ID. NO. 15), 5105 (SEQ. ID. NO. 16), 5106 (SEQ. ID. NO. 17), 5107 (SEQ. ID. NO. 18), 5108 (SEQ. ID. NO. 19), 5109 (SEQ. ID. NO. 20), 5110 (SEQ. ID. NO. 21). The laminin peptides of the present invention may be prepared by known chemical synthetic methods or by biotechnological methods. The invention also provides assays useful for the diagnosis of and following pathological activity course of systemic lupus erythematosus in patients suffering therefrom. In addition, the subject invention concerns a method of treating systemic lupus erythematosus in a subject comprising the extracorporeal removal of lupus antibodies from the subject's plasma and returning the plasma to the subject. In an additional aspect, the invention provides method of reducing anti-R38 antibody levels in a patient's plasma.
摘要翻译：公开了用于治疗哺乳动物受试者的系统性红斑狼疮的方法，包括向所述受试者施用有效剂量的至少一种层粘连蛋白肽或其类似物或衍生物。在一个示例性实施方案中，层粘连蛋白肽选自R38（SEQ ID NO：1），并要求保护的R38类似物及其衍生物，包括5200（SEQ ID NO：10），5104（SEQ ID NO：，编号15），5105（SEQ ID NO：16），5106（SEQ ID NO：17），5107（SEQ ID NO：18），5108（SEQ ID NO：19）， 5109（SEQ ID NO：20），5110（SEQ ID NO：21）。本发明的层粘连蛋白肽可以通过已知的化学合成方法或通过生物技术方法制备。本发明还提供可用于诊断患有系统性红斑狼疮的系统性红斑狼疮病理活动过程的测定法。此外，本发明涉及治疗受试者的系统性红斑狼疮的方法，其包括体外从受试者的血浆中除去狼疮抗体并将血浆返回到受试者。在另一方面，本发明提供降低患者血浆中抗R38抗体水平的方法。

12. 发明授权

US07247305B2 Amino acid sequences, DNA encoding the amino acid sequences, antibodies directed against such sequences and the different uses thereof 有权
标题翻译：氨基酸序列，编码氨基酸序列的DNA，针对这种序列的抗体及其不同用途
公开(公告)号：US07247305B2
公开(公告)日：2007-07-24
申请号：US10853567
申请日：2004-05-24
申请人： Yaakov Naparstek , Rina Ulmansky , Yechezkel Kashi
发明人： Yaakov Naparstek , Rina Ulmansky , Yechezkel Kashi
IPC分类号： A61K39/00
CPC分类号： C07K14/35 , C07K14/47 , Y10S530/806 , Y10S530/82
摘要： The invention is directed to a peptide comprising the amino acid sequence substantially as denoted by SEQ ID NO:1 and biologically functional homologues and derivatives thereof.
摘要翻译：本发明涉及包含基本上如SEQ ID NO：1所示的氨基酸序列的肽和其生物功能同系物及其衍生物。

13. 发明授权

US08642041B2 Adenylyl cyclase-associated protein (CAP1) and uses thereof as a target for immuno-modulation 有权
标题翻译：腺苷酸环化酶相关蛋白（CAP1）及其用作免疫调节的靶标
公开(公告)号：US08642041B2
公开(公告)日：2014-02-04
申请号：US13257633
申请日：2010-03-21
申请人： Yaakov Naparstek , Eli Moallem
发明人： Yaakov Naparstek , Eli Moallem
IPC分类号： A61K39/00
CPC分类号： C07K16/28 , C07K16/1289 , C07K2317/24 , C07K2317/34 , C07K2317/54 , C07K2317/75 , C12N9/00 , C12N15/113 , C12N2310/14
摘要： The present invention relates to the use of Adenylyl Cyclase-Associated Protein (CAP1) as a target for immuno-modulation. More specifically, the invention relates to the use of compounds that interact and bind CAP1, specifically, anti-CAP1 antibodies, and/or to CAP1 molecule or any fragments thereof, for the treatment of immune-related disorders by modulation of the Th1/Th2 balance. The invention further provides screening method for immuno-modulatory compounds that interact with CAP1.
摘要翻译：本发明涉及腺苷酸环化酶相关蛋白（CAP1）作为免疫调节靶标的用途。更具体地，本发明涉及通过调节Th1 / Th2相互作用并结合CAP1，特别是抗CAP1抗体和/或CAP1分子或其任何片段的化合物用于治疗免疫相关疾病的用途平衡。本发明还提供了与CAP1相互作用的免疫调节化合物的筛选方法。

14. 发明申请

US20120076753A1 USE OF NKP46 FOR PREVENTING DIABETES 有权
标题翻译：使用NKP46预防糖尿病
公开(公告)号：US20120076753A1
公开(公告)日：2012-03-29
申请号：US13257349
申请日：2010-03-18
申请人： Ofer Mandelboim , Angel Porgador , Yaakov Naparstek , Chamutal Gur
发明人： Ofer Mandelboim , Angel Porgador , Yaakov Naparstek , Chamutal Gur
IPC分类号： A61K38/17 , A61K39/44 , A61P3/10 , A61K38/28 , A61K38/26 , A61P37/02 , A61K39/395 , A61K38/20
CPC分类号： A61K39/3955 , A61K38/00 , A61K2039/505 , C07K14/705 , C07K14/70503 , C07K16/2803 , C07K16/2851 , C07K2319/30
摘要： The invention relates to use of the natural cytotoxicity receptor NKp46 for preventing and treating diabetes, including type I diabetes (TID) and type 2 diabetes. In particular, the invention provides compositions comprising a fragment of the extracellular region of NKp46 for preventing the onset and progression of diabetes.
摘要翻译：本发明涉及天然细胞毒性受体NKp46用于预防和治疗糖尿病，包括I型糖尿病（TID）和2型糖尿病的用途。特别地，本发明提供了包含NKp46细胞外区域片段的组合物，用于预防糖尿病的发病和进展。

15. 发明申请

US20050123535A1 Novel amino acid sequences, DNA encoding the amino acid sequences, antibodies directed against such sequences and the different uses thereof 失效
标题翻译：新氨基酸序列，编码氨基酸序列的DNA，针对这种序列的抗体及其不同用途
公开(公告)号：US20050123535A1
公开(公告)日：2005-06-09
申请号：US10931944
申请日：2004-08-31
申请人： Yaakov Naparstek , Rina Ulmansky , Yechezkel Kashi
发明人： Yaakov Naparstek , Rina Ulmansky , Yechezkel Kashi
IPC分类号： C07K14/35 , C07K14/47 , G01N33/53 , A61K39/395 , G01N33/537 , G01N33/543
CPC分类号： C07K14/47 , C07K14/35
摘要： B-cell epitope peptides of HSP 65, particularly the peptides comprising the amino acid sequence substantially as denoted by SEQ ID: Nos. 1-5 and their biologically functional homologues and derivatives thereof. Also included are polyclonal and monoclonal antibodies directed against them and their compositions for passive immunization against inflammatory and autoimmune diseases and in the treatment of inflammatory and autoimmune diseases. Also encompassed are diagnostic uses of these antibodies, for identifying people at risk of developing arthritis or diabetes, and a method of monitoring progress of the disease conditions and disease prognosis.
摘要翻译： HSP65的B细胞表位肽，特别是包含基本上如SEQ ID：1-5所示的氨基酸序列的肽及其生物功能同系物及其衍生物。还包括针对它们的多克隆和单克隆抗体及其针对炎症和自身免疫疾病的被动免疫以及治疗炎性和自身免疫性疾病的组合物。还包括这些抗体的诊断用途，用于鉴定发生关节炎或糖尿病风险的人，以及监测疾病状况和疾病预后进展的方法。

16. 发明授权

US5789260A Lupus disease immunoassay methods 失效
标题翻译：狼疮病免疫测定方法
公开(公告)号：US5789260A
公开(公告)日：1998-08-04
申请号：US715097
申请日：1996-09-17
申请人： Yaakov Naparstek
发明人： Yaakov Naparstek
IPC分类号： G01N33/564 , G01N33/543
CPC分类号： G01N33/564 , Y10S436/811
摘要： The invention provides an immunoassay reagent for the binding and detection of antibodies found in the urine of lupus disease patients, comprising extracellular matrix.
摘要翻译：本发明提供用于结合和检测在狼疮病患者尿中发现的抗体的免疫测定试剂，其包含细胞外基质。

17. 发明授权

US08158125B2 B-cell epitope peptides of HSP 65, novel amino acid sequences, DNA encoding the amino acid sequences of said peptides, antibodies directed against said peptides and different uses thereof in the treatment of inflammatory and autoimmune diseases 有权
标题翻译： HSP65的B细胞表位肽，新的氨基酸序列，编码所述肽的氨基酸序列的DNA，针对所述肽的抗体及其在治疗炎性和自身免疫性疾病中的不同用途
公开(公告)号：US08158125B2
公开(公告)日：2012-04-17
申请号：US12344919
申请日：2008-12-29
申请人： Yaakov Naparstek , Rina Ulmansky , Yechezkei Kashi
发明人： Yaakov Naparstek , Rina Ulmansky , Yechezkei Kashi
IPC分类号： A61K39/395
CPC分类号： C07K14/35 , A61K39/00 , A61K2039/505 , C07K14/47 , C07K16/1289 , C07K16/18
摘要： B-cell epitope peptides of HSP 65, particularly the peptides comprising the amino acid sequence substantially as denoted by SEQ ID: NOs. 1-5 and their biologically functional homologues and derivatives thereof. Also included are polyclonal and monoclonal antibodies directed against them and their compositions for passive immunization against inflammatory and autoimmune diseases and in the treatment of inflammatory and autoimmune diseases. Also encompassed are diagnostic uses of these antibodies, for identifying people at risk of developing arthritis or diabetes, and a method of monitoring progress of the disease conditions and disease prognosis.
摘要翻译： HSP65的B细胞表位肽，特别是包含基本上如SEQ ID NO：所示的氨基酸序列的肽。 1-5及其生物功能同系物及其衍生物。还包括针对它们的多克隆和单克隆抗体及其针对炎症和自身免疫疾病的被动免疫以及治疗炎性和自身免疫性疾病的组合物。还包括这些抗体的诊断用途，用于鉴定发生关节炎或糖尿病风险的人，以及监测疾病状况和疾病预后进展的方法。

18. 发明申请

US20080003276A1 Use of Liposomal Glucocorticoids for Treating Inflammatory States 有权
标题翻译：使用脂质体糖皮质激素治疗炎症状态
公开(公告)号：US20080003276A1
公开(公告)日：2008-01-03
申请号：US11662174
申请日：2005-09-11
申请人： Yechezkel Barenholz , Yaakov Naparstek , Yuval Avnir , Rina Ulmansky
发明人： Yechezkel Barenholz , Yaakov Naparstek , Yuval Avnir , Rina Ulmansky
IPC分类号： A61K9/127 , A61K31/56 , A61P19/02 , A61P29/00
CPC分类号： A61K9/127 , A61K9/1271 , A61K31/573
摘要： The present invention provides the use of a glucocorticoid (GC) or of a GC derivative encapsulated in a liposome for the preparation of a pharmaceutical composition for the treatment of an inflammatory associated condition in a subject, provided that said condition is not associated with a neurodegenerative disease or disorder A specific use concerns a liposomal formulation comprising methylprednisolone sodium hemisuccinate (MPS) for the treatment of rheumatoid arthritis.
摘要翻译：本发明提供糖皮质激素（GC）或包封在脂质体中的GC衍生物用于制备用于治疗受试者的炎症相关病症的药物组合物的用途，条件是所述病症与神经变性不相关疾病或病症具体用途涉及包含用于治疗类风湿性关节炎的甲泼尼龙钠半琥珀酸钠（MPS）的脂质体制剂。

19. 发明申请

US20050096285A1 Novel amino acid sequences, DNA encoding the amino acid sequences, antibodies directed against such sequences and the different uses thereof 有权
标题翻译：新氨基酸序列，编码氨基酸序列的DNA，针对这种序列的抗体及其不同用途
公开(公告)号：US20050096285A1
公开(公告)日：2005-05-05
申请号：US10853567
申请日：2004-05-24
申请人： Yaakov Naparstek , Rina Ulmansky , Yechezkel Kashi
发明人： Yaakov Naparstek , Rina Ulmansky , Yechezkel Kashi
IPC分类号： G01N33/53 , A61K39/395 , A61K48/00 , A61P19/02 , A61P29/00 , A61P37/02 , C07K14/35 , C07K14/47 , C07K16/12 , C07K16/18 , C12N5/08 , C12N15/09 , C12N15/31 , C07H21/04 , C07K14/74 , C07K16/28
CPC分类号： C07K14/35 , C07K14/47 , Y10S530/806 , Y10S530/82
摘要： The invention is directed to a peptide comprising the amino acid sequence substantially as denoted by SEQ ID NO:1 and biologically functional homologues and derivatives thereof.
摘要翻译：本发明涉及包含基本上如SEQ ID NO：1所示的氨基酸序列的肽和其生物功能同系物及其衍生物。

20. 发明授权

US06770281B2 B-cell epitope peptides of HSP 65 失效
标题翻译： HSP65的B细胞表位肽
公开(公告)号：US06770281B2
公开(公告)日：2004-08-03
申请号：US09847637
申请日：2001-05-02
申请人： Yaakov Naparstek , Rina Ulmansky , Yechezkel Kashi
发明人： Yaakov Naparstek , Rina Ulmansky , Yechezkel Kashi
IPC分类号： C07K1435
CPC分类号： C07K14/35 , C07K14/47 , Y10S530/806 , Y10S530/82
摘要： The invention is directed to a peptide, comprising the amino acid sequence substantially as denoted by SEQ ID NO:1 and biologically functional homologues and derivatives thereof.
摘要翻译：本发明涉及一种肽，其包含基本上如SEQ ID NO：1所示的氨基酸序列及其生物功能同系物及其衍生物。

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