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11. 发明申请

US20050234112A1 3-Hydroxymethyl-4-hydroxy-phenyl-derivatives for the treatment of respiratory diseases 有权
标题翻译： 3-羟甲基-4-羟基 - 苯基 - 衍生物用于治疗呼吸系统疾病
公开(公告)号：US20050234112A1
公开(公告)日：2005-10-20
申请号：US11028264
申请日：2005-01-03
申请人： Thierry Bouyssou , Frank Buettner , Ingo Konetzki , Sabine Pestel , Andreas Schnapp , Hermann Schollenberger , Kurt Schromm , Claudia Heine
发明人： Thierry Bouyssou , Frank Buettner , Ingo Konetzki , Sabine Pestel , Andreas Schnapp , Hermann Schollenberger , Kurt Schromm , Claudia Heine
IPC分类号： C07D233/54 , C07D249/08 , A61K31/4245 , A61K31/415 , A61K31/4172 , A61K31/4196
CPC分类号： C07D249/08 , C07D233/64
摘要： The present invention relates to the use of the compounds of general formula 1 wherein the groups R1, X and Y may have the meanings given in the claims and in the specification, for preparing a pharmaceutical composition for the treatment of COPD (chronic obstructive pulmonary disease), as well as new compounds of general formula 1 and processes for preparing them.
摘要翻译：本发明涉及通式1化合物的用途，其中基团R 1，X和Y可以具有权利要求书和说明书中给出的含义，用于制备用于治疗COPD（慢性阻塞性肺疾病）以及通式1的新化合物及其制备方法。

12. 发明申请

US20080132556A1 3-HYDROXYMETHYL-4HYDROXY-PHENYL- DERIVATIVES FOR THE TREATMENT OF RESPIRATORY DISEASES 审中-公开
标题翻译：用于治疗呼吸道疾病的3-羟基甲基-4,4-羟基 - 苯基衍生物
公开(公告)号：US20080132556A1
公开(公告)日：2008-06-05
申请号：US12013104
申请日：2008-01-11
申请人： Thierry Bouyssou , Frank Buettner , Ingo Konetzki , Sabine Pestel , Andreas Schnapp , Hermann Schollenberger , Kurt Schromm , Claudia Heine
发明人： Thierry Bouyssou , Frank Buettner , Ingo Konetzki , Sabine Pestel , Andreas Schnapp , Hermann Schollenberger , Kurt Schromm , Claudia Heine
IPC分类号： A61K31/4196 , A61P43/00
CPC分类号： C07D249/08 , C07D233/64
摘要： The present invention relates to the use of the compounds of general formula 1 wherein the groups R1, X and Y may have the meanings given in the claims and in the specification, for preparing a pharmaceutical composition for the treatment of COPD (chronic obstructive pulmonary disease), as well as new compounds of general formula 1 and processes for preparing them.
摘要翻译：本发明涉及通式1化合物的用途，其中基团R 1，X和Y可以具有权利要求书和说明书中给出的含义，用于制备用于治疗COPD（慢性阻塞性肺疾病）以及通式1的新化合物及其制备方法。

13. 发明申请

US20050234134A1 Betamimetics with a prolonged duration of activity, processes for preparing them, and their use as pharmaceutical compositions 审中-公开
公开(公告)号：US20050234134A1
公开(公告)日：2005-10-20
申请号：US11146268
申请日：2005-06-06
申请人： Frank Buettner , Ingo Konetzki , Kurt Schromm , Hermann Schollenberger , Sabine Pestel , Andreas Schnapp , Thierry Bouyssou , Claudia Heine
发明人： Frank Buettner , Ingo Konetzki , Kurt Schromm , Hermann Schollenberger , Sabine Pestel , Andreas Schnapp , Thierry Bouyssou , Claudia Heine
IPC分类号： A61K31/137 , A61K31/18 , A61K45/06 , A61K31/138
CPC分类号： A61K45/06 , A61K31/137 , A61K31/18 , A61K2300/00
摘要： A compound of formula 1 wherein: R1 is C1-C4-alkyl; R2 is C1-C4-alkyl; and R3 is C1-C4-alkyl or phenyl, each optionally mono- or polysubstituted, or R2 and R3 together are —CH2—CH2— or —CH2—CH2—CH2—, or the corresponding acid addition salt with a pharmacologically acceptable acid, processes for preparing such compounds, pharmaceutical compositions containing such compounds, and their use in the treatment of inflammatory and obstructive respiratory diseases.

14. 发明授权

US06951888B2 Betamimetics with a prolonged duration of activity, processes for preparing them, and their use as pharmaceutical compositions 有权
标题翻译：具有延长活性持续时间的贝米霉素，其制备方法及其作为药物组合物的用途
公开(公告)号：US06951888B2
公开(公告)日：2005-10-04
申请号：US10666068
申请日：2003-09-19
申请人： Frank Buettner , Ingo Konetzki , Kurt Schromm , Hermann Schollenberger , Sabine Pestel , Andreas Schnapp , Thierry Bouyssou , Claudia Heine
发明人： Frank Buettner , Ingo Konetzki , Kurt Schromm , Hermann Schollenberger , Sabine Pestel , Andreas Schnapp , Thierry Bouyssou , Claudia Heine
IPC分类号： A61K31/137 , A61K31/18 , A61K45/06 , A61K31/047 , C07C215/58
CPC分类号： A61K45/06 , A61K31/137 , A61K31/18 , A61K2300/00
摘要： A compound of formula 1 wherein: R1 is C1-C4-alkyl; R2 is C1-C4-alkyl; and R3 is C1-C4-alkyl or phenyl, each optionally mono- or polysubstituted, or R2 and R3 together are —CH2—CH2— or —CH2—CH2—CH2—, or the corresponding acid addition salt with a pharmacologically acceptable acid, processes for preparing such compounds, pharmaceutical compositions containing such compounds, and their use in the treatment of inflammatory and obstructive respiratory diseases.
摘要翻译：式1的化合物，其中：R 1是C 1 -C 4 - 烷基; R 2是C 1 -C 4 - 烷基; 和R 3是C 1 -C 4 - 烷基或苯基，各自任选被单取代或多取代，或R 2， SUP>和R 3一起是-CH 2 -CH 2 - 或 - CH 2 -CH _{2 CH 2 - 或与药理学上可接受的酸的相应的酸加成盐，制备这些化合物的方法，含有这些化合物的药物组合物及其在治疗炎症中的用途和阻塞性呼吸道疾病。}

15. 发明授权

US07135500B2 Dihydroxymethylphenyl derivatives, processes for preparing them, and their use as pharmaceuticals 有权
标题翻译：二羟甲基苯基衍生物，其制备方法及其作为药物的用途
公开(公告)号：US07135500B2
公开(公告)日：2006-11-14
申请号：US10697525
申请日：2003-10-30
申请人： Ingo Konetzki , Kurt Schromm , Hermann Schollenberger , Sabine Pestel , Andreas Schnapp , Thierry Bouyssou , Frank Buettner , Claudia Heine
发明人： Ingo Konetzki , Kurt Schromm , Hermann Schollenberger , Sabine Pestel , Andreas Schnapp , Thierry Bouyssou , Frank Buettner , Claudia Heine
IPC分类号： A61K31/425 , C07C213/00
CPC分类号： C07C215/60
摘要： A compound of formula 1 wherein the groups R1, R2, R3, and R4 may have the meanings given in the claims and in the specification, processes for preparing them, and their use as pharmaceutical compositions, particularly for the treatment of inflammatory and obstructive respiratory complaints.
摘要翻译：其中基团R 1，R 2，R 3和R 4的式1化合物可以具有权利要求书和说明书中给出的含义，其制备方法及其作为药物组合物的用途，特别是用于治疗炎性和阻塞性呼吸道疾病。

16. 发明申请

US20050239778A1 Novel medicament combinations for the treatment of respiratory diseases 审中-公开
标题翻译：用于治疗呼吸系统疾病的新型药物组合
公开(公告)号：US20050239778A1
公开(公告)日：2005-10-27
申请号：US11109094
申请日：2005-04-19
申请人： Ingo Konetzki , Thierry Bouyssou , Philipp Lustenberger , Michael Pieper , Andreas Schnapp , Christoph Hoenke , Sabine Pestel , Klaus Rudolf , Michel Pairet
发明人： Ingo Konetzki , Thierry Bouyssou , Philipp Lustenberger , Michael Pieper , Andreas Schnapp , Christoph Hoenke , Sabine Pestel , Klaus Rudolf , Michel Pairet
IPC分类号： A61K31/538 , A61K31/56
CPC分类号： A61K45/06 , A61K31/538 , A61K31/56 , A61K2300/00
摘要： The present invention relates to new medicament combinations which contain in addition to one or more, preferably one, compound of general formula 1 wherein the groups R1, R2 and R3 may have the meanings given in the claims and in the specification, at least one other active substance 2, processes for preparing them and their use as pharmaceutical compositions.
摘要翻译：本发明涉及除了一种或多种，优选一种通式1化合物外还含有基团R 1，R 2和R 2的新药物组合， SUP> 3可以具有权利要求和说明书中给出的含义，至少一种其它活性物质2，其制备方法及其作为药物组合物的用途。

17. 发明授权

US07632834B2 Long acting beta-2-agonists and their use as medicaments 有权
标题翻译：长效β-2-激动剂及其用作药物
公开(公告)号：US07632834B2
公开(公告)日：2009-12-15
申请号：US12101462
申请日：2008-04-11
申请人： Thierry Bouyssou , Ingo Konetzki , Philipp Lustenberger , Juergen Mack , Andreas Schnapp , Dieter Wiedenmayer , Christoph Hoenke , Klaus Rudolf
发明人： Thierry Bouyssou , Ingo Konetzki , Philipp Lustenberger , Juergen Mack , Andreas Schnapp , Dieter Wiedenmayer , Christoph Hoenke , Klaus Rudolf
IPC分类号： A61K31/538 , A61K31/536 , C07D413/12 , C07D413/14
CPC分类号： C07D265/36 , C07D413/12
摘要： A compound of formula 1′″ wherein: V is —CH2—, —NH—, or —O—; Ra and Rb are each independently hydrogen, C1-4-alkyl, or halogen-C1-4-alkyl, or Ra and Rb together are a C2-5-alkylene bridge wherein one or more hydrogen atoms are optionally replaced by halogen; R1 and R1′ are each independently hydrogen, C1-6-alkyl, C3-6-cycloalkyl, halogen-C1-6-alkyl, halogen-C3-6-cycloalkyl, or C1-6-alkylene-C3-6-cycloalkyl, or R1 and R1′ together are a C2-5-alkylene bridge wherein one or more hydrogen atoms are optionally replaced by halogen; R2, R2′, R2″, and R2′″ are each independently hydrogen, C1-6-alkyl, halogen-C1-6-alkylene, OH, HO—C1-6-alkylene, —O—C1-6-alkyl, C6-10-aryl, C6-10-aryl-C1-4-alkylene, C6-10-aryl-C1-6-alkylene-O, COOH, COOC1-6-alkyl, O—C1-6-alkylene-COOH, O—C1-6-alkylene-COOC1-6-alkyl, NHSO2—C1-6-alkyl, CN, NH2, NH—C1-6-alkyl, N(C1-6-alkyl)2, NO2, S—C1-6-alkyl, SO2—C1-6-alkyl, SO—C1-6-alkyl, O(CO)C1-6-alkyl, COC1-6-alkyl, NHCOC1-6-alkyl, or halogen; and n is 0, 1, or 2, or an optical isomer thereof, or a corresponding acid addition salt thereof with a pharmacologically acceptable acid, and the use thereof as pharmaceutical compositions, particularly for the treatment of inflammatory and obstructive respiratory complaints.
摘要翻译：式1“'的化合物，其中：V是-CH 2 - ， - NH-或-O-; R a和R b各自独立地为氢，C 1-4 - 烷基或卤素-C 1-4 - 烷基，或者R a和R b一起是C 2-5亚烷基桥，其中一个或多个氢原子任选被卤素取代; R 1和R 1'各自独立地为氢，C 1-6 - 烷基，C 3-6 - 环烷基，卤素-C 1-6 - 烷基，卤素-C 3-6环烷基或C 1-6亚烷基-C 3-6环烷基，或者R1和R1'一起是C2-5亚烷基桥，其中一个或多个氢原子任选地被卤素取代; R 2，R 2'，R 2“和R 2”各自独立地为氢，C 1-6 - 烷基，卤素-C 1-6亚烷基，OH，HO-C 1-6 - 亚烷基，-O-C 1-6 - 烷基，C 6-10 - 芳基，C 6-10 - 芳基-C 1-4 - 亚烷基，C 6-10 - 芳基-C 1-6 - 亚烷基-O，COOH，COOC 1-6 - 烷基，O-C 1-6亚烷基 - COOH，O-C 1-6亚烷基-COOC 1-6 - 烷基，NHSO 2 -C 1-6 - 烷基，CN，NH 2，NH-C 1-6 - 烷基，N（C 1-6 - 烷基）2，NO 2， C 1-6 - 烷基，SO 2 -C 1-6 - 烷基，SO-C 1-6 - 烷基，O（CO）C 1-6 - 烷基，CO C 1-6 - 烷基，NHCOC 1-6 - 烷基或卤素; 和n为0,1或2，或其光学异构体或其与药理学上可接受的酸的相应的酸加成盐，以及其作为药物组合物的用途，特别是用于治疗炎性和阻塞性呼吸道疾病。

18. 发明授权

US07375104B2 Long acting beta-2-agonists and their use as medicaments 有权
公开(公告)号：US07375104B2
公开(公告)日：2008-05-20
申请号：US11600417
申请日：2006-11-15
申请人： Thierry Bouyssou , Ingo Konetzki , Philipp Lustenberger , Juergen Mack , Andreas Schnapp , Dieter Wiedenmayer , Christoph Hoenke , Klaus Rudolf
发明人： Thierry Bouyssou , Ingo Konetzki , Philipp Lustenberger , Juergen Mack , Andreas Schnapp , Dieter Wiedenmayer , Christoph Hoenke , Klaus Rudolf
IPC分类号： C07D413/12 , C07D413/14 , A61K31/538 , A61K31/536
CPC分类号： C07D265/36 , C07D413/12
摘要： A compound of formula 1′ wherein: V is —CH2—, —NH—, or —O—; Ra and Rb are each independently hydrogen, C1-4-alkyl, or halogen-C1-4-alkyl, or Ra and Rb together are a C2-5-alkylene bridge wherein one or more hydrogen atoms are optionally replaced by halogen; R1 and R1′ are each independently hydrogen, C1-6-alkyl, C3-6-cycloalkyl, halogen-C1-6-alkyl, halogen-C3-6-cycloalkyl, or C1-6-alkylene-C3-6-cycloalkyl, or R1 and R1′ together are a C2-5-alkylene bridge wherein one or more hydrogen atoms are optionally replaced by halogen; R2, R2′, R2″, and R′″ are each independently hydrogen, C1-6-alkyl, halogen-C1-6-alkylene, OH, HO—C1-6-alkylene, —O—C1-6-alkyl, C6-10-aryl, C6-10-aryl-C1-4-alkylene, C6-10-aryl-C1-6-alkylene-O, COOH, COOC1-6-alkyl, O—C1-6-alkylene-COOH, O—C1-6-alkylene-COOC1-6-alkyl, NHSO2—C1-6-alkyl, CN, NH2, NH—C1-6-alkyl, N(C1-6-alkyl)2, NO2, S—C1-6-alkyl, SO2—C1-6-alkyl, SO—C1-6-alkyl, O(CO)C1-6-alkyl, COC1-6-alkyl, NHCOC1-6-alkyl, or halogen; and n is 0, 1, or 2, or an optical isomer thereof, or a corresponding acid addition salt thereof with a pharmacologically acceptable acid, and the use thereof as pharmaceutical compositions, particularly for the treatment of inflammatory and obstructive respiratory complaints.

19. 发明授权

US07423035B2 Substituted cycloalkyl derivatives, process for the manufacture thereof and use thereof as medicament 有权
标题翻译：取代的环烷基衍生物，其制备方法及其作为药物的用途
公开(公告)号：US07423035B2
公开(公告)日：2008-09-09
申请号：US11125757
申请日：2005-05-10
申请人： Ingo Konetzki , Thierry Bouyssou , Philipp Lustenberger , Andreas Schnapp , Christoph Hoenke , Klaus Rudolf , Marco Santagostino
发明人： Ingo Konetzki , Thierry Bouyssou , Philipp Lustenberger , Andreas Schnapp , Christoph Hoenke , Klaus Rudolf , Marco Santagostino
IPC分类号： C07D265/36 , A61K31/538 , A61K31/138
CPC分类号： C07D265/36 , C07C215/60 , C07C215/68 , C07C217/74 , C07C311/08 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D215/227
摘要： The present invention relates to compounds of formula 1 wherein the groups R1, R2, R3, R4, R5, R6, R7, R8, n, m and X may have the meanings given in the claims and in the specification, and the use thereof as pharmaceutical compositions, particularly for the treatment of inflammatory and obstructive respiratory complaints.
摘要翻译：本发明涉及式1化合物，其中基团R 1，R 2，R 3，R 4， >，R 5，R 6，R 7，R 8，n，m和X可以具有在权利要求和说明书中给出的含义，以及作为药物组合物的用途，特别是用于治疗炎性和阻塞性呼吸道疾病。

20. 发明申请

US20050227975A1 New long acting beta-2-agonists and their use as medicaments 有权
标题翻译：新型长效β-2-激动剂及其用作药物
公开(公告)号：US20050227975A1
公开(公告)日：2005-10-13
申请号：US11029451
申请日：2005-01-05
申请人： Thierry Bouyssou , Ingo Konetzki , Philipp Lustenberger , Juergen Mack , Andreas Schnapp , Dieter Wiedenmayer , Christoph Hoenke , Klaus Rudolf
发明人： Thierry Bouyssou , Ingo Konetzki , Philipp Lustenberger , Juergen Mack , Andreas Schnapp , Dieter Wiedenmayer , Christoph Hoenke , Klaus Rudolf
IPC分类号： A61K31/4709 , A61K31/517 , A61K31/538 , C07D265/36 , C07D413/02 , C07D413/12 , C07D43/02
CPC分类号： C07D265/36 , C07D413/12
摘要： The present invention relates to compounds of formula 1 wherein the groups X, Ra, Rb, R1, R1′, R2, R2′, R2″, R2′″, V and n may have the meanings given in the claims and in the specification, and the use thereof as pharmaceutical compositions, particularly for the treatment of inflammatory and obstructive respiratory complaints.
摘要翻译：本发明涉及式1的化合物，其中基团X，R a，R b，R 1，R 1， R 2，R 2，R 2，R“2”，R“2”，R“2” ，V和n可以具有权利要求书和说明书中给出的含义，以及其作为药物组合物的用途，特别是用于治疗炎性和阻塞性呼吸道疾病。

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