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11. 发明授权

US5691319A Pyrimidine nucleoside derivatives having anti-tumor activity, their preparation and use 失效
标题翻译：嘧啶核苷衍生物具有抗肿瘤活性，其制备和用途
公开(公告)号：US5691319A
公开(公告)日：1997-11-25
申请号：US465127
申请日：1995-06-05
申请人： Masakatsu Kaneko , Hitoshi Hotoda , Tomoyuki Shibata , Tomowo Kobayashi , Yoshihiro Mitsuhashi , Akira Matsuda , Takuma Sasaki
发明人： Masakatsu Kaneko , Hitoshi Hotoda , Tomoyuki Shibata , Tomowo Kobayashi , Yoshihiro Mitsuhashi , Akira Matsuda , Takuma Sasaki
IPC分类号： A61K31/505 , A61K31/70 , A61K31/7042 , A61K31/7052 , A61K31/7064 , A61K31/7068 , A61P35/00 , C07D405/04 , C07H19/06 , C07H19/073 , C07H19/09
CPC分类号： C07H19/06 , C07H19/073
摘要： Compounds of formula (I): ##STR1## wherein: R.sup.1, R.sup.2 and R.sup.3 are independently selected from the group consisting of hydrogen atoms, optionally substituted alkanoyl groups and alkenylcarbonyl groups, PROVIDED THAT at least one of R.sup.1, R.sup.2 and R.sup.3 represents an unsubstituted alkanoyl group having from 5 to 24 carbon atoms, said substituted alkanoyl group or said alkenylcarbonyl group; and one of R.sup.4 and R.sup.5 represents a hydrogen atom and the other represents a cyano group; have valuable anti-tumor activity.
摘要翻译：式（I）的化合物：其中：R1，R2和R3独立地选自氢原子，任选取代的烷酰基和烯基羰基，提供了R1，R2和R3中的至少一个表示具有5至24个碳原子的未取代的烷酰基，所述取代的烷酰基或所述烯基羰基; R 4和R 5中的一个表示氢原子，另一个表示氰基; 具有有价值的抗肿瘤活性。

12. 发明授权

US5459254A Process for preparing synthetic intermediates of 2-alkynyladenosines and 2-alkynyladenosines 失效
标题翻译：制备2-炔基腺苷和2-炔基腺苷合成中间体的方法
公开(公告)号：US5459254A
公开(公告)日：1995-10-17
申请号：US149943
申请日：1993-11-10
申请人： Toyofumi Yamaguchi , Takanori Miyashita , Shinji Sakata , Toichi Abiru , Akira Matsuda , Tohru Ueda , Kentaro Kogi
发明人： Toyofumi Yamaguchi , Takanori Miyashita , Shinji Sakata , Toichi Abiru , Akira Matsuda , Tohru Ueda , Kentaro Kogi
IPC分类号： C07H19/16 , C07H19/067
CPC分类号： C07H19/16 , Y02P20/55
摘要： The present invention relates to a novel compound represented by the following formula [I] which is useful as a synthetic intermediate of a 2-alkynyladenosine.The present invention also relates to a process for producing the compound and a process for producing a 2-alkynyladenosine [IV] by way of the compound.Further, the present invention relates to a 2-alkynyladenosine derivative represented by the following formula [V] having excellent storage stability and, to a method of storing the 2-alkynyladenosine in the form of that derivative. ##STR1## [I] A=a leaving group, [II] A=NH.sub.2,[V] A=NHR.sup.4,wherein R.sup.1 through R.sup.4 represent a hydrogen atom or a protective group, and n denotes an integer of 1 to 15, provided that R.sup.1 through R.sup.4 do not represent a hydrogen atom simultaneously.
摘要翻译：本发明涉及可用作2-炔基腺苷合成中间体的下式[I]表示的新型化合物。本发明还涉及该化合物的制备方法和通过该化合物制备2-炔基腺苷[Ⅳ]的方法。此外，本发明涉及具有优异的储存稳定性的由下式[V]表示的2-炔基腺苷衍生物，以及以该衍生物的形式存储2-炔基腺苷的方法。 [I] A =离去基团，[II] A = NH 2，[V] A = NHR 4，其中R 1至R 4表示氢原子或保护基，n表示1至15的整数， R1至R4同时不表示氢原子。

13. 发明授权

US5338618A Electric contact material and electric contact using said material 失效
标题翻译：使用所述材料的电接触材料和电接触
公开(公告)号：US5338618A
公开(公告)日：1994-08-16
申请号：US951587
申请日：1992-09-25
申请人： Satoshi Suzuki , Nobuyuki Shibata , Ryotomo Shirakawa , Akira Matsuda
发明人： Satoshi Suzuki , Nobuyuki Shibata , Ryotomo Shirakawa , Akira Matsuda
IPC分类号： C22C1/10 , C22C5/06 , H01H1/023 , H01H1/0237 , H01H11/04 , H01R39/20 , H01H1/02
CPC分类号： H01H1/0237 , Y10T428/12486 , Y10T428/12882 , Y10T428/12896 , Y10T428/12903
摘要： An electric contact material containing Li oxide of 0.01 to 2.0% by weight when represented in terms of the amount of Li, oxide of at least one rare earth element of 0.05 to 0.18% by weight when represented in terms of the amount of the rare earth element, and Ag or Ag alloy as the remaining portion; an electric contact material containing Li oxide of 0.01 to 2.0% by weight when represented in terms of the amount of Li, at least one rare earth element of 0.05 to 0.18% by weight when represented in terms of the amount of the rare earth element, at least one element selected from a group consisting of In, Sn, Zn, Mn, Pd, Sb, Cu, Mg, Pb, Cd, Cr and Bi by an amount of 0.1 to 1.0% by weight (however, in the case of Zn and Mn, the amount is set less than 0.5% by weight), and/or at least one element selected from a group consisting of Fe, Ni and Co by an amount of 0.03 to 0.6% by weight, and Ag as the remaining portion; and an electric contact formed by using the above material. It is excellent in the arc resistance, wear resistance an lubricity in a small current region and is suitable as the material for a slide contact and rotary slide contact.
摘要翻译：当以稀土量表示的至少一种稀土元素的Li的氧化物为0.05〜0.18重量％表示时，含有0.01〜2.0重量％的Li氧化物的电接触材料元素，Ag或Ag合金作为剩余部分; 当以Li的量表示，含有0.01〜2.0重量％的Li氧化物的电接触材料，当以稀土元素的量表示时，至少一种稀土元素为0.05〜0.18重量％选自由In，Sn，Zn，Mn，Pd，Sb，Cu，Mg，Pb，Cd，Cr和Bi组成的组中的至少一种元素，其量为0.1至1.0重量％（然而，在 Zn和Mn，其含量设定为小于0.5重量％），和/或至少一种选自Fe，Ni和Co的元素的量为0.03至0.6重量％，Ag为剩余量一部分; 以及通过使用上述材料形成的电接触。电弧电阻优良，耐磨性小，在小电流区域具有润滑性，适用于滑动接触和旋转滑动接触的材料。

14. 发明授权

US5278204A Heat-resistant rubber compositions 失效
标题翻译：耐热橡胶组合物
公开(公告)号：US5278204A
公开(公告)日：1994-01-11
申请号：US975955
申请日：1992-11-13
申请人： Tetsuo Tojo , Katsuo Okamoto , Akira Matsuda , Eckhart Louis
发明人： Tetsuo Tojo , Katsuo Okamoto , Akira Matsuda , Eckhart Louis
IPC分类号： C08K3/36 , C08K9/06 , C08L23/16
CPC分类号： C08L23/16 , C08K3/36 , C08K9/06 , C08L2312/00
摘要： Disclosed is a heat-resistant rubber composition comprising (A) 100 parts by weight of an ethylene/.alpha.-olefin copolymer or a modified ethylene/.alpha.-olefin copolymer formed by graft-copolymerization with at least one compound selected from the group consisting of unsaturated carboxylic acids and anhydrides and esters thereof, and (B) (i) 10 to 100 parts by weight of a silica type filler which has been treated with a silane compound represented by the following formula: ##STR1## wherein R.sup.1 stands for an alkenyl group, a chloroalkenyl group or a chloroalkyl group, and R.sup.2 stands for a lower alkyl group, or (ii) a combination of 10 to 100 parts by weight of said silane-treated silica type filler or an untreated silica type filler and 0.5 to 30 parts by weight of a polyorganosiloxane having an average composition represented by the following formula:(R.sup.3).sub.a (R.sup.4).sub.b SiO.sub.(4-a-b)/2 (II)wherein R.sup.3 stands for a monovalent saturated or unsaturated hydrocarbon group, R.sup.4 stands for a chloroalkyl group or an alkenyl group, a is a number of from 1 to 2.5 and b is a number of from 0.01 to 1.2, with the proviso that the sum of a and b is in the range of from 1.8 to 3.
摘要翻译：公开了一种耐热橡胶组合物，其包含（A）100重量份的乙烯/α-烯烃共聚物或改性乙烯/α-烯烃共聚物，其通过与至少一种选自不饱和化合物的化合物接枝共聚而形成羧酸及其酸酐及其酯，（B）（i）10〜100重量份用下式表示的硅烷化合物处理的二氧化硅型填料：其中R1代表烯基，氯链烯基或氯代烷基，R2代表低级烷基，或（ii）10至100重量份所述硅烷处理二氧化硅类填料或未处理的二氧化硅类填料和0.5 30重量份的平均组成由下式表示的聚有机硅氧烷：（R3）a（R4）bSiO（4-ab）/ 2（Ⅱ）其中R3表示一价饱和或不饱和烃基，R4表示对于氯代烷基基团或烯基，a为1〜2.5的数，b为0.01〜1.2的数，条件是a和b之和在1.8〜3的范围内。

15. 发明授权

US5126361A Imidazole derivatives and use thereof 失效
标题翻译：咪唑衍生物及其用途
公开(公告)号：US5126361A
公开(公告)日：1992-06-30
申请号：US702210
申请日：1991-05-15
申请人： Tohru Ueda , Akira Matsuda , Noriaki Minakawa , Takuma Sasaki , Yoshikazu Yanagi
发明人： Tohru Ueda , Akira Matsuda , Noriaki Minakawa , Takuma Sasaki , Yoshikazu Yanagi
IPC分类号： C07D233/90 , C07H19/052
CPC分类号： C07H19/052 , C07D233/90 , Y02P20/55
摘要： Disclosed are imidazole derivatives represented by formula [I]: ##STR1## wherein R is a hydrogen atom or ##STR2## wherein R.sup.2 is a hydrogen atom or a hydroxy protecting group, R.sup.2 protecting either a single hydroxy or two hydroxies together when R.sup.2 is a hydroxy protecting group, and R.sup.3 is a hydrogen atom or OR.sup.2 ; A is CONH.sub.2 or CN; and R.sup.1 is a hydrogen atom, lower alkyl, hydroxy lower alkyl, or phenyl.Also disclosed are six processes for producing these novel compounds among which a typical process comprises reacting a starting imidazole compound having a halogen at the 5-position thereof with an acetylene derivative to alkynylate the 5-position.Furthermore, the compounds have remarkable antitumor activities and therefore can provide novel antitumor agents.

16. 发明授权

US5026835A Pyrimidine 2'-methylidene nucleoside compounds 失效
标题翻译：嘧啶2'-亚甲基核苷化合物
公开(公告)号：US5026835A
公开(公告)日：1991-06-25
申请号：US447512
申请日：1989-12-07
申请人： Tohru Ueda , Takuma Sasaki , Akira Matsuda , Takanori Miyashita , Shinji Sakata , Keiji Yamagami , Akihiro Fujii
发明人： Tohru Ueda , Takuma Sasaki , Akira Matsuda , Takanori Miyashita , Shinji Sakata , Keiji Yamagami , Akihiro Fujii
IPC分类号： C07H19/06
CPC分类号： C07H19/06
摘要： Pyrimidine 2'-deoxy-2'-methylidene nucleoside compounds: ##STR1## wherein R.sup.1 represents amino, hydroxy, silylamino, silyloxy, acylamino or acyloxy; R.sup.2 represents hydrogen, halogen, a lower alkyl, a lower alkenyl, a lower alkynyl or haloalkyl; R.sup.3 and R.sup.4 represent the same or different hydrogen, silyl, acyl or aminoacyl, or a pharmaceutically acceptable salt or hydrate thereof, except that R.sup.1 is amino or hydroxy, and both of R.sup.3 and R.sup.4 are hydrogen.Said compounds possess excellent antitumor and antiviral activities, thus providing novel anticancer and antiviral agent.

17. 发明授权

US4892141A Fin of heat exchanger and method of making it 失效
标题翻译：热交换器翅片及其制作方法
公开(公告)号：US4892141A
公开(公告)日：1990-01-09
申请号：US372158
申请日：1989-06-27
申请人： Shoji Shiga , Akira Matsuda , Hideo Suda , Nobuyuki Shibata
发明人： Shoji Shiga , Akira Matsuda , Hideo Suda , Nobuyuki Shibata
IPC分类号： C23C26/00 , C25D5/50 , C25D7/00 , F28F19/06
CPC分类号： C25D7/00 , C23C26/00 , C25D5/50 , F28F19/06 , Y10S165/905 , Y10S428/941 , Y10T428/12458 , Y10T428/12792
摘要： A fin is provided, wherein a Cu-Zn diffused alloy layer with a Zn content of not less than 1 wt % is formed on at least a portion of the surface of Cu-based substrate for a fin. For the formation of such a Cu-Zn diffused alloy layer, Zn is allowed to diffuse thermally after covered the surface of Cu-based substrate with Zn or Zn alloy, and a rolling processing is carried out after the thermal diffusion to finish to a desired size. The Zn concentration of the fin decreases continuously from the outside surface of the Cu-Zn diffused layer to the interface between that layer and the Cu-based fin substrate.

18. 发明授权

US4818785A Fine particulate crosslinked amorphous copolymer and preparation and use thereof 失效
标题翻译：细颗粒交联无定形共聚物及其制备及应用
公开(公告)号：US4818785A
公开(公告)日：1989-04-04
申请号：US948362
申请日：1986-12-09
申请人： Yasuhiko Otawa , Tetsuo Tojo , Akira Matsuda , Katsuo Okamoto
发明人： Yasuhiko Otawa , Tetsuo Tojo , Akira Matsuda , Katsuo Okamoto
IPC分类号： C08F255/04 , C08F255/06 , C08J3/16 , C08J3/26 , C08L51/06 , C08F8/00 , C08F6/14
CPC分类号： C08J3/26 , C08F255/06 , C08J3/16 , C08L51/06
摘要： A fine particulate crosslinked amorphous copolymer comprising an amorphous copolymer having a constituent unit originating at least from ethylene and .alpha.-olefin, and having an average particle diameter of 0.2 to 50 .mu.m and a hot toluene insolubles content of 15% by weight or more.
摘要翻译： PCT No.PCT / JP86 / 00192 Sec。 371日期1986年12月9日第 102（e）日期1986年12月9日PCT提交1986年4月16日PCT公布。公开号WO86 / 06086 日期：1986年10月23日。一种细颗粒交联无定形共聚物，其包含具有至少来自乙烯和α-烯烃的结构单元，平均粒径为0.2至50μm的无定形共聚物和热甲苯不溶物含量 15重量％以上。

19. 发明授权

US4800130A Laminate excellent in surface gloss and surface hardness, and preparation process and use thereof 失效
标题翻译：表面光泽度和表面硬度优异的层压材料及其制备方法和用途
公开(公告)号：US4800130A
公开(公告)日：1989-01-24
申请号：US3713
申请日：1987-01-15
申请人： Katsuyoshi Yonekura , Akira Uchiyama , Akira Matsuda
发明人： Katsuyoshi Yonekura , Akira Uchiyama , Akira Matsuda
IPC分类号： B32B27/32 , B32B27/00
CPC分类号： B32B27/32 , Y10S100/901 , Y10T428/31917 , Y10T428/31931
摘要： Disclosed is a laminate excellent in the surface gloss and scratch resistance, which comprises a thermoplastic elastomer layer composed mainly of a composition comprising a polyolefin and an olefinic copolymer elastomer, at least one of which is partially crosslinked, and a layer of a partially neutralized ionomer resin or 1-olefin/(meth)acrylic acid copolymer resin having a free carboxyl group, both the layers being tightly bonded to each other.
摘要翻译：公开了一种表面光泽和耐划伤性优异的层压材料，其包括主要由包含聚烯烃和烯烃共聚物弹性体的组合物组成的热塑性弹性体层，其中至少一种部分交联，以及部分中和的离聚物层具有游离羧基的树脂或1-烯烃/（甲基）丙烯酸共聚物树脂，两层彼此紧密结合。

20. 发明授权

US4785045A Thermoplastic elastomer composition 失效
标题翻译：热塑性弹性体组合物
公开(公告)号：US4785045A
公开(公告)日：1988-11-15
申请号：US6282
申请日：1987-01-20
申请人： Katsuyoshi Yonekura , Akira Uchiyama , Akira Matsuda
发明人： Katsuyoshi Yonekura , Akira Uchiyama , Akira Matsuda
IPC分类号： C08L23/02 , C08L23/16 , C08L23/26 , C08L23/18 , C08L23/10
CPC分类号： C08L23/02 , C08L23/16 , C08L2312/00
摘要： A thermoplastic elastomer composition composed of a partially crosslinked product of a blend consisting mainly of (a) 80 to 10 parts by weight of a peroxide-crosslinkable olefinic copolymer rubber, (b) 10 to 80 parts by weight of a peroxide-crosslinkable polyolefin resin having specific properties and (c) 50 to 10 parts by weight of a peroxide-decomposable polyolefin resin, the total amount of (a)+(b)+(c) being 100 parts by weight, the crosslinked product is obtained by dynamically heat-treating said blend in the presence of (d) an organic peroxide. The thermoplastic elastomer has excellent film formability, and is useful as a waterproof sheet.
摘要翻译：由（a）80〜10重量份的过氧化物交联性烯烃共聚物橡胶，（b）10〜80重量份的过氧化物交联性聚烯烃树脂（a）具有特定性质和（c）50〜10重量份的过氧化物可分解的聚烯烃树脂，（a）+（b）+（c）的总量为100重量份，交联产物通过动态加热在（d）有机过氧化物的存在下，将所述共混物加热。热塑性弹性体具有优异的成膜性，可用作防水片。

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