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11. 发明申请

WO2003099192A3 BIS-AROMATIC ALKANOLS 审中-公开
公开(公告)号：WO2003099192A3
公开(公告)日：2003-12-04
申请号：PCT/EP2003/005510
申请日：2003-05-26
申请人： NOVARTIS AG , NOVARTIS Pharma GmbH , IRM LLC , FAN, Yi , GAO, Wenqi , GRAY, Nathanael, S. , HINTERDING, Klaus , LEFEBVRE, Sophie , MI, Yuan , NUSSBAUMER, Peter , PAN, Shifeng , WANG, Wei , ZECRI, Frédéric , PEREZ, Lawrence, Blas , LA MONTAGNE, Kenneth, Richard , ETTMAYER, Peter
发明人： FAN, Yi , GAO, Wenqi , GRAY, Nathanael, S. , HINTERDING, Klaus , LEFEBVRE, Sophie , MI, Yuan , NUSSBAUMER, Peter , PAN, Shifeng , WANG, Wei , ZECRI, Frédéric , PEREZ, Lawrence, Blas , LA MONTAGNE, Kenneth, Richard , ETTMAYER, Peter
IPC分类号： A61K31/133
摘要： The present invention relates to biphenylyl derivatives, processes for their production, their uses and pharmaceutical compositions containing them.

12. 发明申请

WO2004071442A2 NOVEL BICYCLIC COMPOUNDS AND COMPOSITIONS 审中-公开
标题翻译：新型双环化合物和组合物
公开(公告)号：WO2004071442A2
公开(公告)日：2004-08-26
申请号：PCT/US2004/004006
申请日：2004-02-11
申请人： IRM LLC , PAN, Shifeng , GRAY, Nathanael , MI, Yuan , GAO, Wenqi , FAN, Yi , LEFEBVRE, Sophie
发明人： PAN, Shifeng , GRAY, Nathanael , MI, Yuan , GAO, Wenqi , FAN, Yi , LEFEBVRE, Sophie
IPC分类号： A61K
CPC分类号： C07D213/30 , C07C251/48 , C07C251/52 , C07C251/54 , C07D307/42 , C07D333/16 , C07F9/094 , C07F9/655345
摘要： The present invention relates to bicyclic derivatives, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG/S1P receptor mediated signal transduction.
摘要翻译：本发明涉及双环衍生物，其制备方法及其用途和含有它们的药物组合物。本发明提供了一类新颖的化合物，其可用于治疗或预防由淋巴细胞相互作用介导的疾病或病症，特别是与EDG / S1P受体介导的信号转导相关的疾病。

13. 发明申请

WO2007078813A3 2-AMINO-5-PIPERIDINYLIMIDAZOLONE COMPOUNDS AND USE THEREOF FOR β-SECRETASE MODULATION 审中-公开
公开(公告)号：WO2007078813A3
公开(公告)日：2007-07-12
申请号：PCT/US2006/047673
申请日：2006-12-14
申请人： WYETH , ZHOU, Ping , BERNOTAS, Ronald, Charles , LI, Yanfang , NOWAK, Pawel, Wojciech , COLE, Derek, Cecil , MANAS, Eric, Steven , FAN, Yi , YAN, Yinfa
发明人： ZHOU, Ping , BERNOTAS, Ronald, Charles , LI, Yanfang , NOWAK, Pawel, Wojciech , COLE, Derek, Cecil , MANAS, Eric, Steven , FAN, Yi , YAN, Yinfa
IPC分类号： C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , A61K31/454 , A61K31/506 , A61P25/28
摘要： The present invention provides a 2-amino-5-piperidinylimidazolone compound of formula (I) The present invention also provides methods and compositions for the inhibition of ß-secretase (BACE) and the treatment of ß-amyloid deposits and neurofibrillary tangles.

14. 发明申请

WO2008036196A2 INDOLYLALKYLPYRIDIN-2-AMINES FOR THE INHIBITION OF BETA-SECRETASE 审中-公开
标题翻译：用于抑制BETA分泌酶的吲哚乙烯基吡啶-2-胺
公开(公告)号：WO2008036196A2
公开(公告)日：2008-03-27
申请号：PCT/US2007/019945
申请日：2007-09-14
申请人： WYETH , YAN, Yinfa , ZHOU, Ping , FAN, Yi , ROBICHAUD, Albert Jean , MALAMAS, Michael Sotirios
发明人： YAN, Yinfa , ZHOU, Ping , FAN, Yi , ROBICHAUD, Albert Jean , MALAMAS, Michael Sotirios
CPC分类号： C07D401/06
摘要： INDOLYLALKYLPYRIDIN-2-AMINES FOR THE INHIBITION OF ß-SECRETASE The present invention provides an indolylalkylpyridin-2-amine compound of formula I CHEMICAL FORMULA SHOULD BE INSERTED HERE AS IT APPEARS ON THE ABSTRACT IN PAPER FORM. The present invention also provides methods for the use thereof to inhibit ß-secretase (BACE) and treat ß-amyloid deposits and neurofibrillary tangles.
摘要翻译：用于抑制β-分泌酶的吲哚基甲基吡啶-2-胺本发明提供了式I的吲哚基烷基吡啶-2-胺化合物。本文所述的化学式如下：本文摘自纸张形式。本发明还提供了用于抑制β-分泌酶（BACE）和治疗β-淀粉样沉积物和神经原纤维缠结的方法。

15. 发明申请

WO2008020813A1 METHOD OF ELECTRICALLY DETECTING A BIOLOGICAL ANALYTE MOLECULE 审中-公开
标题翻译：电生物分析仪分析方法
公开(公告)号：WO2008020813A1
公开(公告)日：2008-02-21
申请号：PCT/SG2007/000251
申请日：2007-08-14
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , GAO, Zhiqiang , FAN, Yi , CHEN, Xiantong , KONG, Jinming
发明人： GAO, Zhiqiang , FAN, Yi , CHEN, Xiantong , KONG, Jinming
IPC分类号： G01N33/53 , C12Q1/68 , G01N27/00
CPC分类号： G01N33/5438 , C12Q1/6825 , C12Q2565/607 , C12Q2563/155
摘要： The invention provides a method of electrically detecting a biological analyte molecule by means of a pair of electrodes. The electrodes are arranged at a distance from one another within a sensing zone. A capture molecule, which has an affinity to the analyte molecule and which is capable of forming a complex with the analyte molecule, is immobilised on an immobilisation unit. The immobilisation unit is contacted with a solution suspected to comprise the analyte molecule. The analyte molecule is allowed to form a complex with the capture molecule. The invention also provides a probe defined by a nanoparticulate tag that comprises or consists of electrically conducting matter that is capable of chemically interacting with the analyte molecule. In the method of the invention the electrically conducting nanoparticulate tag is added. Thereby the electrically conducting nanoparticulate tag is allowed to associate to the complex formed between the capture molecule and the analyte molecule. The presence of the analyte molecule is determined based on an electrical characteristic, influenced by the electrically conducting nanoparticulate tag, of a region in the sensing zone.
摘要翻译：本发明提供一种通过一对电极电生物分析物分子的电学检测方法。电极在感测区内相互间隔一定距离。捕获分子与分析物分子具有亲和性，并且能够与分析物分子形成复合物，被固定在固定化单元上。固定化单元与疑似包含分析物分子的溶液接触。允许分析物分子与捕获分子形成复合物。本发明还提供由纳米颗粒标签定义的探针，其包含能够与分析物分子进行化学相互作用的导电物质或由导电物质组成。在本发明的方法中，添加导电纳米颗粒标签。由此，导电纳米颗粒标签被允许与形成在捕获分子和分析物分子之间的复合物结合。分析物分子的存在基于感测区域中的区域的导电纳米颗粒标签的电特性来确定。

16. 发明申请

WO2007100536A1 DIHYDROSPIRO[DIBENZO[A,D][7]ANNULENE-5,4'-IMIDAZOL] COMPOUNDS FOR THE INHIBITION OF β-SECRETASE 审中-公开
标题翻译： DIHYDROSPIRO [DIBENZO [A，D] [7] ANNULENE-5,4'-IMIDAZOL]抑制β-分泌酶的化合物
公开(公告)号：WO2007100536A1
公开(公告)日：2007-09-07
申请号：PCT/US2007/004309
申请日：2007-02-16
申请人： WYETH , QUAGLIATO, Dominick Anthony , ANDRAE, Patrick Michael , FAN, Yi
发明人： QUAGLIATO, Dominick Anthony , ANDRAE, Patrick Michael , FAN, Yi
IPC分类号： C07D235/02 , A61K31/4184 , A61P25/28
CPC分类号： C07D235/02 , C07D401/04 , C07D403/04
摘要： The present invention provides a 10,11-dihydrospiro[dibenzo[a,d][7]annulene-5,4'-imidazol]-5'(1'H)-one compound of formula (I). Also provided are methods and compositions for the inhibition of ß-secretase (BACE) and the treatment of ß-amyloid deposits and neurofibrillary tangles.
摘要翻译：本发明提供式（I）的10,11-二氢螺[二苯并[a，d] [7]环烯-5,4'-咪唑] -5'（1'H） - 酮化合物。还提供了用于抑制β-分泌酶（BACE）和β-淀粉样沉积物和神经原纤维缠结的治疗的方法和组合物。

17. 发明申请

WO2005001751A1 SYSTEM FOR BIOMETRIC SIGNAL PROCESSING WITH HARDWARE AND SOFTWARE ACCELARATION 审中-公开
标题翻译：用于硬件和软件增量的生物信号处理系统
公开(公告)号：WO2005001751A1
公开(公告)日：2005-01-06
申请号：PCT/US2004/017545
申请日：2004-06-02
申请人： REGENTS OF THE UNIVERSITY OF CALIFORNIA , VERBAUWHEDE, Ingrid, M. , SCHAUMONT, Patrick, R. , HWANG, David, D. , LAI, Bo-Cheng , YANG, Shenglin , SAKIYAMA, Kazuo , FAN, Yi , HODJAT, Alireza
发明人： VERBAUWHEDE, Ingrid, M. , SCHAUMONT, Patrick, R. , HWANG, David, D. , LAI, Bo-Cheng , YANG, Shenglin , SAKIYAMA, Kazuo , FAN, Yi , HODJAT, Alireza
IPC分类号： G06K9/00
CPC分类号： G06Q20/12 , G06F21/32 , G06Q20/4014 , G07C9/00087 , H04L9/0637 , H04L9/085 , H04L9/16 , H04L9/3231 , H04L9/3242 , H04L2209/12 , H04L2209/56 , H04L2209/805
摘要： A secure embedded system that uses cryptographic and biometric signal processing acceleration is described. In one embodiment, the secure embedded system is configured as a wireless pay-point protocol for brick-and-mortar and e-commerce applications in which biometric information is localized and does not require transmission of biometric data for authentication. In one embodiment, a key-generation function uses a dynamic key generator and static biometric components. In one embodiment, an embedded system design methodology provides hardware and software acceleration transparency.
摘要翻译：描述了使用加密和生物特征信号处理加速的安全嵌入式系统。在一个实施例中，安全嵌入式系统被配置为用于实体和电子商务应用的无线支付点协议，其中生物特征信息被定位并且不需要用于认证的生物特征数据的传输。在一个实施例中，密钥生成功能使用动态密钥生成器和静态生物特征组件。在一个实施例中，嵌入式系统设计方法提供硬件和软件加速透明度。

18. 发明申请

WO2009041917A1 METHOD OF ELECTRICALLY DETECTING A NUCLEIC ACID MOLECULE 审中-公开
标题翻译：电流检测核酸分子的方法
公开(公告)号：WO2009041917A1
公开(公告)日：2009-04-02
申请号：PCT/SG2007/000330
申请日：2007-09-28
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , KONG, Jinming , FAN, Yi , CHEN, Xiantong
发明人： KONG, Jinming , FAN, Yi , CHEN, Xiantong
IPC分类号： G01N33/53
CPC分类号： G01N33/54306 , Y10T436/143333
摘要： The method is performed by means of a pair of electrodes that are arranged at a distance and within a sensing zone. A nucleic acid capture molecule with an uncharged backbone and a nucleotide sequence that is at least partially complementary to at least a portion of a strand of the target nucleic acid molecule, is immobilised on an immobilisation unit. The immobilisation unit, which is arranged within the sensing zone, is contacted with a solution suspected to comprise the target nucleic acid molecule, which hybridiszes to the nucleic acid capture molecule. An activation agent is added, which has an electrostatic net charge complementary to the net charge of the target nucleic acid molecule. It associates to the complex of nucleic acid capture molecule and target nucleic acid molecule. Added is a water soluble polymer with at least one polymer strand and with an electrostatic net charge that is complementary to the net charge of the activation agent. Thus the polymer associates to the activation agent. A metal salt is added, which can act as an oxidant and the metal ions of which have an electrostatic net charge complementary to the net charge of the polymer. The metal ions associate to the polymer. Upon adding a reducing agent, the latter reduces the metal ions, forming a metal wire. The presence of the analyte molecule is determined based on an electrical characteristic of a region in the sensing zone that is affected by the metal wire.
摘要翻译：该方法通过一对电极进行，该对电极被布置在距离和感测区域内。具有不带电荷的骨架的核酸捕获分子和与靶核酸分子的链的至少一部分至少部分互补的核苷酸序列被固定在固定化单元上。布置在感测区内的固定单元与怀疑包含与核酸捕获分子杂交的靶核酸分子的溶液接触。加入活化剂，其具有与靶核酸分子的净电荷互补的静电净电荷。它与核酸捕获分子和靶核酸分子的复合物结合。添加的是具有至少一个聚合物链和具有与活化剂的净电荷互补的静电净电荷的水溶性聚合物。因此，聚合物与活化剂结合。加入金属盐，其可以用作氧化剂，并且其金属离子具有与聚合物的净电荷互补的静电净电荷。金属离子与聚合物缔合。加入还原剂后，还原金属离子，形成金属丝。分析物分子的存在基于受金属线影响的感测区域中的区域的电特性来确定。

19. 发明申请

WO2009041914A1 A BIOSENSOR AND A METHOD FOR DETERMINING THE OHMIC RESISTANCE OF A SENSING CIRCUIT OF A BIOSENSOR 审中-公开
标题翻译：生物传感器和确定生物传感器感测电路的耐电性的方法
公开(公告)号：WO2009041914A1
公开(公告)日：2009-04-02
申请号：PCT/SG2007/000325
申请日：2007-09-26
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , TEO, Tee Hui , OUNG, Kar Liang , CHEN, Xian Tong , GAO, Zhiqiang , FAN, Yi
发明人： TEO, Tee Hui , OUNG, Kar Liang , CHEN, Xian Tong , GAO, Zhiqiang , FAN, Yi
IPC分类号： G01N27/04 , G01N27/327 , G01N27/22 , G01N33/53 , A61B5/00
CPC分类号： G01N27/3276 , G01N27/4145
摘要： A biosensor is provided. The biosensor provided comprises at least one sensing circuit arrangement having a sensing circuit having a sensing capacitance and a sensing ohmic resistance and a transistor circuit having a gate capacitance and a gate ohmic resistance, and at least one detecting circuit having a resistor having a predefined ohmic resistance, an operating mode switching circuit being configured to, in a first operating mode, couple the sensing circuit and the transistor circuit in a parallel configuration, and the parallel configuration in series with the resistor, and in a second operating mode, couple the sensing circuit and the transistor circuit in a series configuration, and a control circuit being configured to determine a time constant of the parallel configuration in accordance with the first operating mode, determine a time constant of the series configuration in accordance with the second operating mode, and determine the sensing ohmic resistance.
摘要翻译：提供生物传感器。提供的生物传感器包括至少一个感测电路装置，其具有感测电路和感测欧姆电阻，以及具有栅极电容和栅极欧姆电阻的晶体管电路，以及至少一个检测电路，具有预定义的欧姆电阻电阻，操作模式切换电路被配置为在第一操作模式中以并联配置耦合所述感测电路和所述晶体管电路，并且所述并联配置与所述电阻器串联，并且在第二操作模式中，耦合所述感测电路和晶体管电路串联配置，并且控制电路被配置为根据第一操作模式确定并行配置的时间常数，根据第二操作模式确定串联配置的时间常数，以及确定感测欧姆电阻。

20. 发明申请

WO2008097190A1 METHODS OF ELECTRICALLY DETECTING A NUCLEIC ACID BY MEANS OF AN ELECTRODE PAIR 审中-公开
标题翻译：通过电极对电流检测核酸的方法
公开(公告)号：WO2008097190A1
公开(公告)日：2008-08-14
申请号：PCT/SG2007/000037
申请日：2007-02-05
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , GAO, Zhiqiang , FAN, Yi , CHEN, Xiantong , KONG, Jinming
发明人： GAO, Zhiqiang , FAN, Yi , CHEN, Xiantong , KONG, Jinming
IPC分类号： C12Q1/26 , C12Q1/68 , C12Q1/28 , G01N27/327
CPC分类号： C12Q1/6825 , C12Q2565/607 , C12Q2527/125 , C12Q2525/107
摘要： Methods of electrically detecting a target nucleic acid molecule. A pair of electrodes is arranged at a distance from one another and within a sensing zone. A PNA capture molecule, with a nucleotide sequence that is at least partially complementary to a portion of the target nucleic acid, is immobilised upon an immobilisation unit. The target nucleic acid molecule hybridises and forms a complex with this capture molecule. A polymerisable positively chargeable precursor with an electrostatic net charge complementary to the target nucleic acid is then added. These precursor associates to the complex formed between the PNA capture molecule and the target nucleic acid. Upon addition of a suitable reactant molecule polymerisation is initiated. The electroconductive polymer that is formed influences the electrical characteristics of the region between the electrodes allowing detection of the presence of the target nucleic acid molecule.
摘要翻译：电检测靶核酸分子的方法。一对电极彼此间隔开并且在感测区内布置。具有与靶核酸的一部分至少部分互补的核苷酸序列的PNA捕获分子被固定在固定化单元上。靶核酸分子与该捕获分子杂交并形成复合物。然后加入具有与靶核酸互补的静电净电荷的可聚合的可带正电的前体。这些前体与PNA捕获分子和靶核酸之间形成的复合体相结合。加入合适的反应物分子后，开始聚合。所形成的导电聚合物影响电极之间的区域的电特性，允许检测目标核酸分子的存在。

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