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11. 发明申请

WO1995022961A1 LIPOSOMES AND USE THEREOF ESPECIALLY TO OBTAIN IMMUNOMODULATING COMPOSITIONS 审中-公开
标题翻译：脂质体及其特别用于获得免疫组织化学品
公开(公告)号：WO1995022961A1
公开(公告)日：1995-08-31
申请号：PCT/FR1995000215
申请日：1995-02-23
申请人： INSTITUT PASTEUR , INSTITUT PASTEUR DE LILLE , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , RIVEAU, Gilles , CAPRON, André , IVANOFF, Nathalie , GRZYCH, Jean-Marie , PHILLIPS, Nigel
发明人： INSTITUT PASTEUR , INSTITUT PASTEUR DE LILLE , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
IPC分类号： A61K09/127
CPC分类号： A61K39/39 , A61K9/127 , A61K39/0003 , A61K2039/543 , A61K2039/55555 , Y02A50/423
摘要： The liposomes of the invention comprise at least one dual layer comprising a mixture formed by a phospholipid (I) with a flow temperature of 20-25 DEG C, and a phospholipid (II) with a flow temperature of 20-60 DEG C. The invention is characterized in that the molar ratio of phospholipid (I) to phospholipid (II) is 5:95 - 30:70. Said liposomes are for use in the production of vaccines.
摘要翻译：本发明的脂质体包含至少一个包含由流动温度为20-25℃的磷脂（I）和流动温度为20-60℃的磷脂（II）形成的混合物的双层。本发明的特征在于磷脂（I）与磷脂（II）的摩尔比为5:95-30:70。所述脂质体用于生产疫苗。

12. 发明申请

WO1992001051A1 IMMUNOGENIC PEPTIDE SEQUENCE FROM ECHINOCOCCUS GRANULOSUS, DNA SEQUENCE CODING FOR SAID PEPTIDE SEQUENCE, AND DIAGNOSTIC AND THERAPEUTIC USES THEREOF 审中-公开
标题翻译：来自ECHINOCOCCUS GRANULOSUS的免疫原性序列，用于确定肽序列的DNA序列编码及其诊断和治疗用途
公开(公告)号：WO1992001051A1
公开(公告)日：1992-01-23
申请号：PCT/FR1991000563
申请日：1991-07-11
申请人： INSTITUT PASTEUR , INSTITUT PASTEUR DE LILLE , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE ... , FACON, Brigitte , CHAMEKH, Mustapha , DISSOUS, Colette , CAPRON, André , TARTAR, André , GRAS MASSE, Hélène
发明人： INSTITUT PASTEUR , INSTITUT PASTEUR DE LILLE , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE ...
IPC分类号： C12N15/12
CPC分类号： C07K16/18 , A61K39/00 , C07K14/4355 , Y10S435/975 , Y10S436/811 , Y10S530/806
摘要： The immunogenic peptide sequence from Echinococcus granulosus antigen 5 is recognized both by sera from patients suffering from hydatidosis and by a monoclonal antibody of isotype IgG1 produced by hybridoma EG 02154/12 and registered with the C.N.C.M on June 25, 1990 under number 1-957.

13. 发明申请

WO1989012683A1 NUCLEIC ACID ENCODING THE P30 PROTEIN OF TOXOPLASMA GONDII 审中-公开
标题翻译：核酸编码TOXOPLASMA GONDII的P30蛋白
公开(公告)号：WO1989012683A1
公开(公告)日：1989-12-28
申请号：PCT/FR1989000322
申请日：1989-06-23
申请人： INSTITUT PASTEUR , INSTITUT PASTEUR DE LILLE , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE ... , CAPRON, André , PIERCE, Raymond , TARTAR, André , LEITE, Paola , CESBRON-DELAUW, Marie-France , MAES, Pierrette , DARCY, Françoise
发明人： INSTITUT PASTEUR , INSTITUT PASTEUR DE LILLE , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE ...
IPC分类号： C12N15/00
CPC分类号： C07K16/20 , A61K38/00 , A61K39/002 , C07K14/45 , C12Q1/6893
摘要： Nucleic acid sequence and/or fragment thereof encoding at least one protein recognized by the anti-P30 antibody of Toxoplasma gondii (TG), expression products of said sequence, process for obtaining said proteins, their application in early diagnosis, monitoring and immunoprotection of toxoplasmosis.

14. 发明申请

WO1992017193A1 MEDICAMENT CONTAINING AN AGENT INHIBITING IN VIVO PATHOLOGICAL APOPTOSIS AND APPLICATIONS THEREOF 审中-公开
标题翻译：药物含有抑制病毒性病变的药物及其应用
公开(公告)号：WO1992017193A1
公开(公告)日：1992-10-15
申请号：PCT/FR1992000265
申请日：1992-03-23
申请人： INSTITUT PASTEUR , INSTITUT PASTEUR DE LILLE , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE ... , AMEISEN, Jean-Claude , GROUX, Hervé , CAPRON, André , AMEISEN, Fabienne
发明人： INSTITUT PASTEUR , INSTITUT PASTEUR DE LILLE , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE ...
IPC分类号： A61K37/02
CPC分类号： C07K16/2818 , A61K31/45 , A61K38/13 , A61K38/168 , A61K38/2006 , C07K16/2809 , A61K38/20 , A61K31/00 , A61K2300/00
摘要： A medicament containing an agent inhibiting in vivo pathological apoptosis may contain: an agent capable of blocking the reception or transduction of signals leading to cell suicide, or an agent providing or generating a co-signal enabling normal cell differentiation and multiplication, or an agent which, alone, causes cell proliferation and differentiation, and generates cells which have lost the suicide capability in pathological conditions, or an agent capable of inhibiting the signals which make a cell capable of responding to activation, by pathological apoptosis. Said medicaments may be used in treating retrovirus related diseases, and in particular diseases related to the lentiviruses such as the HIV in humans.

15. 发明申请

WO1987007303A1 NEW LYMPHOKINE FOR THE SUPPRESSION OF PLATELET ACTIVATION 审中-公开
标题翻译：用于抑制板激活的新型LYMPHOKINE
公开(公告)号：WO1987007303A1
公开(公告)日：1987-12-03
申请号：PCT/FR1987000164
申请日：1987-05-19
申请人： INSTITUT PASTEUR DE LILLE , INSTITUT PASTEUR , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE ... , CAPRON, André , JOSEPH, Michel , PANCRE, Véronique , AURIAULT, Claude
发明人： INSTITUT PASTEUR DE LILLE , INSTITUT PASTEUR , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE ...
IPC分类号： C12P21/00
CPC分类号： C07K14/52 , A61K38/00 , Y02A50/423
摘要： New lymphokine and its isolation and purification process. Said lymphokine is comprised of a factor obtained from T cells stimulated by concanavaline A or by an antigen capable of inhibiting the IgE-dependent platelet citotoxicity with respect to young larvae of S. Mansoni, of strongly reducing the chemiluminescence of blood platelets in a reaction IgE-anti-IgE, which is a correlate of the anti-parasite cytotoxicity, and of inhibiting the platelet activation in non-IgE dependent intolerences. Application as suppressor agent for suppressing platelet activation and as immunomodulator medicament of allergies.
摘要翻译：新型淋巴因子及其分离纯化过程。所述淋巴因子包括由苦参碱A刺激的T细胞获得的因子或相对于S.Mansoni的幼虫幼虫能够抑制IgE依赖性血小板citotoxicity的抗原，强烈地减少反应IgE中血小板的化学发光 -anti-IgE，其是抗寄生虫细胞毒性的相关性，并且在非IgE依赖性遗传中抑制血小板活化。用作抑制血小板活化的抑制剂和作为过敏的免疫调节剂药物。

16. 发明申请

WO1997044667A2 METHOD FOR USING PEPTIDE COMPLEXES/MAJOR HISTOCOMPATIBILITY COMPLEX TO OBTAIN OR PURIFY ANTIGEN-SPECIFIC T CELLS AND TO STIMULATE T CELLS 审中-公开
标题翻译：使用肽复合物/主要组氨酸复合物获得或纯化抗原特异性T细胞并刺激T细胞的方法
公开(公告)号：WO1997044667A2
公开(公告)日：1997-11-27
申请号：PCT/FR1997000892
申请日：1997-05-21
申请人： INSTITUT PASTEUR , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , LANGLADE-DEMOYEN, Pierre , LONE, Yu-Chun , KOURILSKY, Philippe , ABASTADO, Jean-Pierre
发明人： INSTITUT PASTEUR , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
IPC分类号： G01N33/569
CPC分类号： C07K14/005 , C07K14/70539 , C12N2760/16122 , G01N33/56977 , G01N33/574
摘要： The invention features methods for using MHC/peptide complexes. The successful peptide-specific T lymphocyte purification by adsorption on a solid support coupled with a high density of MHC recombinant molecules, charged with a single peptide is disclosed. This method has enabled the isolating, purifying and quantifying of tumoral specific T lymphocytes, from peritoneal exudate and tumor-infiltrating lymphocytes. These purified T lymphocyte populations can be further multiplied in vitro. The resulting cells show a superior cytotoxic activity and an enhanced anti-tumoral action by re-injection in the tumor carrier. This novel approach is important for analysing the T lymphocytes repertoire at the peptide specificity level and to improve novel T lymphocyte adoptive immunotherapy based therapeutic treatments. Further, the MHC/peptide specific complexes can induce or stimulate peptide-specific T lymphocytes. Thus are also disclosed methods to induce cytotoxic T lymphocytes (CTL). These CTL can be used in turn to fight tumoral cell growth in vitro or in vivo. The MHC recombinant molecule charged with a single peptide can be effectively used in polymer form to stimulate specific immune response ex vivo or in vivo after being injected in man or animal.
摘要翻译：本发明的特征在于使用MHC /肽复合物的方法。公开了通过在固体支持物上吸附成功的肽特异性T淋巴细胞，其与高密度的MHC重组分子偶联，装载有单一肽。该方法能够从腹膜渗出液和肿瘤浸润淋巴细胞中分离，纯化和定量肿瘤特异性T淋巴细胞。这些纯化的T淋巴细胞群可以进一步在体外倍增。所得细胞通过在肿瘤载体中重新注射显示出优异的细胞毒性活性和增强的抗肿瘤作用。这种新方法对于分析肽特异性水平的T淋巴细胞谱和改善基于T淋巴细胞过继免疫治疗的治疗方法是重要的。此外，MHC /肽特异性复合物可以诱导或刺激肽特异性T淋巴细胞。因此，还公开了诱导细胞毒性T淋巴细胞（CTL）的方法。这些CTL可以依次用于在体外或体内抗肿瘤细胞生长。带有单个肽的MHC重组分子可以有效地以聚合物形式使用，以便在人或动物注射后离体或体内刺激特异性免疫应答。

17. 发明申请

WO1995014785A1 COMPOSITION FOR THE IN VIVO PRODUCTION OF THERAPEUTIC PRODUCTS 审中-公开
标题翻译：用于生产治疗产品的组合物
公开(公告)号：WO1995014785A1
公开(公告)日：1995-06-01
申请号：PCT/FR1994001359
申请日：1994-11-22
申请人： RHONE-POULENC RORER S.A. , INSTITUT PASTEUR , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE , BEUZARD, Yves , DANOS, Olivier , DESCAMPS, Vincent , HEARD, Jean-Michel , MOULLIER, Philippe , NAFFAKH, Nadia , PERRICAUDET, Michel , VAINCHENKER, William
发明人： RHONE-POULENC RORER S.A. , INSTITUT PASTEUR , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
IPC分类号： C12N15/86
CPC分类号： A61K38/1816 , A61K48/00 , C07K14/505
摘要： The present invention provides cell compositions for in vivo implantation, and designed for the sustained and controlled delivery of therapeutic substances.
摘要翻译：本发明提供用于体内植入的细胞组合物，并且被设计用于治疗物质的持续和控制递送。

18. 发明申请

WO1995011307A1 NUCLEOTIDE VECTOR, COMPOSITION CONTAINING SUCH VECTOR AND VACCINE FOR IMMUNIZATION AGAINST HEPATITIS 审中-公开
标题翻译：核苷酸载体，含有此类载体和疫苗的组合物用于抗艾滋病毒的免疫
公开(公告)号：WO1995011307A1
公开(公告)日：1995-04-27
申请号：PCT/FR1994000483
申请日：1994-04-27
申请人： INSTITUT PASTEUR , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , UNIVERSITE D'OTTAWA , DAVIS, Heather, Lynn , WHALEN, Robert, Gérald , MICHEL, Marie-Louise
发明人： INSTITUT PASTEUR , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , UNIVERSITE D'OTTAWA
IPC分类号： C12N15/85
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/292 , A61K48/00 , A61K2039/53 , A61K2039/57 , C12N2730/10122 , C12N2730/10134 , Y02A50/464
摘要： Nucleotide vector comprising at least one gene or one complementary DNA coding for at least a portion of a protein of a virus, and a promoter providing for the expression of such gene in muscle cells. The gene may be the S gene of the hepatitis B virus. A vaccine preparation containing said bare DNA is injected into the host previously treated with a substance capable of inducing a coagulating necrosis of the muscle fibers.
摘要翻译：包含编码病毒蛋白质的至少一部分的至少一个基因或一个互补DNA的核苷酸载体和提供在肌肉细胞中表达该基因的启动子。该基因可能是乙型肝炎病毒的S基因。将含有裸DNA的疫苗制剂注射到预先用能够引起肌纤维凝固性坏死的物质处理的宿主中。

19. 发明申请

WO1994019022A1 COMPOSITION FOR USE IN THE TREATMENT OF TUMOURS AND THE IMMUNIZATION OF HUMANS AND ANIMALS 审中-公开
标题翻译：用于治疗肿瘤的组合物和人与动物的免疫
公开(公告)号：WO1994019022A1
公开(公告)日：1994-09-01
申请号：PCT/FR1994000192
申请日：1994-02-21
申请人： INSTITUT PASTEUR , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , UNIVERSITE PIERRE ET MARIE CURIE , ROTH, Claude , KOURILSKY, Philippe , MIR, Lluis , KLATZMANN, David , SALZMANN, Jean-Loup
发明人： INSTITUT PASTEUR , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , UNIVERSITE PIERRE ET MARIE CURIE
IPC分类号： A61K48/00
CPC分类号： A61K48/00 , A61K35/12 , A61K35/13 , A61K38/191 , A61K38/193 , A61K38/2013 , A61K38/2026 , A61K38/2046 , A61K38/217 , A61K38/45 , A61K38/50 , A61K2035/11 , C12N15/86 , C12N2740/13032 , C12N2740/13043 , A61K2300/00
摘要： Composition for use in the treatment of tumors and the immunization of humans or animals comprising a synergistic association of cells, viruses, or bacteria expressing, transitorily, in organisms at least one gene for producing in vivo one or more immunomodulators, and viruses, or cells producing viruses, said viruses preferably infecting dividing cells of the treated organisms and carrying within their genome at least one gene whose expression in the dividing cells will cause their destruction.
摘要翻译：用于治疗肿瘤和免疫人体或动物的组合物，包括细胞，病毒或细菌的协同关联，细胞，病毒或细菌在生物体中表达至少一种用于在体内产生一种或多种免疫调节剂和病毒或细胞的基因所述病毒优选地感染经处理的生物体的分裂细胞并在其基因组内携带至少一种在分裂细胞中表达会导致其破坏的基因。

20. 发明申请

WO1992001056A1 NUCLEIC SEQUENCES FROM THE GENOME OF SALMONELLA TYPHI, AND USES THEREOF PARTICULARLY FOR THE IN VITRO DIAGNOSIS OF THE PRESENCE OF SALMONELLA BACTERIA IN FOODSTUFFS 审中-公开
标题翻译：来自SALMONELLA TYPHI基因的核苷酸序列及其特别用于食品中存在沙门氏菌细菌的体外诊断
公开(公告)号：WO1992001056A1
公开(公告)日：1992-01-23
申请号：PCT/FR1991000564
申请日：1991-07-11
申请人： INSTITUT PASTEUR , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE ... , POPOFF, Michel, Yvan , DION, Michel, Pierre
发明人： INSTITUT PASTEUR , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE ...
IPC分类号： C12N15/31
CPC分类号： C12Q1/689 , C07K14/255 , C07K16/1235 , Y02A50/59
摘要： New nucleic acid sequence (I) contains all or part of the genetic information necessary for in vitro infection activity for Salmonella in Hela cultured cells. Also new are (1) any sequence which hybridises with (I) under stringent conditions; (2) sequences (II) of about 200-500 nucleotides from (I) useful as probes, and sequences (III) of 10-30 nucleotides useful as amplification primers; (3) polypeptides (IV) encoded by (I); (4) poly- or mono-clonal antibodies (Ab) recognising (IV) specifically; (5) recombinant nucleic acid (Ia) contg. (I) inserted into a heterologous sequence; and (6) vectors contg. (Ia).

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