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11. 发明专利

ES2674043T5 Polimerasas modificadas para una incorporación mejorada de análogos de nucleótidos 未知
公开(公告)号：ES2674043T5
公开(公告)日：2021-11-03
申请号：ES13712657
申请日：2013-03-14
申请人： ILLUMINA INC
发明人： CHEN CHENG-YAO , HE MOLLY , BOMATI ERIN , PEISAJOVICH SERGIO
IPC分类号： C12N9/12 , C12Q1/6844

12. 发明专利

PL3161154T3 ZMODYFIKOWANE POLIMERAZY DO ULEPSZONEGO WŁĄCZANIA ANALOGÓW NUKLEOTYDÓW 未知
公开(公告)号：PL3161154T3
公开(公告)日：2020-10-19
申请号：PL15739706
申请日：2015-06-25
申请人： ILLUMINA INC
发明人： CHEN CHENG-YAO , BOMATI ERIN , HE MOLLY
IPC分类号： C12Q1/68 , C12N9/12

13. 发明专利

SG10201809312QA NUCLEIC ACID SYNTHESIS TECHNIQUES 未知
公开(公告)号：SG10201809312QA
公开(公告)日：2018-11-29
申请号：SG10201809312Q
申请日：2015-05-14
申请人： ILLUMINA INC
发明人： RONAGHI MOSTAFA , HE MOLLY , CHEN CHENG-YAO , PREVITE MICHAEL , BOWEN SHANE
摘要： NUCLEIC ACID SYNTHESIS TECHNIQUES A method for synthesizing a nucleic acid includes synthesizing one or more nucleic acid fragments on a substrate. The synthesized one or more nucleic acid fragments may be amplified on the substrate. The method also includes sequencing the synthesized or amplified one or more nucleic acid fragments on the substrate. The sequencing may provide feedback to designs of the one or more nucleic acid fragments. The method further includes harvesting the synthesized or amplified one or more nucleic acid fragments based on sequencing. The synthesized or amplified one or more nucleic acid fragments may be assembled to generate a target nucleic acid. FIG. 60

14. 发明专利

CA2965995A1 TRANSPOSASE COMPOSITIONS FOR REDUCTION OF INSERTION BIAS 未知
公开(公告)号：CA2965995A1
公开(公告)日：2016-05-12
申请号：CA2965995
申请日：2015-11-05
申请人： ILLUMINA INC
发明人： GLOECKNER CHRISTIAN , KIA AMIRALI , HE MOLLY , OSOTHPRAROP TRINA FAYE , STEEMERS FRANK J , GUNDERSON KEVIN L , AMINI SASAN , JENDRISAK JEROME
IPC分类号： C40B50/06 , C12N9/12 , C12N9/22 , C12N15/10 , C12P19/34 , C12Q1/68 , C40B40/06
摘要： Presented herein are methods and compositions for tagmentation of nucleic acids. The methods are useful for generating tagged DNA fragments that are qualitatively and quantitatively representative of the target nucleic acids in the sample from which they are generated.

15. 发明专利

CA2951416A1 MODIFIED POLYMERASES FOR IMPROVED INCORPORATION OF NUCLEOTIDE ANALOGUES 未知
公开(公告)号：CA2951416A1
公开(公告)日：2015-12-30
申请号：CA2951416
申请日：2015-06-25
申请人： ILLUMINA INC
发明人： CHEN CHENG-YAO , BOMATI ERIN , HE MOLLY
IPC分类号： C12N9/12 , C12N15/54 , C12P19/14 , C12Q1/68
摘要： Presented herein are polymerase enzymes for improved incorporation of nucleotide analogues, in particular nucleotides which are modified at the 3' sugar hydroxyl, as well as methods and kits using the same.

16. 发明专利

CA2931533A1 METHODS AND COMPOSITIONS FOR TARGETED NUCLEIC ACID SEQUENCING 未知
公开(公告)号：CA2931533A1
公开(公告)日：2015-06-18
申请号：CA2931533
申请日：2014-12-05
申请人： ILLUMINA INC
发明人： PANTOJA RIGO , HU MARIE , BOMATI ERIN , HE MOLLY
IPC分类号： C12N15/10 , C12Q1/68
摘要： Embodiments provided herein relate to methods and compositions for obtaining nucleic acid sequence information. Some embodiments provided herein include methods and compositions for preparing nucleic acid libraries. In some embodiments, such nucleic acid libraries are useful for targeted nucleic acid sequencing.

17. 发明专利

CA2898459A1 MODIFIED POLYMERASES FOR IMPROVED INCORPORATION OF NUCLEOTIDE ANALOGUES 未知
公开(公告)号：CA2898459A1
公开(公告)日：2014-09-18
申请号：CA2898459
申请日：2013-03-14
申请人： ILLUMINA INC
发明人： CHEN CHENG-YAO , HE MOLLY , BOMATI ERIN , PEISAJOVICH SERGIO
IPC分类号： C12Q1/68 , C12N9/12 , C12N15/10
摘要： Presented herein are polymerase enzymes for improved incorporation of nucleotide analogues, in particular nucleotides which are modified at the 3' sugar hydroxyl, as well as methods and kits using the same.

18. 发明专利

IL255188A Platform for discovery and analysis of therapeutic agents 未知
公开(公告)号：IL255188A
公开(公告)日：2022-04-01
申请号：IL25518817
申请日：2017-10-22
申请人： ILLUMINA INC , KELLINGER MATTHEW WILLIAM , BOUTELL JONATHAN MARK , HE MOLLY , PREVITE MICHAEL , GOLYNSKIY MISHA , PEISAJOVICH SERGIO
发明人： KELLINGER MATTHEW WILLIAM , BOUTELL JONATHAN MARK , HE MOLLY , PREVITE MICHAEL , GOLYNSKIY MISHA , PEISAJOVICH SERGIO
IPC分类号： C12N15/10 , B01J19/00 , C40B20/04 , C40B50/16 , G01N33/53 , G01N33/58 , G01N33/68
摘要： A method of characterizing candidate agents including steps of (a) providing a library of candidate agents attached to nucleic acid tags; (b) contacting the library with a solid support to attach the candidate agents to the solid support, whereby an array of candidate agents is formed; (c) contacting the array with a screening agent, wherein one or more candidate agents in the array react with the screening agent; (d) detecting the array to determine that at least one candidate agent in the array reacts with the screening agent; (e) sequencing the nucleic acid tag to determine the tag sequences attached to candidate agents in the array; and (f) identifying the at least one candidate agent in the array that reacts with the screening agent based on the tag sequence that is attached to the at least one candidate agent.

19. 发明专利

AU2015247779B2 Modified transposases for improved insertion sequence bias and increased DNA input tolerance 未知
公开(公告)号：AU2015247779B2
公开(公告)日：2021-06-24
申请号：AU2015247779
申请日：2015-04-15
申请人： ILLUMINA INC
发明人： BURGESS JOSHUA , GLOECKNER CHRISTIAN , KIA AMIRALI , BOMATI ERIN , HE MOLLY , GRUNENWALD HAIYING LI , KUERSTEN SCOTT , OSOTHPRAROP TRINA FAYE , HASKINS DARIN , KHANNA ANUPAMA , SCHLINGMAN DANIEL , VAIDYANATHAN RAMESH
IPC分类号： C12N9/22
摘要： Presented herein are transposase enzymes and reaction conditions for improved fragmentation and tagging of nucleic acid samples, in particular altered transposases and reaction conditions which exhibit improved insertion sequence bias, as well as methods and kits using the same.

20. 发明专利

ES2826880T3 Plataforma para el descubrimiento y análisis de agentes terapéuticos 未知
公开(公告)号：ES2826880T3
公开(公告)日：2021-05-19
申请号：ES16793337
申请日：2016-05-09
申请人： ILLUMINA INC
发明人： HE MOLLY , PREVITE MICHAEL , GOLYNSKIY MISHA , KELLINGER MATTHEW WILLIAM , PEISAJOVICH SERGIO , BOUTELL JONATHAN MARK
IPC分类号： C12Q1/68 , C12N15/10 , G01N21/76 , G01N33/53 , G01N33/569 , G01N33/573
摘要： Un método para caracterizar agentes candidatos, que comprende (a) sintetizar de forma combinatoria una biblioteca de agentes candidatos, en la que las reacciones individuales de la síntesis combinatoria que se llevan a cabo en cada agente candidato se rastrean mediante la adición de una firma única de uno o más nucleótidos a una etiqueta de ácido nucleico que se une a cada uno de los agentes candidatos, proporcionando así una biblioteca de agentes candidatos, en la que cada agente candidato está unido a una etiqueta de ácido nucleico única que tiene una secuencia de etiqueta; (b) poner en contacto la biblioteca de agentes candidatos con un soporte sólido para unir los agentes candidatos al soporte sólido, mediante lo cual se forma una matriz de agentes candidatos que comprende características individuales en el soporte sólido que cada una se une a un agente candidato individual de la biblioteca; (c) poner en contacto la matriz de agentes candidatos con un agente de cribado, en el que uno o más agentes candidatos de la matriz reaccionan con el agente de cribado; (d) detectar la matriz durante o después del contacto de la matriz con el agente de cribado, determinando de ese modo que al menos un agente candidato en la matriz reacciona con el agente de cribado; (e) secuenciar las etiquetas de ácido nucleico en la matriz para determinar la secuencia de etiqueta que se une a cada uno de los agentes candidatos; e (f) identificar el al menos un agente candidato en la matriz que reacciona con el agente de cribado en base a la secuencia de etiqueta que está unida al menos a un agente candidato.

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