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11. 发明申请

WO2016061517A3 CONTIGUITY PRESERVING TRANSPOSITION 审中-公开
标题翻译：保持运输的连续性
公开(公告)号：WO2016061517A3
公开(公告)日：2016-06-23
申请号：PCT/US2015056040
申请日：2015-10-16
申请人： ILLUMINA CAMBRIDGE LTD , STEEMERS FRANK J , GUNDERSON KEVIN L , ZHANG FAN , BETLEY JASON RICHARD , GORMLEY NIALL ANTHONY , MEULEMAN WOUTER , WEIR JACQUELINE , IOANNOU AVGOUSTA , JENKINS GARETH , JACKSON ROSAMOND , MORRELL NATALIE , POKHOLOK DMITRY K , NORBERG STEVEN J , HE MOLLY , KIA AMIRALI , GORYSHIN IGOR , PANTOJA RIGO
发明人： STEEMERS FRANK J , GUNDERSON KEVIN L , ZHANG FAN , BETLEY JASON RICHARD , GORMLEY NIALL ANTHONY , MEULEMAN WOUTER , WEIR JACQUELINE , IOANNOU AVGOUSTA , JENKINS GARETH , JACKSON ROSAMOND , MORRELL NATALIE , POKHOLOK DMITRY K , NORBERG STEVEN J , HE MOLLY , KIA AMIRALI , GORYSHIN IGOR , PANTOJA RIGO
IPC分类号： C12N15/10
CPC分类号： C12N15/1093 , C12N15/1065 , C12Q2525/191 , C12Q2563/179 , C12Q2565/514
摘要： Embodiments provided herein relate to methods and compositions for preparing an immobilized library of barcoded DNA fragments of a target nucleic acid, identifying genomic variants, determining the contiguity information, phasing information, and methylation status of the target nucleic acid.
摘要翻译：本文提供的实施方案涉及用于制备靶核酸的条形码DNA片段的固定化文库，鉴定基因组变体，确定目标核酸的邻接信息，定相信息和甲基化状态的方法和组合物。

12. 发明专利

IL287853D0 Contiguity preserving transposition 未知
公开(公告)号：IL287853D0
公开(公告)日：2022-01-01
申请号：IL28785321
申请日：2021-11-04
申请人： ILLUMINA CAMBRIDGE LTD , STEEMERS FRANK J , GUNDERSON KEVIN L , ZHANG FAN , BETLEY JASON RICHARD , GORMLEY NIALL ANTHONY , MEULEMAN WOUTER , WEIR JACQUELINE , IOANNOU AVGOUSTA , JENKINS GARETH , JACKSON ROSAMOND , MORRELL NATALIE , POKHOLOK DMITRY K , NORBERG STEVEN J , HE MOLLY , KIA AMIRALI , GORYSHIN IGOR , PANTOJA RIGO
发明人： STEEMERS FRANK J , GUNDERSON KEVIN L , ZHANG FAN , BETLEY JASON RICHARD , GORMLEY NIALL ANTHONY , MEULEMAN WOUTER , WEIR JACQUELINE , IOANNOU AVGOUSTA , JENKINS GARETH , JACKSON ROSAMOND , MORRELL NATALIE , POKHOLOK DMITRY K , NORBERG STEVEN J , HE MOLLY , KIA AMIRALI , GORYSHIN IGOR , PANTOJA RIGO
IPC分类号： C12N15/10
摘要： Embodiments provided herein relate to methods and compositions for preparing an immobilized library of barcoded DNA fragments of a target nucleic acid, identifying genomic variants, determining the contiguity information, phasing information, and methylation status of the target nucleic acid.

13. 发明专利

IL251737D0 Contiguity preserving transposition 未知
公开(公告)号：IL251737D0
公开(公告)日：2017-06-29
申请号：IL25173717
申请日：2017-04-13
申请人： ILLUMINA CAMBRIDGE LTD , STEEMERS FRANK J , GUNDERSON KEVIN L , ZHANG FAN , BETLEY JASON RICHARD , GORMLEY NIALL ANTHONY , MEULEMAN WOUTER , WEIR JACQUELINE , IOANNOU AVGOUSTA , JENKINS GARETH , JACKSON ROSAMOND , MORRELL NATALIE , POKHOLOK DMITRY K , NORBERG STEVEN J , HE MOLLY , KIA AMIRALI , GORYSHIN IGOR , PANTOJA RIGO
发明人： STEEMERS FRANK J , GUNDERSON KEVIN L , ZHANG FAN , BETLEY JASON RICHARD , GORMLEY NIALL ANTHONY , MEULEMAN WOUTER , WEIR JACQUELINE , IOANNOU AVGOUSTA , JENKINS GARETH , JACKSON ROSAMOND , MORRELL NATALIE , POKHOLOK DMITRY K , NORBERG STEVEN J , HE MOLLY , KIA AMIRALI , GORYSHIN IGOR , PANTOJA RIGO
IPC分类号： C12N20060101
摘要： Embodiments provided herein relate to methods and compositions for preparing an immobilized library of barcoded DNA fragments of a target nucleic acid, identifying genomic variants, determining the contiguity information, phasing information, and methylation status of the target nucleic acid.

14. 发明申请

WO2016130704A3 METHODS AND COMPOSITIONS FOR ANALYZING CELLULAR COMPONENTS 审中-公开
标题翻译：用于分析细胞成分的方法和组合物
公开(公告)号：WO2016130704A3
公开(公告)日：2016-10-06
申请号：PCT/US2016017391
申请日：2016-02-10
申请人： ILLUMINA INC
发明人： GUNDERSON KEVIN L , STEEMERS FRANK J , FISHER JEFFREY S , RIGATTI ROBERTO
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6806 , C12Q2537/143 , C12Q2563/149 , C12Q2563/159 , C12Q2563/185
摘要： Embodiments of the present invention relate to analyzing components of a cell. In some embodiments, the present invention relate to analyzing components of a single cell. In some embodiments, the methods and compositions relate to sequencing nucleic acids. In some embodiments, the methods and compositions relate to identifying and/or quantitating nucleic acid, proteins, organelles, and/or cellular metabolites.
摘要翻译：本发明的实施例涉及分析小区的组件。在一些实施例中，本发明涉及分析单个细胞的组分。在一些实施方案中，所述方法和组合物涉及测序核酸。在一些实施方案中，所述方法和组合物涉及鉴定和/或定量核酸，蛋白质，细胞器和/或细胞代谢物。

15. 发明申请

WO2016010975A2 BIOCHEMICALLY ACTIVATED ELECTRONIC DEVICE 审中-公开
标题翻译：生化活化电子器件
公开(公告)号：WO2016010975A2
公开(公告)日：2016-01-21
申请号：PCT/US2015040296
申请日：2015-07-14
申请人： ILLUMINA INC
发明人： BOYANOV BOYAN , MANDELL JEFFREY G , BAI JINGWEI , GUNDERSON KEVIN L , CHEN CHENG-YAO , PERBOST MICHEL
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6874 , B01J2219/00653 , B01J2219/00722 , B82Y15/00 , C12Q1/6869 , G01N27/4145 , C12Q2525/197 , C12Q2535/122 , C12Q2563/113 , C12Q2563/116 , C12Q2565/107 , C12Q2565/607 , C12Q2565/629 , C12Q2521/101
摘要： A method of nucleic acid sequencing. The method can include the steps of (a) providing a polymerase tethered to a solid support charge sensor; (b) providing one or more nucleotides, whereby the presence of the nucleotide can be detected by the charge sensor; and (c) detecting incorporation of the nucleotide into a nascent strand complementary to a template nucleic acid.
摘要翻译：一种核酸测序的方法。该方法可以包括以下步骤：（a）提供连接至固体支持物电荷传感器的聚合酶; （b）提供一个或多个核苷酸，由此可以通过电荷传感器检测核苷酸的存在; 和（c）检测核苷酸掺入与模板核酸互补的新生链中。

16. 发明申请

WO2015081211A3 COMPOSITIONS AND METHODS FOR POLYNUCLEOTIDE SEQUENCING 审中-公开
标题翻译：多核苷酸序列的组合物和方法
公开(公告)号：WO2015081211A3
公开(公告)日：2015-08-06
申请号：PCT/US2014067639
申请日：2014-11-26
申请人： ILLUMINA INC
发明人： STAVA ERIC , GUNDLACH JENS H , MANDELL JEFFREY G , GUNDERSON KEVIN L , DERRINGTON IAN M , MOHIMANI HOSEIN
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6869 , C07K14/35 , G01N27/447 , C12Q2521/513 , C12Q2565/631
摘要： Methods and compositions for characterizing a target polynucleotide, including, characterizing the sequence of the target polynucleotide, using the fractional translocation steps of the target polynucleotide's translocation through a pore by a Hel308 helicase.
摘要翻译：使用目标多核苷酸通过Hel308解旋酶通过孔的易位的分数易位步骤来表征靶多核苷酸的方法和组合物，包括表征靶多核苷酸的序列。

17. 发明申请

WO2015187670A3 COMPOSITIONS, SYSTEMS, AND METHODS FOR DETECTING EVENTS USING TETHERS ANCHORED TO OR ADJACENT TO NANOPORES 审中-公开
标题翻译：用于检测活动的组合物，系统和方法，使用锚固或邻近纳米比亚
公开(公告)号：WO2015187670A3
公开(公告)日：2016-02-25
申请号：PCT/US2015033749
申请日：2015-06-02
申请人： ILLUMINA INC
发明人： MANDELL JEFFREY G , GUNDERSON KEVIN L , GUNDLACH JENS H
IPC分类号： C12Q1/00 , C12Q1/68 , G01N33/53
CPC分类号： C12Q1/6869 , G01N27/44743 , G01N27/44791 , C12Q2525/197 , C12Q2565/607 , C12Q2565/631
摘要： Compositions, systems, and methods for detecting events are provided. A composition can include a nanopore including a first side, a second side, and an aperture extending through the first and second sides; and a permanent tether including head and tail regions and an elongated body disposed therebetween. The head region can be anchored to or adjacent to the first or second side of the nanopore. The elongated body including a reporter region can be movable within the aperture responsive to a first event occurring adjacent to the first side of the nanopore. For example, the reporter region is translationally movable toward the first side responsive to the first event, then toward the second side, then toward the first side responsive to a second event. The first event can include adding a first nucleotide to a polynucleotide. The second event can include adding a second nucleotide to the polynucleotide.
摘要翻译：提供了用于检测事件的组合，系统和方法。组合物可以包括纳米孔，其包括第一侧，第二侧和延伸穿过第一和第二侧的孔; 以及包括头部和尾部区域的永久系绳以及设置在它们之间的细长体。头部区域可以锚固到或邻近纳米孔的第一或第二侧。包括报告器区域的细长体可响应于邻近纳米孔第一侧发生的第一事件而在孔内可移动。例如，响应于第一事件，然后朝向第二侧，然后响应于第二事件朝向第一侧，报告器区域可平移地朝向第一侧移动。第一个事件可以包括向多核苷酸添加第一个核苷酸。第二个事件可以包括向多核苷酸添加第二个核苷酸。

18. 发明申请

WO2015095226A3 PRESERVING GENOMIC CONNECTIVITY INFORMATION IN FRAGMENTED GENOMIC DNA SAMPLES 审中-公开
标题翻译：保留碎片基因组DNA样本中的基因连锁信息
公开(公告)号：WO2015095226A3
公开(公告)日：2015-09-03
申请号：PCT/US2014070658
申请日：2014-12-16
申请人： ILLUMINA INC
发明人： FISHER JEFFREY S , STEEMERS FRANK J , AMINI SASAN , GUNDERSON KEVIN L
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6874 , C12Q2535/119 , C12Q2535/122 , C12Q2565/513 , C12Q2565/543
摘要： A method of sequencing a target nucleic acid polymer by (a) modifying a target nucleic acid polymer to produce a modified nucleic acid polymer; (b) producing fragments of the modified nucleic acid polymer, wherein the fragments are attached to locations on a solid support surface (c) determining nucleotide sequences from the fragments at the locations; and (d) producing a representation of the nucleotide sequence for the target nucleic acid polymer based on the nucleotide sequences from the fragments and the relative distances between the locations on the solid support surface.
摘要翻译：通过（a）修饰靶核酸聚合物以产生修饰的核酸聚合物来测序靶核酸聚合物的方法; （b）产生修饰的核酸聚合物的片段，其中所述片段连接到固体支持物表面上的位置;（c）从所述片段的位置确定核苷酸序列; 和（d）基于来自片段的核苷酸序列和固体支持物表面上的位置之间的相对距离产生目标核酸聚合物的核苷酸序列的表示。

19. 发明公开

EP3294908A1 FIELD-EFFECT APPARATUS AND METHODS FOR SEQUENCING NUCLEIC ACIDS 有权
公开(公告)号：EP3294908A1
公开(公告)日：2018-03-21
申请号：EP16727012
申请日：2016-05-11
申请人： ILLUMINA INC , UNIV CALIFORNIA
发明人： GUNDERSON KEVIN L , BAI JINGWEI , CHEN CHENG YAO , MANDELL JEFFREY G , PEISAJOVICH SERGIO , BOYANOV BOYAN , COLLINS PHILIP G , WEISS GREGORY A
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6869 , C12Q2521/543 , C12Q2565/607
摘要： The present disclosure provides a method for sequencing nucleic acids. The method can include polymerase catalyzed incorporation of nucleotides into a nascent nucleic acid strand against a nucleic acid template, wherein the polymerase is attached to a charge sensor that detects nucleotide incorporation events. One or more non-natural nucleotide types that each produce a unique signatures at the charge sensor can be used to uniquely identify different nucleotides in the template nucleic acid.

20. 发明专利

DK3428290T3 SAMMENSÆTNINGER OG FREMGANGSMÅDER TIL AMPLIFIKATION AF NUKLEINSYRER 未知
公开(公告)号：DK3428290T3
公开(公告)日：2022-07-04
申请号：DK18183934
申请日：2013-02-21
申请人： ILLUMINA INC
发明人： FAN JIAN-BING , GUNDERSON KEVIN L , STEEMERS FRANK J , POKHOLOK DMITRY K , KAPER FIONA
IPC分类号： C12Q1/6844

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