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11. 发明授权

EP3256604B1 METHODS AND COMPOSITIONS FOR ANALYZING CELLULAR COMPONENTS 有权
公开(公告)号：EP3256604B1
公开(公告)日：2020-03-25
申请号：EP16711039.4
申请日：2016-02-10
申请人： Illumina, Inc.
发明人： GUNDERSON, Kevin L. , STEEMERS, Frank J. , FISHER, Jeffrey S. , RIGATTI, Roberto
IPC分类号： C12Q1/6806 , C12Q1/6869 , C12N15/10

12. 发明授权

EP3133169B1 METHODS FOR SELECTING AND AMPLIFYING POLYNUCLEOTIDES 有权
公开(公告)号：EP3133169B1
公开(公告)日：2019-10-16
申请号：EP16180028.9
申请日：2009-08-25
申请人： Illumina, Inc.
发明人： SABOT, Andrea , RIGATTI, Roberto , SHEN, Min-jui, Richard
IPC分类号： C12Q1/68

13. 发明公开

EP3133169A1 METHODS FOR SELECTING AND AMPLIFYING POLYNUCLEOTIDES 有权
标题翻译： VERFAHREN ZUR AUSWAHL UND AMPLIFATIONATION VON POLYNUKLEOTIDEN
公开(公告)号：EP3133169A1
公开(公告)日：2017-02-22
申请号：EP16180028.9
申请日：2009-08-25
申请人： Illumina, Inc.
发明人： SABOT, Andrea , RIGATTI, Roberto , SHEN, Min-jui, Richard
IPC分类号： C12Q1/68
CPC分类号： C12N15/1068 , C12Q1/6806 , C12Q1/6837 , C12Q1/6874 , C12Q2565/543 , C12Q2565/507 , C12Q2531/107
摘要： The invention provides methods for controlling the density of different molecular species on the surface of a solid support. A first mixture of different molecular species is attached to a solid support under conditions to attach each species at a desired density, thereby producing a derivatized support having attached capture molecules. The derivatized support is treated with a second mixture of different molecular species, wherein different molecular species in the second mixture bind specifically to the different capture molecules attached to the solid support. One or more of the capture molecules can be reversibly modified such that the capture molecules have a different activity before and after the second mixture of molecular species are attached. In particular embodiments, the different molecular species are nucleic acids that are reversibly modified to have different activity in an amplification reaction.
摘要翻译：本发明提供了控制固体支持物表面上不同分子种类的密度的方法。将不同分子种类的第一混合物连接到固体支持物上，以便以期望的密度附着每种物质，从而产生具有附着捕获分子的衍生化载体。衍生的载体用不同分子种类的第二混合物处理，其中第二混合物中的不同分子物质特异性地结合到与固体支持物连接的不同捕获分子。可以可逆地修饰一个或多个捕获分子，使得捕获分子在分子物质的第二混合物附着之前和之后具有不同的活性。在具体实施方案中，不同的分子种类是可逆修饰以在扩增反应中具有不同活性的核酸。

14. 发明授权

EP2633069B1 SEQUENCING METHODS 有权转让
标题翻译：测序方法
公开(公告)号：EP2633069B1
公开(公告)日：2015-07-01
申请号：EP11776423.3
申请日：2011-10-26
申请人： Illumina, Inc.
发明人： RIGATTI, Roberto , BOUTELL, Jonathan Mark , BETLEY, Jason Richard , GORMLEY, Niall Anthony , RONAGHI, Mostafa , EVERS, Dirk
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6874 , C12Q2565/514 , C12Q2537/155 , C12Q2525/186 , C12Q2525/185 , C12Q2537/113 , C12Q2525/204

15. 发明公开

EP2633069A1 SEQUENCING METHODS 有权转让
标题翻译：测序方法
公开(公告)号：EP2633069A1
公开(公告)日：2013-09-04
申请号：EP11776423.3
申请日：2011-10-26
申请人： Illumina, Inc.
发明人： RIGATTI, Roberto , BOUTELL, Jonathan Mark , BETLEY, Jason Richard , GORMLEY, Niall Anthony , RONAGHI, Mostafa , EVERS, Dirk
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6874 , C12Q2565/514 , C12Q2537/155 , C12Q2525/186 , C12Q2525/185 , C12Q2537/113 , C12Q2525/204
摘要： The present technology relates to molecular sciences, such as genomics. More particularly, the present technology relates to nucleic acid sequencing.
摘要翻译：本技术涉及分子科学，例如基因组学。更具体地说，本技术涉及核酸测序。

16. 发明授权

EP3094743B1 POLYNUCLEOTIDE MODIFICATION ON SOLID SUPPORT 有权转让
公开(公告)号：EP3094743B1
公开(公告)日：2020-01-22
申请号：EP14828467.2
申请日：2014-12-23
申请人： Illumina Cambridge Limited , Illumina, Inc.
发明人： RIGATTI, Roberto , GORMLEY, Niall , ECKHARDT, Allen E. , BOUTELL, Jonathan Mark
IPC分类号： C12Q1/6806 , C12Q1/6853 , C12Q1/6869

17. 发明授权

EP2670864B1 METHODS FOR REDUCING NUCLEIC ACID DAMAGE 有权
标题翻译：程序对于核酸损失减少
公开(公告)号：EP2670864B1
公开(公告)日：2017-03-08
申请号：EP12741790.5
申请日：2012-01-12
申请人： Illumina, Inc. , Illumina Cambridge Limited
发明人： KLAUSING, Kay , SHEN, Min-Jui Richard , MOORE, John , SMITH, Vincent , HALL, Kevin , GORMLEY, Niall Anthony , IOANNOU, Avgousta , FRITZILAS, Epameinondas , RIGATTI, Roberto
IPC分类号： C12Q1/68 , C12Q1/48 , G01N33/53 , C12P19/34 , C12N15/10
CPC分类号： C12P19/34 , C12N15/1003 , C12Q1/6806 , C12Q2521/531 , C12Q2527/125 , C12Q2563/131

18. 发明授权

EP2470669B1 METHODS FOR SELECTING AND AMPLIFYING POLYNUCLEOTIDES 有权转让
标题翻译：方法多核苷酸的选择和扩增
公开(公告)号：EP2470669B1
公开(公告)日：2014-06-18
申请号：EP09848830.7
申请日：2009-08-25
申请人： Illumina, Inc.
发明人： SABOT, Andrea , RIGATTI, Roberto , SHEN, Min-jui, Richard
IPC分类号： C12Q1/68
CPC分类号： C12N15/1068 , C12Q1/6806 , C12Q1/6837 , C12Q1/6874 , C12Q2565/543 , C12Q2565/507 , C12Q2531/107
摘要： The invention provides methods for controlling the density of different molecular species on the surface of a solid support. A first mixture of different molecular species is attached to a solid support under conditions to attach each species at a desired density, thereby producing a derivatized support having attached capture molecules. The derivatized support is treated with a second mixture of different molecular species, wherein different molecular species in the second mixture bind specifically to the different capture molecules attached to the solid support. One or more of the capture molecules can be reversibly modified such that the capture molecules have a different activity before and after the second mixture of molecular species are attached. In particular embodiments, the different molecular species are nucleic acids that are reversibly modified to have different activity in an amplification reaction.

19. 发明公开

EP2670864A2 METHODS FOR REDUCING NUCLEIC ACID DAMAGE 有权
标题翻译：程序对于核酸损失减少
公开(公告)号：EP2670864A2
公开(公告)日：2013-12-11
申请号：EP12741790.5
申请日：2012-01-12
申请人： Illumina, Inc. , Illumina Cambridge Limited
发明人： KLAUSING, Kay , SHEN, Min-Jui Richard , MOORE, John , SMITH, Vincent , HALL, Kevin , GORMLEY, Niall Anthony , IOANNOU, Avgousta , FRITZILAS, Epameinondas , RIGATTI, Roberto
IPC分类号： C12Q1/68 , C12Q1/48 , G01N33/53
CPC分类号： C12P19/34 , C12N15/1003 , C12Q1/6806 , C12Q2521/531 , C12Q2527/125 , C12Q2563/131
摘要： Provided herein is a method of inhibiting degradation of nucleic acids during a nucleic acid processing step selected from fragmentation and detection comprising contacting the nucleic acids with a solution comprising gallic acid, analogues, derivatives thereof or mixtures thereof, during the processing step, wherein the contacting inhibits degradation of the nucleic acids. Also provided herein is a method of inhibiting light-induced degradation of nucleic acids. Additionally, provided herein is a method of reducing or inhibiting nucleic acid damage during preparation of a nucleic acid sample comprising fragmenting the nucleic acid sequences in the sample in a solution comprising one of more compounds, the compounds inhibiting degradation of the nucleic acid sequences in the sample.

20. 发明公开

EP2539464A2 AMPLIFICATION METHODS TO MINIMISE SEQUENCE SPECIFIC BIAS 有权转让
标题翻译：程序，用于减小序列依赖AMPLIFIKATIONSUNTERSCHIEDE
公开(公告)号：EP2539464A2
公开(公告)日：2013-01-02
申请号：EP11747961.8
申请日：2011-02-23
申请人： Illumina, Inc.
发明人： RIGATTI, Roberto , BOUTELL, Jonathan Mark , SHEN, Min-Jui Richard
IPC分类号： C12Q1/68 , C12N15/10
CPC分类号： C12P19/34 , C09K3/00 , C12Q1/686 , C12Q2565/518 , C12Q2527/137
摘要： Methods for amplifying nucleic acids are provided. The methods can be used to minimise sequence specific bias caused by the preferential amplification of certain nucleic acid sequences. Methods are described which can lower the efficiency of AT rich templates relative to GC rich templates, thereby minimising GC bias during amplification reactions with multiple templates of different sequence. The methods are suited to solid phase amplification, for example, utilising flow cells

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