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11. 发明专利

CA2887578A1 2'-CHLORO NUCLEOSIDE ANALOGS FOR HCV INFECTION 未知
公开(公告)号：CA2887578A1
公开(公告)日：2014-04-17
申请号：CA2887578
申请日：2013-10-07
申请人： IDENIX PHARMACEUTICALS INC , CENTRE NAT RECH SCIENT , UNIV MONTPELLIER II
发明人： GOSSELIN GILLES , PARSY CHRISTOPHE CLAUDE , ALEXANDRE FRANCOIS-RENE , RAHALI HOUCINE , GRIFFON JEAN-FRANCOIS , SURLERAUX DOMINIQUE , DOUSSON CYRIL B , PIERRA CLAIRE , MOUSSA ADEL M , MAYES BENJAMIN ALEXANDER , DUKHAN DAVID , STEWART ALISTAIR JAMES
IPC分类号： C07H19/00 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61P31/04 , C07H19/06 , C07H19/16 , C07H19/20
摘要： Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. In certain embodiments, the compounds are 2'-chloro nucleosides according to Formula 2001: (2001); or a pharmaceutically acceptable salt, solvate, stereoisomeric form, tautomeric form or polymorphic form thereof, wherein B, Z and PD are as described herein.

12. 发明专利

ES2351603T3 ANALOGOS DE NUCLEOSIDOS DE PURINA PARA EL TRATAMIENTO DE ENFERMEDADES CAUSADAS POR FLAVIRIDAE INCLUYENDO HEPATITIS C. 未知
公开(公告)号：ES2351603T3
公开(公告)日：2011-02-08
申请号：ES04744307
申请日：2004-07-26
申请人： IDENIX PHARMACEUTICALS INC , CENTRE NAT RECH SCIENT , UNIV MONTPELLIER II
发明人： DUKHAN DAVID , GOSSELIN GILLES , LEROY FREDERIC , STORER RICHARD
IPC分类号： C07H19/044 , A61K31/00 , A61K31/706 , A61P31/14 , C07H19/052 , C07H19/056
摘要： Un compuesto de la estructura general de la Fórmula (I): **(Ver fórmula)**o una sal farmacológicamente aceptable del mismo, donde: R es H; mono-, di- o trifosfato; o fosfonato; X es O; R1 y R1' son independientemente H, alquilo, ácido, ciano, alquenilo, alquinilo, -C(O)-(alquilo), -C(O)(O)(alquenilo), -C(O) (O)(alquinilo), C(O) NH2,-C(O)NH(alquilo), -C(O)N(alquilo)2, -C(H)=N-NH2, C(S)NH(alquilo), o C(S)N(alquilo)2; donde alquilo, alquenilo, y/o alquinilo puede sustituirse de manera opcional; R2 y R3 es independientemente H, OH, NH2, SH, F, Cl, Br, I, CN, NO2, -C(O)NH2, -C(O)NH(alquilo), y -C(O)N(alquilo)2, N3, alquilo opcionalmente sustituido, alquenilo or alquinilo opcionalmente sustituido, -C(O)O-(alquilo), C(O)O-(alquenilo), -C(O)O-(alquinilo), O(acilo), -O(alquilo), -O(alquenilo), -O(alquinilo), -OC(O)NH2, NC, C(O)OH, SCN, OCN, -S(alquilo), -S(alquenilo), -S(alquinilo), NH(alquilo), -N(alquilo)2, -NH(alquenilo), -NH(alquinilo), un residuo de aminoácido o un derivado, o un anillo heterocíclico de 3-7 miembros opcionalmente sustituido que tiene O, S y/o N independientemente como un heteroátomo tomado solo o en combinación; R2' es alquilo, alquenilo, o alquinilo opcionalmente sustituido; halógeno, ácido o ciano; R3' es H; alquilo, alquenilo, o alquinilo opcionalmente sustituido; C(O)O-(alquilo), -C(O)O-(alquenilo), -C(O)O-(alquinilo), -C(O)NH2, C(O)NH(alquilo), halógeno, ácido, ciano, NO2, -S(alquilo), S(alquenilo), -S(alquinilo), NH2, -NH(alquilo), -N(alquilo)2, NH(alquenilo),-NH(alquinilo), -NH(acilo) o N(acilo)2; y Base se selecciona del grupo consistente en: **(Ver fórmula)**donde cada R' and R independientemente es H, C1-6 alquilo, C2-6 alquenilo, C2-6 alquinilo, halógeno, alquilo halogenado, OH, CN, N3, carboxi, C1-4 alcoxicarbonilo,NH2, C1-4 alquiloamino, di(C1-4 alquilo)amino,C16 alcoxi,C1-6 alquilosulfonilo, o (C1-4 alquilo)0-2 aminometilo; cada W es independientemente H, Cl, Br, I, F, alquilo halogenado, alcoxi, OH, SH, O-alquilo, S-alquilo, O-alquenilo, O-alquinilo, Salquenilo, S-alquinilo, -OC(O)NR4R4, O-acilo, S-acilo, CN, SCN, OCN, NO2, N3, NH2, NH(alquilo), N(alquilo)2, NH-cicloalquilo, NHacilo, NH=NH, CONH2, CONH(alquilo), o CON(alquilo)2; y cada R4 es independientemente H, acilo, o C1-6 alquilo; y cada Z es independientemente O, S, NH, N-OH, N-NH2, N(alquilo), N(alquilo)2, N-cicloalquilo, alcoxi, CN, SCN, OCN, SH, NO2, N3, NH=NH, CONH2, CONH(alquilo), o CON(alquilo)2.

13. 发明专利

AT478886T 未知
公开(公告)号：AT478886T
公开(公告)日：2010-09-15
申请号：AT04744307
申请日：2004-07-26
申请人： IDENIX PHARMACEUTICALS INC , CENTRE NAT RECH SCIENT , UNIV MONTPELLIER II
发明人： STORER RICHARD , GOSSELIN GILLES , DUKHAN DAVID , LEROY FREDERIC
IPC分类号： C07H19/044 , A61K31/00 , A61K31/706 , A61P31/14 , C07H19/052 , C07H19/056
摘要： This invention is directed to a method for treating a host, especially a human, infected with hepatitis C, flavivirus and/or pestivirus, comprising administering to that host an effective amount of an anti-HCV biologically active pentofuranonucleoside where the pentofuranonucleoside base is an optionally substituted 2-azapurine. The optionally substituted pentofuranonucleoside, or a salt or prodrug thereof, may be administered alone or in combination with one or more optionally substituted pentofuranonucleosides or other anti-viral agents.

14. 发明专利

DE602004028841D1 PURIN NUCLEOSIDE FÜR DIE BEHANDLUNG VON DURCH FLAVIVIDRAE VERURSACHTEN KRANKHEITEN, EINSCHLIESSLICH HEPATITIS C 未知
公开(公告)号：DE602004028841D1
公开(公告)日：2010-10-07
申请号：DE602004028841
申请日：2004-07-26
申请人： CENTRE NAT RECH SCIENT , IDENIX PHARMACEUTICALS INC , UNIV MONTPELLIER II MONTPELLIE
发明人： STORER RICHARD , GOSSELIN GILLES , DUKHAN DAVID , LEROY FREDERIC
IPC分类号： C07H19/044 , A61K31/00 , A61K31/706 , A61P31/14 , C07H19/052 , C07H19/056

15. 发明专利

AU2013329521A1 2'-chloro nucleoside analogs for HCV infection 未知
公开(公告)号：AU2013329521A1
公开(公告)日：2015-05-28
申请号：AU2013329521
申请日：2013-10-07
申请人： IDENIX PHARMACEUTICALS INC , UNIV MONTPELLIER II , CENTRE NAT RECH SCIENT
发明人： GOSSELIN GILLES , PARSY CHRISTOPHE CLAUDE , ALEXANDRE FRANCOIS-RENE , RAHALI HOUCINE , GRIFFON JEAN-FRANCOIS , SURLERAUX DOMINIQUE , DOUSSON CYRIL B , PIERRA CLAIRE , MOUSSA ADEL M , MAYES BENJAMIN ALEXANDER , STEWART ALISTAIR JAMES , DUKHAN DAVID
IPC分类号： C07H19/00 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61P31/04 , C07H19/06 , C07H19/16 , C07H19/20
摘要： Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. In certain embodiments, the compounds are 2'-chloro nucleosides according to Formula 2001: (2001); or a pharmaceutically acceptable salt, solvate, stereoisomeric form, tautomeric form or polymorphic form thereof, wherein B, Z and PD are as described herein.

16. 发明专利

DK1658302T3 Purinnukleosidanaloge til behandling af sygdomme forårsaget af Flavirividae, herunder hepatitis C 未知
公开(公告)号：DK1658302T3
公开(公告)日：2010-11-22
申请号：DK04744307
申请日：2004-07-26
申请人： IDENIX PHARMACEUTICALS INC , UNIV MONTPELLIER II , CENTRE NAT RECH SCIENT
发明人： STORER RICHARD , GOSSELIN GILLES , DUKHAN DAVID , LEROY FREDERIC
IPC分类号： C07H19/044 , A61K31/00 , A61K31/706 , A61P31/14 , C07H19/052 , C07H19/056

17. 发明专利

PT1658302E ANÁLOGOS DO NUCLEÓSIDO PURINA PARA O TRATAMENTO DE DOENÇAS PROVOCADAS POR FLAVIVIRIDAE INCLUINDO HEPATITE C 未知
公开(公告)号：PT1658302E
公开(公告)日：2010-10-25
申请号：PT04744307
申请日：2004-07-26
申请人： CENTRE NAT RECH SCIENT , IDENIX PHARMACEUTICALS INC , UNIV MONTPELLIER II
发明人： STORER RICHARD , GOSSELIN GILLES , DUKHAN DAVID , LEROY FREDERIC
IPC分类号： A61K31/00 , A61K31/706 , A61P31/14 , C07H19/044 , C07H19/052 , C07H19/056

18. 发明申请

WO2010101967A3 PHOSPHOTHIOPHENE AND PHOSPHOTHIAZOLE HCV POLYMERASE INHIBITORS 审中-公开
标题翻译：磷酸二苯酯和磷酰氯HCV聚合酶抑制剂
公开(公告)号：WO2010101967A3
公开(公告)日：2010-11-11
申请号：PCT/US2010025991
申请日：2010-03-03
申请人： IDENIX PHARMACEUTICALS INC , DOUSSON CYRIL , SURLERAUX DOMINIQUE , PAPARIN JEAN-LAURENT , PIERRA CLAIRE , GRIFFON JEAN-FRANCOIS , LEROY FREDERIC , DUKHAN DAVID
发明人： DOUSSON CYRIL , SURLERAUX DOMINIQUE , PAPARIN JEAN-LAURENT , PIERRA CLAIRE , GRIFFON JEAN-FRANCOIS , LEROY FREDERIC , DUKHAN DAVID
IPC分类号： C07F9/572 , A61K31/664 , A61P31/14 , C07F9/6553 , C07F9/6558
CPC分类号： C07F9/6561 , C07F9/655345 , C07F9/65586
摘要： Provided herein are phosphothiophene and phosphothiazole compounds, for example, of any of Formulae I, IA, HA, IIIA, IVA, VA, VIA, VIIA, IB, HB, IIIB, IVB, VB, VIB and VIIB disclosed herein, pharmaceutical compositions comprising the compounds, and processes of preparation thereof. Also provided are methods of their use for the treatment of an HCV infection in a host infected with HCV.
摘要翻译：本文提供的是磷酸噻吩和磷酸噻唑化合物，例如本文公开的式I，IA，HA，IIIA，IVA，VA，VIA，VIIA，IB，HB，IIIB，IVB，VB，VIB和VIIB中任一项的药物组合物，化合物及其制备方法。还提供了它们用于在感染HCV的宿主中治疗HCV感染的方法。

19. 发明专利

EA030189B8 АНАЛОГИ 2'-ХЛОРОНУКЛЕОЗИДОВ ДЛЯ ИНФЕКЦИИ ВГС 未知
公开(公告)号：EA030189B8
公开(公告)日：2018-10-31
申请号：EA201500304
申请日：2013-10-07
申请人： IDENIX PHARMACEUTICALS LLC , CENTRE NAT RECH SCIENT , UNIV MONTPELLIER
发明人： GOSSELIN GILLES , PARSY CHRISTOPHE CLAUDE , ALEXANDRE FRANCOIS-RENE , RAHALI HOUCINE , GRIFFON JEAN-FRANCOIS , SURLERAUX DOMINIQUE , DOUSSON CYRIL B , PIERRA CLAIRE , MOUSSA ADEL M , MAYES BENJAMIN ALEXANDER , STEWART ALISTAIR JAMES , DUKHAN DAVID
IPC分类号： C07H19/00 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61P31/04 , C07H19/06 , C07H19/16 , C07H19/20
摘要： Вдокументеописываютсясоединения, композициии способылеченияинфекций, вызываемыхфлавивирусами, включаяинфекцииВГС, аименносоединениепоформуле (40ii):илиегофармацевтическиприемлемаясоль, сольват, стереоизомернаяформа, таутомернаяформаилиполиморфнаяформа.

20. 发明专利

PE20151318A1 ANALOGOS DE 2'-CLORO NUCLEOSIDO PARA INFECCION POR VHC 未知
公开(公告)号：PE20151318A1
公开(公告)日：2015-10-03
申请号：PE2015000459
申请日：2013-10-07
申请人： IDENIX PHARMACEUTICALS INC , CENTRE NAT RECH SCIENT , UNIV MONTPELLIER
发明人： GOSSELIN GILLES , PARSY CHRISTOPHE CLAUDE , ALEXANDRE FRANCOIS-RENE , RAHALI HOUCINE , GRIFFON JEAN-FRANCOIS , SURLERAUX DOMINIQUE , DOUSSON CYRIL B , PIERRA CLAIRE , MOUSSA ADEL M , MAYES BENJAMIN ALEXANDER , STEWART ALISTAIR JAMES , DUKHAN DAVID
IPC分类号： C07H19/00 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61P31/04 , C07H19/06 , C07H19/16 , C07H19/20
摘要： La invencion proporciona compuestos, composiciones y metodos para el tratamiento de infecciones por Flaviviridae, incluyendo infecciones por VHC. En ciertas realizaciones, se revelan compuestos y composiciones de derivados de nucleosidos, que se pueden administrar solos o en combinacion con otros agentes antivirales. En ciertas realizaciones, los compuestos son 2'-cloro nucleosidos de acuerdo con la Formula 2001: o una sal, solvato, forma estereoisomerica, forma tautomerica o forma polimorfica farmaceuticamente aceptable de los mismos, caracterizados por que B, Z y PD son tal como se describen en el documento

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