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11. 发明申请

US20110027311A1 COMBINATION OF PROTEIN VACCINE AND MESENCHYMAL STEM CELLS FOR TREATING CANCER 有权
标题翻译：用于治疗癌症的蛋白疫苗和骨髓干细胞的组合
公开(公告)号：US20110027311A1
公开(公告)日：2011-02-03
申请号：US12844044
申请日：2010-07-27
申请人： Win-Ping DENG , Hsiu-Kang Chang , Hung-Chien Wei , Tsang-Hsien Alexander Wu
发明人： Win-Ping DENG , Hsiu-Kang Chang , Hung-Chien Wei , Tsang-Hsien Alexander Wu
IPC分类号： A61K39/12 , A61K39/00
CPC分类号： A61K39/0011 , A61K2035/124 , A61K2039/5156 , A61K2039/5158 , A61K2039/545 , A61K2039/6037 , C12N2710/20022
摘要： A method for inhibiting growth and/or metastasis of a tumor in a mammal is disclosed. The method comprises administering to a mammal in need thereof an effective amount of stem cells comprising a transgene encoding at least one oncogenic protein, wherein the stem cells are immortal and show no signs of neoplastic transformation, and administering to the mammal a vaccine composition comprising an effective amount of at least one immunogenic protein capable of eliciting at least one antibody specific against the at least one oncogenic protein, and thereby inhibiting growth and/or metastasis of a tumor in the mammal. A therapeutic kit for inhibiting growth and/or metastasis of a tumor in a mammal is also disclosed.
摘要翻译：公开了抑制哺乳动物肿瘤生长和/或转移的方法。所述方法包括向有需要的哺乳动物施用有效量的包含编码至少一种致癌蛋白的转基因的干细胞，其中所述干细胞是永生的并且不显示肿瘤转化的迹象，以及向所述哺乳动物施用包含有效量的至少一种免疫原性蛋白质能够引发至少一种抗至少一种致癌蛋白质特异性的抗体，从而抑制哺乳动物肿瘤的生长和/或转移。还公开了用于抑制哺乳动物肿瘤生长和/或转移的治疗试剂盒。

12. 发明授权

US07618635B2 Super-antigen fusion proteins and the use thereof 有权
标题翻译：超抗原融合蛋白及其用途
公开(公告)号：US07618635B2
公开(公告)日：2009-11-17
申请号：US11183796
申请日：2005-07-19
申请人： Hsiu-Kang Chang , Chao-We Liao , Wen-Fang Cheng
发明人： Hsiu-Kang Chang , Chao-We Liao , Wen-Fang Cheng
IPC分类号： A61K39/00 , A61K39/12 , A61K39/215 , A61K38/00
CPC分类号： C07K14/005 , A61K38/00 , C07K14/21 , C07K2319/55 , C12N2770/20022
摘要： The present invention relates to a super-antigen fusion protein, comprising: a peptide fragment whose sequence corresponds to a partial SARS E2 spike protein; and a translocating peptide fragment for transporting a protein into a cell and translocating the protein in cytosol; wherein, the amino acid sequence of the peptide fragment corresponding to the partial SARS E2 spike protein includes SEQ ID NO. 1, SEQ ID NO. 2, SEQ ID NO. 3 or SEQ ID NO. 4. The present invention further relates to DNA sequences corresponding to the partial SARS E2 spike protein includes SEQ ID NO. 5, SEQ ID NO. 6, SEQ ID NO. 7, or SEQ ID NO. 8; wherein the DNA sequences are able to express specific proteins in an E. Coli expression system.
摘要翻译：本发明涉及超抗原融合蛋白，其包含：序列对应于部分SARS E2尖峰蛋白的肽片段; 以及用于将蛋白质输送到细胞中并将蛋白质转移到胞质溶胶中的易位肽片段; 其中，对应于部分SARS E2尖峰蛋白的肽片段的氨基酸序列包括SEQ ID NO： 1，SEQ ID NO： 2，SEQ ID NO： 3或SEQ ID NO。本发明还涉及对应于部分SARS E2尖峰蛋白的DNA序列，包括SEQ ID NO： 5，SEQ ID NO。 6，SEQ ID NO： 7，或SEQ ID NO。 8; 其中所述DNA序列能够在大肠杆菌表达系统中表达特异性蛋白质。

13. 发明申请

US20090203884A1 CHIMERIC HIV FUSION PROTEINS AS VACCINES 审中-公开
标题翻译： CHIMERIC艾滋病毒融合蛋白作为疫苗
公开(公告)号：US20090203884A1
公开(公告)日：2009-08-13
申请号：US12358659
申请日：2009-01-23
申请人： Chao-Wei LIAO , Hsiu-Kang Chang
发明人： Chao-Wei LIAO , Hsiu-Kang Chang
IPC分类号： C07K2/00
CPC分类号： C07K14/21 , A61K39/12 , A61K39/21 , A61K2039/5254 , A61K2039/54 , A61K2039/545 , A61K2039/55566 , A61K2039/57 , C07K14/005 , C07K2319/00 , C07K2319/10 , C07K2319/40 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234 , C12N2740/16322 , C12N2740/16334
摘要： A chimeric fusion protein useful as an immunogen for inducing HIV antigen-specific immune responses contains a first polypeptidyl region and a second polypeptidyl region. The first polypeptidyl region includes a Pseudomonas Exotoxin A (PE) binding domain and a PE translocation domain. The second polypeptidyl region includes (i) a first peptidyl segment containing a fragment of gp120 C1 domain, located at the N-terminus of the second peptidyl region; (ii) a second peptidyl segment containing a fragment of gp120 C5 domain, located at the C-terminus of the first peptidyl segment; and (iii) a third peptidyl segment containing a fragment of gp41, located at the C-terminus of the second peptidyl segment. The second polypeptidyl region contains an antigenic determinant specific to one subtype of HIV. An intermediate polypeptide containing a non-Env, HIV antigenic determinant selected from Gag24, Nef, Tat and Rev may be included.
摘要翻译：可用作诱导HIV抗原特异性免疫应答的免疫原的嵌合融合蛋白包含第一多肽基区和第二多肽基区。第一多肽基区包括假单胞菌外毒素A（PE）结合域和PE易位结构域。第二多肽基区包括（i）含有位于第二肽基区N末端的gp120 C1结构域片段的第一肽基区段; （ii）含有位于第一肽段的C末端的gp120 C5结构域片段的第二肽段; 和（iii）含有位于第二肽段的C末端的gp41片段的第三肽基片段。第二个多肽基区域包含一个特异于HIV亚型的抗原决定簇。可以包括含有选自Gag24，Nef，Tat和Rev的非Env，HIV抗原决定簇的中间多肽。

14. 发明申请

US20080008722A1 Fusion protein of porcine reproductive and respiratory syndrome virus as PRRS vaccine 有权
标题翻译：猪繁殖与呼吸综合征病毒融合蛋白作为PRRS疫苗
公开(公告)号：US20080008722A1
公开(公告)日：2008-01-10
申请号：US11480387
申请日：2006-07-05
申请人： Hsiu-Kang Chang , Chao-Wei Liao
发明人： Hsiu-Kang Chang , Chao-Wei Liao
IPC分类号： A61K39/02 , C07K14/195
CPC分类号： C07K14/21 , A61K39/12 , A61K39/385 , A61K2039/552 , A61K2039/55566 , A61K2039/6037 , C07K14/005 , C07K2319/02 , C07K2319/04 , C12N2770/10022 , C12N2770/10034
摘要： The present invention provides a PRRSV subunit vaccine comprising a fusion protein having neutralization titers evoked, PE-PQGAB-K3, which comprises a chimeric polypeptide containing N-terminal portions of PRRSV ORF5 and ORF6 structure proteins; a portion of Pseudomonas exotoxin A binding and translocation domain; and a carboxyl terminal domain containing KDEL-KDEL-KDEL(K3) sequence. Less inflammation of PE-PQGAB-K3 vaccine group in their lungs post being PRRSV-challenged indicates that PQGAB without an antigen-specific allergy effect. Importantly, PE-PQGAB-K3 vaccine presents a good protection against PRRSV infection than control groups in pig challenged experiment.
摘要翻译：本发明提供一种PRRSV亚单位疫苗，其包含具有诱发中和滴度的融合蛋白质，PE-PQGAB-K3，其包含含有PRRSV ORF5和ORF6结构蛋白的N-末端部分的嵌合多肽; 一部分假单胞菌外毒素A结合和易位结构域; 和含有KDEL-KDEL-KDEL（K3）序列的羧基末端结构域。在PRRSV攻击后肺部PE-PQGAB-K3疫苗组炎症较少表明PQGAB无抗原特异性过敏作用。重要的是，PE-PQGAB-K3疫苗与猪受试实验中的对照组相比，对PRRSV感染具有良好的保护作用。

15. 发明申请

US20060134753A1 Super-antigen fusion proteins and the use thereof 有权
标题翻译：超抗原融合蛋白及其用途
公开(公告)号：US20060134753A1
公开(公告)日：2006-06-22
申请号：US11183796
申请日：2005-07-19
申请人： Hsiu-Kang Chang , Chao-We Liao , Wen-Fang Cheng
发明人： Hsiu-Kang Chang , Chao-We Liao , Wen-Fang Cheng
IPC分类号： C12P21/06 , C07H21/04 , C12N1/21 , C07K14/195 , C07K14/165 , C12N15/74
CPC分类号： C07K14/005 , A61K38/00 , C07K14/21 , C07K2319/55 , C12N2770/20022
摘要： The present invention relates to a super-antigen fusion protein, comprising: a peptide fragment encoding a partial SARS E2 spike protein; and a translocating peptide fragment for transporting a protein into a cell and translocating the protein in cytosol; wherein, the amino acid of the peptide fragment encoding the partial SARS E2 spike protein includes SEQ ID NO.1, SEQ ID NO.2, SEQ ID NO.3 or SEQ ID NO.4. The present invention further relates to DNA sequences encoding the partial SARS E2 spike protein includes SEQ ID NO.5, SEQ ID NO.6, SEQ ID NO.7, or SEQ ID NO.8; wherein the DNA sequences are able to express specific proteins in an E. Coli expression system.
摘要翻译：本发明涉及超抗原融合蛋白，其包含：编码部分SARS E2尖峰蛋白的肽片段; 以及用于将蛋白质输送到细胞中并将蛋白质转移到胞质溶胶中的易位肽片段; 其中编码部分SARS E2尖峰蛋白的肽片段的氨基酸包括SEQ ID NO.1，SEQ ID NO.2，SEQ ID NO.3或SEQ ID NO.4。本发明还涉及编码部分SARS E2尖峰蛋白的DNA序列包括SEQ ID NO.5，SEQ ID NO.6，SEQ ID NO.7或SEQ ID NO.8; 其中所述DNA序列能够在大肠杆菌表达系统中表达特异性蛋白质。

16. 发明授权

US06461592B1 Method for transferring one or more active ingredients between different phase carriers 失效
标题翻译：用于在不同相载体之间转移一种或多种活性成分的方法
公开(公告)号：US06461592B1
公开(公告)日：2002-10-08
申请号：US09612955
申请日：2000-07-10
申请人： Hsiu-Kang Chang , Huei Lung Chang , Tiao Ling Hsieh , Chun Hsieh Tsai
发明人： Hsiu-Kang Chang , Huei Lung Chang , Tiao Ling Hsieh , Chun Hsieh Tsai
IPC分类号： B05B900
CPC分类号： A61K9/0078 , A61K9/0048 , A61K9/12 , Y10S514/912
摘要： The present invention relates to a method for transferring one or more active ingredients between different phase carriers, which includes: (a) providing a solid, semi-solid, or nonaqueous liquid drug which contains at least one active ingredient; (b) admixing said drug with water or water solution to form an admixture; and (c) nebulizing said admixture to form liquid fine drops containing said active ingredient. This method enables the active ingredient stored in a solid phase carrier to transfer into an aqueous phase carrier, or enables the active ingredient stored in a non-aqueous liquid carrier to transfer into an aqueous phase carrier. The aqueous phase carrier contains the active ingredient can then be nebulized with a nebulizer by means of ultrasonic vibration. The present invention provides a new method for controlling administration by transferring the active ingredient between different phase carriers.
摘要翻译：本发明涉及一种在不同相载体之间转移一种或多种活性成分的方法，其包括：（a）提供含有至少一种活性成分的固体，半固体或非水性液体药物; （b）将所述药物与水或水溶液混合以形成混合物; 和（c）将所述混合物雾化以形成含有所述活性成分的液体细滴。该方法使存储在固相载体中的活性成分能够转移到水相载体中，或使存储在非水液体载体中的活性成分转移到水相载体中。含有活性成分的水相载体然后可以用喷雾器通过超声波振动雾化。本发明提供了一种通过在不同相载体之间转移活性成分来控制给药的新方法。

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