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11. 发明申请

US20110036729A1 CONTROL LIQUID JUDGING METHOD AND ANALYSIS DEVICE 审中-公开
标题翻译：控制液体判断方法与分析装置
公开(公告)号：US20110036729A1
公开(公告)日：2011-02-17
申请号：US12449101
申请日：2008-01-23
申请人： Hirokazu Matsuda , Yoshiharu Sato
发明人： Hirokazu Matsuda , Yoshiharu Sato
IPC分类号： G01N27/26 , G01N27/416
CPC分类号： G01N27/3274
摘要： The present invention relates to a method for distinguishing between a sample and a control liquid in a system for analyzing a specific component in the sample by using an analyzing tool having a working electrode and an counter electrode. This discriminating method includes a first step of applying a voltage between the working electrode and the counter electrode, a second step of measuring a response current at certain intervals by use of the working electrode and the counter electrode, a third step of calculating a relative value for a peak value or an end value of the response current, a fourth step of calculating a change rate of the relative value, and a fifth step of distinguishing between the sample and the control liquid based on the change rate.
摘要翻译：本发明涉及用于通过使用具有工作电极和对电极的分析工具来分析样品中的特定成分的系统中的样品和对照液之间的区别的方法。这种识别方法包括在工作电极和对电极之间施加电压的第一步骤，通过使用工作电极和对电极以一定间隔测量响应电流的第二步骤，计算相对值对于响应电流的峰值或结束值，计算相对值的变化率的第四步骤，以及基于变化率来区分样品和控制液体的第五步骤。

12. 发明申请

US20060062906A1 Crayon 失效
标题翻译：蜡笔
公开(公告)号：US20060062906A1
公开(公告)日：2006-03-23
申请号：US11182799
申请日：2005-07-18
申请人： Hidetoshi Fukuo , Hirokazu Matsuda
发明人： Hidetoshi Fukuo , Hirokazu Matsuda
IPC分类号： C09D13/00
CPC分类号： C09D13/00
摘要： The invention provides a crayon comprising an organic solvent, a resin soluble in the organic solvent, a coloring agent, a gelling agent and an interferential pearl luster pigment. The crayon provides a metallic or pearly coating film, and has characteristics such that the color tone of the coating film varies with an angle for viewing the coating film, namely, a visual angle for the coating film. Therefore, for example, when applied to a flaw caused in metallic or pearly coating of automobiles, the crayon is adapted to such coating of automobiles to form an integrated coating film, so that it is suitably used for repairing such a flaw.
摘要翻译：本发明提供了包含有机溶剂，可溶于有机溶剂的树脂，着色剂，胶凝剂和干性珍珠光泽颜料的蜡笔。该蜡笔提供金属或珍珠色的涂膜，其特征在于涂膜的色调随着用于观察涂膜的角度而变化，即涂膜的视角。因此，例如，当应用于汽车金属或珍珠质涂层引起的缺陷时，该蜡笔适用于这样的汽车涂布以形成一体的涂膜，从而适合用于修补这种缺陷。

13. 发明授权

US08642008B2 Molecular probe for imaging of pancreatic islets and use of the same 有权
标题翻译：胰岛成像用分子探针及其用途
公开(公告)号：US08642008B2
公开(公告)日：2014-02-04
申请号：US12872837
申请日：2010-08-31
申请人： Nobuya Inagaki , Hideo Saji , Kentaro Toyoda , Hiroyuki Kimura , Yu Ogawa , Konomu Hirao , Kenji Nagakawa , Hirokazu Matsuda
发明人： Nobuya Inagaki , Hideo Saji , Kentaro Toyoda , Hiroyuki Kimura , Yu Ogawa , Konomu Hirao , Kenji Nagakawa , Hirokazu Matsuda
IPC分类号： A61K51/08
CPC分类号： A61K51/088
摘要： To provide a molecular probe for imaging of pancreatic islets. A molecular probe for use in imaging of pancreatic islets is provided. The molecular probe includes any one of the following polypeptides: polypeptides represented by the following formulae (1), (5), and (9); and polypeptides having homology with the foregoing polypeptides: Z-DLSXQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2 (1) Z-DLSKQMEEEAVRLFIEWLXNGGPSSGAPPPS-NH2 (5) B-DLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2 (9) where X in the formulae (1) and (5) and B- in the formula (9) indicate that an amino group is labeled with a group represented by the formula (I) below having an aromatic ring, wherein A represents either an aromatic hydrocarbon group or an aromatic heterocyclic group, R1 represents a substituent that contains radioactive iodine, R2 represents either a hydrogen atom or a substituent different from that represented by R1, and R3 represents any one of a bond, a methylene group, and an oxymethylene group.
摘要翻译：为胰岛成像提供分子探针。提供了一种用于胰岛成像的分子探针。分子探针包括以下多肽之一：由下式（1），（5）和（9）表示的多肽。和与前述多肽具有同源性的多肽：Z-DLSXQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2（1）Z-DLSKQMEEEAVRLFIEWLXNGGPSSGAPPPS-NH2（5）B-DLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2（9）其中式（1）和（5）中的X和式（9）表示氨基用具有芳环的下式（I）表示的基团标记，其中A表示芳香族烃基或芳香族杂环基，R 1表示含有放射性碘的取代基， R2表示氢原子或与R1表示的不同的取代基，R3表示键，亚甲基和氧亚甲基中的任一个。

14. 发明授权

US08147330B2 Game apparatus and storage medium having game program stored thereon 有权
标题翻译：具有存储有游戏程序的游戏装置和存储介质
公开(公告)号：US08147330B2
公开(公告)日：2012-04-03
申请号：US11546405
申请日：2006-10-12
申请人： Hirokazu Matsuda , Masafumi Kawamura , Yoshiaki Koizumi
发明人： Hirokazu Matsuda , Masafumi Kawamura , Yoshiaki Koizumi
IPC分类号： A63F13/00
CPC分类号： A63F13/54 , A63F13/10 , A63F13/213 , A63F13/57 , A63F2300/1006 , A63F2300/6063 , A63F2300/6081 , A63F2300/64 , A63F2300/8011 , A63F2300/807
摘要： A game apparatus determines whether or not a predetermined first condition is fulfilled. When the first condition is fulfilled, the game apparatus causes the second speaker to generate a sound and moves an object in a virtual game space. When a predetermined second condition regarding a position of the object is fulfilled as a result of the object being moved by the moving control means, the game apparatus causes the first speaker to generate a sound. The game apparatus causes a display device to display the game space.
摘要翻译：游戏装置确定是否满足预定的第一条件。当满足第一条件时，游戏装置使第二扬声器产生声音并在虚拟游戏空间中移动对象。作为对象被移动控制装置移动的结果，当满足关于对象的位置的预定的第二条件时，游戏装置使第一扬声器产生声音。游戏装置使显示装置显示游戏空间。

15. 发明申请

US20110081663A1 Molecular Probe for Imaging of Pancreatic Islets and Use of the Same 有权
标题翻译：胰岛成像用分子探针及其用途
公开(公告)号：US20110081663A1
公开(公告)日：2011-04-07
申请号：US12893896
申请日：2010-09-29
申请人： Hideo Saji , Nobuya Inagaki , Kentaro Toyoda , Hiroyuki Kimura , Konomu Hirao , Kenji Nagakawa , Hirokazu Matsuda
发明人： Hideo Saji , Nobuya Inagaki , Kentaro Toyoda , Hiroyuki Kimura , Konomu Hirao , Kenji Nagakawa , Hirokazu Matsuda
IPC分类号： G01N33/53 , C07K14/00
CPC分类号： A61K51/08
摘要： A molecular probe for imaging of pancreatic islets is provided. The molecular probe includes a polypeptide represented by the following formula (1), or a polypeptide that has a homology with the foregoing polypeptide. (SEQ ID NO. 1) Z-HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPSX-NH2 (1) Wherein “X” represents a lysine residue, an amino group of a side chain of the lysine residue being labeled with a group represented by the following chemical formula (I), wherein A represents an aromatic hydrocarbon group or an aromatic heterocyclic group; R1 represents a substituent that contains 11C, 13N, 15O, 18F, 64Cu, 67Ga, 68Ga, 75Br, 76Br, 77Br, 99mTc, 111In, 123I, 124I, 125I, or 131I; R2 represents either a hydrogen atom, or a substituent different from that represented by R1; and R3 represents any one of a bond, an alkylene group having 1 to 6 carbon atoms, and an oxyalkylene group having 1 to 6 carbon atoms.
摘要翻译：提供了用于胰岛成像的分子探针。分子探针包括由下式（1）表示的多肽，或与前述多肽具有同源性的多肽。（SEQ ID NO.1）Z-HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPSX-NH2（1）其中，“X”表示赖氨酸残基，赖氨酸残基的侧链的氨基用下述化学式（I）表示的基团标记，其中A表示芳族烃基或芳族杂环基; R1表示含有11C，13N，150C，18F，64Cu，67Ga，68Ga，75Br，76Br，77Br，99mTc，111In，123I，124I，125I或131I的取代基; R2表示氢原子或与R1表示的取代基不同的取代基; R3表示碳原子数1〜6的亚烷基，碳原子数1〜6的氧亚烷基。

16. 发明申请

US20110033381A1 MOLECULAR PROBE FOR IMAGING OF PANCREATIC ISLET AND THE PRECURSOR, AND USE OF THE SAME 审中-公开
标题翻译：用于成像胰腺和前列腺的分子探针及其用途
公开(公告)号：US20110033381A1
公开(公告)日：2011-02-10
申请号：US12854007
申请日：2010-08-10
申请人： Nobuya Inagaki , Hideo Saji , Kentaro Toyoda , Hiroyuki Kimura , Yu Ogawa , Konomu Hirao , Kenji Nagakawa , Hirokazu Matsuda
发明人： Nobuya Inagaki , Hideo Saji , Kentaro Toyoda , Hiroyuki Kimura , Yu Ogawa , Konomu Hirao , Kenji Nagakawa , Hirokazu Matsuda
IPC分类号： A61K51/08 , C07K14/00 , A61K49/00
CPC分类号： A61K51/08 , C07K14/435 , C07K14/57563 , Y02P20/55
摘要： A precursor of molecular probe for imaging of pancreatic islets is provided. A polypeptide represented by any one of the following formulae (1) to (4), or a polypeptide having a homology with the foregoing polypeptide. *-DLSK* QMEEEAVRLFIEWLK* NGGPSSGAPPPSK-NH2(1) *-LSK* QMEEEAVRLFIEWLK* NGGPSSGAPPPSK-NH2(2) *-SK* QMEEEAVRLFIEWLK* NGGPSSGAPPPSK-NH2(3) *-K* QMEEEAVRLFIEWLK* NGGPSSGAPPPSK-NH2,(4) wherein *- indicates that an α-amino group at an N-terminus is protected by a protecting group or modified with a modifying group having no electric charge; K* indicates that an amino group of a side chain of a lysine is protected by a protecting group; and —NH2 indicates that a carboxyl group at a C-terminus is amidated.
摘要翻译：提供了用于胰岛成像的分子探针的前体。由下式（1）至（4）中任一项表示的多肽或与前述多肽具有同源性的多肽。 * -DLSK * QMEEEAVRLFIEWLK * NGGPSSGAPPPSK-NH2（1）* -LSK * QMEEEAVRLFIEWLK * NGGPSSGAPPPSK-NH2（2）* -SK * QMEEEAVRLFIEWLK * NGGPSSGAPPPSK-NH2（3）* -K * QMEEEAVRLFIEWLK * NGGPSSGAPPPSK-NH2，（4）其中 *表示N-末端的α-氨基被保护基保护或用不带电的修饰基团修饰; K *表示赖氨酸的侧链的氨基被保护基保护; 并且-NH 2表示C末端的羧基被酰胺化。

17. 发明授权

US07384459B2 Crayon 失效
标题翻译：蜡笔
公开(公告)号：US07384459B2
公开(公告)日：2008-06-10
申请号：US11182799
申请日：2005-07-18
申请人： Hidetoshi Fukuo , Hirokazu Matsuda
发明人： Hidetoshi Fukuo , Hirokazu Matsuda
IPC分类号： C09D13/00
CPC分类号： C09D13/00
摘要： The invention provides a crayon comprising an organic solvent, a resin soluble in the organic solvent, a coloring agent, a gelling agent and an interferential pearl luster pigment. The crayon provides a metallic or pearly coating film, and has characteristics such that the color tone of the coating film varies with an angle for viewing the coating film, namely, a visual angle for the coating film. Therefore, for example, when applied to a flaw caused in metallic or pearly coating of automobiles, the crayon is adapted to such coating of automobiles to form an integrated coating film, so that it is suitably used for repairing such a flaw.
摘要翻译：本发明提供了包含有机溶剂，可溶于有机溶剂的树脂，着色剂，胶凝剂和干性珍珠光泽颜料的蜡笔。该蜡笔提供金属或珍珠色的涂膜，其特征在于涂膜的色调随着用于观察涂膜的角度而变化，即涂膜的视角。因此，例如，当应用于汽车金属或珍珠质涂层引起的缺陷时，该蜡笔适用于这样的汽车涂布以形成一体的涂膜，从而适合用于修补这种缺陷。

18. 发明授权

US09278146B2 Peptide derivative and use of the same 有权
标题翻译：肽衍生物和使用相同
公开(公告)号：US09278146B2
公开(公告)日：2016-03-08
申请号：US13269345
申请日：2011-10-07
申请人： Hideo Saji , Nobuya Inagaki , Hiroyuki Kimura , Kentaro Toyoda , Konomu Hirao , Hirokazu Matsuda
发明人： Hideo Saji , Nobuya Inagaki , Hiroyuki Kimura , Kentaro Toyoda , Konomu Hirao , Hirokazu Matsuda
IPC分类号： A61K51/00 , A61M36/14 , A61K51/08 , C07K14/575
CPC分类号： A61K51/08 , A61K51/088 , C07K14/57563
摘要： A new peptide derivative is provided. The peptide derivative is represented by the following general formula (I), where polypeptide ExP is polypeptide that contains completely or partially the amino acid sequence of exendin-4, and a -L-Z group represents a group represented by the following formula (II) that is bonded to an amino acid side chain of or the α-amino group at the N-terminus of the polypeptide ExP,
摘要翻译：提供了一种新的肽衍生物。肽衍生物由以下通式（I）表示，其中多肽ExP是完全或部分含有毒蜥外泌肽-4的氨基酸序列的多肽，-LZ基团表示由下式（II）表示的基团，与多肽ExP的N末端的氨基酸侧链或α-氨基键合，

19. 发明授权

US09238083B2 Molecular probe for imaging of pancreatic islets and use of the same 有权
标题翻译：胰岛成像用分子探针及其用途
公开(公告)号：US09238083B2
公开(公告)日：2016-01-19
申请号：US12893896
申请日：2010-09-29
申请人： Hideo Saji , Nobuya Inagaki , Kentaro Toyoda , Hiroyuki Kimura , Konomu Hirao , Kenji Nagakawa , Hirokazu Matsuda
发明人： Hideo Saji , Nobuya Inagaki , Kentaro Toyoda , Hiroyuki Kimura , Konomu Hirao , Kenji Nagakawa , Hirokazu Matsuda
IPC分类号： A61K51/08 , C07K14/00
CPC分类号： A61K51/08
摘要： A molecular probe for imaging of pancreatic islets is provided. The molecular probe includes a polypeptide represented by the following formula (1), or a polypeptide that has a homology with the foregoing polypeptide. (SEQ ID NO. 1) Z-HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPSX-NH2 (1) Wherein “X” represents a lysine residue, an amino group of a side chain of the lysine residue being labeled with a group represented by the following chemical formula (I), wherein A represents an aromatic hydrocarbon group or an aromatic heterocyclic group; R1 represents a substituent that contains 11C, 13N, 15O, 18F, 64Cu, 67Ga, 68Ga, 75Br, 76Br, 77Br, 99mTc, 111In, 123I, 124I, 125I, or 131I; R2 represents either a hydrogen atom, or a substituent different from that represented by R1; and R3 represents any one of a bond, an alkylene group having 1 to 6 carbon atoms, and an oxyalkylene group having 1 to 6 carbon atoms.
摘要翻译：提供了用于胰岛成像的分子探针。分子探针包括由下式（1）表示的多肽，或与前述多肽具有同源性的多肽。（SEQ ID NO.1）Z-HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPSX-NH2（1）其中，“X”表示赖氨酸残基，赖氨酸残基的侧链的氨基用下述化学式（I）表示的基团标记，其中A表示芳族烃基或芳族杂环基; R1表示含有11C，13N，150C，18F，64Cu，67Ga，68Ga，75Br，76Br，77Br，99mTc，111In，123I，124I，125I或131I的取代基; R2表示氢原子或与R1表示的取代基不同的取代基; R3表示碳原子数1〜6的亚烷基，碳原子数1〜6的氧亚烷基。

20. 发明授权

US08980220B2 Molecular probe for imaging of pancreatic islets and use of the same 有权
标题翻译：胰岛成像用分子探针及其用途
公开(公告)号：US08980220B2
公开(公告)日：2015-03-17
申请号：US12964486
申请日：2010-12-09
申请人： Hideo Saji , Nobuya Inagaki , Kentaro Toyoda , Hiroyuki Kimura , Konomu Hirao , Kenji Nagakawa , Hirokazu Matsuda
发明人： Hideo Saji , Nobuya Inagaki , Kentaro Toyoda , Hiroyuki Kimura , Konomu Hirao , Kenji Nagakawa , Hirokazu Matsuda
IPC分类号： C07K14/605 , G01N33/74 , A61K51/08
CPC分类号： G01N33/74 , A61K51/088 , C07K14/605
摘要： A molecular probe for use in imaging of pancreatic islets is provided. The molecular probe comprises a polypeptide represented by the following formula (1), (2), or (3), or a polypeptide having homology with the foregoing polypeptide, (SEQ ID NO. 1) Z-HGEGTFTSDLSXQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2 (1) (SEQ ID NO. 2) Z-HGEGTFTSDLSKQMEEEAVRLFIEWLXNGGPSSGAPPPS-NH2 (2) (SEQ ID NO. 3) B-HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2 (3) where, in the formulae (1) and (2), “X” represents a lysine residue, an amino group of a side chain of the lysine residue being labeled with a radioactive nuclide, and “Z—” indicates that an α-amino group at an N-terminus is not modified, or is modified with a modifying group having no electric charge; in the formula (3), “B—” indicates that an α-amino group at an N-terminus is labeled with a radioactive nuclide; and in the formulae (1), (2), and (3), “—NH2” indicates that a carboxyl group at a C-terminus is amidated.
摘要翻译：提供了一种用于胰岛成像的分子探针。分子探针包含由下式（1），（2）或（3）表示的多肽，或与前述多肽具有同源性的多肽（SEQ ID NO.1）Z-HGEGTFTSDLSXQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2（1）（ SEQ ID NO.2）Z-HGEGTFTSDLSKQMEEEAVRLFIEWLXNGGPSSGAPPPS-NH2（2）（SEQ ID NO.3）B-HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2（3）其中，在式（1）和（2）中，“X”表示赖氨酸残基，赖氨酸残基的侧链的氨基被放射性核素标记，“Z-”表示N末端的α-氨基未被修饰，或者是用不具有电荷的修饰基团修饰 ; 在式（3）中，“B-”表示N末端的α-氨基用放射性核素标记; 在式（1），（2）和（3）中，“-NH 2”表示C末端的羧基被酰胺化。

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