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11. 发明授权

US08193224B2 Medicinal composition for prevention or treatment of parasitic protozoan infection 有权
标题翻译：用于预防或治疗寄生原生动物感染的药物组合物
公开(公告)号：US08193224B2
公开(公告)日：2012-06-05
申请号：US11576429
申请日：2005-09-30
申请人： Masataka Ihara , Kiyosei Takasu , Khanitha Pudhom , Hiroshi Kitaguchi , Masayuki Kawakami , Kozo Sato
发明人： Masataka Ihara , Kiyosei Takasu , Khanitha Pudhom , Hiroshi Kitaguchi , Masayuki Kawakami , Kozo Sato
IPC分类号： A61K31/427 , A61K31/428 , C07D277/66 , C07D277/04 , C07D277/84
CPC分类号： C07D277/84 , A61K31/427 , A61K31/428 , A61K31/4439 , A61K31/4709 , C07D277/64 , C07D417/14 , Y02A50/409 , Y02A50/411 , Y02A50/414
摘要： The present invention is to provide a medicinal composition for preventing or treating parasitic protozoan infections, having a high selective toxicity against parasitic protozoan infection, and a superior preventive or treating effect. A medicinal composition for preventing or treating parasitic protozoan infections comprises a compound shown by the following general formula (1) as an active ingredient (wherein R represents an alkyl group, aryl group or heterocyclic group; A and B each independently represents a 5- or 6-membered ring containing at least one hetero atom, or a condensation ring wherein 1 or more 3- to 8-membered ring is condensed thereto; Y represents S, O, Se, or —NR1— (R1 represents an alkyl group, aryl group or heterocyclic group); L1, L2, L3, L4 and L5 each independently represents a methine group; Q represents a physiologically acceptable anion; k represents an integer of 0 to 2, necessary to make the electric charge of the whole molecule 0; p and q each represents an integer of 0 to 3, wherein the sum of p and q is 1 or more, and 6 or less).
摘要翻译：本发明提供一种用于预防或治疗对寄生原虫感染具有高选择性毒性的寄生原虫感染的药物组合物，以及优异的预防或治疗效果。用于预防或治疗寄生原生动物感染的药物组合物包含由以下通式（1）表示的化合物作为活性成分（其中R表示烷基，芳基或杂环基; A和B各自独立地表示5-或含有至少一个杂原子的6元环或其中1个以上3〜8元环稠合的缩合环; Y表示S，O，Se或-NR1-（R1表示烷基，芳基基团或杂环基）; L1，L2，L3，L4和L5各自独立地表示次甲基; Q表示生理上可接受的阴离子; k表示使整个分子0的电荷所必需的0至2的整数; p和q各自表示0〜3的整数，p和q的和为1以上且6以下）。

12. 发明授权

US4675277A Heat developable light-sensitive material 失效
标题翻译：热可显影的感光材料
公开(公告)号：US4675277A
公开(公告)日：1987-06-23
申请号：US780132
申请日：1985-09-25
申请人： Kozo Sato , Hiroshi Kitaguchi , Hiroyuki Hirai
发明人： Kozo Sato , Hiroshi Kitaguchi , Hiroyuki Hirai
IPC分类号： G03C8/40 , G03C1/34 , G03C1/498 , G03C7/00 , G03C1/06
CPC分类号： G03C1/49845 , Y10S430/156
摘要： A heat developable light-sensitive material comprising a support having provided thereon at least a light-sensitive silver halide, a binder, and a compound capable of ring-closure to produce a benzimidazole ring upon heat development can be developed to an increased maximum density with less fogging at a relatively low temperature in a short period of time.
摘要翻译：包含其上提供有至少一种感光卤化银，粘合剂和能够闭合以在热显影时产生苯并咪唑环的化合物的支持体的可热显影的感光材料可以发展成具有增加的最大密度，在较短的时间内在相对较低的温度下减少雾化。

13. 发明授权

US07795285B2 Anti-trypanosomiasis agent 有权
标题翻译：抗锥虫病药
公开(公告)号：US07795285B2
公开(公告)日：2010-09-14
申请号：US11576426
申请日：2005-09-29
申请人： Masataka Ihara , Kiyosei Takasu , Khanitha Pudhom , Hiroshi Kitaguchi , Masayuki Kawakami , Kozo Sato
发明人： Masataka Ihara , Kiyosei Takasu , Khanitha Pudhom , Hiroshi Kitaguchi , Masayuki Kawakami , Kozo Sato
IPC分类号： A01N43/78
CPC分类号： C07D417/14 , A61K31/428 , A61K31/4439 , A61K31/4709 , Y02A50/414
摘要： The present invention is to provide an anti-trypanosomiasis agent having a high selective toxicity, and high preventing or treating effect against trypanosomiasis, comprising a compound shown by the following general formula (1) as an active ingredient (wherein R1 and R2 each independently represents a hydrogen atom, halogen atom, hydroxyl group, oxygen atom, C1-5 alkyl group, C1-5 alkoxy group, C5-8 aryl group, C5-8 aryloxy group, C2-6 alkoxycarbonyl group or C2-6 alkylaminocarbonyl group, and may be bound to each other; R3, R4, and R5 each independently represents a C1-5 alkyl group or C5-8 aryl group; R6 and R7 each independently represents a hydrogen atom, halogen atom, hydroxyl group, oxygen atom, C1-8 alkyl group, C1-5 alkoxy group, C5-8 aryl group, C5-8 aryloxy group, or C2-6 alkoxycarbonyl group, and may be bound to each other; Y and Z each independently represents an atom group necessary to form a 5- or 6-membered heterocycle; m and n each represent 0 or 1; Q represents a physiologically acceptable anion; k represents an integer of 0 to 2, necessary to make the electric charge of the whole molecule 0).
摘要翻译：本发明提供具有高选择性毒性和对锥虫病的高预防或治疗作用的抗锥虫病药，其包含由以下通式（1）表示的化合物作为活性成分（其中R 1和R 2各自独立地表示氢原子，卤素原子，羟基，氧原子，C 1-5烷基，C 1-5烷氧基，C 5-8芳基，C 5-8芳氧基，C 2-6烷氧基羰基或C 2-6烷基氨基羰基，可以相互结合; R3，R4和R5各自独立地表示C1-5烷基或C5-8芳基; R6和R7各自独立地表示氢原子，卤素原子，羟基，氧原子，C1- 8个烷基，C 1-5烷氧基，C 5-8芳基，C 5-8芳氧基或C 2-6烷氧基羰基，并且可以彼此结合; Y和Z各自独立地表示形成 5-或6-元杂环; m和n各自表示0或1; Q表示物理生理上可接受的阴离子 k表示0〜2的整数，使整个分子的电荷为0）。

14. 发明申请

US20100113789A1 MEDICINAL COMPOSITION FOR PREVENTION OR TREATMENT OF PARASITIC PROTOZOAN INFECTION 有权
标题翻译：用于预防或治疗PARASITIC PROTOZOAN感染的药物组合物
公开(公告)号：US20100113789A1
公开(公告)日：2010-05-06
申请号：US11576429
申请日：2005-09-30
申请人： Masataka Ihara , Kiyosei Takasu , Khanitha Pudhom , Hiroshi Kitaguchi , Masayuki Kawakami , Kozo Sato
发明人： Masataka Ihara , Kiyosei Takasu , Khanitha Pudhom , Hiroshi Kitaguchi , Masayuki Kawakami , Kozo Sato
IPC分类号： C07D417/14
CPC分类号： C07D277/84 , A61K31/427 , A61K31/428 , A61K31/4439 , A61K31/4709 , C07D277/64 , C07D417/14 , Y02A50/409 , Y02A50/411 , Y02A50/414
摘要： The present invention is to provide a medicinal composition for preventing or treating parasitic protozoan infections, having a high selective toxicity against parasitic protozoan infection, and a superior preventive or treating effect. A medicinal composition for preventing or treating parasitic protozoan infections comprises a compound shown by the following general formula (1) as an active ingredient (wherein R represents an alkyl group, aryl group or heterocyclic group; A and B each independently represents a 5- or 6-membered ring containing at least one hetero atom, or a condensation ring wherein 1 or more 3- to 8-membered ring is condensed thereto; Y represents S, O, Se, or —NR1— (R1 represents an alkyl group, aryl group or heterocyclic group); L1, L2, L3, L4 and L5 each independently represents a methine group; Q represents a physiologically acceptable anion; k represents an integer of 0 to 2, necessary to make the electric charge of the whole molecule 0; p and q each represents an integer of 0 to 3, wherein the sum of p and q is 1 or more, and 6 or less.)
摘要翻译：本发明提供一种用于预防或治疗对寄生原虫感染具有高选择性毒性的寄生原虫感染的药物组合物，以及优异的预防或治疗效果。用于预防或治疗寄生原生动物感染的药物组合物包含由以下通式（1）表示的化合物作为活性成分（其中R表示烷基，芳基或杂环基; A和B各自独立地表示5-或含有至少一个杂原子的6元环或其中1个以上3〜8元环稠合的缩合环; Y表示S，O，Se或-NR1-（R1表示烷基，芳基基团或杂环基）; L1，L2，L3，L4和L5各自独立地表示次甲基; Q表示生理上可接受的阴离子; k表示使整个分子0的电荷所必需的0至2的整数; p和q各自表示0〜3的整数，p和q的和为1以上6以下）

15. 发明申请

US20080045574A1 Anti-Trypanosomiasis Agent 有权
标题翻译：抗锥虫病药
公开(公告)号：US20080045574A1
公开(公告)日：2008-02-21
申请号：US11576426
申请日：2005-09-29
申请人： Masataka Ihara , Kiyosei Takasu , Khanitha Pudhom , Hiroshi Kitaguchi , Masayuki Kawakami , Kozo Sato
发明人： Masataka Ihara , Kiyosei Takasu , Khanitha Pudhom , Hiroshi Kitaguchi , Masayuki Kawakami , Kozo Sato
IPC分类号： A61K31/426 , A61P33/00
CPC分类号： C07D417/14 , A61K31/428 , A61K31/4439 , A61K31/4709 , Y02A50/414
摘要： The present invention is to provide an anti-trypanosomiasis agent having a high selective toxicity, and high preventing or treating effect against trypanosomiasis, comprising a compound shown by the following general formula (1) as an active ingredient (wherein R1 and R2 each independently represents a hydrogen atom, halogen atom, hydroxyl group, oxygen atom, C1-5 alkyl group, C1-5 alkoxy group, C5-8 aryl group, C5-8 aryloxy group, C2-6 alkoxycarbonyl group or C2-6 alkylaminocarbonyl group, and may be bound to each other; R3, R4, and R5 each independently represents a C1-5 alkyl group or C5-8 aryl group; R6 and R7 each independently represents a hydrogen atom, halogen atom, hydroxyl group, oxygen atom, C1-8 alkyl group, C1-5 alkoxy group, C5-8 aryl group, C5-8 aryloxy group, or C2-6 alkoxycarbonyl group, and may be bound to each other; Y and Z each independently represents an atom group necessary to form a 5- or 6-membered heterocycle; m and n each represent 0 or 1; Q represents a physiologically acceptable anion; k represents an integer of 0 to 2, necessary to make the electric charge of the whole molecule 0).
摘要翻译：本发明提供具有高选择性毒性和对锥虫病的高预防或治疗作用的抗锥虫病药，其包含由以下通式（1）表示的化合物作为活性成分（其中R 1， / O 2和R 2各自独立地表示氢原子，卤素原子，羟基，氧原子，C 1-5烷基，C 1-5 C 5〜8芳基，C 5〜8芳氧基，C 2-6烷氧基羰基或C 2-6个亚烷基氨基羰基，并且可以彼此结合; R 3，R 4和R 5 >各自独立地表示C 1-5烷基或C 5-8芳基; R 6和R 7， SUP各自独立地表示氢原子，卤素原子，羟基，氧原子，C 1-8烷基，C 1-5烷氧基，C 1〜 5-8芳基，C 5-8芳氧基，或C 1〜并且可以相互结合; Y和Z各自独立地表示形成5-或6-元杂环所必需的原子团; m和n各自表示0或1; Q表示生理上可接受的阴离子; k表示0〜2的整数，使整个分子的电荷为0）。

16. 依法登记的发明

USH691H Heat developable photographic element 失效
标题翻译：可热成像的照相材料
公开(公告)号：USH691H
公开(公告)日：1989-10-03
申请号：US153535
申请日：1988-02-01
申请人： Hiroshi Kitaguchi , Masatoshi Kato
发明人： Hiroshi Kitaguchi , Masatoshi Kato
IPC分类号： G03C8/40 , G03C1/06 , G03C1/34 , G03C1/498 , G03C7/00
CPC分类号： G03C1/49845
摘要： A heat-developable photographic element containing a light-sensitive silver halide and a binder on a support, and in addition, a base precursor and a photographic reagent capable of releasing a compound represented by the general formula (I) by reaction with a base in a light-sensitive layer and/or an image receiving layer. ##STR1## wherein Y is an atomic group necessary for forming a 5-, 6- or 9-membered heterocyclic ring.The photographic material has excellent temperature compensation capability and low fog.

17. 发明授权

US4656126A Heat-developable color light-sensitive material 失效
标题翻译：可热显色的感光材料
公开(公告)号：US4656126A
公开(公告)日：1987-04-07
申请号：US711885
申请日：1985-03-14
申请人： Masatoshi Kato , Hiroshi Kitaguchi
发明人： Masatoshi Kato , Hiroshi Kitaguchi
IPC分类号： C09B62/523 , C09B62/78 , G03C1/498 , G03C7/00 , G03C8/40 , G03C1/40 , G03C1/06
CPC分类号： G03C1/49845 , G03C8/408 , Y10S430/156
摘要： A heat-developable color light-sensitive material is described, comprising a support having thereon at least (1) a light-sensitive silver halide emulsion, (2) a dye providing substance which releases a dye having a different diffusibility from that of the dye providing substance in correspondence or countercorrespondence to the light-sensitive silver halide when the light-sensitive silver halide is reduced under the condition of high temperature and (3) an organic acid precursor containing a structural moiety bonded to carbon atoms that is represented by formula (I) ##STR1## The heat-developable color light-sensitive material can provide color images having a high S/N ratio and a high image density.
摘要翻译：描述了一种可热显色的感光材料，其包含至少（1）感光卤化银乳剂的支撑体，（2）提供染料的染料提供物质，其释放与染料不同的扩散性的染料当光敏卤化银在高温条件下降低时，提供与感光卤化银对应或对应的物质，和（3）含有结合部分与碳原子结合的有机酸前体，所述结构部分由式（（I）图像（I）可热显色的感光材料可以提供具有高S / N比和高图像密度的彩色图像。

18. 发明授权

US4983494A Image forming process including heating step 失效
标题翻译：图像形成过程包括加热步骤
公开(公告)号：US4983494A
公开(公告)日：1991-01-08
申请号：US423674
申请日：1989-10-18
申请人： Hiroshi Kitaguchi , Masatoshi Kato
发明人： Hiroshi Kitaguchi , Masatoshi Kato
IPC分类号： G03C1/498 , G03C7/305
CPC分类号： G03C7/30511 , G03C1/49845 , Y10S430/158 , Y10S430/161
摘要： An image is formed in a photographic element by a process comprising a step of heating a heat-developable photosensitive material in the presence of a specific compound which typically releases a phenylmercaptotetrazole having a substituted benzene ring and serving as a development retarder.
摘要翻译：通过包括在特定化合物的存在下加热可热显影的感光材料的方法形成照相元件，所述特定化合物通常释放具有取代苯环的苯基巯基四唑并用作展开延迟剂。

19. 发明授权

US4670373A Acid precursor 失效
标题翻译：酸性前体
公开(公告)号：US4670373A
公开(公告)日：1987-06-02
申请号：US672643
申请日：1984-11-19
申请人： Hiroshi Kitaguchi , Masatoshi Kato
发明人： Hiroshi Kitaguchi , Masatoshi Kato
IPC分类号： C07D333/22 , C07C67/00 , C07C239/00 , C07C251/66 , C07C301/00 , C07C311/16 , C07C313/00 , C07C317/44 , C07C323/47 , C07D209/14 , C07D213/53 , C07D307/52 , G03C1/06 , G03C1/43 , G03C1/498 , G03C8/40
CPC分类号： G03C1/43 , G03C8/408
摘要： An organic acid precursor having a structural moiety of the following formula ##STR1## bonded to a carbon atom. This acid precursor is useful as a development stopping agent in a photographic heat-developable process.
摘要翻译：具有与碳原子键合的下式结构部分（I）的有机酸前体。该酸性前体可用作摄影热显影过程中的显影阻止剂。

20. 发明授权

US4639408A Process for image formation comprising a heating step 失效
标题翻译：用于图像形成的方法，包括加热步骤
公开(公告)号：US4639408A
公开(公告)日：1987-01-27
申请号：US799996
申请日：1985-11-20
申请人： Hiroshi Kitaguchi , Masatoshi Kato
发明人： Hiroshi Kitaguchi , Masatoshi Kato
IPC分类号： C09B57/00 , G03C1/498 , G03C7/00 , G03C7/305 , G03C8/40 , G03C1/40 , G03C1/06 , G03C1/42 , G03C5/54
CPC分类号： G03C8/408 , G03C1/49845 , G03C7/30511 , Y10S430/156 , Y10S430/158 , Y10S430/159 , Y10S430/16
摘要： A process for forming an image comprising a heating step is described, wherein a photographic material is heated in the presence of a compound represented by formula (I) ##STR1## wherein X represents an atomic group completing a carbocyclic aromatic ring or a heterocyclic aromatic ring; R.sup.1 is selected from groups represented by formulae (A), (B), and (C) ##STR2## in which R.sup.11 and R.sup.12 each represents a substituted or unsubstituted alkyl group, a cycloalkyl group, a substituted or unsubstituted alkenyl group, an aralkyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted heterocyclic group, an alkyloxy or aryloxy group, an alkylthio or arylthio group, or a substituted or unsubstituted amino group, or R.sup.11 and R.sup.12 together form a 5-membered or 6-membered ring; R.sup.2 represents a group selected from the groups represented by R.sup.11 ; R.sup.1 and R.sup.2 together form a 5-membered or 6-membered ring; Q represents a hydrogen atom, an alkyl group, or an aryl group; TIME represents a timing group; PUG represents a photographically useful group; and n represents 0 or an integer.
摘要翻译：描述了一种用于形成包括加热步骤的图像的方法，其中在由式（I）表示的化合物（I）的存在下照相材料加热，其中X表示完成碳环芳环或杂环芳环; 其中R 11选自由式（A），（B）和（C）表示的基团，其中R 11和R 12各自表示取代或未取代的烷基基团，环烷基，取代或未取代的烯基，芳烷基，取代或未取代的芳基，取代或未取代的杂环基，烷氧基或芳氧基，烷硫基或芳硫基，或取代或未取代的氨基，或R 11和R 12一起形成5元或6元环; R2表示选自由R11表示的基团的基团; R1和R2一起形成5元或6元环; Q表示氢原子，烷基或芳基; TIME代表一个时间组; PUG代表一个摄影有用的组; n表示0或整数。

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