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11. 发明授权

US07521430B2 N-glucoside compounds having an inhibitory activity against sodium-dependent glucose transporter 失效
标题翻译：对钠依赖性葡萄糖转运蛋白具有抑制活性的N-葡萄糖苷化合物
公开(公告)号：US07521430B2
公开(公告)日：2009-04-21
申请号：US10566585
申请日：2004-07-30
申请人： Sumihiro Nomura , Toshiaki Sakamoto , Kiichiro Ueta
发明人： Sumihiro Nomura , Toshiaki Sakamoto , Kiichiro Ueta
IPC分类号： A01N43/04 , A61K31/70 , C07H5/06 , C07H19/00
CPC分类号： C07H15/203 , C07H5/04 , C07H17/02
摘要： A compound of the formula: wherein Ring A and Ring B are (1) Ring A is an optionally substituted unsaturated monocyclic heterocyclic ring, and Ring B is an optionally substituted unsaturated monocyclic heterocyclic ring, an optionally substituted unsaturated fused heterobicyclic ring, or an optionally substituted benzene ring, (2) Ring A is an optionally substituted benzene ring, and Ring B is an optionally substituted unsaturated monocyclic heterocyclic ring, an optionally substituted unsaturated fused heterobicyclic ring, or an optionally substituted benzene ring, or (3) Ring A is an optionally substituted unsaturated fused heterobicyclic ring, wherein —NR— group and —CH2— group are both on the same ring of the unsaturated fused heterobicyclic ring, and Ring B is an optionally substituted monocyclic unsaturated heterocyclic ring, an optionally substituted unsaturated fused heterobicyclic ring, or an optionally substituted benzene ring; and R is a hydrogen atom, a lower alkyl group, a lower alkanoyl group or a lower alkoxycarbonyl group, or a pharmaceutically acceptable salt thereof, or a prodrug thereof.
摘要翻译：下式的化合物：其中环A和环B是（1）环A是任选取代的不饱和单环杂环，环B是任选取代的不饱和单环杂环，任选取代的不饱和稠合杂双环或任选地取代的苯环，（2）环A是任选取代的苯环，环B是任选取代的不饱和单环杂环，任选取代的不饱和稠合杂双环或任选取代的苯环，或（3）环A是任选取代的不饱和稠合杂双环，其中-NR-基和-CH2-基都在不饱和稠合杂双环的相同环上，环B是任选取代的单环不饱和杂环，任选取代的不饱和稠合杂双环，或任选取代的苯环; 或其前体药物，R为氢原子，低级烷基，低级烷酰基或低级烷氧基羰基，或其药学上可接受的盐。

12. 发明授权

US08987445B2 Sulfonamide compounds having TRPM8 antagonistic activity 有权
标题翻译：具有TRPM8拮抗活性的磺酰胺化合物
公开(公告)号：US08987445B2
公开(公告)日：2015-03-24
申请号：US14004911
申请日：2012-03-15
申请人： Yasuyuki Tsuzuki , Daisuke Sawamoto , Toshiaki Sakamoto , Taku Kato , Yasuki Niwa , Nobumasa Awai
发明人： Yasuyuki Tsuzuki , Daisuke Sawamoto , Toshiaki Sakamoto , Taku Kato , Yasuki Niwa , Nobumasa Awai
IPC分类号： C07D487/04 , C07D405/12 , C07D401/12 , C07D409/12 , C07D471/04 , C07D417/12 , C07D413/12 , C07D217/22
CPC分类号： C07D413/12 , C07D215/38 , C07D217/22 , C07D401/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D471/04 , C07D487/04
摘要： Sulfonamide compounds having TRPM8 antagonistic activity are provided. A sulfonamide compound of formula (I) or a pharmaceutically acceptable salt thereof, or a prodrug thereof: (I) wherein Ring A is bicyclic aromatic heterocycle comprised of (a) pyridine is condensed with benzene; or (b) pyridine is condensed with monocyclic aromatic heterocycle, and Ring A binds to a sulfonylamino moiety on a carbon atom adjacent to a nitrogen atom of the pyridine ring constituting Ring A, Ring B is (a) monocyclic or bicyclic aromatic hydrocarbon; (b) monocyclic or bicyclic alicyclic hydrocarbon; (c) monocyclic or bicyclic aromatic heterocycle; or (d) monocyclic or bicyclic non-aromatic heterocycle, Ring C is (a) benzene; or (b) monocyclic aromatic heterocycle, and other symbols are the same as defined in the specification.
摘要翻译：提供了具有TRPM8拮抗活性的磺酰胺化合物。式（I）的磺酰胺化合物或其药学上可接受的盐或其前药：（I）其中环A是由（a）吡啶组成的双环芳族杂环与苯稠合; 或（b）吡啶与单环芳族杂环稠合，环A与构成环A的吡啶环的氮原子相邻的碳原子上的磺酰基氨基部分结合，环B为（a）单环或双环芳烃; （b）单环或双环脂环烃; （c）单环或双环芳族杂环; 或（d）单环或双环非芳族杂环，环C为（a）苯; 或（b）单环芳族杂环，以及其他符号与说明书中所定义的相同。

13. 发明申请

US20070060545A1 Novel compounds 失效
标题翻译：新型化合物
公开(公告)号：US20070060545A1
公开(公告)日：2007-03-15
申请号：US10566585
申请日：2004-07-30
申请人： Sumihiro Nomura , Toshiaki Sakamoto , Kiichiro Ueta
发明人： Sumihiro Nomura , Toshiaki Sakamoto , Kiichiro Ueta
IPC分类号： A61K31/7008 , C07H5/04
CPC分类号： C07H15/203 , C07H5/04 , C07H17/02
摘要： A compound of the formula: wherein Ring A and Ring B are (1) Ring A is an optionally substituted unsaturated monocyclic heterocyclic ring, and Ring B is an optionally substituted unsaturated monocyclic heterocyclic ring, an optionally substituted unsaturated fused heterobicyclic ring, or an optionally substituted benzene ring, (2) Ring A is an optionally substituted benzene ring, and Ring B is an optionally substituted unsaturated monocyclic heterocyclic ring, an optionally substituted unsaturated fused heterobicyclic ring, or an optionally substituted benzene ring, or (3) Ring A is an optionally substituted unsaturated fused heterobicyclic ring, wherein —NR— group and —CH2— group are both on the same ring of the unsaturated fused heterobicyclic ring, and Ring B is an optionally substituted monocyclic unsaturated heterocyclic ring, an optionally substituted unsaturated fused heterobicyclic ring, or an optionally substituted benzene ring; and R is a hydrogen atom, a lower alkyl group, a lower alkanoyl group or a lower alkoxycarbonyl group, or a pharmaceutically acceptable salt thereof, or a prodrug thereof.
摘要翻译：下式的化合物：其中环A和环B是（1）环A是任选取代的不饱和单环杂环，环B是任选取代的不饱和单环杂环，任选取代的不饱和稠合杂双环或任选取代的不饱和单环杂环取代的苯环，（2）环A是任选取代的苯环，环B是任选取代的不饱和单环杂环，任选取代的不饱和稠合杂双环或任选取代的苯环，或（3）环A是任选取代的不饱和稠合杂双环，其中-NR-基团和-CH 2 - 基团都在不饱和稠合杂双环环的相同环上，环B是任选取代的单环不饱和杂环，任选取代的不饱和稠合杂双环，或任选取代的苯环; 或其前体药物，R为氢原子，低级烷基，低级烷酰基或低级烷氧基羰基，或其药学上可接受的盐。

14. 外观设计

USD551092S1 Hub clock 有权
标题翻译：中枢时钟
公开(公告)号：USD551092S1
公开(公告)日：2007-09-18
申请号：US29241408
申请日：2005-10-26
申请人： Toshiaki Sakamoto
设计人： Toshiaki Sakamoto

15. 发明申请

US20070029200A1 Cationic electrodeposition coating composition and coated article therewith 审中-公开
标题翻译：阳离子电沉积涂料组合物及其涂覆制品
公开(公告)号：US20070029200A1
公开(公告)日：2007-02-08
申请号：US11498727
申请日：2006-08-04
申请人： Toshiaki Sakamoto , Masaru Sakamoto , Yoshinori Hirahara , Tsutomu Shigenaga
发明人： Toshiaki Sakamoto , Masaru Sakamoto , Yoshinori Hirahara , Tsutomu Shigenaga
IPC分类号： C25B7/00 , C25D13/00
CPC分类号： C25D13/02 , C25D13/10 , C25D13/12
摘要： The present invention relates to a cationic electrodeposition coating composition comprising silica particles having pore volume of 0.44 to 1.8 ml/g and average particle size of no more than 10 μm, the composition showing square root of diffusion coefficient (√Tc) of no less than 2.5 upon diffusing a solution onto a coating film therewith; a cationic electrodeposition coating composition comprising silica particles having pore volume of 0.44 to 1.8 ml/g and average particle size of no more than 10 μm, wherein the composition shows minimum deposition pH of 11.90 to 12.00 during electrodeposition coating, and film resistance of 1,000 to 1,500 kΩ·cm2 at film thickness of 15 μm and applied voltage of 240 V; and an article coated with such cationic electrodeposition coating composition. Therefore, the present invention can also provide a coating film formed with the cationic electrodeposition coating composition which can ensure higher corrosion resistance and higher throwing power in addition to other excellent coating properties, even if the resulting coating has extremely thin film thickness (e.g., about 7 μm).
摘要翻译：本发明涉及一种阳离子电沉积涂料组合物，其包含孔体积为0.44〜1.8ml / g，平均粒径为10μm以下的二氧化硅粒子，扩散系数平方根（√Tc）的组成不小于将溶液扩散到其上的涂膜上; 包含孔体积为0.44〜1.8ml / g，平均粒径为10μm以下的二氧化硅粒子的阳离子电沉积涂料组合物，其中组合物在电沉积涂布期间显示最小沉积pH为11.90至12.00，膜电阻为1000〜薄膜厚度为15μm，施加电压为240V时为1500kOgg·cm 2·2; 和涂有这种阳离子电沉积涂料组合物的制品。因此，本发明还可以提供一种形成有阳离子电沉积涂料组合物的涂膜，除了其它优异的涂料性能外，还可以确保更高的耐腐蚀性和更高的抛光力，即使所得到的涂层具有非常薄的膜厚度（例如约 7个妈妈）。

16. 发明授权

US5418263A Epoxy resin-based cathodic electrodeposition paint containing hydrophobic monoepoxide-amine adducts 失效
标题翻译：含有疏水单环氧化物 - 胺加合物的环氧树脂基阴极电沉积涂料
公开(公告)号：US5418263A
公开(公告)日：1995-05-23
申请号：US229612
申请日：1994-04-19
申请人： Toshiaki Sakamoto , Yoshio Kojima , Kenshiro Tobinaga
发明人： Toshiaki Sakamoto , Yoshio Kojima , Kenshiro Tobinaga
IPC分类号： C09D5/44 , C09D175/00 , C09D175/04 , C08K3/20
CPC分类号： C09D5/4457
摘要： A cathodic electrodeposition paint containing as a binder resin an amine-epoxy resin adduct and a blocked polyisocyanate crosslinker is disclosed. The binder resin and the crosslinker are emulsified in an aqueous medium containing a neutralizing agent with the aid of amine adduct of a monoepoxide compound having a hydrophobic group or block. Not only the amine-monoepoxide adduct functions as a surfactant but also it is deposited electrically and then cured with the crosslinker integrally with the binder resin.
摘要翻译：公开了一种含有胺 - 环氧树脂加合物和封端多异氰酸酯交联剂作为粘合剂树脂的阴极电沉积涂料。借助于具有疏水基团或嵌段的单环氧化物的胺加合物，将粘合剂树脂和交联剂在含有中和剂的水性介质中乳化。胺单环氧化物加合物不仅起表面活性剂的作用，而且还被电沉积，然后与交联剂与粘合剂树脂一体固化。

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