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11. 发明申请

US20050042204A1 Method to protect transgenes from silencing 审中-公开
标题翻译：保护转基因免于沉默的方法
公开(公告)号：US20050042204A1
公开(公告)日：2005-02-24
申请号：US10667359
申请日：2003-09-23
申请人： Masao Matsuoka , Koji Akasaka
发明人： Masao Matsuoka , Koji Akasaka
IPC分类号： C12N15/09 , A61K48/00 , C12N15/85 , C12N15/86
CPC分类号： C12N15/85 , A61K48/00 , C12N15/86 , C12N2740/15043
摘要： According to the present invention, a method to protect a transgene from silencing, wherein an insulator from sea urchin arylsulfatase gene is introduced concurrently with the transgene so as to provide a novel method for stabilization of a viral vector expression, is provided. Furthermore, according to this invention, a method for introducing a gene, wherein an insulator from sea urchin arylsulfatase gene is introduced concurrently with a transgene so as to protect the transgene from silencing, is provided. Furthermore, according to this invention, a method for production of a vector, wherein an insulator from sea urchin arylsulfatase gene is introduced into the vector so as to protect the vector from silencing, is provided. Because the viral vector containing an insulator from sea urchin arylsulfatase gene can protect a transgene from silencing, a novel useful method for gene therapy is provided.
摘要翻译：根据本发明，提供了保护转基因免于沉默的方法，其中来自海胆芳基硫酸酯酶基因的绝缘体与转基因同时引入，以提供用于稳定病毒载体表达的新方法。此外，根据本发明，提供了一种引入基因的方法，其中来自海胆芳基硫酸酯酶基因的绝缘体与转基因同时引入，以保护转基因免于沉默。此外，根据本发明，提供了一种生产载体的方法，其中将来自海胆芳基硫酸酯酶基因的绝缘体引入载体中以保护载体免于沉默。因为含有海胆芳基硫酸酯酶基因的绝缘体的病毒载体可以保护转基因免于沉默，因此提供了一种新颖的基因治疗方法。

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