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    • 17. 发明授权
    • Process for producing fluorine-containing alkylsulfonylaminoethyl α-substituted acrylate
    • 含氟烷基磺酰氨基乙基α-取代丙烯酸酯的制备方法
    • US07598413B2
    • 2009-10-06
    • US12187823
    • 2008-08-07
    • Takeo KomataRyo NadanoMakoto Matsuura
    • Takeo KomataRyo NadanoMakoto Matsuura
    • C07C69/52
    • C07C303/38C07C311/09
    • There is provided a process for producing a fluorine-containing alkylsulfonylaminoethyl α-substituted acrylate of the formula [3] by reaction of an aminoethyl α-substituted acrylate of the formula [1a] with a fluorine-containing alkylsulfonic fluoride of the formula [2], or by reaction of an aminoethyl a-substituted acrylate salt of the formula [1b] with a fluorine-containing alkylsulfonic fluoride of the formula [2] in the presence of a base, wherein a fluorine-containing compound is used as a reaction solvent: where R1 is a hydrogen atom, methyl group, ethyl group, n-propyl group, isopropyl group, n-butyl group, sec-butyl group, tertbutyl group, fluoromethyl group, difluoromethyl group, trifluoromethyl group or perfluoroethyl group; R2 is a fluorine-containing alkyl group having a carbon number of 1 to 6; Xn− is a counter anion (n is a positive integer); and Y is a fluorine atom, chlorine atom or bromine atom.
    • 提供了通式[1a]的α-氨基乙基α取代丙烯酸酯与式[2]的含氟烷基磺酸氟化物反应制备式[3]的含氟烷基磺酰氨基乙基α-取代丙烯酸酯的方法, 或通过式[1b]的氨基乙基α-取代的丙烯酸盐与式[2]的含氟烷基磺酸氟化物在碱的存在下反应,其中使用含氟化合物作为反应溶剂 :其中R1是氢原子,甲基,乙基,正丙基,异丙基,正丁基,仲丁基,叔丁基,氟甲基,二氟甲基,三氟甲基或全氟乙基; R2是碳数为1〜6的含氟烷基; Xn-为抗衡阴离子(n为正整数); Y是氟原子,氯原子或溴原子。