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11. 发明授权

US08143418B2 Dimeric small molecule potentiators of apoptosis 有权
标题翻译：二聚体小分子增强细胞凋亡
公开(公告)号：US08143418B2
公开(公告)日：2012-03-27
申请号：US13022033
申请日：2011-02-07
申请人： Patrick G. Harran , Xiaodong Wang , Jef K. De Brabander , Lin Li , Ranny Mathew Thomas , Hidetaka Suzuki
发明人： Patrick G. Harran , Xiaodong Wang , Jef K. De Brabander , Lin Li , Ranny Mathew Thomas , Hidetaka Suzuki
IPC分类号： C07D249/04 , A61K31/42
CPC分类号： C07D413/14 , A61K31/41 , A61K31/422 , C07D207/08 , C07D401/10 , C07D403/10 , C07D403/14 , C07D405/10 , C07D409/10 , C07D413/04 , C07D413/06 , C07D413/10 , C07D417/04 , C07D417/10 , C07D417/14 , C07D495/04 , C07K5/06026 , C07K5/06034
摘要： Caspase activity and apoptosis are promoted using active, dimeric Smac peptide mimetics of the general formula M1-L-M2, wherein moieties M1 and M2 are monomeric Smac mimetics and L is a covalent linker. Target cancerous or inflammatory cells are contacted with an effective amount of an active, dimeric Smac mimetic, and a resultant increase in apoptosis of the target cells is detected. The contacting step may be effected by administering to a pharmaceutical composition comprising a therapeutically effective amount of The compoundic mimetic, wherein the individual may be subject to concurrent or antecedent radiation or chemotherapy for treatment of a neoproliferative pathology.
摘要翻译：使用通式M1-L-M2的活性二聚体Smac肽模拟物促进胱天蛋白酶活性和凋亡，其中部分M1和M2是单体Smac模拟物，L是共价连接体。靶向癌性或炎性细胞与有效量的活性二聚体Smac模拟物接触，并且检测到靶细胞凋亡的最终增加。接触步骤可以通过给予包含治疗有效量的复合模拟物的药物组合物来实现，其中个体可以同时或先前放射或化疗用于治疗新生血管病变。

12. 发明申请

US20110124585A1 Dimeric Small Molecule Potentiators of Apoptosis 有权
标题翻译：二聚体小分子细胞凋亡电位
公开(公告)号：US20110124585A1
公开(公告)日：2011-05-26
申请号：US13022033
申请日：2011-02-07
申请人： Patrick G. Harran , Xiaodong Wang , Jef K. De Brabander , Lin Li , Ranny Mathew Thomas , Hidetaka Suzuki
发明人： Patrick G. Harran , Xiaodong Wang , Jef K. De Brabander , Lin Li , Ranny Mathew Thomas , Hidetaka Suzuki
IPC分类号： A61K38/05 , C07D403/14 , C07D413/14 , A61P35/00 , A61P29/00
CPC分类号： C07D413/14 , A61K31/41 , A61K31/422 , C07D207/08 , C07D401/10 , C07D403/10 , C07D403/14 , C07D405/10 , C07D409/10 , C07D413/04 , C07D413/06 , C07D413/10 , C07D417/04 , C07D417/10 , C07D417/14 , C07D495/04 , C07K5/06026 , C07K5/06034
摘要： Caspase activity and apoptosis are promoted using active, dimeric Smac peptide mimetics of the general formula M1-L-M2, wherein moieties M1 and M2 are monomeric Smac mimetics and L is a covalent linker. Target cancerous or inflammatory cells are contacted with an effective amount of an active, dimeric Smac mimetic, and a resultant increase in apoptosis of the target cells is detected. The contacting step may be effected by administering to a pharmaceutical composition comprising a therapeutically effective amount of The compoundic mimetic, wherein the individual may be subject to concurrent or antecedent radiation or chemotherapy for treatment of a neoproliferative pathology.
摘要翻译：使用通式M1-L-M2的活性二聚体Smac肽模拟物促进胱天蛋白酶活性和凋亡，其中部分M1和M2是单体Smac模拟物，L是共价连接体。靶向癌性或炎性细胞与有效量的活性二聚体Smac模拟物接触，并且检测到靶细胞凋亡的最终增加。接触步骤可以通过给予包含治疗有效量的复合模拟物的药物组合物来实现，其中个体可以同时或先前放射或化疗用于治疗新生血管病变。

13. 发明授权

US4994820A Plane antenna 失效
标题翻译：平面天线
公开(公告)号：US4994820A
公开(公告)日：1991-02-19
申请号：US446841
申请日：1989-12-06
申请人： Hidetaka Suzuki , Harumi Okazaki , Motoki Hirano
发明人： Hidetaka Suzuki , Harumi Okazaki , Motoki Hirano
IPC分类号： H01Q13/08 , H01Q1/32 , H01Q9/04 , H01Q9/40 , H01Q13/18
CPC分类号： H01Q9/0414 , H01Q1/3275 , H01Q9/40
摘要： A plane antenna comprising first and second plates made of a synthetic resin. The first plate has a first metal film formed thereon and the second plate has a second metal film formed thereon. A plurality of pins extend between the first and second plates for maintaining the first and second plates in spaced-parallel relation to each other with the first and second films facing to each other. The pins include at least one first pin for providing an electric connection between the first and second metal films and a second pin insulated from the second metal film for providing an electric connection of the first metal film to a lead wire. The first and second metal films have a spacific resistance .rho. [m] and a permeability .mu. [H/m]. The first and second metal films have a thickness greater than a value t [m] calculated from an equation as follows: ##EQU1## where f is a signal frequency [Hz] for which the plane antenna is used.
摘要翻译：一种平面天线，包括由合成树脂制成的第一和第二板。第一板具有形成在其上的第一金属膜，第二板具有形成在其上的第二金属膜。多个销在第一和第二板之间延伸，用于将第一和第二板彼此间隔开平行，以使第一和第二膜彼此面对。销包括至少一个用于在第一和第二金属膜之间提供电连接的第一引脚和与第二金属膜绝缘的第二引脚，用于提供第一金属膜与引线的电连接。第一和第二金属膜具有空间电阻rho [m]和磁导率μ[H / m]。第一和第二金属膜的厚度大于从以下等式计算的值t [m]：其中f是使用平面天线的信号频率[Hz]。

14. 发明授权

US4942534A Signal-transmission type production supervising system including IC card and wireless type interface unit 失效
标题翻译：信号传输型生产监控系统包括IC卡和无线接口单元
公开(公告)号：US4942534A
公开(公告)日：1990-07-17
申请号：US278888
申请日：1988-12-02
申请人： Masaharu Yokoyama , Koichi Ogino , Hidetaka Suzuki
发明人： Masaharu Yokoyama , Koichi Ogino , Hidetaka Suzuki
IPC分类号： G01S13/74 , B23Q41/00 , B23Q41/08 , G01S13/82 , G01S15/74 , G01S17/74 , G05B19/12 , G06K19/07 , G06Q50/00 , G06Q50/04 , G07C3/00 , H04B11/00
CPC分类号： G06K19/0728 , B23Q41/00 , G01S13/825 , G01S15/74 , G01S17/74 , G05B19/128 , G06K19/0723 , G07C3/00 , H04B11/00 , Y02P90/10
摘要： In a production supervising system of a work, a wireless type production supervising data processing apparatus is mounted on the work. The wireless type production supervising data processing apparatus includes a wireless type interface unit, and an IC card. The IC card includes CPU, EEPROM for storing the production supervising data, ROM for storing the program data, and RAM capable of storing other data than the production supervising data. The wireless type interface unit includes antennas, a receiver, a transmitter, a demodulator connected to the receiver, and a modulator connected to the transmitter. During the production of the work, the production supervising data previously stored in EEPROM are read from the IC card and processed in the interface unit and thereafter transmitted from the interface unit toward the external data controlling apparatus.
摘要翻译：在工作的生产监督系统中，将无线型生产监督数据处理装置安装在工作上。无线型生产监控数据处理装置包括无线型接口单元和IC卡。 IC卡包括CPU，用于存储生产监控数据的EEPROM，用于存储程序数据的ROM，以及能够存储除了生产监督数据之外的其他数据的RAM。无线类型接口单元包括天线，接收机，发射机，连接到接收机的解调器和连接到发射机的调制器。在生产过程中，先前存储在EEPROM中的生产监督数据从IC卡读取，并在接口单元中进行处理，然后从接口单元向外部数据控制装置发送。

15. 发明授权

US09399635B2 Pyrazole derivative 有权
标题翻译：吡唑衍生物
公开(公告)号：US09399635B2
公开(公告)日：2016-07-26
申请号：US14110188
申请日：2012-04-11
申请人： Hachiro Sugimoto , Michiaki Okuda , Takashi Takahashi , Ichiro Hijikuro , Hidetaka Suzuki , Shinichi Nakayama
发明人： Hachiro Sugimoto , Michiaki Okuda , Takashi Takahashi , Ichiro Hijikuro , Hidetaka Suzuki , Shinichi Nakayama
IPC分类号： C07D401/14 , C07D403/10 , C07D405/14 , C07D209/12 , C07D401/12 , C07D403/06 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/12 , C07D417/14 , C07H15/203 , C07D403/14 , C07H15/26
CPC分类号： C07D401/14 , C07D209/12 , C07D401/12 , C07D403/06 , C07D403/10 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D417/12 , C07D417/14 , C07H15/203 , C07H15/26
摘要： Provided is a novel therapeutic means for Alzheimer's disease. In particular, provided is a compound represented by the following general formula (I): [wherein Ar1 represents 2-methoxy-4-(2-pyridylmethoxy)phenyl etc. and Ar2 represents a 1H-indol-6-yl group etc.] or a salt thereof.
摘要翻译：提供了阿尔茨海默病的新型治疗方法。特别地，提供由以下通式（I）表示的化合物：[其中Ar 1表示2-甲氧基-4-（2-吡啶基甲氧基）苯基等，Ar 2表示1H-吲哚-6-基等] 或其盐。

16. 发明申请

US20140088029A1 NOVEL PYRAZOLE DERIVATIVE 有权
标题翻译：新型吡咯衍生物
公开(公告)号：US20140088029A1
公开(公告)日：2014-03-27
申请号：US14110188
申请日：2012-04-11
申请人： Hachiro Sugimoto , Michiaki Okuda , Takashi Takahashi , Ichiro Hijikuro , Hidetaka Suzuki , Shinichi Nakayama
发明人： Hachiro Sugimoto , Michiaki Okuda , Takashi Takahashi , Ichiro Hijikuro , Hidetaka Suzuki , Shinichi Nakayama
IPC分类号： C07D401/14 , C07D403/10 , C07H15/26 , C07D405/14 , C07D403/06
CPC分类号： C07D401/14 , C07D209/12 , C07D401/12 , C07D403/06 , C07D403/10 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D417/12 , C07D417/14 , C07H15/203 , C07H15/26
摘要： Provided is a novel therapeutic means for Alzheimer's disease. In particular, provided is a compound represented by the following general formula (I): [wherein Ar1 represents 2-methoxy-4-(2-pyridylmethoxy)phenyl etc. and Ar2 represents a 1H-indol-6-yl group etc.] or a salt thereof.
摘要翻译：提供了阿尔茨海默病的新型治疗方法。特别地，提供由以下通式（I）表示的化合物：[其中Ar 1表示2-甲氧基-4-（2-吡啶基甲氧基）苯基等，Ar 2表示1H-吲哚-6-基等] 或其盐。

17. 发明授权

US07884211B2 Dimeric small molecule potentiators of apoptosis 有权
标题翻译：二聚体小分子增强细胞凋亡
公开(公告)号：US07884211B2
公开(公告)日：2011-02-08
申请号：US12509218
申请日：2009-07-24
申请人： Patrick G. Harran , Xiaodong Wang , Jef K. De Brabander , Lin Li , Ranny Mathew Thomas , Hidetaka Suzuki
发明人： Patrick G. Harran , Xiaodong Wang , Jef K. De Brabander , Lin Li , Ranny Mathew Thomas , Hidetaka Suzuki
IPC分类号： C07D249/04 , A61K31/42
CPC分类号： C07D413/14 , A61K31/41 , A61K31/422 , C07D207/08 , C07D401/10 , C07D403/10 , C07D403/14 , C07D405/10 , C07D409/10 , C07D413/04 , C07D413/06 , C07D413/10 , C07D417/04 , C07D417/10 , C07D417/14 , C07D495/04 , C07K5/06026 , C07K5/06034
摘要： Caspase activity and apoptosis are promoted using active, dimeric Smac peptide mimetics of the general formula M1-L-M2, wherein moieties M1 and M2 are monomeric Smac mimetics and L is a covalent linker. Target cancerous or inflammatory cells are contacted with an effective amount of an active, dimeric Smac mimetic, and a resultant increase in apoptosis of the target cells is detected. The contacting step may be effected by administering to a pharmaceutical composition comprising a therapeutically effective amount of The compoundic mimetic, wherein the individual may be subject to concurrent or antecedent radiation or chemotherapy for treatment of a neoproliferative pathology.
摘要翻译：使用通式M1-L-M2的活性二聚体Smac肽模拟物促进胱天蛋白酶活性和凋亡，其中部分M1和M2是单体Smac模拟物，L是共价连接体。靶向癌性或炎性细胞与有效量的活性二聚体Smac模拟物接触，并且检测到靶细胞凋亡的最终增加。接触步骤可以通过给予包含治疗有效量的复合模拟物的药物组合物来实现，其中个体可以同时或先前放射或化疗用于治疗新生血管病变。

18. 发明授权

US07638544B2 Dimeric small molecule potentiators of apoptosis 有权
标题翻译：二聚体小分子增强细胞凋亡
公开(公告)号：US07638544B2
公开(公告)日：2009-12-29
申请号：US11958365
申请日：2007-12-17
申请人： Patrick G. Harran , Xiaodong Wang , Jef K. De Brabander , Lin Li , Ranny Mathew Thomas , Hidetaka Suzuki
发明人： Patrick G. Harran , Xiaodong Wang , Jef K. De Brabander , Lin Li , Ranny Mathew Thomas , Hidetaka Suzuki
IPC分类号： A61K31/42
CPC分类号： C07D413/14 , A61K31/41 , A61K31/422 , C07D207/08 , C07D401/10 , C07D403/10 , C07D403/14 , C07D405/10 , C07D409/10 , C07D413/04 , C07D413/06 , C07D413/10 , C07D417/04 , C07D417/10 , C07D417/14 , C07D495/04 , C07K5/06026 , C07K5/06034
摘要： Caspase activity and apoptosis are promoted using active, dimeric Smac peptide mimetics of the general formula M1-L-M2, wherein moieties M1 and M2 are monomeric Smac mimetics and L is a covalent linker. Target cancerous or inflammatory cells are contacted with an effective amount of an active, dimeric Smac mimetic, and a resultant increase in apoptosis of the target cells is detected. The contacting step may be effected by administering to a pharmaceutical composition comprising a therapeutically effective amount of the dimeric mimetic, wherein the individual may be subject to concurrent or antecedent radiation or chemotherapy for treatment of a neoproliferative pathology.
摘要翻译：使用通式M1-L-M2的活性二聚体Smac肽模拟物促进胱天蛋白酶活性和凋亡，其中部分M1和M2是单体Smac模拟物，L是共价连接体。靶向癌性或炎性细胞与有效量的活性二聚体Smac模拟物接触，并且检测到靶细胞凋亡的最终增加。接触步骤可以通过给包含治疗有效量的二聚模拟物的药物组合物施用，其中个体可以同时或先前放射或化学治疗用于治疗新生血管病变。

19. 发明申请

US20050197403A1 Dimeric small molecule potentiators of apoptosis 有权
标题翻译：二聚体小分子增强细胞凋亡
公开(公告)号：US20050197403A1
公开(公告)日：2005-09-08
申请号：US11070733
申请日：2005-03-01
申请人： Patrick Harran , Xiaodong Wang , Jef De Brabander , Lin Li , Ranny Thomas , Hidetaka Suzuki
发明人： Patrick Harran , Xiaodong Wang , Jef De Brabander , Lin Li , Ranny Thomas , Hidetaka Suzuki
IPC分类号： A61K31/165
CPC分类号： C07D413/14 , A61K31/41 , A61K31/422 , C07D207/08 , C07D401/10 , C07D403/10 , C07D403/14 , C07D405/10 , C07D409/10 , C07D413/04 , C07D413/06 , C07D413/10 , C07D417/04 , C07D417/10 , C07D417/14 , C07D495/04 , C07K5/06026 , C07K5/06034
摘要： Caspase activity and apoptosis are promoted using active, dimeric Smac peptide mimetics of the general formula M1-M2, wherein moieties M1 and M2 are monomeric Smac mimetics and L is a covalent linker. Target cancerous or inflammatory cells are contacted with an effective amount of an active, dimeric Smac mimetic, and a resultant increase in apoptosis of the target cells is detected. The contacting step may be effected by administering to a pharmaceutical composition comprising a therapeutically effective amount of the dimeric mimetic, wherein the individual may be subject to concurrent or antecedent radiation or chemotherapy for treatment of a neoproliferative pathology.
摘要翻译：使用通式M1-M2的活性二聚体Smac肽模拟物促进胱天蛋白酶活性和凋亡，其中部分M1和M2是单体Smac模拟物，L是共价连接体。靶向癌性或炎性细胞与有效量的活性二聚体Smac模拟物接触，并且检测到靶细胞凋亡的最终增加。接触步骤可以通过给包含治疗有效量的二聚模拟物的药物组合物施用，其中个体可以同时或先前放射或化学治疗用于治疗新生血管病变。

20. 发明授权

US5289184A Road map displaying system for automotive vehicle 失效
标题翻译：汽车道路图显示系统
公开(公告)号：US5289184A
公开(公告)日：1994-02-22
申请号：US836905
申请日：1992-02-19
申请人： Hidetaka Suzuki
发明人： Hidetaka Suzuki
IPC分类号： G01C21/00 , G08G1/0969 , G08G1/133 , G09B29/10 , G08G1/09
CPC分类号： G08G1/0969 , G08G1/133
摘要： A road map displaying system for an automotive vehicle for displaying road information transmitted by a radio beacon transmitter (1) on a display unit (6) of an automotive vehicle comprises: a radio receiver (3) for receiving road information including position data and traffic snarl data transmitted by the radio beacon transmitter; a memory unit (4) for storing various road maps; and a processing unit (5) for selecting a current road map on the basis of the received position data, displaying traffic snarl information on the selected road map on the basis of the received traffic snarl data, measuring time elapsed after the road information has been received, and in particular, deleting the traffic snarl information displayed on the selected road map, when a predetermined timer or distance-related condition is satisfied after the road information has been received. Since the old traffic snarl information can be deleted, a more reliable traffic information can be provided to the driver, without confusing the driver with the old road information.
摘要翻译：一种用于在汽车的显示单元（6）上显示由无线电信标发射机（1）发送的道路信息的机动车辆的路线图显示系统，包括：无线电接收机（3），用于接收包括位置数据和业务的道路信息由无线电信标发射机发送的咆哮数据; 存储单元（4），用于存储各种路线图; 以及处理单元（5），用于基于所接收的位置数据选择当前的道路图，基于接收的交通咆哮数据显示所选路线图上的交通咆哮信息，测量道路信息已经过去的时间并且特别地，当在接收到道路信息之后满足预定的定时器或距离相关条件时，删除显示在所选择的路线图上的交通咆哮信息。由于可以删除旧的交通咆哮信息，所以可以向驾驶员提供更可靠的交通信息，而不会使驾驶员与旧的道路信息混淆。

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