专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明授权

US07998972B2 1H-imidazo[4,5-c]quinoline derivatives in the treatment of protein kinase dependent diseases 有权
标题翻译： 1H-咪唑并[4,5-c]喹啉衍生物在治疗蛋白激酶依赖性疾病中的应用
公开(公告)号：US07998972B2
公开(公告)日：2011-08-16
申请号：US10515126
申请日：2003-05-20
申请人： Carlos Garcia-Echeverria , Hans-Georg Capraro , Pascal Furet
发明人： Carlos Garcia-Echeverria , Hans-Georg Capraro , Pascal Furet
IPC分类号： A61K31/4166 , A61K31/4188 , C07D471/04
CPC分类号： C07D471/04
摘要： The invention relates to the use of imidazoquinolines and salts thereof in the treatment of protein kinase dependent diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases, imidazoquinolines for use in the treatment of protein kinase dependent diseases, a method of treatment against said diseases, comprising administering the imidazoloquinolines to a warm-blooded animal, especially a human, pharmaceutical preparations comprising an imidazoquinoline, especially for the treatment of a protein kinase dependent disease, novel imidazoquinolines, and a process for the preparation of the novel imidazoquinolines.
摘要翻译：本发明涉及咪唑并喹啉及其盐在治疗蛋白激酶依赖性疾病中的用途，以及用于制备用于治疗所述疾病的药物制剂，用于治疗蛋白激酶依赖性疾病的咪唑并喹啉，所述疾病包括将咪唑并喹啉给予包含咪唑并喹啉的温血动物，特别是用于治疗蛋白激酶依赖性疾病的新型咪唑并喹啉的药物制剂，以及制备新的咪唑并喹啉的方法。

12. 发明申请

US20080261973A1 Sulphonamidoaniline Derivatives Being Janus Kinase Inhibitors 审中-公开
标题翻译：磺酰胺苯胺衍生物作为Janus激酶抑制剂
公开(公告)号：US20080261973A1
公开(公告)日：2008-10-23
申请号：US12158764
申请日：2006-12-20
申请人： Hans-Georg Capraro , Bernard Coupez , Pascal Furet , Paul W. Manley , Carole Pissot Soldermann
发明人： Hans-Georg Capraro , Bernard Coupez , Pascal Furet , Paul W. Manley , Carole Pissot Soldermann
IPC分类号： C07D473/32 , C07D487/04 , A61K31/52 , A61K31/5377
CPC分类号： C07D473/16 , C07D473/18 , C07D487/04 , C07D519/00
摘要： The invention relates to sulphonamidoanilines of formula I, wherein A is N or CH, W, X, Y and Z are N or CH under the proviso that at least one of the three symbols W, X and Y represent CH, R1 represents NR4R5 or OR4, wherein R4 represents optionally substituted alkyl, optionally substituted cycloalkyl optionally comprising one or two nitrogen or oxygen atoms, or substituted aryl, and R5 represents hydrogen or unsubstituted or substituted alky, or R4 and R5 together with the nitrogen to which they are attached represent an optionally substituted five- or six-membered nitrogen containing monocyclic ring, an optionally substituted nitrogen containing fully saturated bicyclic ring, or an spirocyclic fully saturated ring system containing one or two nitrogen atoms, R2 is hydrogen, lower alkenyl or alkyl, R3 is alkyl which is unsubstituted or mono-, di- or trisubstituted by halogen; alkenyl or aryl, and their salts; processes for their preparation, their application in the treatment of the human or animal body, the use thereof—alone or in combination with one or more other pharmaceutically active compounds—for the treatment of diseases, a method for the treatment of such a disease and the use of such a compound—alone or in combination with one or more other pharmaceutically active compounds—for the manufacture of a pharmaceutical preparation for the treatment of a proliferative disease.
摘要翻译：本发明涉及式I的磺酰氨基苯胺，其中A是N或CH，W，X，Y和Z是N或CH，条件是三个符号W，X和Y中的至少一个表示CH， 1表示NR 4 R 5或OR 4，其中R 4表示任选取代的烷基，任选包含一个或两个氮原子或氧原子的任选取代的环烷基或取代的芳基，R 5表示氢或未取代或取代的烷基，或R 4和R 3，与它们所连接的氮一起代表任选取代的五元或六元含氮单环，任选取代的含氮完全饱和双环，或含有一个或两个氮原子，R 2是氢，低级烯基或烷基，R 3是未被取代的或被卤素单 - ，二 - 或三取代的烷基; 烯基或芳基，及其盐; 其制备方法，它们在人体或动物体内的治疗中的应用，单独使用或与一种或多种其它药学活性化合物组合用于治疗疾病，治疗这种疾病的方法和使用这种化合物单独或与一种或多种其它药学活性化合物组合，用于制备用于治疗增殖性疾病的药物制剂。

13. 发明授权

US07326699B2 4-Amino-5-phenyl-7-cyclobutyl-pyrrolo(2,3-d)pyrimidine derivatives 失效
标题翻译： 4-氨基-5-苯基-7-环丁基 - 吡咯并（2,3-d）嘧啶衍生物
公开(公告)号：US07326699B2
公开(公告)日：2008-02-05
申请号：US10477594
申请日：2002-05-13
申请人： Hans-Georg Capraro , Pascal Furet , Carlos Garcia-Echeverria , Paul William Manley
发明人： Hans-Georg Capraro , Pascal Furet , Carlos Garcia-Echeverria , Paul William Manley
IPC分类号： C07D417/06 , C07D417/12 , C07D487/04 , C07D403/06 , C07D403/12 , C07D413/06 , C07D413/12 , A61K31/55 , A61K31/541 , A61K31/5355 , A61K31/497 , A61K31/519 , A61P35/04
CPC分类号： C07D487/04
摘要： The invention relates to new 4-amino-5-phenyl-7-cyclobutyl-pyrrolo[2,3-d]pyrimidine derivatives, processes for the preparation thereof, the application thereof in a process for the treatment of the human or animal body, the use thereof-alone or in combination with one or more other pharmaceutically active compounds-for the treatment of a disease, especially a proliferative disease, such as a tumour disease, a method for the treatment of such diseases in mammals, especially in humans, and the use of such a compound-alone or in combination with one or more other pharmaceutically active compounds-for the preparation of a pharmaceutical composition (medicament) for the treatment especially of a proliferative disease, such as a tumour.
摘要翻译：本发明涉及新的4-氨基-5-苯基-7-环丁基 - 吡咯并[2,3-d]嘧啶衍生物，其制备方法及其在治疗人或动物体的方法中的应用，其用途 - 单独使用或与一种或多种其它药学活性化合物组合用于治疗疾病，特别是增殖性疾病，例如肿瘤疾病，哺乳动物，特别是人类中的这些疾病的治疗方法，以及这种化合物单独使用或与一种或多种其它药学活性化合物组合的用途，用于制备特别是增殖性疾病如肿瘤的药物组合物（药物）。

14. 发明申请

US20050245562A1 1h-imidazo[4,5-c]quinoline derivatives in the treatment of protein kinase dependent diseases 有权
标题翻译： 1h-咪唑并[4,5-c]喹啉衍生物在治疗蛋白激酶依赖性疾病中的应用
公开(公告)号：US20050245562A1
公开(公告)日：2005-11-03
申请号：US10515126
申请日：2003-05-20
申请人： Carlos Garcia-Echeverria , Hans-Georg Capraro , Pascal Furet
发明人： Carlos Garcia-Echeverria , Hans-Georg Capraro , Pascal Furet
IPC分类号： A61K31/4745 , A61P13/08 , A61P17/06 , A61P35/00 , A61P35/02 , A61P43/00 , C07D471/04
CPC分类号： C07D471/04
摘要： The invention relates to the use of imidazoquinolines and salts thereof in the treatment of protein kinase dependent diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases, imidazoquinolines for use in the treatment of protein kinase dependent diseases, a method of treatment against said diseases, comprising administering the imidazoloquinolines to a warm-blooded animal, especially a human, pharmaceutical preparations comprising an imidazoquinoline, especially for the treatment of a protein kinase dependent disease, novel imidazoquinolines, and a process for the preparation of the novel imidazoquinolines.
摘要翻译：本发明涉及咪唑并喹啉及其盐在治疗蛋白激酶依赖性疾病中的用途，以及用于制备用于治疗所述疾病的药物制剂，用于治疗蛋白激酶依赖性疾病的咪唑并喹啉，所述疾病包括将咪唑并喹啉给予包含咪唑并喹啉的温血动物，特别是用于治疗蛋白激酶依赖性疾病的新型咪唑并喹啉的药物制剂，以及制备新的咪唑并喹啉的方法。

15. 发明授权

US08026247B2 Bicyclic amides as kinase inhibitors 有权
标题翻译：双环酰胺作为激酶抑制剂
公开(公告)号：US08026247B2
公开(公告)日：2011-09-27
申请号：US11575025
申请日：2005-09-14
申请人： Guido Bold , Hans-Georg Capraro , Giorgio Caravatti , Andreas Floersheimer , Pascal Furet , Paul W. Manley , Andrea Vaupel
发明人： Guido Bold , Hans-Georg Capraro , Giorgio Caravatti , Andreas Floersheimer , Pascal Furet , Paul W. Manley , Andrea Vaupel
IPC分类号： C07D239/46 , C07D403/12 , C07D413/12 , A61K31/505
CPC分类号： C07D239/47 , C07D403/12 , C07D413/12
摘要： The invention relates to compounds of formula (I) and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising a compound of formula I and to the use of a compound of formula I for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of proliferative diseases, such as in particular tumour diseases.
摘要翻译：本发明涉及式（I）化合物及其在治疗动物或人体中的用途，包括式I化合物的药物组合物和式I化合物在制备药物组合物中的用途用于治疗蛋白激酶依赖性疾病，特别是增殖性疾病，特别是肿瘤疾病。

16. 发明申请

US20080287427A1 Bicyclic Amides as Kinase Inhibitors 有权
标题翻译：双环酰胺作为激酶抑制剂
公开(公告)号：US20080287427A1
公开(公告)日：2008-11-20
申请号：US11575025
申请日：2005-09-14
申请人： Guido Bold , Hans-Georg Capraro , Giorgio Caravatti , Andreas Floersheimer , Pascal Furet , Paul W. Manley , Andreas Vaupel , Carole Pissot Soldermann , Francois Gessier , Christian Schnell , Amanda Jane Littlewood-Evans , Prasad Koteswara Kapa , Joginder S. Bajwa , Xinglong Jiang
发明人： Guido Bold , Hans-Georg Capraro , Giorgio Caravatti , Andreas Floersheimer , Pascal Furet , Paul W. Manley , Andreas Vaupel , Carole Pissot Soldermann , Francois Gessier , Christian Schnell , Amanda Jane Littlewood-Evans , Prasad Koteswara Kapa , Joginder S. Bajwa , Xinglong Jiang
IPC分类号： A61K31/5377 , C07D403/12 , A61K31/506 , C07D213/72 , C07D413/02
CPC分类号： C07D239/47 , C07D403/12 , C07D413/12
摘要： The invention relates to compounds of formula (I) and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising en a compound of formula I and to the use of a compound of formula I for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of proliferative diseases, such as in particular tumour diseases.
摘要翻译：本发明涉及式（I）化合物及其在治疗动物或人体中的用途，包括式I化合物的药物组合物和式I化合物在制备药物组合物中的用途用于治疗蛋白激酶依赖性疾病，特别是增殖性疾病，特别是肿瘤疾病。

17. 发明申请

US20070213355A1 1H-Imidazo[4,5-C]Quinoline Derivatives in the Treatment of Protein Kinase Dependent Diseases 审中-公开
标题翻译： 1H-咪唑并[4,5-C]喹啉衍生物在治疗蛋白激酶依赖性疾病中的应用
公开(公告)号：US20070213355A1
公开(公告)日：2007-09-13
申请号：US10579876
申请日：2004-11-19
申请人： Hans-Georg Capraro , Pascal Furet , Carlos Garcia-Cheverria , Frederic Stauffer
发明人： Hans-Georg Capraro , Pascal Furet , Carlos Garcia-Cheverria , Frederic Stauffer
IPC分类号： A61K31/437 , C07D471/04
CPC分类号： C07D471/04 , A61K31/41
摘要： The invention relates to the use of imidazoquinolines and salts thereof in the treatment of protein kinase dependent diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases, imidazoquinolines for use in the treatment of protein kinase dependent diseases, a method of treatment against said diseases, comprising administering the imidazoquinolines to a warm-blooded animal, especially a human, pharmaceutical preparations comprising an imidazoquinoline, especially for the treatment of a protein kinase dependent disease, novel imidazoquinolines, and a process for the preparation of the novel imidazoquinolines.
摘要翻译：本发明涉及咪唑并喹啉及其盐在治疗蛋白激酶依赖性疾病中的用途，以及用于制备用于治疗所述疾病的药物制剂，用于治疗蛋白激酶依赖性疾病的咪唑并喹啉，所述疾病包括向包含咪唑并喹啉的温血动物，特别是用于治疗蛋白激酶依赖性疾病的新型咪唑并喹啉的温血动物，特别是人的药物制剂，以及制备新的咪唑并喹啉的方法施用咪唑并喹啉。

18. 发明授权

US07390805B2 4-amino-6-phenyl-pyrrolo[2,3-d]pyrimidine derivatives 失效
标题翻译： 4-氨基-6-苯基 - 吡咯并[2,3-d]嘧啶衍生物
公开(公告)号：US07390805B2
公开(公告)日：2008-06-24
申请号：US11686023
申请日：2007-03-14
申请人： Guido Bold , Hans-Georg Capraro , Giorgio Caravatti , Peter Traxler
发明人： Guido Bold , Hans-Georg Capraro , Giorgio Caravatti , Peter Traxler
IPC分类号： C07D413/10 , C07D487/04 , A61K31/519 , A61K31/5377 , A61K31/497 , A06P35/04
CPC分类号： C07D487/04
摘要： The invention relates to 7H-pyrrolo[2,3-d]pyrimidine derivatives of formula I wherein the symbols and substituents are as defined in the description, to processes for the preparation thereof, to pharmaceutical compositions comprising such derivatives and to the use of such derivatives—alone or in combination with one or more other pharmaceutically active compounds—for the preparation of pharmaceutical compositions for the treatment especially of a proliferative disease, such as a tumour.
摘要翻译：本发明涉及式I的7H-吡咯并[2,3-d]嘧啶衍生物，其中符号和取代基如说明书中所定义，其制备方法，包含该衍生物的药物组合物及其用途衍生物 - 单独或与一种或多种其它药学活性化合物组合 - 用于制备用于治疗特别是增殖性疾病如肿瘤的药物组合物。

19. 发明授权

US06225345B1 Azahexane derivatives as substrate isosters of retroviral asparate proteases 失效
标题翻译：氮杂己烷衍生物作为逆转录病毒天冬氨酸蛋白酶的底物等价物
公开(公告)号：US06225345B1
公开(公告)日：2001-05-01
申请号：US09068876
申请日：1998-05-21
申请人： Alexander Fässler , Guido Bold , Hans-Georg Capraro , Marc Lang
发明人： Alexander Fässler , Guido Bold , Hans-Georg Capraro , Marc Lang
IPC分类号： A61K3127
CPC分类号： C07C271/22 , Y10S514/934
摘要： The invention relates to compounds of formula (I): wherein R1 and R10 are each independently of the other lower alkoxycarbonyl; either R2, R3 and R4 are each independently of the other C1-C4alkyl and R7, R8 and R9 are each selected from hydrogen and C1-C4alkyl, with not more than 2 of the radicals being hydrogen; or R7, R8 and R9 are each independently of the other C1-C4alkyl and R2, R3 and R4 are each selected from hydrogen and C1-C4alkyl, with 1 or 2 of the radicals being hydrogen; R5 is phenyl or cyclohexyl; and R6 is phenyl or cyanophenyl; or salts thereof; those compounds are inhibitors of retroviral aspartate proteases and are effective, for example, against HIV.
摘要翻译：本发明涉及式（I）化合物：其中R 1和R 10各自独立地为低级烷氧基羰基; R 2，R 3和R 4各自独立地为C 1 -C 4烷基，R 7，R 8和R 9各自选自氢和C 1 -C 4烷基，不超过2个基团为氢; 或R 7，R 8和R 9各自独立地为C 1 -C 4烷基，R 2，R 3和R 4各自选自氢和C 1 -C 4烷基，其中1或2个是氢; R5是苯基或环己基; R6为苯基或氰基苯基; 或其盐; 这些化合物是逆转录病毒天冬氨酸蛋白酶的抑制剂，并且是有效的，例如针对HIV。

20. 发明授权

US5935976A Antiviral ethers of aspartate protease substrate isosteres 失效
标题翻译：天冬氨酸蛋白酶底物等位基因的抗病毒醚
公开(公告)号：US5935976A
公开(公告)日：1999-08-10
申请号：US138076
申请日：1998-08-21
申请人： Guido Bold , Hans-Georg Capraro , Alexander Fassler , Marc Lang , Shripad Subray Bhagwat , Satish Chandra Khanna , Janis Karlis Lazdins , Jurgen Mestan
发明人： Guido Bold , Hans-Georg Capraro , Alexander Fassler , Marc Lang , Shripad Subray Bhagwat , Satish Chandra Khanna , Janis Karlis Lazdins , Jurgen Mestan
IPC分类号： C07D295/12 , A61K31/075 , A61K31/16 , A61K31/165 , A61K31/275 , A61K31/325 , A61K31/35 , A61K31/351 , A61K31/352 , A61K31/395 , A61K31/425 , A61K31/426 , A61K31/44 , A61K31/4406 , A61K31/4418 , A61K31/4427 , A61K31/445 , A61K31/47 , A61K31/495 , A61K31/535 , A61K31/5375 , A61K31/695 , A61K38/05 , A61P31/12 , A61P31/18 , C07C237/22 , C07C255/60 , C07C271/22 , C07C311/19 , C07C311/42 , C07C317/50 , C07D207/12 , C07D207/16 , C07D207/26 , C07D207/28 , C07D209/18 , C07D209/42 , C07D211/40 , C07D211/46 , C07D211/48 , C07D211/60 , C07D211/62 , C07D213/30 , C07D213/65 , C07D213/81 , C07D213/82 , C07D277/06 , C07D277/20 , C07D277/40 , C07D277/56 , C07D295/155 , C07D295/215 , C07D307/20 , C07D307/33 , C07D309/04 , C07D309/12 , C07D311/24 , C07D317/60 , C07D401/04 , C07K5/00
CPC分类号： C07D207/26 , A61K31/47 , A61K31/495 , C07C255/60 , C07C271/22 , C07C311/19 , C07C311/42 , C07C317/50 , C07D207/28 , C07D209/42 , C07D211/46 , C07D211/62 , C07D213/30 , C07D213/82 , C07D277/06 , C07D277/40 , C07D295/155 , C07D307/20 , C07D309/04 , C07D309/12 , C07D311/24 , C07D317/60 , C07C2101/14 , C07C2102/10
摘要： Antiretroviral compounds (which are effective, for example, against HIV) of the formula I ##STR1## in which R.sub.1 is an acyl radical lower-alkoxy-lower-alkanoyl whose lower alkoxy radical is unsubstituted or is substituted by halogen, phenyl, lower alkoxy or a heterocyclic radical selected from piperidinyl, pyrrolidinyl, tetrahydropyranyl, tetrahydrofuranyl, thiazolidinyl, thiazolyl, indolyl or 4H-1-benzopyranyl which is unsubstituted or substituted by oxo, hydroxyl, amino, lower alkyl, lower-alkoxycarbonyl and/or phenyl-lower-alkoxycarbonyl; lower alkanoyl which is unsubstituted or is substituted by one of the said unsubstituted or substituted heterocyclic radicals; arylcarbonyl or heterocyclylcarbonyl which are substituted by heterocyclyl or heterocyclyl-lower-alkyl; phenyl-lower-alkanoyl which is substituted by hydroxyl and lower alkyl; or arylsulfonyl;or the residue of an amino acid which is defined in accordance with the description (and which may be acylated on the amino nitrogen by one of the abovementioned acyl radicals);R.sub.2 and R.sub.3 are in each case cyclohexyl, cyclohexenyl, phenyl, naphthyl or tetrahydronaphthyl which are unsubstituted or substituted by lower alkyl, phenyl, cyanophenyl, phenyl-lower-alkyl, halogen, halo-lower-alkyl, cyano, hydroxyl, lower alkoxy, phenyl-lower-alkoxyl, pyridyl-lower-alkoxy, lower-alkoxy-lower-alkoxy, lower-alkoxycarbonyl-lower-alkoxy, carboxyl-lower-alkoxy, hydroxyl-lower-alkoxy, carbamoyl-lower-alkoxy, cyano-lower-alkoxy, and phenyl-lower-alkanesulfonyl which is unsubstituted or substituted by halogen;R.sub.4 is lower alkyl, cyclohexyl or phenyl; and R.sub.5 is lower alkyl; and n is 1 or 2,or salts thereof, are novel.
摘要翻译：其中R1是其低级烷氧基未被取代或被卤素，苯基，低级烷氧基或杂环取代的酰基低级烷氧基 - 低级 - 烷酰基的抗逆转录酶病毒化合物（其例如抗HIV）选自哌啶基，吡咯烷基，四氢吡喃基，四氢呋喃基，噻唑烷基，噻唑基，吲哚基或4H-1-苯并吡喃基，其未被取代或被氧代，羟基，氨基，低级烷基，低级烷氧基羰基和/或苯基 - 低级 - 烷氧基羰基取代。低级烷酰基，其未被取代或被所述未取代或取代的杂环基之一取代; 被杂环基或杂环基 - 低级烷基取代的芳基羰基或杂环基羰基; 被羟基和低级烷基取代的苯基 - 低级 - 烷酰基; 或芳基磺酰基; 或根据描述定义的氨基酸的残基（并且可以通过上述酰基之一在氨基氮上酰化）; 苯基，氰基苯基，苯基 - 低级 - 烷基，卤素，卤代低级烷基，氰基，羟基，低级烷氧基，低级烷氧基，低级烷氧基，低级烷氧基，低级烷氧基，低级烷氧基 - 低级烷氧基，低级烷氧基 - 低级 - 烷氧基，低级烷氧基 - 低级 - 烷氧基，羧基 - 低级 - 烷氧基，羟基 - 低级 - 烷氧基，氨基甲酰基 - 低级烷氧基，烷氧基和未被卤素取代的苯基 - 低级烷基磺酰基; R4是低级烷基，环己基或苯基; R5为低级烷基; n为1或2，或其盐为新颖的。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式